|
T7121 |
Sulfaclozine
|
Sulfachloropyrazine,Sulfachloropyrazine sodium |
Antibacterial
,
Antibiotic
,
Parasite
|
|
Sulfachloropyrazine sodium(Sulfachloropyrazine) is an antiprotozoal,with antibacterial and anticoccidial effects |
|
T16501 |
PF-3644022
|
|
p38 MAPK
,
Serine Protease
,
MAPK
|
|
PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhib... |
|
T15549 |
Icosabutate
|
|
Others
|
|
Icosabutate is a structurally engineered and orally active ω-3 polyunsaturated fatty acid. Icosabutate is well tolerated, and efficacious in lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels in persist... |
|
T3544 |
SHP099 hydrochloride
|
|
Phosphatase
,
Others
|
|
SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor. |
|
T2338 |
JZL195
|
|
FAAH
,
Lipase
,
Autophagy
|
|
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor. |
|
T14217 |
AMG 579
|
AMG-579 |
PDE
|
|
AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM). |
|
T12462 |
PI3Kδ-IN-1
|
|
PI3K
|
|
PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM). |
|
T3692 |
GNE-477
|
GNE 477 |
PI3K
,
mTOR
|
|
GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor. |
|
T36526 |
IL-17 modulator 4
|
|
Interleukin
|
|
IL-17 modulator 4 is a prodrug of IL-17 modulator 1 which is an efficacious modulator of IL-17. |
|
T6148 |
CX-6258 hydrochloride
|
CX-6258 HCl,Pim-Kinase Inhibitor X |
Pim
|
|
CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM). |
|
T4690 |
Betrixaban hydrochloride(330942-05-7(free base))
|
PRT054021 hydrochloride |
Factor Xa
|
|
Betrixaban hydrochloride(330942-05-7(free base)) (PRT054021 hydrochloride) is a potent, selective, and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM). |
|
T16996 |
TAS6417
|
|
Apoptosis
,
EGFR
|
|
TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM). |
|
T14302 |
Olorinab
|
APD 371 |
Cannabinoid Receptor
|
|
Olorinab (APD 371) (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2. |
|
T12181 |
NaV1.7 inhibitor-1
|
|
Sodium Channel
|
|
NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7). |
|
T2030 |
Tiplaxtinin
|
PAI-039,Tiplasinin |
PAI-1
,
Apoptosis
|
|
Tiplaxtinin (Tiplasinin)(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 uM. |
|
T28073 |
MLS1547
|
MLS000051547,MLS 1547,MLS-1547 |
Dopamine Receptor
|
|
MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assa... |
|
T11980 |
MD-224
|
|
Mdm2
,
E1/E2/E3 Enzyme
,
PROTACs
|
|
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent. |
|
T14087 |
ABT-239
|
|
TRP/TRPV Channel
|
|
ABT-239 is a novel, highly efficacious antagonist belonging to the non-imidazole class of histamine H3 receptor (H3R) antagonists. It also acts as a transient receptor potential vanilloid type 1 (TRPV1) antagonist. |
|
T12165 |
NAChR agonist 1
|
DUN71755 |
AChR
|
|
nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator. |
|
T3564 |
SHP099
|
SHP099 free base,SHP 099,SHP-099 |
Phosphatase
,
PERK
|
|
SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM). SHP099 shows dose-dependent pathway inhib... |
|
T22360 |
MDR-652
|
|
TRP/TRPV Channel
|
|
MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1 respectively and EC50s for hTRPV1 and rTRPV1 ... |
|
TP1618L |
PACAP-38 (31-38), human, mouse, rat acetate
|
PACAP-38 (31-38), human, mouse, rat acetate(138764-85-9 Free base) |
PACAP
|
|
PACAP-38 (31-38), human, mouse, rat acetate is an activator of PAC1 receptor. PACAP-38 (31-38), human, mouse, rat acetate demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY an... |
|
T10964 |
DB1976
|
|
Apoptosis
,
Others
|
|
DB1976 is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA comp... |
|
T4615 |
Balsalazide sodium hydrate
|
Balsalazide disodium dihydrate,Balsalazide disodium salt dihydrate,Balsalazide disodium |
STAT
,
Interleukin
|
|
Balsalazide sodium hydrate (Balsalazide disodium) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Balsalazide sodium hydrate is a new 5-aminosalicylic acid (5-ASA) containing prodrug.... |
|
T26542 |
AC-7954
|
|
|
|
AC-7954 is a potent and efficacious agonist of urotensin II receptor. |
|
T69886 |
FE-200041
|
|
|
|
FE-200041 is a peripheral efficacious kappa opioid agonist. |
|
T11275 |
Fesoterodine L-mandelate
|
|
Others
|
|
Fesoterodine L-mandelate is a efficacious antimuscarinic agent for the overactive bladder (OAB). |
|
T15193 |
EBI-1051
|
|
MEK
|
|
EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM). |
|
T16877 |
SHP394
|
|
Others
|
|
SHP394 is an orally efficacious inhibitor of protein tyrosine phosphatase SHP2 (IC50: 23 nM). |
|
T40281 |
KRAS G12D inhibitor 6
|
|
|
|
KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D. |
|
T15346 |
FR-190809
|
|
Others
|
|
FR-190809 is a nonadrenotoxic and orally efficacious inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) (IC50: 45 nM). |
|
T16953 |
Sulfaclozine sodium
|
Sulfachloropyrazine sodium |
Antibacterial
|
|
Sulfaclozine sodium is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine sodium is commonly used for the treatment of various poultry diseases. |
|
T27378 |
FR-193879
|
FR193879 |
|
|
FR-193879 is an efficacious cephem derivative, it has extremely potent therapeutic efficacy against H. pylori. |
|
T71353 |
CCT239065
|
|
|
|
CCT239065 is a novel, selective, and efficacious nanomolar pyridopyrazinone V600EBRAF and LCK inhibitor. |
|
T16020 |
MB05032
|
|
Others
|
|
MB05032 targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase), which is a special and efficacious inhibitor of GNG. |
|
T40321 |
TNF-α-IN-6
|
|
|
|
TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM). |
|
T27481 |
GSK-554418A
|
GSK554418A |
|
|
GSK-554418A, a novel azaindole CB(2) agonists, is used for the treatment of chronic pain. It is efficacious in the acute model and the chronic joint pain model. |
|
T27938 |
LY2922083
|
LY 2922083,LY-2922083 |
|
|
LY2922083 is a Potent and Selective GPR40 agonist. LY2922083 demonstrates potent, efficacious and durable dose dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion. |
|
TP1618 |
PACAP-38 (31-38), human, mouse, rat
|
|
|
|
PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. |
|
T36883 |
BM-1074
|
|
|
|
BM-1074 is a potent and highly efficacious inhibitor of Bcl-2/Bcl-xL with Ki value of < 1nM [1]. |
|
T13835 |
PROTAC BRD4 Degrader-3
|
|
Epigenetic Reader Domain
|
|
PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4. |
|
T15365 |
G-744
|
|
BTK
|
|
G-744 is a selective and orally active inhibitor of Btk (IC50: 2 nM). G-744 is well-tolerated, metabolically stable. It also has an efficacious to treat arthritis. |
|
T40107 |
IL-17 modulator 4 sulfate
|
|
|
|
IL-17 modulator 4 sulfate is a prodrug of IL-17 modulator 1 . IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator. |
|
T40220 |
TRV055
|
TRV055 |
|
|
TRV055 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling. TRV055 can be used to develop the Gq-biased AT1R agonists. |
|
T77933 |
SJ995973
|
|
PROTACs
|
|
SJ995973 (PROTAC) represents a highly efficacious degrader of bromodomain and extra-terminal (BET) proteins. |
|
T71307 |
JNJ-40413269
|
|
|
|
JNJ-40413269 is a competitive inhibitor of fatty acid amide hydrolase (FAAH), which demonstrates robust central target engagement, and shows efficacious in a rat model of neuropathic pain. |
|
T17175 |
Troxacitabine
|
BCH-4556,SGX-145,SGX145,SPD-758,BCH4556,beta-L-OddC |
Others
|
|
Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious ... |
|
T13834 |
PROTAC BRD4 Degrader-2
|
|
Epigenetic Reader Domain
|
|
PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM). |
|
T39937 |
M-808
|
|
|
|
M-808 is a potent and efficacious covalent inhibitor, targeting the interaction between Menin and MLL. It demonstrates a high binding affinity with an IC50 value of 2.6 nM. |
|
T10527 |
Betrixaban-d6
|
Betrixaban D6 |
Others
|
|
Betrixaban D6 is a deuterium-labeled Betrixaban. Betrixaban is a selective and orally efficacious FXa inhibitor. |
