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天然化合物

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カタログ番号	製品名	別名	ターゲット
T2176	2,3-Butanedione 2-Monoxime	Diacetyl monoxime,2,3-Butanedione-2-monoxime	Akt
	2,3-Butanedione 2-Monoxime (Diacetyl monoxime) is an inhibitor of skeletal and cardiac muscle contraction.		Akt
T4054	Dantrolene sodium hemiheptahydrate	Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,Sodium dantrolene	Calcium Channel , Autophagy
	Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from t...		Calcium Channel , Autophagy
T25719	Lidamidine	Lidamidina,Lidamidinum	Others
	Lidamidine (Lidamidinum) is an effective antidiarrheal agent that inhibits intestinal secretion, reduces intestinal transit, and inhibits smooth muscle contraction.		Others
T25372	EMD57033	EMD-57033,(+)-EMD 57033,EMD 57033	Calcium Channel , Carbonic Anhydrase
	EMD57033 is a cardiac troponin C (cTnC) activator, a dominant Ca2+ sensitizer, which functions by binding to cardiac/slow skeletal troponin C heterodimers to promote cardiac contraction.		Calcium Channel , Carbonic Anhydrase
T34280	Regrelor disodium	INS-50589,INS50589,Regrelor sodium,Regrelor,INS 50589	P2Y Receptor
	Regrelor disodium (INS 50589) is a p2y12 receptor antagonist that prevents thrombosis, effectively inhibits vascular smooth muscle cell contraction, inhibits cell proliferation, and reduces inflammation.		P2Y Receptor
TP2419	V-9-M Cholecystokinin nonapeptide	V 9 M,Prepro CCK Fragment V-9-M,Val-pro-val-glu-ala-val-asp-pro-met,Cholecystokinin Precursor (24-32),V9M,V-9-M	Beta Amyloid
	V-9-M Cholecystokinin nonapeptide (Prepro CCK Fragment V-9-M) is a precursor compound of cholecystokinin (CCK). Cholecystokinin (CCK) is a brain-intestinal peptide that stimulates gallbladder contraction and pancreatic e...		Beta Amyloid
T28164	Nexopamil	LU49938,LU 49938,LU-49938	Calcium Channel , 5-HT Receptor
	Nexopamil (LU-49938) is a calcium channel antagonist and a 5-hydroxytryptamine 2A receptor antagonist. Nexopamil inhibits 5-HT-induced contraction and proliferation of mesenchymal cells.		Calcium Channel , 5-HT Receptor
TP1883	[Lys5,MeLeu9,Nle10]-NKA(4-10)		Neurokinin receptor
	Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).		Neurokinin receptor
TP2036L	DPDPE TFA (88373-73-3 free base)	DPDPE TFA	Opioid Receptor
	DPDPE TFA is selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2 nM), and is antinociceptive in vivo.		Opioid Receptor
T10101	Calcium channel-modulator-1		Others , Calcium Channel
	Calcium channel-modulator-1 is a calcium channel-modulator (IC50:0.8 μM) with specialisation to block aortic constriction.		Others , Calcium Channel
T1215	Nicardipine hydrochloride	RS-69216,Nicardipine HCl,YC-93 Hydrochloride	Calcium Channel , Adrenergic Receptor , AChR , Autophagy
	Nicardipine hydrochloride (YC-93 Hydrochloride) is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine Family) blocks cal...		Calcium Channel , Adrenergic Receptor , AChR , Autophagy
T6625	Ozagrel hydrochloride	Ozagrel HCl,OKY-046 HCl	Thrombin , Prostaglandin Receptor
	Ozagrel hydrochloride (OKY-046 HCl) is a selective thromboxane A(2) synthetase inhibitor used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.		Thrombin , Prostaglandin Receptor
TP1198	Sincalide ammonium	SQ19844 ammonium,CCK-8 ammonium,Cholecystokinin octapeptide ammonium	cholecystokinin
	Sincalide ammonium (CCK-8 ammonium) is a potent analog of the amino acid peptide hormone cholecystokinin (CCK), an active fragment that retains much of the biological activity of CCK.Sincalide ammonium promotes bile secr...		cholecystokinin
T6236	Ozagrel	OKY-046,Domenan	Thrombin , Prostaglandin Receptor
	Ozagrel (Domenan) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral isch...		Thrombin , Prostaglandin Receptor
T11918L	Lysipressin acetate(50-57-7(fb_acetate))	Lysine vasopressin acetate,[Lys8]-Vasopressin acetate	Others
	Lysipressin acetate(50-57-7(fb_acetate)) ([Lys8]-Vasopressin acetate) , Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase. Lysipressin is Antidiuretic hormone that have been foun...		Others
T5856	Barnidipine hydrochloride	YM-09730-5 hydrochloride,Mepirodipine (hydrochloride)	Calcium Channel
	Barnidipine hydrochloride (YM-09730-5 hydrochloride) is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery		Calcium Channel
T4132	BPTU	BMS-646786	P2Y Receptor
	BPTU (BMS-646786) is an allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibition of spontaneous contraction of rat and mouse colon induced...		P2Y Receptor
TP2279L	Obestatin (rat) acetate		GHSR
	Obestatin (rat) acetate is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin (rat) acetate has anti-inflammatory, anti-myocardial infarction and antioxidant properties. Obestatin (rat) acetate supp...		GHSR
T0077	Dantrolene sodium	Lapatinib ditosylate monohydrate,Dantrolene sodium salt	Others , Calcium Channel
	Dantrolene sodium (Lapatinib ditosylate monohydrate) salt is a skeletal muscle relaxant and can interfere with excitation-contraction coupling in the muscle fiber. It is used for the treatment of spasticity and other neu...		Others , Calcium Channel
T1613	Hydralazine hydrochloride	Hydralazine HCl,Apresoline	MAO , HIF/HIF Prolyl-Hydroxylase
	Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release an...		MAO , HIF/HIF Prolyl-Hydroxylase
T72038	YM-58790	YM-58790 free base	AChR
	YM-58790 free base is a potent mAChR antagonist.YM-58790 free base inhibited M1 mAChR, M2 mAChR, and M3 mAChR with Ki values of 28 nM, 260 nM, and 15 nM, respectively.YM-58790 free base inhibits reflex rhythmic bladder c...		AChR
TP2106L	Urantide acetate(669089-53-6 free base)		Neurotensin Receptor
	Urantide acetate is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced ...		Neurotensin Receptor
T2525	Alosetron hydrochloride	Lotronex,GR 68755C,GR 68755,GR 68755X	5-HT Receptor
	Alosetron hydrochloride (GR 68755) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system,...		5-HT Receptor
T1115	Doxylamine succinate	Decapryn	Histamine Receptor
	Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and ...		Histamine Receptor
T68123	Oxodipine		Calcium Channel
	Oxodipine, a dihydropyridine-type calcium antagonist , inhibited KCl-induced aortic contraction in rabbits and reduced cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventri...		Calcium Channel
T1139	Salbutamol	Albuterol,AH-3365	Adrenergic Receptor
	Salbutamol (Albuterol) stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3', 5'-adenosine monophosphate (cAMP). Salbutamol ...		Adrenergic Receptor
T21610	Bradykinin (acetate)		Bradykinin Receptor
	Bradykinin (acetate) is an active peptide that is generated by the kallikrein-kinin system. It is a inflammatory mediator and also recognized as a neuromediator and regulator of several vascular and renal functions. Enzy...		Bradykinin Receptor
T1577	Midodrine hydrochloride	Pro-Amatine	Adrenergic Receptor
	Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This c...		Adrenergic Receptor
T6707	Tiotropium Bromide hydrate	BA-679 BR hydrate,BA 679BR	AChR
	Tiotropium Bromide hydrate (BA-679 BR hydrate) is a potent anticholinergic and bronchodilator, serving as a muscarinic receptor antagonist, specifically targeting mAChR. It is developed for treating chronic obstructive a...		AChR
T27364	FR 75513	FR-75513,FR75513
	FR 75513 inhibits the contraction of guinea pig detrusor muscle .
TP1098	Motilin, canine	Motilin (canine)
	Motilin canine, a 22-amino acid peptide, functions as a robust gastrointestinal smooth muscle contraction agonist.
T27829	Lidamidine Hydrochloride	WHR1142A,WHR-1142A,Lidaral,WHR 1142A
	Lidamidine Hydrochloride is an alpha2-adrenergic receptor agonist. Lidamidine Hydrochloride inhibits intestinal secretion, reduces intestinal transit, and inhibits smooth muscle contraction.
T68882	Clodanolene sodium
	Clodanolene sodium is a skeletal muscle contraction antagonist.
T71579	GOE-5438
	GOE-5438 is a calcium antagonist that has been shown to inhibit the excitation and contraction of single cardiomyocytes.
T70917	NA 0362
	NA 0362 is a derivative of SF 2370 that inhibits smooth muscle contraction.
T71443	Amphidinolide D
	Amphidinolide D is a powerful activator of actomyosin ATPase enhances skeletal muscle contraction.
T34458	Ryanodol
	Ryanodol is a complex diterpenoid that modulates intracellular calcium-ion release at ryanodine receptors, ion channels critical for skeletal and cardiac muscle excitation-contraction coupling and synaptic transmission.
T23739	Antho-riamide I
	Antho-Riamide I is an active peptide. It also inhibits the spontaneous contraction of sea anemone muscles.
T26970	CD-349	CD 349,CD349
	CD-349 is a calcium channel antagonist. CD-349 inhibits the noradrenaline (NA)-induced contraction of aortas in Ca2(+)-free medium.
T40563	Sandaracopimaric acid
	Sandaracopimaric acid is an anti-inflammatory diterpenoid compound that effectively reduces the contraction of phenylephrine-induced pulmonary arteries. With an EC50 of 43.93 μM, it exhibits noteworthy anti-inflammatory ...
T68698	VPC 23153
	VPC 23153 is a sphingosine 1-phosphate 4 receptor agonist. This hygroscopic phospholipid causes contraction of pulmonary artries in rats.
T27164	DHP-218	PAK-9,PAK9,PAK 9,DHP218
	DHP-218 is a calcium channel antagonist. DHP-218 inhibits Calcium-induced contraction of the rat aorta in high K+ solution with the pA2 value of 9.11. The IC50 value for the inhibitory effects of DHP-218 in high K+-induc...
T11629	Ifenprodil glucuronide		Others
	Ifenprodil glucuronide, a derivative of Ifenprodil, is a vasodilator and an inhibitor of platelet aggregation. In contrast to Ifenprodil, Ifenprodil glucuronide does not affect platelet aggregation nor arterial contracti...		Others
T71021	Fendiline
	Fendiline is a coronary vasodilator that inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as an antiarrhythmic and antianginal agent.
T34762	T-0201	T 0201,TA0201,TA-0201,TA 0201
	T-0201 (TA 0201) is a highly potent, long-acting, orally active, and selective ETA receptor antagonist. T-0201 also inhibited ET-1-induced pulmonary artery contraction in isolated rabbits.
T37493	11-trans Leukotriene D4	11-trans Leukotriene D4
	11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency fo...
T78030	GRGESP
	GRGESP is a collagen gel contraction inhibitor that impedes the spreading of human fibroblasts within collagen gels and significantly reduces gel contraction, thus serving as a valuable agent for research in connective t...
TP1224	[Sar1, Ile8]-Angiotensin II TFA	Angiotensin 2 TFA,AngiotensinII TFA
	[Sar1, Ile8]-Angiotensin II (TFA) is a peptide compound that exerts various effects on vascular smooth muscle. These effects include the contraction of normal arteries as well as the hypertrophy or hyperplasia of culture...
T11918	Lysipressin	Lysine vasopressin,[Lys8]-Vasopressin	Others
	Lysipressin ([Lys8]-Vasopressin), Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase. Lysipressin is Antidiuretic hormone that have been found in pigs and some marsupial families.		Others
T34958	TRK-380	TAC301,TAC 301,TAC-301,TRK 380,TRK380
	TRK-380 (TAC-301) is an effective and selective β3-adrenergic receptor agonist. TRK-380 improves formalin-induced frequent urination in rats and carbachol-induced bladder contraction in dogs (a decrease of 37.6%).

Compounds

2,3-Butanedione 2-Monoxime

T2176

Synonym: Diacetyl monoxime,2,3-Butanedione-2-monoxime

Target: Akt

Dantrolene sodium hemiheptahydrate

T4054

Synonym: Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,Sodium dantrolene

Target: Calcium Channel, Autophagy

Lidamidine

T25719

Synonym: Lidamidina,Lidamidinum

Target: Others

EMD57033

T25372

Synonym: EMD-57033,(+)-EMD 57033,EMD 57033

Target: Calcium Channel, Carbonic Anhydrase

Regrelor disodium

T34280

Synonym: INS-50589,INS50589,Regrelor sodium,Regrelor,INS 50589

Target: P2Y Receptor

V-9-M Cholecystokinin nonapeptide

TP2419

Synonym: V 9 M,Prepro CCK Fragment V-9-M,Val-pro-val-glu-ala-val-asp-pro-met,Cholecystokinin Precursor (24-32),V9M,V-9-M

Target: Beta Amyloid

Nexopamil

T28164

Synonym: LU49938,LU 49938,LU-49938

Target: Calcium Channel, 5-HT Receptor

[Lys5,MeLeu9,Nle10]-NKA(4-10)

TP1883

Synonym:

Target: Neurokinin receptor

DPDPE TFA (88373-73-3 free base)

TP2036L

Synonym: DPDPE TFA

Target: Opioid Receptor

Calcium channel-modulator-1

T10101

Synonym:

Target: Others, Calcium Channel

Nicardipine hydrochloride

T1215

Synonym: RS-69216,Nicardipine HCl,YC-93 Hydrochloride

Target: Calcium Channel, Adrenergic Receptor, AChR, Autophagy

Ozagrel hydrochloride

T6625

Synonym: Ozagrel HCl,OKY-046 HCl

Target: Thrombin, Prostaglandin Receptor

Sincalide ammonium

TP1198

Synonym: SQ19844 ammonium,CCK-8 ammonium,Cholecystokinin octapeptide ammonium

Target: cholecystokinin

Ozagrel

T6236

Synonym: OKY-046,Domenan

Target: Thrombin, Prostaglandin Receptor

Lysipressin acetate(50-57-7(fb_acetate))

T11918L

Synonym: Lysine vasopressin acetate,[Lys8]-Vasopressin acetate

Target: Others

Barnidipine hydrochloride

T5856

Synonym: YM-09730-5 hydrochloride,Mepirodipine (hydrochloride)

Target: Calcium Channel

Obestatin (rat) acetate

Synonym: Lapatinib ditosylate monohydrate,Dantrolene sodium salt

Target: Others, Calcium Channel

Hydralazine hydrochloride

T1613

Synonym: Hydralazine HCl,Apresoline

Target: MAO, HIF/HIF Prolyl-Hydroxylase

YM-58790

T72038

Synonym: YM-58790 free base

Target: AChR

Urantide acetate(669089-53-6 free base)

TP2106L

Synonym:

Target: Neurotensin Receptor

Alosetron hydrochloride

T2525

Synonym: Lotronex,GR 68755C,GR 68755,GR 68755X

Target: 5-HT Receptor

Doxylamine succinate

T1115

Synonym: Decapryn

Target: Histamine Receptor

Oxodipine

T68123

Synonym:

Target: Calcium Channel

Salbutamol

T1139

Synonym: Albuterol,AH-3365

Target: Adrenergic Receptor

Bradykinin (acetate)

T21610

Synonym:

Target: Bradykinin Receptor

Midodrine hydrochloride

T1577

Synonym: Pro-Amatine

Target: Adrenergic Receptor

Tiotropium Bromide hydrate

T6707

Synonym: BA-679 BR hydrate,BA 679BR

Target: AChR

FR 75513

T27364

Synonym: FR-75513,FR75513

Target:

Motilin, canine

TP1098

Synonym: Motilin (canine)

Target:

Lidamidine Hydrochloride

T27829

Synonym: WHR1142A,WHR-1142A,Lidaral,WHR 1142A

Synonym: CD 349,CD349

Target:

Sandaracopimaric acid

Synonym: PAK-9,PAK9,PAK 9,DHP218

Target:

Ifenprodil glucuronide

Synonym: T 0201,TA0201,TA-0201,TA 0201

Target:

11-trans Leukotriene D4

T37493

Synonym: 11-trans Leukotriene D4

[Sar1, Ile8]-Angiotensin II TFA

TP1224

Synonym: Angiotensin 2 TFA,AngiotensinII TFA

Target:

Lysipressin

T11918

Synonym: Lysine vasopressin,[Lys8]-Vasopressin

Target: Others

TRK-380

T34958

Synonym: TAC301,TAC 301,TAC-301,TRK 380,TRK380

Target:

カタログ番号	製品名	別名	ターゲット
T14865	Carboprost tromethamine		Prostaglandin Receptor
	Carboprost tromethamine, a synthetic 15-methyl analogue of prostaglandin F2α, effectively promotes uterine contractions and significantly reduces bleeding during and post-delivery.		Prostaglandin Receptor
T3A2467	Allocryptopine	Thalictrimine,Fagarine I	Potassium Channel
	Allocryptopine (Thalictrimine) induces muscle contraction and relaxation in urinary bladder and ileum, respectively.		Potassium Channel
T6S0109	Sipeimine	Kashmirine,Imperialine	Others
	1. Sipeimine (Kashmirine) has antiasthmatic effect, on tracheal M receptor antagonist. 2. Sipeimine can make Kaba cholinergic induced contraction of tracheal strips of the dose-response curve to the right.		Others
T20604L	Litorin acetate(55749-97-8 Free base)		Bombesin Receptor
	Litorin acetate, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. It stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the n...		Bombesin Receptor
T4739	Sodium creatine phosphate dibasic tetrahydrate	Creatine phosphate disodium salt tetrahydrate	Others , Endogenous Metabolite
	Sodium creatine phosphate dibasic tetrahydrate (Creatine phosphate disodium salt tetrahydrate) mainly exists in the skeletal muscles of vertebrates. It is a substrate for the determination of creatine kinase and can be u...		Others , Endogenous Metabolite
T5014	Prostaglandin E2	PGE2,Dinoprostone,Prostaglandin E2 (PGE2)	Endogenous Metabolite , Prostaglandin Receptor
	Prostaglandin E2 (PGE2) is a naturally occurring hormone involved in a variety of physiological processes in the body, including smooth muscle contraction and relaxation, regulation of vasodilatation and constriction, re...		Endogenous Metabolite , Prostaglandin Receptor
T7995	α-Angelica lactone	Alpha-Angelica Lactone	Others , GST
	α-Angelica lactone has cardiotonic activity, may exert their effects by providing an increased contraction-dependent calcium pool to be released upon systolic depolarization.		Others , GST
TN1528	Cotoin		AChE
	Cotoin is a natural product isolated from the stem bark of Garcinia virgate.Cotoin has antispasmodic activity and reduces the tone and contraction of isolated rabbit intestine. It partially inhibits the effects of acetyl...		AChE
T4S0998	Trifolirhizin		TNF , Tyrosinase
	Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolirhizin possesses potential anti-inflammatory and anti-cancer ...		TNF , Tyrosinase
T0962	L-Hyoscyamine	Daturine,Hyoscyamine	AChR
	L-Hyoscyamine (Daturine) functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as w...		AChR
T4S1619	L-Hyoscyamine sulfate	Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate	AChR
	L-Hyoscyamine sulfate (Levsin Sulfate) is the sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits ...		AChR
T3229	Cytochalasin D		ATPase , p38 MAPK , Calcium Channel , Akt , PI3K
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head dec...		ATPase , p38 MAPK , Calcium Channel , Akt , PI3K
TN4484	Macrophylline		Others
	Macrophylline A shows weak inhibitory action on KCl-induced contraction.		Others
T20604	Litorin
	Litorin, an amphibian bombesin peptide derivative, is found to suppress the nutriment, to stimulate the contraction of smooth muscle, to stimulate gastrin, gastric acid, and pancreatic secretion.
TN4812	Pluviatolide		AChR
	(-)-Pluviatolide can inhibit electrically-induced and acetylcholine-induced contraction in the isolated guinea-pig ileum.		AChR
TN4051	Fargesone B		cAMP , Calcium Channel
	Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium influxes in a nonselective manner.		cAMP , Calcium Channel
TN4713	Onitisin		5-HT Receptor
	Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum.		5-HT Receptor
T10913	Cyclobuxine D		Others
	Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclostatin D has obvious bradycardia effect on rat heart, and inhibits acetylcholine and Ba ++ induced longitudinal muscle contraction isolated fro...		Others
T38609	Mycalolide B
	Mycalolide-B is a marine sponge-derived compound that functions as a selective inhibitor of actomyosin ATPase. It effectively hinders ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+.
TN3483	Bakkenolide D		IL Receptor , Histamine Receptor
	Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have obvious anti-histamine activities.		IL Receptor , Histamine Receptor
TN5330	Lacinilene C	3,10-Dihydroxy-1,3,5,7-cadinatetraen-9-one
	Lacinilene C, lacinilene C 7-methyl ether, scopoletin, 2-hydroxy-7-methoxycadalene and 2,7-dihydroxycadalene are 5 induced phytoalexins in cotton leaves. Lacinilene C methyl ether elicits contraction of TSM by enhancing ...
T83454	13-Hydroxylupanine hydrochloride	Hydroxylupanine hydrochloride
	13-Hydroxylupanine, a characteristic alkaloid of sweet lupins, inhibits ganglionic transmission, reduces cardiac contractility, and induces contraction of uterine smooth muscle [1].
T75520	Aplyronine A
	Aplyronine A, an actin-depolymerizing agent, exhibits antitumor and apoptosis effects. It is valuable in cancer research and studies on muscle contraction, cell motility, and cell division [1].
TN5061	Stephanine		Adrenergic Receptor , Antifection
	l-Stephanine is a potent and highly selective alpha 1 adrenoceptor blocker, inhibits anococcygeus muscle contraction induced by phenylephrine with pA2 values of 6.76. Stephanine shows significant antiplasmodial activitie...		Adrenergic Receptor , Antifection
TN1790	Isopteropodine	Uncarine E	5-HT Receptor , Antibacterial , AChR
	Isopteropodine (Uncarine E) is an isoyohimbine-type octindole alkaloid isolated from Hamelia patens micropropagated and has antimicrobial activity and stimulates the immune system. Isopteropodine has antimicrobial activi...		5-HT Receptor , Antibacterial , AChR

天然物製品

Carboprost tromethamine

T14865

Synonym:

Target: Prostaglandin Receptor

Allocryptopine

T3A2467

Synonym: Thalictrimine,Fagarine I

Target: Potassium Channel

Sipeimine

T6S0109

Synonym: Kashmirine,Imperialine

Target: Others

Litorin acetate(55749-97-8 Free base)

T20604L

Synonym:

Target: Bombesin Receptor

Sodium creatine phosphate dibasic tetrahydrate

T4739

Synonym: Creatine phosphate disodium salt tetrahydrate

Target: Others, Endogenous Metabolite

Prostaglandin E2

T5014

Synonym: PGE2,Dinoprostone,Prostaglandin E2 (PGE2)

Target: Endogenous Metabolite, Prostaglandin Receptor

α-Angelica lactone

T7995

Synonym: Alpha-Angelica Lactone

Target: TNF, Tyrosinase

L-Hyoscyamine

T0962

Synonym: Daturine,Hyoscyamine

Target: AChR

L-Hyoscyamine sulfate

T4S1619

Synonym: Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate

Target: ATPase, p38 MAPK, Calcium Channel, Akt, PI3K

Target: cAMP, Calcium Channel

Onitisin

TN4713

Synonym:

Target: 5-HT Receptor

Target: IL Receptor, Histamine Receptor

Lacinilene C

TN5330

Synonym: 3,10-Dihydroxy-1,3,5,7-cadinatetraen-9-one

Target:

13-Hydroxylupanine hydrochloride

T83454

Synonym: Hydroxylupanine hydrochloride

Target: Adrenergic Receptor, Antifection

Isopteropodine

TN1790

Synonym: Uncarine E

Target: 5-HT Receptor, Antibacterial, AChR

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-02253	TPM2 Protein, Human, Recombinant (His)	Human	E. coli
	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contra...
TMPH-03212	TPM1 Protein, Rabbit, Recombinant (His & Myc)	Rabbit	Baculovirus Insect Cells
	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contra...
TMPH-02252	TPM3 Protein, Human, Recombinant (GST)	Human	E. coli
	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contra...
TMPH-00780	CACNA1C Protein, Guinea Pig, Recombinant (His)	Guinea pig	E. coli
	Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm...
TMPH-01727	Myosin-6/MYH6 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Muscle contraction. Myosin-6/MYH6 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 76.8 kDa and the accession number is P13533.
TMPH-01728	Myosin-6/MYH6 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Muscle contraction. Myosin-6/MYH6 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 80.8 kDa and the accession number is P13533.
TMPH-03213	TPM1 Protein, Rabbit, Recombinant (E. coli, His & Myc)	Rabbit	E. coli
	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contra...
TMPH-00285	Myosin-1 Protein, Bovine, Recombinant (His & Myc)	Bovine	E. coli
	Muscle contraction. Myosin-1 Protein, Bovine, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 30.9 kDa and the accession number is Q9BE40.
TMPH-02308	CACNA2D1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
TMPH-01820	OXT Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Neurophysin 1 specifically binds oxytocin.; Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR). OXT Protein, Human, Recombinant (His) is e...
TMPH-00763	Parvalbumin beta Protein, Gadus morhua subsp. callarias, Recombinant (His)	Gadus callarias	E. coli
	In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. Parvalbumin beta Protein, Gadus morhua subsp. callarias, Recombinant (His) is expressed in E. coli expression s...
TMPJ-01261	PPP1R14A Protein, Human, Recombinant (His)	Human	E. coli
	Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP...
TMPH-00762	Parvalbumin beta Protein, Gadus morhua, Recombinant (His & SUMO)	Gadus morhua	E. coli
	In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. Parvalbumin beta Protein, Gadus morhua, Recombinant (His & SUMO) is expressed in E. coli expression system with...
TMPY-03600	TPM4 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TPM4, also known as tropomyosin 4, is a member of the tropomyosin family. Members of this family are actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-mu...
TMPJ-00044	TNNC1 Protein, Human, Recombinant (His)	Human	E. coli
	Troponin I, also known as TNI, is a 24 kDa component of a protein complex on striated muscle thin filaments.Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I...
TMPH-01821	OXT Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Neurophysin 1 specifically binds oxytocin.; Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR). OXT Protein, Human, Recombinant (His & Myc...
TMPH-01730	MYBPC3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATP...
TMPH-01032	Calponin-2/CNN2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inh...
TMPH-03753	MYLK Protein, Human, Recombinant (His)	Human	E. coli
	Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phos...
TMPH-03749	CYSLTR1 Protein, Human, Recombinant (His)	Human	E. coli
	Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and...
TMPH-01731	MYBPC2 Protein, Human, Recombinant (His)	Human	E. coli
	Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATP...
TMPY-03438	Calsequestrin 1 Protein, Human, Recombinant	Human	E. coli
	Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction,...
TMPJ-00793	TPM3 Protein, Human, Recombinant	Human	E. coli
	Tropomyosin Alpha-3 Chain (TPM3) is a member of the Tropomyosin family. TPM3 exists as a heterodimer consisting of an alpha and a beta chain. TPM3 plays a central role in association with the Troponin complex and in the ...
TMPY-03458	Sorcin/SRI Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	Sorcin was originally identified in multidrug-resistant cells. It is a calcium-binding protein. Sorcin modulates excitation-contraction coupling in the heart, contributes to calcium homeostasis in the heart sarcoplasmic ...
TMPH-02405	LqqIT1 Protein, Leiurus quinquestriatus quinquestriatus, Recombinant (His & Myc)	Egyptian scorpion	E. coli
	Excitatory insect beta-toxins induce a spastic paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium ch...
TMPH-03107	Complement C5a Protein, Pig, Recombinant (His)	Sus scrofa (Pig)	P. pastoris (Yeast)
	Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, ...
TMPJ-00475	Kallikrein 1/KLK1 Protein, Human, Recombinant (aa 19-262, His)	Human	HEK293 Cells
	Kallikrein-1 (KLK1) is a member of human tissue Kallikrein family. Human KLK1 precursor contains a singal peptide (residues 1 to 18), a short pro peptide (residues 19 to 24) and a mature chain (residues 25 to 262). The f...
TMPY-03267	Sorcin/SRI Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Sorcin was originally identified in multidrug-resistant cells. It is a calcium-binding protein. Sorcin modulates excitation-contraction coupling in the heart, contributes to calcium homeostasis in the heart sarcoplasmic ...
TMPJ-01112	PRKG1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one pro...
TMPY-03984	TPM1 Protein, Human, Recombinant (His)	Human	E. coli
	TPM1, also known as tropomyosin-1, is a member of the tropomyosin family. Members of this family are highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth m...
TMPY-03957	Troponin C Protein, Human, Recombinant	Human	E. coli
	Troponin I, also known as TNNC1, is part of the troponin complex. This complex contains 3 subunits: troponin I (TnI), troponin T (TnT) and troponin C (TnC). Troponin I is the inhibitory subunit, blocking actin-myosin int...
TMPH-01640	MRGPRX2 Protein, Human, Recombinant (His)	Human	E. coli
	Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules ...
TMPY-04207	Motilin Protein, Human, Recombinant (His)	Human	HEK293 Cells
	MLN (Motilin) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal c...
TMPY-02945	Prokineticin 1/EG-VEGF Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	EG-VEGF, also known as prokineticin-1, is a member of the AVIT (prokineticin) family. Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. EG-VEG...
TMPJ-00734	KNG1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role ...
TMPY-02977	PDE1C Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds ...
TMPY-02081	PDE2A Protein, Human, Recombinant (aa 215-900, His)	Human	Baculovirus Insect Cells
	cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 sub...
TMPY-01854	DPP10 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Inactive dipeptidyl peptidase 1, also known as Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPL2 and DPP1, is a single-pass type II membrane protein w...
TMPJ-00029	CALM1 Protein, Human, Recombinant	Human	E. coli
	Calmodulin (CaM) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the binding of Ca2+ is required f...
TMPY-04385	ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP ...

TPM2 Protein, Human, Recombinant (His)

TMPH-02253

Species: Human

Expression System: E. coli

TPM1 Protein, Rabbit, Recombinant (His & Myc)

TMPH-03212

Species: Rabbit

Expression System: Baculovirus Insect Cells

TPM3 Protein, Human, Recombinant (GST)

TMPH-02252

Species: Human

Expression System: E. coli

CACNA1C Protein, Guinea Pig, Recombinant (His)

TMPH-00780

Species: Guinea pig

Expression System: E. coli

Myosin-6/MYH6 Protein, Human, Recombinant (His)

TMPH-01727

Species: Human

Expression System: P. pastoris (Yeast)

Myosin-6/MYH6 Protein, Human, Recombinant (E. coli, His)

TMPH-01728

Species: Human

Expression System: E. coli

TPM1 Protein, Rabbit, Recombinant (E. coli, His & Myc)

TMPH-03213

Species: Rabbit

Expression System: E. coli

Myosin-1 Protein, Bovine, Recombinant (His & Myc)

TMPH-00285

Species: Bovine

Expression System: E. coli

CACNA2D1 Protein, Human, Recombinant (His & SUMO)

TMPH-02308

Species: Human

Expression System: E. coli

OXT Protein, Human, Recombinant (His)

TMPH-01820

Species: Human

Expression System: P. pastoris (Yeast)

Parvalbumin beta Protein, Gadus morhua subsp. callarias, Recombinant (His)

TMPH-00763

Species: Gadus callarias

Expression System: E. coli

PPP1R14A Protein, Human, Recombinant (His)

TMPJ-01261

Species: Human

Expression System: E. coli

Parvalbumin beta Protein, Gadus morhua, Recombinant (His & SUMO)

TMPH-00762

Species: Gadus morhua

Expression System: E. coli

TPM4 Protein, Human, Recombinant (His)

TMPY-03600

Species: Human

Expression System: HEK293 Cells

TNNC1 Protein, Human, Recombinant (His)

TMPJ-00044

Species: Human

Expression System: E. coli

OXT Protein, Human, Recombinant (His & Myc & SUMO)

TMPH-01821

Species: Human

Expression System: E. coli

MYBPC3 Protein, Human, Recombinant (His & SUMO)

TMPH-01730

Species: Human

Expression System: E. coli

Calponin-2/CNN2 Protein, Human, Recombinant (His & SUMO)

TMPH-01032

Species: Human

Expression System: E. coli

MYLK Protein, Human, Recombinant (His)

TMPH-03753

Species: Human

Expression System: E. coli

CYSLTR1 Protein, Human, Recombinant (His)

TMPH-03749

Species: Human

Expression System: E. coli

MYBPC2 Protein, Human, Recombinant (His)

TMPH-01731

Species: Human

Expression System: E. coli

Calsequestrin 1 Protein, Human, Recombinant

TMPY-03438

Species: Human

Expression System: E. coli

TPM3 Protein, Human, Recombinant

TMPJ-00793

Species: Human

Expression System: E. coli

Sorcin/SRI Protein, Human, Recombinant

TMPY-03458

Species: Human

Expression System: Baculovirus Insect Cells

LqqIT1 Protein, Leiurus quinquestriatus quinquestriatus, Recombinant (His & Myc)

TMPH-02405

Species: Egyptian scorpion

Expression System: E. coli

Complement C5a Protein, Pig, Recombinant (His)

TMPH-03107

Species: Sus scrofa (Pig)

Expression System: P. pastoris (Yeast)

Kallikrein 1/KLK1 Protein, Human, Recombinant (aa 19-262, His)

TMPJ-00475

Species: Human

Expression System: HEK293 Cells

Sorcin/SRI Protein, Human, Recombinant (His & GST)

TMPY-03267

Species: Human

Expression System: Baculovirus Insect Cells

PRKG1 Protein, Human, Recombinant (His)

TMPJ-01112

Species: Human

Expression System: HEK293 Cells

TPM1 Protein, Human, Recombinant (His)

TMPY-03984

Species: Human

Expression System: E. coli

Troponin C Protein, Human, Recombinant

TMPY-03957

Species: Human

Expression System: E. coli

MRGPRX2 Protein, Human, Recombinant (His)

TMPH-01640

Species: Human

Expression System: E. coli

Motilin Protein, Human, Recombinant (His)

TMPY-04207

Species: Human

Expression System: HEK293 Cells

Prokineticin 1/EG-VEGF Protein, Human, Recombinant (His)

TMPY-02945

Species: Human

Expression System: Baculovirus Insect Cells

KNG1 Protein, Human, Recombinant (His)

TMPJ-00734

Species: Human

Expression System: HEK293 Cells

PDE1C Protein, Human, Recombinant (His & GST)

TMPY-02977

Species: Human

Expression System: Baculovirus Insect Cells

PDE2A Protein, Human, Recombinant (aa 215-900, His)

TMPY-02081

Species: Human

Expression System: Baculovirus Insect Cells

DPP10 Protein, Human, Recombinant (His)

TMPY-01854

Species: Human

Expression System: HEK293 Cells

CALM1 Protein, Human, Recombinant

TMPJ-00029

Species: Human

Expression System: E. coli

ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST)

TMPY-04385

Species: Human

Expression System: Baculovirus Insect Cells

カタログ番号	製品名
L5400	Anti-Cardiovascular Disease Compound Library	1408 compounds
	A unique collection of 1408 cardiovascular diseases related compounds for high throughput screening (HTS) and high content screening (HCS);
L7200	Calcium Channel Compound Library	140 compounds
	A unique collection of 140 calcium channel blockers and agonists for high throughput and high content screening;
L1310	Cytoskeletal Signaling Pathway Compound Library	759 compounds
	A unique collection of 759 cytoskeleton-related compounds, can be used for HTS and HCS；

ライブラリー

Anti-Cardiovascular Disease Compound Library

L5400

Compounds: 1408

Calcium Channel Compound Library

L7200

Compounds: 140

Cytoskeletal Signaling Pathway Compound Library

L1310

Compounds: 759