検索結果

Search Results for " elevation "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T7127	DC260126		Apoptosis , GPR
	DC260126 is a small-molecule antagonist of FFA1 (GPR40)		Apoptosis , GPR
T3543	NS-638	NS 638	Calcium Channel
	NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM).		Calcium Channel
T69795	Crobenetine	BIII 890 CL,Crobenetine Free Base	Calcium Channel , Sodium Channel
	Crobenetine (BIII 890 CL) Free Base is a selective NaV channel blocker that eliminates VTD-induced [Ca2+] elevation.		Calcium Channel , Sodium Channel
T10595	BQ-788	BQ788	Endothelin Receptor
	BQ-788 is a selective and potent ETB receptor antagonist with potential hypertensive activity.BQ-788 inhibits ET-1 binding to ETB receptors and inhibits exogenous ET-1-induced elevation of coronary artery perfusion press...		Endothelin Receptor
T15648	KDM5-C70		Histone Demethylase
	KDM5-C70 is an ethyl ester derivative of KDM5-C49. KDM5-C70 is an effective, cell-permeable, and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, inducing a genome-wide e...		Histone Demethylase
T28958	TG6-129	TG6 129	Prostaglandin Receptor
	TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 reduces the expression of COX-2, IL-1β, IL-6, IL-12, IL-23 and...		Prostaglandin Receptor
T21704	5-fluoro 203	5F-203,NSC-703786	Others
	5-fluoro 203 (NSC-703786) is a cytotoxic molecule leading to cell death by forming DNA adducts. 5-fluoro 203 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. 5-fluoro 203 treatment of cells...		Others
T41005	PA-8		PACAP
	PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vp...		PACAP
T15017	CU-T12-9		TLR
	CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activat...		TLR
T1577	Midodrine hydrochloride	Pro-Amatine	Adrenergic Receptor
	Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This c...		Adrenergic Receptor
T70993	WO-459
	WO-459 is a novel GPR52 agonist, dose-dependently inducing elevation of intracellular cAMP in HEK293/GPR52 cells.
T23583	58-G3	58G3
	58-G3 is an agonist of methuselah (Mth)-specific that acts by inducing dose-dependent calcium elevation and membrane translocation of β-arrestin2.
T14068	A-192621		Others
	A-192621 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. A-192621 promotes apoptosis in PASMCs and it also causes elevation of arteri...		Others
T27331	Flerobuterol HCl	CRL-40996,CRL40996,CRL 40996,Flerobuterol hydrochloride
	Flerobuterol is a β adrenergic receptor agonist potentially for the treatment of major depressive disorder. Flerobuterol enhances serotonergic neurotransmission. Flerobuterol acutely increases 5-HT synthesis, in part, th...
T61137	VEGFR-2-IN-19
	VEGFR-2-IN-19 (Compound 15b) is a highly efficacious inhibitor of VEGFR2, a receptor involved in angiogenesis. Its mechanism of action involves the induction of cellular apoptosis and elevation of intracellular reactive ...
T70865	BMY-42393
	BMY-42393 is orally active and selective platelet aggregation inhibitor. BMY-42393 is also a prostacyclin partial agonist that inhibited ADP, collagen and thrombin-induced platelet aggregation (IC50 range 0.3 - 2.0 mic...
T68364	GS-9160
	GS-9160 is a novel and potent inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN) that specifically targets the process of strand transfer. It is an authentic inhibitor of HIV-1 integration, since tre...
T77026	Goflikicept
	Goflikicept (RPH 104), a hybrid protein, selectively targets and neutralizes circulating IL-1ß and IL-1α. This compound shows promise for the investigation of ST-segment elevation myocardial infarction (STEMI) [1].
T40750	12,14-Dichlorodehydroabietic acid
	12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, exhibits potent calcium-activated potassium (BK) channel opening activity. It effectively inhibits GABA-dependent chloride influx in the mammalian brain, funct...
T69991	Difenamizole HCl
	Difenamizole HCl is the salt form of Difenamizole, a non-steroidal anti-inflammatory drug (NSAID) and analgesic of the pyrazolone group related to metamizole. It has monoaminergic properties, including inhibition of mono...
T27228	E-3030 free acid	E-3030,E3030,E 3030
	E-3030 free acid is a peroxisome proliferator-activated receptor (PPAR) agonist. E-3030 decreased blood glucose, triglyceride, non-esterified fatty acids, and insulin levels and increased blood adiponectin levels. Trigly...
T68760	Luminespib mesylate
	Luminespib, also known as AUY-922, NVP-AUY922, VER52296, is a derivative of 4,5-diarylisoxazole and a third-generation heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Hsp90 inhibitor AUY92...
T63088	NOD2 antagonist 1
	NOD2 antagonist 1 (compound 32) is an effective and selective NOD2 antagonist (IC50: 5.23μM). NOD2 antagonist 1 in THP-1 cells repress Muramyl DiDP (MDP) -induced IL-8 secretion. NOD2 antagonist 1 in PBMCs cells inhibits...
T73083	Nipradolol	KT 210 ; K 351 ; Hypadil,Hypadil,KT 210,K 351
	Nipradolol (KT-210; K-351), an alpha-1-adrenergic receptor antagonist, effectively inhibits the elevation of intraocular pressure (IOP) induced by Phenylephrine in an albino rabbit model and suppresses noradrenaline (NA)...
T81249	Ru3		PARP
	Ru3 is a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor that prompts apoptosis in MCF-7 cells through various mechanisms, including DNA damage induction, inhibition of DNA repair, alteration of cell cycle distribution, ...		PARP
T70763	KR-67607
	KR-67607, also known as NTX-101 is novel selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor. KR-67607 decreased 4-hydroxynonenal expression and increased antioxidant and mucus secretion in BAC-treated rat ...
T63248	NTU281
	NTU281 is a potent inhibitor of transglutaminase-2 that reduces the elevation of serum creatinine and proteinuria in diabetic rats and decreases glomerular type I collagen accumulation, Hic-5 and α-SMA expression, as wel...
T65252	Pepsin
	Pepsin is an endopeptidase that breaks down proteins into smaller peptides and amino acids that can be easily absorbed in the small intestine[1]. Pepsin is stable at pH ranges as high as pH 6. Above this pH, pepsin is ra...

Compounds

DC260126

T7127

Synonym:

Target: Apoptosis, GPR

NS-638

T3543

Synonym: NS 638

Target: Calcium Channel

Crobenetine

T69795

Synonym: BIII 890 CL,Crobenetine Free Base

Target: Calcium Channel, Sodium Channel

BQ-788

T10595

Synonym: BQ788

Target: Endothelin Receptor

KDM5-C70

T15648

Synonym:

Target: Histone Demethylase

TG6-129

T28958

Synonym: TG6 129

Target: Prostaglandin Receptor

5-fluoro 203

T21704

Synonym: 5F-203,NSC-703786

Midodrine hydrochloride

T1577

Synonym: Pro-Amatine

Target: Adrenergic Receptor

Synonym: CRL-40996,CRL40996,CRL 40996,Flerobuterol hydrochloride

12,14-Dichlorodehydroabietic acid

Synonym: E-3030,E3030,E 3030

Synonym: KT 210 ; K 351 ; Hypadil,Hypadil,KT 210,K 351

カタログ番号	製品名	別名	ターゲット
T19924	Rhododendrol	Betuligenol,Frambinol	Others
	Rhododendrol (Frambinol) is a melanin synthesis and acts by preventing high-fat diet-induced elevation in body weight and increasing lipolysis in white adipocytes in male mice. Rhododendrol can be used as the lightening/...		Others
T21344	1-Deoxynojirimycin hydrochloride	Moranoline,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin	PI3K , Antibacterial , Antibiotic , Glucosidase
	1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of postprandial hyperglycemia.		PI3K , Antibacterial , Antibiotic , Glucosidase
T3273	Bifendate	Bifendatatum	HBV , Reverse Transcriptase
	Bifendate (Bifendatatum) is commonly used to treat the transaminase elevation that caused by viral hepatitis and drug-induced liver injury.		HBV , Reverse Transcriptase
T0611	Vanillylmandelic acid	4-Hydroxy-3-methoxymandelic acid	Others
	Vanillylmandelic acid (4-Hydroxy-3-methoxymandelic acid), is the end product of catecholamine,epinephrine and norepinephrine metabolism, is commonly used to aid in diagnosis of pheochromocytoma,and which elevation is rel...		Others
T2S1778	DL-Goitrin	Goitrin	Others
	DL-Goitrin is a potent antithyroid compound found naturally in crucifers. DL-Goitrin is responsible for the induction of glutathione S-transferases. DL-Goitrin is a moderate inhibitor of purified bovine adrenal dopamine ...		Others
TN1011	Rhodionin		P450 , AChE
	Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs; they can significantly suppress the elevation of ...		P450 , AChE
T2860	Vanillyl Alcohol	4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,Vanillin alcohol,Vanillic alcohol	Apoptosis , Others
	Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) possesses anti-angiogenic, anticonvulsive, anti-inflammatory, anti-oxidant, neuroprotective, and anti-nociceptive activities. Vanillyl alcohol can effectively inhibit ...		Apoptosis , Others
T4713	Phosphorylcholine chloride calcium salt tetrahydrate	Phosphocholine chloride calcium salt tet,CalciuM Phosphorylcholine Tetrahydrate	Others , Endogenous Metabolite
	Phosphorylcholine chloride calcium salt tetrahydrate (Phosphocholine chloride calcium salt tet) is a small haptenic molecule, is found in a wide variety of organisms. Human hepatic tumors undergo an elevation in the conc...		Others , Endogenous Metabolite
T4877	L-Homocystine		Endogenous Metabolite
	Homocystine is the double-bonded form of homocysteine, but it occurs only transiently before being converted to the harmless cystathionine via a vitamin B6-dependent enzyme. Increasing evidence supports a role for an ele...		Endogenous Metabolite
T4S2326	Cornuside	7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside	ERK , p38 MAPK , NF-κB , JNK
	1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...		ERK , p38 MAPK , NF-κB , JNK
T5S1632	Barlerin	8-O-Acetylshanzhiside methyl ester,ND01	VEGFR , TNF , NF-κB , Akt , Caspase
	Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ e...		VEGFR , TNF , NF-κB , Akt , Caspase
T13752	L-(+)-Arabinose		Endogenous Metabolite
	L-(+)-Arabinose selectively inhibits intestinal sucrase activity in a non-competitive manner, inhibiting glucose elevation caused by sucrose intake.		Endogenous Metabolite
TN4317	Isopedicin		NADPH-oxidase , cAMP , p38 MAPK , PKA , JNK , PDE
	Isopedicin has anti-inflammatory functions, it inhibits the O(2)()(-) production in human neutrophils by an elevation* of cellular cAMP and activation of PKA through its inhibition of cAMP-specific PDE.		NADPH-oxidase , cAMP , p38 MAPK , PKA , JNK , PDE
TN2224	Soyasapogenol A		TNF
	Soyasapogenol A shows estrogenic and hepatoprotective activities, it directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-α±, which consequently resulted in the prevention of liv...		TNF
T27564	Hymenidin		5-HT Receptor
	Hymenidin, an alkaloid isolated from the Okinawan sponge Hymeniacidon sp. is a 5-hydroxytryptaminergic receptor antagonist and voltage-gated potassium channel inhibitor with potential antiprotozoal effects.It selectively...		5-HT Receptor
TN2169	Saikogenin D		IL Receptor , Calcium Channel , Prostaglandin Receptor
	Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of [Ca2+]i that is attributed to Ca2+ release from intracellu...		IL Receptor , Calcium Channel , Prostaglandin Receptor
TN4582	Moracin T		c-Myc , COX
	Moracin treatment can inhibit the double 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment-induced morphological changes reflecting inflammatory response, including leucocyte infiltration, hyperplasia and cell prolife...		c-Myc , COX

天然物製品

Rhododendrol

T19924

Synonym: Betuligenol,Frambinol

Target: Others

1-Deoxynojirimycin hydrochloride

T21344

Synonym: Moranoline,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin

Target: PI3K, Antibacterial, Antibiotic, Glucosidase

Bifendate

T3273

Synonym: Bifendatatum

Target: HBV, Reverse Transcriptase

Vanillylmandelic acid

T0611

Synonym: 4-Hydroxy-3-methoxymandelic acid

Synonym: 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,Vanillin alcohol,Vanillic alcohol

Target: Apoptosis, Others

Phosphorylcholine chloride calcium salt tetrahydrate

T4713

Synonym: Phosphocholine chloride calcium salt tet,CalciuM Phosphorylcholine Tetrahydrate

Target: Others, Endogenous Metabolite

L-Homocystine

T4877

Synonym:

Target: Endogenous Metabolite

Cornuside

T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

Barlerin

T5S1632

Synonym: 8-O-Acetylshanzhiside methyl ester,ND01

Target: VEGFR, TNF, NF-κB, Akt, Caspase

L-(+)-Arabinose

T13752

Synonym:

Target: Endogenous Metabolite

Isopedicin

TN4317

Synonym:

Target: NADPH-oxidase, cAMP, p38 MAPK, PKA, JNK, PDE

Target: 5-HT Receptor

Saikogenin D

TN2169

Synonym:

Target: IL Receptor, Calcium Channel, Prostaglandin Receptor

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-02881	Renin-2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Renin is a highly specific endopeptidase, related to pepsin, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood...
TMPK-01229	IL-19 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Interleukin-19 (IL-19) has been shown to be involved in coronary artery diseases and atherosclerosis, while its expression in myocardial infarction is poorly understood. In this study, the dynamic increase in circulating...
TMPJ-01118	GNMT Protein, Human, Recombinant (His)	Human	E. coli
	Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyzes the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation b...
TMPY-04464	GALK1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Galactokinase, also known as Galactose kinase, GALK and GALK1, is a protein which belongs to theGHMP kinase family and GalK subfamily. Galactokinase / GALK1 is a major enzyme for galactose metabolism. Galactokinase (G...
TMPY-03851	BPIFB1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	BPIFB1, also known as LPLUNC1, belongs to the BPI/LBP/Plunc superfamily, plunc family. BPIFB1 may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. BPIFB1 is express...
TMPJ-00379	AOC3 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycop...
TMPY-01290	CHIT1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Chitotriosidase, also known as Chitinase-1 and CHIT1, is a member of the glycosyl hydrolase 18 family and Chitinase class II subfamily. It is a member of the mammalian chitinase family, structurally homologous to chitina...
TMPY-01869	SIRT1 Protein, Human, Recombinant (His)	Human	E. coli
	SIRT1 belongs to the sirtuin family. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT1 is included in class I of the sirtuin family. It is a NAD-dependent prote...