|
T9576 |
AMP-945
|
|
FAK
|
|
AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor. |
|
T3041 |
ALK inhibitor 2
|
|
FAK
,
ALK
|
|
ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase. |
|
T2001 |
PF-573228
|
PF 573228 |
Apoptosis
,
FAK
|
|
PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM. |
|
T9973 |
FAK-IN-7
|
|
FAK
|
|
FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor. |
|
T10285 |
ALK inhibitor 1
|
|
FAK
,
IGF-1R
,
ALK
|
|
ALK inhibitor 1 is a selective ALK kinase inhibitor. |
|
T6997 |
SU6656
|
|
FAK
,
Akt
,
Src
|
|
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively. |
|
T8528 |
AC1903
|
|
TRP/TRPV Channel
|
|
AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss. |
|
T0680 |
Lamotrigine
|
LTG,BW430C |
5-HT Receptor
,
Sodium Channel
,
Autophagy
|
|
Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
|
T2314 |
PF-431396
|
|
FAK
,
PYK2
|
|
PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM). |
|
T2281 |
GSK2256098
|
GSK 2256098,GSK-2256098,GTPL7939 |
Apoptosis
,
FAK
|
|
GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor. |
|
T1996 |
Defactinib
|
PF-04554878,VS-6063 |
FAK
|
|
Defactinib (VS-6063) is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. |
|
T5480 |
BI-4464
|
|
FAK
,
Ligands for Target Protein for PROTAC
|
|
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC |
|
T2465 |
PF-562271
|
PF562271,PF 562271 |
FAK
,
PYK2
,
CDK
|
|
PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM). |
|
T0263 |
Chloropyramine hydrochloride
|
Nilfan,Alergosan,Halopyramine hydrochloride |
FAK
,
VEGFR
,
Histamine Receptor
|
|
Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist. |
|
T24730 |
Roslin 2 bromide
|
Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2 |
FAK
,
p53
|
|
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effects. |
|
T6177 |
PF-562271 besylate
|
PF-00562271 Besylate |
FAK
,
PYK2
,
CDK
|
|
PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, exc... |
|
T2609 |
Masitinib
|
AB1010 |
Apoptosis
,
FAK
,
c-Fms
,
FGFR
,
Bcr-Abl
,
PDGFR
,
Src
,
c-Kit
,
Hck
|
|
Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has been distributed under the commercial name Masivet... |
|
T2655 |
CEP-37440
|
CEP37440 |
FAK
,
ALK
|
|
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK). |
|
T1918 |
NVP-TAE 226
|
TAE226 |
Apoptosis
,
FAK
,
c-Met/HGFR
,
PYK2
,
IGF-1R
|
|
NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK. |
|
T21768 |
PF-562271 hydrochloride
|
PF-562271 HCl |
FAK
,
PYK2
,
CDK
|
|
PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other pr... |
|
T1950 |
PND-1186
|
PND1186,PND 1186,VS-4718,SR-2516 |
Apoptosis
,
FAK
|
|
PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM). |
|
T7119 |
Y15
|
1,2,4,5-Benzenetetramine tetrahydrochlor,FAK Inhibitor 14 |
FAK
|
|
Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth. |
|
T27828 |
Licostinel
|
CGP 63446,ACEA1021,ACEA 1021,ACEA-1021,CGP-63446 |
GluR
|
|
Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia. |
|
T33824 |
Orotirelin
|
CG 3509,Orotireline |
Others
|
|
Orotirelin(CG 3509), a thyrotropin-releasing hormone analog, reversed pentobarbital-induced sleep time.Orotirelin may be beneficial in animals with focal cerebral ischemia. |
|
T40109 |
APOL1-IN-1
|
APOL1-IN-1 |
Others
|
|
APOL1-IN-1 is a potent inhibitor of apolipoprotein L1 (APOL1) that can be used to study the pathogenesis of focal segmental glomerulosclerosis (FSGS) and nondiabetic kidney disease (NDKD), facilitating research into thes... |
|
T76681 |
Fresolimumab
|
GC1008 |
TGF-beta/Smad
|
|
Fresolimumab (GC1008) is a specific human anti-transforming growth factor β monoclonal antibody that binds to the active forms of human TGFβ1, TGFβ2, and TGFβ3 and can be used to study focal segmental glomerulosclerosis ... |
|
T67843 |
GSK215
|
|
FAK
|
|
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4). GSK215 is designed by the FAK inhibitor VS-4718 and a binder for the VHL E3 ligase. GSK215 can induce rapid and prolonged FAK deg... |
|
TP2137L |
Pp60 c-src (521-533) (phosphorylated) acetate
|
|
Others
|
|
pp60 c-src (521-533) (phosphorylated) acetate is a regulator of focal adhesion formation and cell spreading. pp60 c-src (521-533) (phosphorylated) acetate also regulates cell motility and is a key component in the signal... |
|
T15367 |
Gadoxetate Disodium
|
Gd-EOB-DTPA Disodium,ZK 139834 |
Others
|
|
Gadoxetate Disodium is used to evaluate focal liver lesions, such as hepatocellular carcinoma or liver metastasis on T1-weighted imaging. It is a contrast agent in magnetic resonance imaging (MRI) of the hepatobiliary sy... |
|
T30087 |
Antroquinonol
|
|
Reactive Oxygen Species
,
Nrf2
|
|
Antroquinonol is a ubiquinone derivative from Antrodia camphorata with anti-inflammatory and anticancer activities.Antroquinonol reduces oxidative stress and inhibits inflammation and sclerosis in mice with focal segment... |
|
T0153 |
Oltipraz
|
NSC 347901,RP 35972 |
HIF/HIF Prolyl-Hydroxylase
,
HIV Protease
,
Reverse Transcriptase
,
Nrf2
,
HIF
|
|
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quin... |
|
T23539 |
Y 11
|
|
Others
|
|
focal adhesion kinase (FAK) inhibitor |
|
T28277 |
OXA-11
|
OXA 11 |
|
|
OXA-11 is a potent inhibitor of focal adhesion kinase (FAK) with anti-tumor activity. |
|
T22397 |
PF-4618433
|
|
Others
|
|
PF-4618433 is a dual inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). |
|
T70724 |
GSK-2256098 HCl
|
|
|
|
GSK-2256098 HCl is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. |
|
T11260 |
FAK inhibitor 2
|
|
FAK
|
|
FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM . |
|
T71450 |
Ilacirnon sodium
|
|
|
|
Ilacirnon sodium is a potent CCR2 antagonist that may be useful in the treatment of renal diseases including Focal Segmental Glomerulosclerosis and Diabetic Nephropathy. |
|
T35075 |
VSWRAPTA
|
|
|
|
VSWRAPTA is a promoter of neuronal branching via transcellular activation of the focal adhesion kinase (FAK) and the ERK1/2 signaling pathway in vitro. |
|
T38068 |
Aptiganel hydrochloride
|
|
|
|
Potent and noncompetitive NMDA receptor antagonist (IC50 = 36 nM). Exhibits >70-fold selectivity for NMDA receptor over σ receptor. Neuroprotective in a rat model of focal ischemia. |
|
T27897 |
LY 215490
|
LY215490,LY-215490 |
|
|
LY 215490 is a selective, competitive and systemically active antagonist of AMPA receptor. LY 215490 has neuroprotective effect against focal ischaemia in a model of permanent MCA occlusion in the rat. |
|
T13840 |
PROTAC FAK degrader 1
|
|
Others
|
|
PROTAC FAK degrader 1 is a selective and potent degrader of focal adhesion kinase (Fak) (IC50 of 6.5 nM). |
|
T68740 |
NVP-TAC544
|
|
|
|
NVP-TAC544 is a novel focal adhesion kinase (FAK) inhibitor, potently blocking kinase activity of FAK along with Aurora A, activated Cdc42-associated kinase 1 (ACK1), Met, insulin receptor (IR), TrkA, and IGF-1R. |
|
T16292 |
NFPS
|
|
Thrombin
|
|
NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competitive glycine transporter-1 (GlyT1) inhibitor (IC50s: 2.8 nM a... |
|
T21586 |
Methsuximide
|
|
|
|
Methsuximide is an anticonvulsant agent which appeared to be effective in petit mal, psychomotor and focal motor attacks [1]. |
|
T11806 |
L-NIO dihydrochloride
|
|
NOS
|
|
L-NIO dihydrochloride, a potent and non-selective NADPH-dependent nitric oxide synthase (NOS) inhibitor, consistently induces focal ischemic infarct in rats. It exhibits inhibitory constants (Kis) of 1.7, 3.9, and 3.9 μM... |
|
T60667 |
NAT
|
|
|
|
NAT, an initial NAMPT activator, targets NAMPT, a crucial enzyme in the NAD salvage pathway and a key focal point for researching a variety of diseases linked to NAD depletion, including neurodegenerative diseases[1]. |
|
T60492 |
Lamotrigine hydrate
|
|
|
|
Lamotrigine hydrate is an effective oral active anticonvulsant or antiepileptic agent that selectively blocks voltage-gated Na + channels, stabilizes presynaptic neuronal membranes and inhibits glutamate release. Lamotri... |
|
T41164 |
FC 11
|
|
|
|
FC 11 is a highly potent focal adhesion Ki nase (FAK) PROTAC®Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding lig... |
|
T70352 |
PH11
|
|
|
|
PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K)/AKT path... |
|
T76523 |
HCV Core Protein (107-114)
|
|
|
|
HCV Core Protein (107-114), identified as the binding site within the region 101-118, is a minimally immunogenic fragment of the primary linear HCV core regions. This segment, comprising two residues that vary between ge... |
