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Search Results for " GABAA "

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天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T11349	GABAA receptor agent 1		GABA Receptor
	GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor.		GABA Receptor
T61668	GABAA receptor agent 5
	GABAA Receptor Agent 5 (compound 018) serves as a potent γ-GABAAR antagonist, possessing a Ki of 0.020 μM. This compound exhibits γ-GABAAR antagonist properties, yet it demonstrates low cellular membrane permeability [1]...
T60842	GABAA receptor agonist 1
	GABAA receptor agonist 1 (compound 3e) is a potent agonist of GABAA receptor that binds at the GABA binding site of GABAA receptor to produce GABAergic effects. GABAA receptor agonist 1 has anti-depression activities in ...
T60481	GABAA receptor agent 4
	GABAA receptor agent 4 (compound 1e) is a potent antagonist of γ-GABAAR with Ki of 0.18 µM. GABAA receptor agent 4 has immunomodulatory potential which was shown to efficiently rescue the inhibition of T cell proliferati...
T60817	GABAA receptor agent 6
	GABAA receptor agent 6 (compound 2027) is a potent γ-GABAAR antagonist with low cellular membrane permeability (Ki = 0.56 μM) [1].
T61625	GABAA receptor agonist 2
	GABAA receptor agonist 2 (compound 4c) is a highly potent GABAA receptor agonist which exhibits anti-depressive properties in classical mouse models of depression, such as the FST and TST. By binding to the GABA binding ...
T61052	GABAA receptor agent 7
	GABAA receptor agent 7 (compoud 5c) has anticonvulsant activity both in vitro and in vivo with low neurotoxicity which can be used in epilepsy research. GABAA receptor agent 7 is a potent positive modulator of GABAA rece...
T60826	GABAA receptor agent 8
	GABAA receptor agent 8 (compoud 5e) has the potential in epilepsy research. GABAA receptor agent 8 is a potent positive modulator of GABAA receptor with anticonvulsant activity both in vitro and in vivo as well as low ne...
T62885	GABAA receptor modulator-2
	GABAA receptor modulator-2 (Compound 20) is a selective, orally active α5-GABAAR negative conformation modulator (Ki: 4.1 nM). gABAA receptor modulator-2 exhibits high metabolic stability and a good central nervous syste...
T62426	GABAA receptor agent 2 TFA
	GABAA receptor agent 2 TFA is a potent, high-affinity GABAA receptor antagonist with an IC50 of 24 nM (human α1β2γ2GABAA-expressing tsA201 cells) and a Ki of 28 nM (rat GABAA receptor). GABAA receptor agent 2 TFA has no ...
T8887	2'MeO6MF		GABA Receptor
	2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors.It offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response...		GABA Receptor
T7165	Basmisanil	RG1662,RO5186582	GABA Receptor
	Basmisanil (RG1662) is a negative allosteric modulator/inverse agonist of GABAAα5 receptors.Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndro...		GABA Receptor
T11277	FG 7142	ZK 39106,LSU-65	GABA Receptor
	FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cereb...		GABA Receptor
T7794	Zuranolone		GABA Receptor
	Zuranolone is an agonist of GABAA receptor.		GABA Receptor
T17144	TPA 023		GABA Receptor
	TPA 023 is an agonist of the GABAA α2/α3 subtype-selective (Ki: 0.19-0.41 nM).		GABA Receptor
T23339	SCS		GABA Receptor
	SCS is a GABAA receptor antagonist.		GABA Receptor
T7622	Gabazine	SR95531	GABA Receptor
	Gabazine (SR95531) is an antagonist of GABAA receptors (Ki : 74-150 nM)		GABA Receptor
TQ0151	L-655708		GABA Receptor
			GABA Receptor
T3644	U93631		GABA Receptor
	GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude...		GABA Receptor
T11061	DMCM hydrochloride		GABA Receptor
	DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 ...		GABA Receptor
T22655	CGS 20625		Others
	partial agonist for the benzodiazepine binding site of the GABAA receptor		Others
T28479	PZ-II-029	PZ-II029,PZ II-029,PZII-029,PZII029,PZ II029	GABA Receptor
	PZ-II-029 is a modulator of α6β3γ2-selective GABAA channel.		GABA Receptor
TQ0040	ONO-8590580	CS-2894	GABA Receptor
	ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5.		GABA Receptor
T35336	Furosemide sodium	Frusemide Sodium,Lasix	Na-K-Cl cotransporter
	Furosemide sodium (Frusemide Sodium) is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity ...		Na-K-Cl cotransporter
T50048	4,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one		Others
	4,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one is a benzodiazepine derivative. It is an orthosteric modulator of the GABAA receptor and selectively binds to the benzodiazepine site of the GABAA receptor. It h...		Others
T27838	Lirequinil	RO413696,RO-413696,RO41-3696,RO 413696,Ro 41-3696,Ro-41-3696	GABA Receptor
	Lirequinil (Ro 41-3696) is a small molecule GABAA receptor agonist used to study neurological disorders.		GABA Receptor
T20657	Muscimol HBr	Agarin hydrobromide,Muscimol Hydrobromide,Agarin HBr	GABA Receptor
	Muscimol HBr (Agarin HBr) is an agonist of GABAA receptor.		GABA Receptor
T28303	Pazinaclone	A-77000,DN-2327,DN2327,DN 2327,A 77000,A77000	GABA Receptor
	Pazinaclone is a non-benzodiazepine (GABAA) partial agonist with sedative and anxiolytic activity.		GABA Receptor
T7793	6-(4-Methoxyphenyl)-3-pyridazinamine		GABA Receptor
	6-(4-Methoxyphenyl)-3-pyridazinamine is a GABAA receptor antagonist		GABA Receptor
T23104	Ocinaplon	DOV 273547	GABA Receptor
	Ocinaplon (DOV 273547) is a GABAA receptors modulator.		GABA Receptor
T8568	Suritozole	MDL-26479	GABA Receptor
	Suritozole (MDL-26479) is a negative modulator at the gamma-aminobutyric acidA (GABAA) receptor		GABA Receptor
T19418L	Methionine	D-Methionine,MRX-1024	Endogenous Metabolite
	Methionine (D-Methionine) (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.		Endogenous Metabolite
T5375	Loreclezole		GABA Receptor
	Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.		GABA Receptor
TNU0685	Dipropofol	4,4-Bis(2,6-di-isopropylphenol)	GABA Receptor
	Dipropofol (4,4-Bis(2,6-di-isopropylphenol)) is a small molecule GABAA receptor agonist that can be used to study epilepsy.		GABA Receptor
T22348	Isonipecotic acid	4-Piperidinecarboxylic acid,Hexahydroisonicotinic acid,4-Carboxypiperidine	GABA Receptor
	Isonipecotic acid (4-Piperidinecarboxylic acid) is a heterocyclic compound. Isonipecotic acid mainly characterized as a GABAA receptor partial agonist.		GABA Receptor
T34146	Propanidid	FBA 1420,Epontol,Sombrevin,Fabontal,Fabantol	GABA Receptor
	Propanidid (Sombrevin) is a gamma-aminobutyric acid type A receptor (GABAA) agonist and a fast-acting intravenous anesthetic that lowers arterial blood pressure.		GABA Receptor
T11684	Isoguvacine hydrochloride	1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride	GABA Receptor
	Isoguvacine hydrochloride (1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride) is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2...		GABA Receptor
TQ0023	Lorediplon		GABA Receptor
	Lorediplon is a novel hypnotic drug acting as a GABAA receptor modulator, differentially active at the α1-subunit, associated with promoting sleep.		GABA Receptor
T24381	L-822179	L822179,L 822,179,L 822179,L822,179,L-822,179	GABA Receptor
	L-822179 (α5IA) is a selective inverse agonist for the Α5 subtype of GABAA receptor with higher intrinsic activity at the A5 subtype than other drugs.		GABA Receptor
T23466	TP003		GABA Receptor
	TP003 is a novel non-selective GABAA receptor benzodiazepine site agonist with affinity for α1β2gam2, α2β3gam2, α3β3gam2, α5β2gam2, EC50 of 20.3, 10.6, 3.24, 5.64 nM, respectively. TP003 has antianxiety and partial antic...		GABA Receptor
T23470	Tracazolate hydrochloride	Tracazolate (hydrochloride)	GABA Receptor
	Tracazolate hydrochloride (Tracazolate (hydrochloride)) is a modulator of the GABAA receptor with anxiolytic and anticonvulsant activity. Tracazolate hydrochloride potentiates α1β1γ2s and α1β3γ2 with EC50s of 13.2 μM and...		GABA Receptor
T22301	L-838417 D9	CTP354,CTP354 (C-21191),C-21191	GABA Receptor
	L-838417 D9 (C-21191) is a novel deuterated subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes[1].		GABA Receptor
T8572	CL 218872		GABA Receptor
	CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptor...		GABA Receptor
T15775	Lotilaner		GABA Receptor , Parasite
	Lotilaner is a parasiticide. It is used as a potent non-competitive antagonist of insects GABACl receptors (IC50 of 23.84 nM for Drosophila melanogaster GABA receptor). It also has no effect on a dog GABAA receptor.		GABA Receptor , Parasite
T23444	TCS 1105	N-(4-fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide	Others
	TCS 1105 is a GABAA benzodiazepine receptor (BZR) ligand. TCS 1105 blocks Sema3A induced axonal growth cones collapse. TCS 1105 reduces anxiety-like behavior and enhances offensive behavior and social dominance in mice.		Others
T12492	Pivagabine	CXB-722	GABA Receptor
	Pivagabine (CXB-722), a hydrophobic 4-aminobutyric acid derivative, exhibits neuromodulatory activity and successfully penetrates the blood-brain barrier in rats. It counteracts the impact of foot shock on GABAA receptor...		GABA Receptor
T26834	BL-1020 Mesylate	CYP-1020 Mesylate	Dopamine Receptor , GABA Receptor
	BL-1020 Mesylate (CYP-1020 Mesylate) is an orally available GABA A receptor agonist and D2 antagonist that decreases dopamine activity and enhances GABAA activity.BL-1020 Mesylate has been used in the study of schizophre...		Dopamine Receptor , GABA Receptor
T14983	Clomethiazole	Distraneurin,Chlormethiazole,5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE	P450 , GABA Receptor
	Clomethiazole (Distraneurin) is an orally active GABAA agonist and it is an anticonvulsant agent. It also has the potential for treating convulsive status epilepticus. Chlormethiazole inhibits cytochrome P450 isoforms: C...		P450 , GABA Receptor
T4993	Afloqualone	HQ-495	GABA Receptor
	Afloqualone (HQ-495) is a agonist of GABA Receptor . Target: GABA Receptor in vitro: Afloqualone is a quinazolinone family GABAergic drug. It has sedative and muscle-relaxant effects, resulting from its agonist activity ...		GABA Receptor
T16489	Darigabat	CVL-865,PF-6372865,PF-06372865	GABA Receptor
	Darigabat (PF-06372865) is an orally active and selective GABAA receptor modulator that crosses the blood-brain barrier and exhibits anxiolytic activity, with Ki values of 2.9 nM, 21 nM, and 134 nM for α2, α1 PAM, and α2...		GABA Receptor

Compounds

GABAA receptor agent 1

T11349

Synonym:

Target: GABA Receptor

GABAA receptor agent 5

T61668

Synonym:

Target:

GABAA receptor agonist 1

T60842

Synonym:

Target:

GABAA receptor agent 4

T60481

Synonym:

Target:

GABAA receptor agent 6

T60817

Synonym:

Target:

GABAA receptor agonist 2

T61625

Synonym:

Target:

GABAA receptor agent 7

T61052

Synonym:

Target:

GABAA receptor agent 8

T60826

Synonym:

Target:

GABAA receptor modulator-2

T62885

Synonym:

Target:

GABAA receptor agent 2 TFA

Target: GABA Receptor

Basmisanil

T7165

Synonym: RG1662,RO5186582

Target: GABA Receptor

FG 7142

T11277

Synonym: ZK 39106,LSU-65

Target: GABA Receptor

Zuranolone

T7794

Synonym:

Target: GABA Receptor

TPA 023

T17144

Synonym:

Target: GABA Receptor

SCS

T23339

Synonym:

Target: GABA Receptor

Gabazine

T7622

Synonym: SR95531

Target: GABA Receptor

L-655708

TQ0151

Synonym:

Target: GABA Receptor

U93631

T3644

Synonym:

Target: GABA Receptor

DMCM hydrochloride

T11061

Synonym:

Target: GABA Receptor

Synonym: PZ-II029,PZ II-029,PZII-029,PZII029,PZ II029

Target: GABA Receptor

ONO-8590580

TQ0040

Synonym: CS-2894

Target: GABA Receptor

Furosemide sodium

T35336

Synonym: Frusemide Sodium,Lasix

Target: Na-K-Cl cotransporter

4,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

Synonym: RO413696,RO-413696,RO41-3696,RO 413696,Ro 41-3696,Ro-41-3696

Target: GABA Receptor

Muscimol HBr

T20657

Synonym: Agarin hydrobromide,Muscimol Hydrobromide,Agarin HBr

Target: GABA Receptor

Pazinaclone

T28303

Synonym: A-77000,DN-2327,DN2327,DN 2327,A 77000,A77000

Target: GABA Receptor

6-(4-Methoxyphenyl)-3-pyridazinamine

T7793

Synonym:

Target: GABA Receptor

Ocinaplon

T23104

Synonym: DOV 273547

Target: GABA Receptor

Suritozole

T8568

Synonym: MDL-26479

Target: GABA Receptor

Methionine

T19418L

Synonym: D-Methionine,MRX-1024

Target: Endogenous Metabolite

Loreclezole

T5375

Synonym:

Target: GABA Receptor

Dipropofol

TNU0685

Synonym: 4,4-Bis(2,6-di-isopropylphenol)

Target: GABA Receptor

Isonipecotic acid

T22348

Synonym: 4-Piperidinecarboxylic acid,Hexahydroisonicotinic acid,4-Carboxypiperidine

Target: GABA Receptor

Propanidid

T34146

Synonym: FBA 1420,Epontol,Sombrevin,Fabontal,Fabantol

Target: GABA Receptor

Isoguvacine hydrochloride

T11684

Synonym: 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride

Target: GABA Receptor

Lorediplon

TQ0023

Synonym:

Target: GABA Receptor

L-822179

T24381

Synonym: L822179,L 822,179,L 822179,L822,179,L-822,179

Target: GABA Receptor

TP003

T23466

Synonym:

Target: GABA Receptor

Tracazolate hydrochloride

T23470

Synonym: Tracazolate (hydrochloride)

Target: GABA Receptor

L-838417 D9

T22301

Synonym: CTP354,CTP354 (C-21191),C-21191

Target: GABA Receptor

CL 218872

T8572

Synonym:

Target: GABA Receptor

Lotilaner

T15775

Synonym:

Target: GABA Receptor, Parasite

TCS 1105

T23444

Synonym: N-(4-fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide

Target: GABA Receptor

BL-1020 Mesylate

T26834

Synonym: CYP-1020 Mesylate

Target: Dopamine Receptor, GABA Receptor

Clomethiazole

T14983

Synonym: Distraneurin,Chlormethiazole,5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE

Target: P450, GABA Receptor

Afloqualone

T4993

Synonym: HQ-495

Target: GABA Receptor

Darigabat

T16489

Synonym: CVL-865,PF-6372865,PF-06372865

Target: GABA Receptor

カタログ番号	製品名	別名	ターゲット
T4S1999	Valepotriate	Valtrate	Apoptosis , HIV Protease
	Valepotriate (Valtrate) fraction can have sedative effects and affect behavioral parameters related to recognition memory. Valepotriates, a new class of cytotoxic and antitumor agents, they are very potent cytotoxic agen...		Apoptosis , HIV Protease
T5S1882	Songorine	Napellonine,Zongorine,Bullatine G	Others , GABA Receptor
	Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.		Others , GABA Receptor
T2S1464	Thiocolchicoside	Thiocolchicine 2-glucoside analog,Coltramyl	Others , GABA Receptor
	Thiocolchicoside (Thiocolchicine 2-glucoside analog) (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine rece...		Others , GABA Receptor
TN1325	(2S)-6-Prenylnaringenin	6-Prenylnaringenin,6-PN	GABA Receptor
	(2S)-6-Prenylnaringenin (6-Prenylnaringenin) is an isomer of the potent phytoestrogen, 8-prenylnaringenin. (2S)-6-Prenylnaringenin is the most potent compound in the forebrain and acts as a positive allosteric modulator ...		GABA Receptor
T2850	Bicuculline	(+)-Bicuculline,d-Bicuculline	GABA Receptor
	Bicuculline ((+)-Bicuculline) is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungos...		GABA Receptor
T8268	6,2'-Dihydroxyflavone		GABA Receptor
	6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor.		GABA Receptor
T3S2100	(-)-Securinine	Securinine	GABA Receptor
	(-)-Securinine (Securinine) is plant-derived alkaloid and also a GABAA receptor antagonist.		GABA Receptor
T16535	Picrotoxinin		Chloride channel , GABA Receptor
	Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties.		Chloride channel , GABA Receptor
TN1202	(-)-α-Pinene	(1S)-(-)-Alpha-Pinene	Virus Protease , GABA Receptor , Endogenous Metabolite , Antibacterial
	(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directl...
TN6773	Acetoxyvalerensre	acetylvalerenolic acid	GABA Receptor
	Acetoxyvalerensre (acetylvalerenolic acid) (acetylvalerenolic acid) is a derivative of valerenic acid, which is a a GABAA receptor modulator.		GABA Receptor
T8036	6-Methylflavone		GABA Receptor
	6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.		GABA Receptor
TQ0119	Cirsimaritin		GABA Receptor
			GABA Receptor
T3318	Wogonoside	Glychionide B,Wogonin 7-O-glucuronide,Oroxindin	GABA Receptor , Autophagy
	Wogonoside (Wogonin 7-O-glucuronide) acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.		GABA Receptor , Autophagy
T2983	3,4,5-Trimethoxycinnamic acid	3-(3,4,5-Trimethoxyphenyl)acrylic Acid,O-Methylsinapic acid	GABA Receptor , Endogenous Metabolite
	3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.		GABA Receptor , Endogenous Metabolite
T8040	Cholesterol myristate	Cholesteryl myristate,Cholesteryl tetradecanoate	Others , Potassium Channel , GABA Receptor , Endogenous Metabolite , AChR
	Cholesterol Myristate (Cholesteryl Myristate) is a natural steroid found in traditional Chinese medicine that interacts with various ion channels, including the GABAA receptor, nicotinic acetylcholine receptor, and the i...
T8162	Cannabidivarin	Cannabidivarin,GWP-42006,GWP42006,GWP 42006	GABA Receptor
	Cannabidivarin (GWP42006) is a potent inhibitor against gamma 2 subunit of GABAA receptors. it may serve as a novel drug with definite control over childhood absence epilepsy.		GABA Receptor
T4S1616	Sanggenon D	Sanggenone D	NOS , COX , GABA Receptor
	Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflammatory activity, it can inhibit NO production from lipopolysa...		NOS , COX , GABA Receptor
T3836	Eudesmin		MAPK , S6 Kinase
	Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m...		MAPK , S6 Kinase
T7033	Rosmanol		Antioxidant , COX
	Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and a...		Antioxidant , COX
T0508	γ-Aminobutyric acid	Gamma-aminobutyric acid,4-Aminobutyric acid,GABA,4-Aminobutanoic acid,Piperidic acid	GABA Receptor , Endogenous Metabolite
	γ-Aminobutyric acid (4-Aminobutyric acid) is the most common inhibitory neurotransmitter in the central nervous system.		GABA Receptor , Endogenous Metabolite
T6S2227	Spinosin	Flavoayamenin	Others
	1. Spinosin (Flavoayamenin) ameliorated memory impairment induced through AβO, the serotonergic neurotransmitter system, and these effects were regulated, in part, through neuroprotective activity via the anti-inflammato...		Others
TMS0418	Dihydroergotoxine mesylate	Ergoloid mesylates	GABA Receptor
	Dihydroergotoxine mesylate (Ergoloid mesylates) is mainly used to improve symptoms and physical symptoms of mental degeneration related to aging.		GABA Receptor
TCS0102	Pulegone	(+)-Pulegone	Calcium Channel , Endogenous Metabolite , TRP/TRPV Channel
	1. Pulegone ((+)-Pulegone) has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a verapamil-sensitive psychostimulant effect t...		Calcium Channel , Endogenous Metabolite , TRP/TRPV Channel
T5754	Kavain		NF-κB , GABA Receptor
	Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of transcriptional factors such as NF-kB and LITAF.		NF-κB , GABA Receptor
T8193	α-Thujone	Thujone,ALPHA-(-)-THUJONE	Apoptosis , Reactive Oxygen Species , GABA Receptor , AChR , Parasite , Autophagy
	α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
T3343	5-methoxyflavone	5-methoxy-2-phenylchromen-4-one	DNA/RNA Synthesis
	5-methoxyflavone (5-methoxy-2-phenylchromen-4-one) is a naturally occurring, low molecular weight flavonoids compound that associated with a wide wariety of biological activities.		DNA/RNA Synthesis
T4590	(+)-Kavain	Kavain,L-KAWAIN,(R)-KAWAIN	Calcium Channel , GABA Receptor , Sodium Channel , Monoamine Transporter
	(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.
T3403	Glabridin	Q-100692,KB-289522,LS-176045	Reactive Oxygen Species , Tyrosinase , GABA Receptor , Antibacterial , PPAR
	Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on...
T2979	DL-Menthol	Hexahydrothymol,(±)-Menthol	GABA Receptor , AChE
	DL-Menthol ((±)-Menthol) is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (+)-menthol in nature and exhibits analgesic, anti...		GABA Receptor , AChE
T80776	Withasomniferolide A
	Withasomniferolide A, a withanolide extracted from the roots of Withania somnifera, has been identified as a positive activator of the GABAA receptor, isolated using a methanol extract [1].
TN5608	Paspalinine
	Paspalinine can inhibit binding of [125I]charybdotoxin (ChTX) to maxi-K channels in bovine aortic smooth muscle sarcolemmal membranes. Paspalinine shows tremorgenic action, which may be due in part to their inhibition of...
TN3868	Dihydroxyaflavinine		GABA Receptor
	Dihydroxyaflavinine is a fungal toxin, it inhibits non-competitively GABAA receptor channel expressed in Xenopus oocytes.Dihydroxyaflavinine shows oral toxicity to the fall armyworm (Spodoptera frugiperda) and corn earwo...		GABA Receptor
TN1842	Kushenol I		GABA Receptor , Antifection
	Kushenol I is a GABAA receptor modulator, it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).Kushenol I is shown to be active against the plant pathogenic fungus Cladosporium cucumeri...		GABA Receptor , Antifection
TN4322	Isopulegol		ATPase , Potassium Channel , GABA Receptor
	Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly related to positive modulation of benzodiazepine-sensitive GA...		ATPase , Potassium Channel , GABA Receptor
T0051	Urethane	Ethyl carbamate,Ethylurethane,Carbamic acid ethyl ester	Chloride channel , GABA Receptor , Antibacterial , GluR , NMDAR , AChR , Parasite
	Urethane (Ethylurethane) was an antineoplastic agent .Now is used for other medicinal purposes.
TN3351	Aflatrem		GABA Receptor
	Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocampal neurotransmitter systems. Aflatrem potentiates the gamm...		GABA Receptor
T75557	Withasomniferolide B
	Withasomniferolide B, a withanolide, can be obtained through isolation from a methanol extract of Withania somnifera roots, which acts as a positive activator of the GABA(A) receptor [1].

天然物製品

Valepotriate

T4S1999

Synonym: Valtrate

Target: Apoptosis, HIV Protease

Songorine

T5S1882

Synonym: Napellonine,Zongorine,Bullatine G

Target: Others, GABA Receptor

Thiocolchicoside

T2S1464

Synonym: Thiocolchicine 2-glucoside analog,Coltramyl

Target: Others, GABA Receptor

(2S)-6-Prenylnaringenin

TN1325

Synonym: 6-Prenylnaringenin,6-PN

Target: GABA Receptor

Bicuculline

T2850

Synonym: (+)-Bicuculline,d-Bicuculline

Target: GABA Receptor

6,2'-Dihydroxyflavone

T8268

Synonym:

Target: GABA Receptor

(-)-Securinine

T3S2100

Synonym: Securinine

Target: GABA Receptor

Picrotoxinin

T16535

Synonym:

Target: Chloride channel, GABA Receptor

(-)-α-Pinene

TN1202

Synonym: (1S)-(-)-Alpha-Pinene

Target: Virus Protease, GABA Receptor, Endogenous Metabolite, Antibacterial

Acetoxyvalerensre

TN6773

Synonym: acetylvalerenolic acid

Target: GABA Receptor

6-Methylflavone

T8036

Synonym:

Target: GABA Receptor

Cirsimaritin

TQ0119

Synonym:

Target: GABA Receptor

Wogonoside

T3318

Synonym: Glychionide B,Wogonin 7-O-glucuronide,Oroxindin

Target: GABA Receptor, Autophagy

3,4,5-Trimethoxycinnamic acid

T2983

Synonym: 3-(3,4,5-Trimethoxyphenyl)acrylic Acid,O-Methylsinapic acid

Target: GABA Receptor, Endogenous Metabolite

Cholesterol myristate

T8040

Synonym: Cholesteryl myristate,Cholesteryl tetradecanoate

Target: Others, Potassium Channel, GABA Receptor, Endogenous Metabolite, AChR

Cannabidivarin

T8162

Synonym: Cannabidivarin,GWP-42006,GWP42006,GWP 42006

Target: GABA Receptor

Sanggenon D

T4S1616

Synonym: Sanggenone D

Target: NOS, COX, GABA Receptor

Eudesmin

T3836

Synonym:

Target: MAPK, S6 Kinase

Rosmanol

T7033

Synonym:

Target: Antioxidant, COX

γ-Aminobutyric acid

T0508

Synonym: Gamma-aminobutyric acid,4-Aminobutyric acid,GABA,4-Aminobutanoic acid,Piperidic acid

Target: GABA Receptor, Endogenous Metabolite

Spinosin

T6S2227

Synonym: Flavoayamenin

Target: Others

Dihydroergotoxine mesylate

TMS0418

Synonym: Ergoloid mesylates

Target: GABA Receptor

Pulegone

TCS0102

Synonym: (+)-Pulegone

Target: Calcium Channel, Endogenous Metabolite, TRP/TRPV Channel

Kavain

T5754

Synonym:

Target: NF-κB, GABA Receptor

α-Thujone

T8193

Synonym: Thujone,ALPHA-(-)-THUJONE

Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, AChR, Parasite, Autophagy

5-methoxyflavone

T3343

Synonym: 5-methoxy-2-phenylchromen-4-one

Target: DNA/RNA Synthesis

(+)-Kavain

T4590

Synonym: Kavain,L-KAWAIN,(R)-KAWAIN

Target: Calcium Channel, GABA Receptor, Sodium Channel, Monoamine Transporter

Glabridin

T3403

Synonym: Q-100692,KB-289522,LS-176045

Target: Reactive Oxygen Species, Tyrosinase, GABA Receptor, Antibacterial, PPAR

DL-Menthol

T2979

Synonym: Hexahydrothymol,(±)-Menthol

Target: GABA Receptor, AChE

Target: GABA Receptor

Kushenol I

TN1842

Synonym:

Target: GABA Receptor, Antifection

Isopulegol

TN4322

Synonym:

Target: ATPase, Potassium Channel, GABA Receptor

Urethane

T0051

Synonym: Ethyl carbamate,Ethylurethane,Carbamic acid ethyl ester

Target: Chloride channel, GABA Receptor, Antibacterial, GluR, NMDAR, AChR, Parasite

Aflatrem

TN3351

Synonym:

Target: GABA Receptor

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-03991	DBI Protein, Human, Recombinant (His)	Human	E. coli
	The diazepam binding inhibitor (DBI), alternatively known as the acyl-CoA binding protein (ACBP), is involved in multiple biological actions. The polypeptide binds to the peripheral, or mitochondrial, benzodiazepine rece...

DBI Protein, Human, Recombinant (His)

TMPY-03991

Species: Human

Expression System: E. coli