|
T1460 |
Dicyclomine hydrochloride
|
|
AChR
|
|
Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence. |
|
T6870 |
L-685458
|
L-685,458 |
Apoptosis
,
Gamma-secretase
|
|
L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM. |
|
T16133 |
MRK-560
|
|
Gamma-secretase
|
|
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase. |
|
T12165 |
NAChR agonist 1
|
DUN71755 |
AChR
|
|
nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator. |
|
T3198L |
PRE-084 hydrochloride
|
|
Sigma receptor
|
|
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay). |
|
T9725 |
GSK-3β inhibitor 10
|
|
Others
|
|
GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities. |
|
T2171 |
SEW2871
|
SEW2871 |
S1P Receptor
,
LPL Receptor
|
|
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an... |
|
TQ0003 |
740 Y-P
|
740YPDGFR,PDGFR 740Y-P |
PI3K
,
Autophagy
|
|
740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K. |
|
T16079 |
Mirodenafil
|
SK3530 |
PDE
|
|
Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction. |
|
T15199 |
Edicotinib
|
JNJ-527,JNJ-40346527 |
c-Fms
,
FLT
,
CSF-1R
,
c-Kit
|
|
Edicotinib (JNJ-527) is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT and FLT3 (IC50: 20 nM and 190 nM). It has the pote... |
|
T3619 |
VU0357017 hydrochloride
|
ML071 hydrochloride,CID-25010775,VU 0357017 hydrochloride |
AChR
|
|
VU0357017 hydrochloride (ML071 hydrochloride) is highly selective M1 agonists act at an allosteric site to activate the receptor (EC50: 477 ± 172 nM; Pec50: 6.37 ± 0.15). |
|
TQ0126 |
Mirodenafil dihydrochloride
|
SK-3530 dihydrochloride |
PDE
|
|
Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction. |
|
T1637 |
Deferoxamine Mesylate
|
desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM |
Mitophagy
,
Beta Amyloid
,
Others
,
Ferroptosis
,
HIF/HIF Prolyl-Hydroxylase
,
Autophagy
|
|
Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF-1α levels and i... |
|
TP2045 |
CH 275
|
|
|
|
Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin r... |
|
T12901 |
SHIP2-IN-1
|
|
Phosphatase
|
|
SHIP2-IN-1 is a potent SHIP2 inhibitor(IC50 : 2 µM),and used in the research of Alzheimer’s disease. |
|
T9379 |
L-Threonic acid magnesium salt
|
|
Others
|
|
L-Threonic acid magnesium salt (L-TAMS) increases synapse density and memory ability in both aged rats and late stage Alzheimer’s disease (AD) model mice. |
|
T10841 |
CM-675
|
|
HDAC
,
PDE
|
|
CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to treat Alzheimer’s disease. |
|
T10630 |
BuChE-IN-TM-10
|
TM-10 |
AChR
|
|
BuChE-IN-TM-10 (TM-10) is a potent inhibitor of butyrylcholinesterase (BuChE), exhibiting an IC50 of 8.9 nM. It effectively inhibits and disaggregates self-induced Aβ aggregation, displays significant antioxidant activit... |
|
T16037 |
GLN-1062
|
|
Others
|
|
Memogain is a pro-drug of galantamine. It is used for the treatment of Alzheimer’s disease. |
|
T28735 |
SCH-900229
|
SCH 900229,SCH900229 |
|
|
SCH-900229, a potent presenilin 1 selective γ-secretase inhibitor, used to treat Alzheimer’s Disease. |
|
T30266 |
AZD8926
|
AZD 8926,AZD-8926 |
|
|
AZD8926 is a potent and selective inhibitor of GSK3β(glycogen synthase kinase-3β). AZD8926 is potential for treating Alzheimer’s disease (AD), schizophrenia, and chronic as well as acute neurodegenerative diseases. |
|
T11423 |
Glutaminyl Cyclase Inhibitor 4
|
|
Others
|
|
Glutaminyl Cyclase Inhibitor 4 is a potent, selective glutaminyl cyclase (QC) inhibitor (IC50: 6.1 nM). It is a potent anti-Alzheimer’s agent. |
|
T61423 |
Transthyretin-IN-1
|
|
|
|
Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer’s disease [1]. |
|
TP1673 |
β-Amyloid (11-22)
|
β-Amyloid 11-22 |
|
|
β-Amyloid (11-22) is a peptide fragment of β-Amyloid.Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be the cause of Alzheimer’s Disease (AD). A... |
|
T70484 |
AD-35
|
|
|
|
AD-35 is a neuroprotectant for treating Alzheimer’s diseases by significantly inhibiting the production and release of proinflammatory cytokines TNF-α and IL-1β. |
|
T76738 |
Bapineuzumab
|
|
|
|
Bapineuzumab, an anti-β-amyloid protein (APP) monoclonal antibody, is utilized in Alzheimer’s disease (AD) research [1]. |
|
T37531 |
Glycerophosphorylethanolamine (sodium salt)
|
|
|
|
Glycerophosphorylethanolamine is an active phosphodiester metabolite of phosphatidylethanolamine.1,2It promotes aggregation of amyloid-β (1-40) (Aβ40)in vitro, and levels of glycerophosphorylethanolamine are elevated in ... |
|
TP1866 |
β-Amyloid (1-11)
|
β-amyloid 1-11 |
|
|
Anionic interaction of Beta-amyloid (1-11) with Factor XII is suspected to cause massive activation of the C4 (complement 4) system in the cerebrospinal fluid of Alzheimer’s disease patients. |
|
T11422 |
Glutaminyl Cyclase Inhibitor 3
|
|
Others
|
|
Glutaminyl Cyclase Inhibitor 3, a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor (IC50: 4.5 nM). It significantly reduced the brain concentrations of pyroform Aβ and total Aβ and ... |
|
T11448 |
GOAT-IN-1
|
|
Others
|
|
|
|
T76827 |
Solanezumab
|
|
|
|
Solanezumab, a humanized monoclonal IgG1 antibody targeting the mid-domain of the amyloid-β (Aβ) peptide, shows promise for Alzheimer’s disease research [1]. |
|
T80878 |
Vanutide cridificar
|
PF 05236806,ACC-001 |
|
|
Vanutide cridificar (ACC-001) is an aminoterminal Aβ1-7 peptide conjugate, employed in Alzheimer’s disease (AD) research [1]. |
|
T35892 |
Q134R
|
Q134R |
|
|
Q134R, a neuroprotective derivative of hydroxyquinoline, effectively inhibits nuclear factor of activated T-cell (NFAT) signaling and possesses the ability to cross the blood-brain barrier. This compound shows promise fo... |
|
T76926 |
Bepranemab
|
|
|
|
Bepranemab (UCB 0107), a humanized full-length IgG4 monoclonal antibody, targets the central tau epitope (amino acids 235-250) and is utilized in Alzheimer’s disease (AD) research [1]. |
|
T75780 |
LPYFD-NH2 TFA
|
|
|
|
LPYFD-NH2 TFA, a pentapeptide, exhibits an inhibitory effect on Aβ(1-42) aggregation, indicating its potential utility in Alzheimer’s disease research [1]. |
|
TP2171 |
β-amyloid (12-28) (TFA) (107015-83-8 free base)
|
Amyloid β-Protein (12-28) (TFA),β-amyloid (12-28) (TFA) |
Others
|
|
β-amyloid (12-28) TFA, a peptide fragment of β-amyloid protein (β1-42), is the major component of senile plaque cores. β-amyloid (12-28) has aggregation properties and the potential for Alzheimer’s disease research. |
|
T68257 |
Hydromethylthionine HBr
|
|
|
|
Hydromethylthionine, also known as LMTM and Leucomethylene Blue, is a apotent tau aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. Hydromethylthionine showed pharmacologi... |
|
T76464 |
FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)
|
|
|
|
FITC-β-Ala-Amyloid β-Protein (1-42) ammonium, a fluorescein isothiocyanate (FITC)-tagged monomer peptide of Aβ1-42, is instrumental in Alzheimer’s disease pathogenesis [1]. |
|
T80695 |
β-Amyloid precursor protein (96-110), cyclized (human)
|
|
|
|
β-Amyloid precursor protein (96-110), cyclized (human), a segment of the amyloid precursor protein, serves as a research tool in Alzheimer’s disease studies [1]. |
|
T77028 |
Gosuranemab
|
|
|
|
Gosuranemab (BMS-986168), a humanized IgG4 anti-tau monoclonal antibody, specifically targets human N-terminal tau residues 15-22. It holds potential for Alzheimer’s disease (AD) research [1] [2]. |
|
T38005 |
P11149
|
|
|
|
P11149, a derivative of Galanthamine, acts as a competitive, orally active, and selective AChE inhibitor with the ability to weakly penetrate the blood-brain barrier (BBB). It demonstrates selective inhibition, exhibitin... |
|
T72808 |
(R)-TTBK1-IN-1
|
|
|
|
(R)-TTBK1-IN-1 is a potent, selective, and brain-penetrant inhibitor of tau tubulin kinase 1 (TTBK1), serving as an enantiomer of TTBK1-IN-1. It finds application in the research of Alzheimer’s disease and related tauopa... |
|
T72471 |
Antioxidant agent-2
|
|
|
|
Antioxidant agent-2 (comp 3c), a BBB-penetrating and selective metal ion chelator, exhibits significant neuroprotective and hepatoprotective effects, making it beneficial for Alzheimer’s disease research. |
|
T35560 |
SAR502250
|
|
|
|
SAR502250 is a potent, selective, ATP-competitive, orally active, and brain-penetrant GSK3 inhibitor with a human GSK-3β IC50 value of 12 nM. It exhibits antidepressant-like activity and is being researched for potential... |
|
T79011 |
TrkB-IN-1
|
|
Trk receptor
|
|
TrkB-IN-1 is a potent, orally active agonist of the TrkB receptor, with favorable pharmacokinetic (PK) properties. It has been shown to reverse cognitive deficits in an Alzheimer's disease (AD) mouse model, thus serving ... |
|
T83204 |
Acetly-β Amyloid(15-20), Amide
|
|
|
|
Acetyl-β Amyloid (15-20), Amide is a peptide fragment that inhibits β-sheet formation and stabilizes the structure of the Aβ (1–40) peptide, making it a useful tool in Alzheimer’s disease research [1]. |
|
T75779 |
β-Amyloid (12-28) (TFA)
|
|
|
|
β-Amyloid (12-28) (TFA), a peptide fragment of the β-amyloid protein (β1-42)—a 42 amino acid protein primarily found in senile plaque cores—exhibits aggregation properties. This compound holds significance for research i... |
|
T79503 |
PD25
|
|
|
|
PD25, an inhibitor of both AChE and BuChE, demonstrates inhibitory constants of hAChE IC50: 1.58 μM, eeAChE IC50: 1.63 μM, and eqBuChE IC50: 2.39 μM. It exhibits antioxidant properties with a DPPH IC50 of 29.55 μM. This ... |
|
T75930 |
β-Amyloid (1-43)(human) TFA
|
|
|
|
β-Amyloid (1-43)(human) TFA exhibits greater aggregation tendencies and heightened toxicity compared to its well-established counterpart, Aβ1-42. Additionally, this compound demonstrates associations with both sAPPα and ... |
|
T27051 |
CM-414
|
CM 414,CM414 |
|
|
CM-414 is a dual inhibitor of HDACs and PDE5 for the Treatment of Alzheimer’s Disease (IC50 values of 60 nM, 310 nM, 490 nM, 322 nM, and 91 nM against PDE5, HDAC1, HDAC2, HDAC3, and HDAC6, respectively). Chronic treatmen... |
