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天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T15656	KGA-2727		SGLT
	KGA-2727 is a potent and selective SGLT1 inhibitor, with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA...		SGLT
T38843	Enavogliflozin	DWP-16001	SGLT
	Enavogliflozin (DWP-16001) is an orally available small molecule and sodium glucose transporter 2 inhibitor.		SGLT
T9590	T-1095		SGLT , transporter
	T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2).		SGLT , transporter
T1766	Empagliflozin	BI 10773	SGLT
	Empagliflozin (BI 10773) is an SGLT-2 inhibitor (IC50=3.1 nM) that is potent and selective, with more than 300-fold selectivity for SGLT-1/4/5/6. Empagliflozin is used for the treatment of type 2 diabetes.		SGLT
T2385	Ipragliflozin	ASP1941	SGLT
	Ipragliflozin (ASP1941) is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.		SGLT
T2389	Dapagliflozin	BMS-512148	SGLT , HIF
	Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.		SGLT , HIF
T3547	Sotagliflozin	LX-4211,LP-802034	SGLT
	Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.		SGLT
T4999	Ertugliflozin	MK-8835,PF-04971729	SGLT
	PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).		SGLT
T5016	Tofogliflozin (hydrate)	Tofogliflozin hydrate,CSG-452 hydrate	SGLT , Reactive Oxygen Species , ROS
	Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2).		SGLT , Reactive Oxygen Species , ROS
T15244	Ertugliflozin L-pyroglutamic acid	PF-04971729 L-pyroglutamic acid	Others , SGLT
	Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a selective and orally active hSGLT2 inhibitor with an IC50 of 0.877 nM. Ertugliflozin L-pyroglutamic acid can be used for studies about the treatmen...		Others , SGLT
T83710	Gastric Inhibitory Peptide (22-51) (human) TFA	GIP (22-51),Glucose-dependent Insulinotropic Peptide (22-51)
	Gastric inhibitory peptide (GIP) (22-51), a pro-atherogenic peptide comprised of 30 amino acids from the residues 22-51 of its precursor protein proGIP, is present in human plasma. It activates the degradation of IκB-α a...
T83694	Gastric Inhibitory Peptide (1-42) (porcine) TFA	GIP (1-42),Glucose-dependent Insulinotropic Polypeptide (1-42)
	Gastric inhibitory peptide (GIP) (1-42), an endogenous incretin hormone comprising 42 amino acids, promotes insulin secretion. Expressed in the intestinal neuroendocrine K cells and submandibular gland, it enters circula...
T1782	Canagliflozin	JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754	SGLT
	Canagliflozin (JNJ 28431754AAA), a sodium-glucose transporter 2( SGLT2) and P-Glycoprotein inhibitor, is used in type 2 diabetes.		SGLT
T83696	Gastric Inhibitory Peptide 1 (3-42) (human) TFA	Glucose-dependent Insulinotropic Polypeptide 3-42,GIP-1 (3-42)
	Gastric inhibitory peptide 1 (GIP-1) (3-42), a fragment of the incretin hormone GIP and antagonist to the GIP receptor, is generated through the action of serum dipeptidyl peptidase 4 (DDP-4). When administered at 25 nmo...
T4460	Dapagliflozin ((2S)-1,2-propanediol, hydrate)	BMS-512148 (2S)-1,2-propanediol, hydrate,Dapagliflozin propanediol monohydrate	SGLT
	Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2). It is in development for the tre...		SGLT
T15752	Licogliflozin	LIK066	SGLT
	Licogliflozin (LIK066) is an inhibitor of sodium-glucose cotransporter (SGLT1 and SGLT2).		SGLT
T16083	Mizagliflozin	GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base	SGLT
	Mizagliflozin (GSK-1614235 free base) is a sodium-glucose transporter inhibitor( Ki of 27 nM for human SGLT1). Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that ca...		SGLT
T37588L	GIP (1-30) amide, porcine acetate		IGF-1R
	GIP (1-30) amide, porcine acetate is an agonist of fully glucose-dependent insulinotropic polypeptide (GIP) receptor. GIP (1-30) amide, porcine acetate can weakly inhibit gastric acid secretion and strongly stimulate ins...		IGF-1R
TP2018L	GIP (human) acetate	GIP (human) acetate(100040-31-1 Free base)	IGF-1R
	GIP (human) acetate is a stimulator of glucose-dependent insulin secretion and a weak inhibitor of gastric acid secretion. GIP (human) acetate plays a vital role in lipid metabolism and the development of obesity.		IGF-1R
TP1111	Tirzepatide	LY-3298176	Glucagon Receptor
	Tirzepatide (LY-3298176) is a dual agonist of glucose-dependent polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor with neuroprotective activity for the study of diabetes and obesity.		Glucagon Receptor
T76279L1	Retatrutide sodium salt	Retatrutide sodium salt(2381089-83-2 free base),LY3437943 sodium salt	Glucagon Receptor
	Retatrutide sodium salt is a potent triple agonist peptide for glucagon receptor (GCGR), glucose-dependent proinsulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R) Retatrutide sodium s...		Glucagon Receptor
T76279	Retatrutide	LY3437943	Glucagon Receptor
	Retatrutide (LY3437943) is a triple agonist of the glucagon receptor, glucose-dependent insulinotropic polypeptide receptor, and glucagon-like peptide-1 receptor (GLP-1R), and inhibits GCGR, GIPR, and GLP-1R.Retatrutide ...		Glucagon Receptor
T69146	Suksdorfin		PPAR
	Suksdorfin has hypoglycemic effects, promotes adipocyte differentiation and enhances lipocalin production, activates peroxisome proliferator-activated receptor gamma (PPARγ), promotes insulin-dependent glucose uptake by ...		PPAR
T16277	NCT-502	N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide	Dehydrogenase
	NCT-502 (N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide) is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells. It decreases glucose-d...		Dehydrogenase
T40413	SW157765		transporter
	SW157765 is a selective glucose transporter GLUT8 (SLC2A8) inhibitor, a prodrug of many compounds, that selectively inhibits the uptake of fluorescent 2-deoxyglucose (2DG) in SW157765-sensitive cells in a dose-dependent ...		transporter
T21399	Luseogliflozin	TS71,TS-071,TS 71,TS071,TS-71,TS 071
	Luseogliflozin, a potent and competitive inhibitor of sodium-dependent glucose cotransporter 2 (SGLT2), competitively inhibits human SGLT2-mediated glucose uptake with a Ki value of 1.10 nM.
TP1566	GIP (1-30) amide (Human) (TFA)
	GIP (1-30) amide (Human) TFA is a glucose-dependent insulinotropic polypeptide fragment. Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone that stimulates insulin secretion and reduces postprandia...
T30169	ASP-8497	UNII-GC7THT248G,ASP8497,ASP 8497
	ASP8497 is a potent, long-acting DPP-IV inhibitor that improves glucose tolerance by elevating GLP-1 levels in a glucose-dependent insulin-stimulating manner. The compound is used as a therapeutic agent for impaired gluc...
T40694	4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid
	4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid exhibits hypoglycemic activity and operates through a mechanism dependent on the response to oral glucose overload.
T34600	Secretin (1-6)	Secretin,N-terminal hexapeptide
	Secretin (1-6) is the N-terminal part of secretin. It can produce vitro glucose-dependent insulin release induced by secretin.
T3074L	CHIR98014 HCl (252935-94-7 free base)	CT-98014,CHIR-98014 hydrochloride,CHIR-98014,CHIR98014 HCl,CHIR98014,CHIR 98014
	CHIR98014 is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50s: 0.65 and 0.58 nM). Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50: 106 nM), potentiates insulin-dependent...
T27938	LY2922083	LY 2922083,LY-2922083
	LY2922083 is a Potent and Selective GPR40 agonist. LY2922083 demonstrates potent, efficacious and durable dose dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion.
TP1110	Tirzepatide hydrochloride	LY3298176 hydrochloride
	Tirzepatide hydrochloride (LY3298176 hydrochloride) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist.
TP1584	GIP (1-30) amide,human	GIP (1-30) amide (Human)
	GIP (1-30) amide (Human) is an insulin-dependent glucose-dependent polypeptide.The sugar-dependent insulin polypeptide (GIP) is an insulin secreting hormone, which can stimulate the secretion of insulin and reduce the oc...
T41028	α-Glucosidase	α-D-Glucosidase
	α-Glucosidase (α-D-Glucosidase) is a carbohydrate hydrolyzing enzyme that catalyzes the release of α-glucose from the non-reducing end of the substrate. It plays a vital role in facilitating glucose absorption by the sma...
T15797	LX2761		Others
	LX2761 is a chemically stable and effective inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 (IC50s: 2.2 nM and 2.7nM for hSGLT1 and hSGLT2). However, it shows specific SGLT1 inhibition in the...		Others
T12892	SGL5213		SGLT
	SGL5213 is an oral active and low-absorbable inhibitor of sodium-dependent glucose cotransporter 1 (SGLT1)(hSGLT1 and hSGLT2 with IC50 values of 29 nM and 20 nM , respectively),and has potential to treat type 2 diabetes.		SGLT
T71020	PF-04671536
	PF-04671536 is a highly potent and selective inhibitor of phosphodiesterase 8B (PDE8B) phosphodiesterase 8A (PDE8A). In primary human pancreatic islets, PF-04671536 increases insulin secretion in a glucose-dependent mann...
T68236	TP0438836
	TP0438836 is a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor for the treatment of type 2 diabetes. TP0438836 showed IC50 values 28nM and 7 nM for hSGLT1 and hSGLT2 resepctively.
T76309	Gastric Inhibitory Peptide, porcine
	Gastric Inhibitory Peptide (porcine), also known as a glucose-dependent insulinotropic polypeptide, is a 42-amino acid intestinal hormone that influences fat and glucose metabolism [1].
T23945	DA-11004	DA11004,UNII-48M66E9ER2
	DA-11004 is a potent NADP-dependent isocitrate dehydrogenase inhibitor (IC50: 1.49 μM for IDPc). DA-11004 inhibited fatty acid synthesis in adipose tissues via IDPc inhibition. It also decreased the plasma glucose levels...
T33444	MK-912	MK912,MK 912
	MK-912 is a potent novel selective alpha2-adrenergic receptor antagonist with oral activity to study the effect of short-term selective alpha2-blockers on fasting glucose (FPG) and islet function in non-insulin-dependent...
T6203L	Saxagliptin hydrochloride	BMS477118,Saxagliptin,BMS 477118,Saxagliptin HCl,BMS-477118
	Saxagliptin is a new oral hypoglycemic of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Saxagliptin is a competitive DPP4 inhibitor that slows the inactivation of the incretin hormones and reducing fas...
TP2017	GIP (1-39)
	Endogenous truncated form of the incretin hormone GIP. More potent at stimulating glucose-dependent insulin secretion from rat pancreatic β-cells than GIP.
T24620	PF-06372222	PF-0637222,PF0637222,PF 0637222
	PF-06372222 is a small-molecule negative allosteric modulator of the glucagon receptor (GCGR). PF-06372222 is also an antagonist for glucagon-like peptide-1 receptor GLP-1R, which inhibits glucagon secretion and glucose...
T73434	BI-2081
	BI-2081, a GPR40 (FFAR1) partial agonist with an EC50 of 4 nM, promotes glucose-dependent insulin secretion and lowers plasma glucose levels. This compound is utilized in metabolic disease research, specifically targetin...
T37601	GIP (1-30) amide, porcine TFA
	GIP (1-30) amide, porcine TFA is a high-affinity full agonist of the glucose-dependent insulinotropic polypeptide (GIP) receptor, having a similar potency as the native GIP(1-42) [1]. Furthermore, GIP (1-30) amide, porci...
T37589L	GIP (3-42), human acetate	GIP (3-42), human acetate(1802086-25-4 Free base)	IGF-1R
	GIP (3-42), human acetate is an antagonist of a glucose-dependent insulinotropic polypeptide (GIP) receptor and regulates insulin secretion and GIP metabolism in vivo.		IGF-1R
T37799	PF 04671536 hydrochloride
	Potent and selective PDE8B/8A inhibitor ( IC50 values are 1.3 and 1.9 nM, respectively). Exhibits selectivity for PDE8A/B over other PDEs (IC50 values are >10 μM) and a range of other targets. Increases glucose-dependen...
T76006	Tirzepatide TFA	Tirzepatide TFA(2023788-19-2 free base),LY3298176 TFA
	Tirzepatide TFA (LY3298176 TFA), a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, is under development for type 2 diabetes treatment [1].

Compounds

Target: SGLT, transporter

Synonym: LX-4211,LP-802034

Target: SGLT

Ertugliflozin

T4999

Synonym: MK-8835,PF-04971729

Target: SGLT

Tofogliflozin (hydrate)

T5016

Synonym: Tofogliflozin hydrate,CSG-452 hydrate

Target: SGLT, Reactive Oxygen Species, ROS

Ertugliflozin L-pyroglutamic acid

T15244

Synonym: PF-04971729 L-pyroglutamic acid

Target: Others, SGLT

Gastric Inhibitory Peptide (22-51) (human) TFA

T83710

Synonym: GIP (22-51),Glucose-dependent Insulinotropic Peptide (22-51)

Target:

Gastric Inhibitory Peptide (1-42) (porcine) TFA

T83694

Synonym: GIP (1-42),Glucose-dependent Insulinotropic Polypeptide (1-42)

Target:

Canagliflozin

T1782

Synonym: JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754

Target: SGLT

Gastric Inhibitory Peptide 1 (3-42) (human) TFA

T83696

Synonym: Glucose-dependent Insulinotropic Polypeptide 3-42,GIP-1 (3-42)

Target:

Dapagliflozin ((2S)-1,2-propanediol, hydrate)

T4460

Synonym: BMS-512148 (2S)-1,2-propanediol, hydrate,Dapagliflozin propanediol monohydrate

Synonym: GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base

Target: SGLT

GIP (1-30) amide, porcine acetate

Synonym: GIP (human) acetate(100040-31-1 Free base)

Target: Glucagon Receptor

Retatrutide sodium salt

T76279L1

Synonym: Retatrutide sodium salt(2381089-83-2 free base),LY3437943 sodium salt

Target: Glucagon Receptor

Retatrutide

T76279

Synonym: LY3437943

Target: Glucagon Receptor

Synonym: N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide

Target: Dehydrogenase

Synonym: TS71,TS-071,TS 71,TS071,TS-71,TS 071

Target:

GIP (1-30) amide (Human) (TFA)

Synonym: UNII-GC7THT248G,ASP8497,ASP 8497

Target:

4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid

Synonym: Secretin,N-terminal hexapeptide

Target:

CHIR98014 HCl (252935-94-7 free base)

T3074L

Synonym: CT-98014,CHIR-98014 hydrochloride,CHIR-98014,CHIR98014 HCl,CHIR98014,CHIR 98014

Target:

LY2922083

T27938

Synonym: LY 2922083,LY-2922083

Target:

Tirzepatide hydrochloride

TP1110

Synonym: LY3298176 hydrochloride

Target:

GIP (1-30) amide,human

TP1584

Synonym: GIP (1-30) amide (Human)

Target:

α-Glucosidase

T41028

Synonym: α-D-Glucosidase

Gastric Inhibitory Peptide, porcine

Synonym: DA11004,UNII-48M66E9ER2

Target:

MK-912

T33444

Synonym: MK912,MK 912

Target:

Saxagliptin hydrochloride

T6203L

Synonym: BMS477118,Saxagliptin,BMS 477118,Saxagliptin HCl,BMS-477118

Synonym: PF-0637222,PF0637222,PF 0637222

GIP (1-30) amide, porcine TFA

T37601

Synonym:

Target:

GIP (3-42), human acetate

T37589L

Synonym: GIP (3-42), human acetate(1802086-25-4 Free base)

Target: IGF-1R

PF 04671536 hydrochloride

Synonym: Tirzepatide TFA(2023788-19-2 free base),LY3298176 TFA

Target:

カタログ番号	製品名	別名	ターゲット
T2924	Phloretin	Dihydronaringenin,NSC 407292,RJC 02792	SGLT , transporter , Endogenous Metabolite
	Phloretin (NSC-407292) is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leav...		SGLT , transporter , Endogenous Metabolite
TN7108	Urolithin C		Apoptosis , Calcium Channel , Reactive Oxygen Species , IGF-1R , Endogenous Metabolite
	Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
T2S0731	Trilobatin	P-Phlorizin	Amylase
	Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory respon...		Amylase
T2922	Phlorizin	Floridzin,NSC 2833,Phloridzin	ATPase , SGLT
	Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .		ATPase , SGLT
T3386	Kaempferitrin	Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside	cell cycle arrest , Glucokinase , IGF-1R
	Kaempferitrin (Lespenephryl) has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against HeLa cells. Kaempferitrin stimulates glucos...		cell cycle arrest , Glucokinase , IGF-1R
T3794	Pentagalloylglucose	Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose	Influenza Virus
	1, 2, 3, 4, 6-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) and gallic acid from Pistacia lentiscus have antimutagenic and antioxidant activities. 2. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose (PGG) possesses poten...		Influenza Virus
T2P2919	(2S,3R,4S)-4-Hydroxyisoleucine	(4S)-4-Hydroxy-L-isoleucine,Hydroxyisoleucine	PI3K
	(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid. HIL stimulates glucose-dependent insulin secr...		PI3K
TWO2727	Propane-1,2,3-triyl tripalmitate	Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate	Others , Endogenous Metabolite
	Propane-1,2,3-triyl tripalmitate (Glycerol Tripalmitate) is a triacylglycerol found in dietary fats. Tripalmitin increases body weight and plasma LDL levels and reduces hepatic LDL receptor mRNA levels in hamsters fed a ...		Others , Endogenous Metabolite
T2S2043	Dracorhodin perchlorate	Dracorhodin perochlorate,Dracohodin perochlorate	Apoptosis , Others
	Dracorhodin perchlorate inhibits cell growth, and induces apoptosis in fibroblasts in a dose-and time-dependent manner, arresting cell cycle at G1 phase, may as a candidate for anti-breast cancer. Dracorhodin perchlorate...		Apoptosis , Others
T5S1097	Neferine	(R)-1,2-Dimethoxyaporphine,(-)-Neferine	Apoptosis , NF-κB , Autophagy
	1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to a...		Apoptosis , NF-κB , Autophagy
T5S1805	5,7-Dihydroxychromone	5,7-Dihydroxy-4H-Chromen-4-One	Others , Virus Protease , PARP , Caspase , Nrf2
	1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5,7-Dihydroxychromone exerts neuroprotective effect agai...		Others , Virus Protease , PARP , Caspase , Nrf2
T5S1632	Barlerin	8-O-Acetylshanzhiside methyl ester,ND01	VEGFR , TNF , NF-κB , Akt , Caspase
	Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ e...		VEGFR , TNF , NF-κB , Akt , Caspase
TN1847	Kushenol X		Others
	Kushenol X exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).		Others
TN1841	Kushenol A	Leachianone E	cAMP
	Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushenol A and kushenol C exhibit inhibitory activity against So...		cAMP
TN1842	Kushenol I		GABA Receptor , Antifection
	Kushenol I is a GABAA receptor modulator, it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).Kushenol I is shown to be active against the plant pathogenic fungus Cladosporium cucumeri...		GABA Receptor , Antifection
TN3532	Borapetoside E		Others
	Borapetoside E has anti-hyperglycemic activity, it can significantly reduce serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.		Others
TN1462	Cajanin		ERK , MEK , Akt
	Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol efflux and RCT, it can significantly improve basal glucose up...		ERK , MEK , Akt
TN4399	Kushenol C		SGLT , NF-κB , ROS , BACE , Antifection
	Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). Kushenol C shows antimicrobial activity against Staphyloco...		SGLT , NF-κB , ROS , BACE , Antifection
T74199	Beauverolide Ka
	Beauverolide Ka, a cyclotetradepsipeptide derived from the Beauveria bassiana fungus, enhances glucose absorption in rat L6 myoblasts cultured at a concentration of 50 μM and exhibits protective effects on HEI-OC1 cells ...
TN5164	Trans-Hinokiresinol		IL Receptor , TNF , NOS , LTR
	Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyaso...		IL Receptor , TNF , NOS , LTR

天然物製品

Phloretin

T2924

Synonym: Dihydronaringenin,NSC 407292,RJC 02792

Target: SGLT, transporter, Endogenous Metabolite

Urolithin C

TN7108

Synonym:

Target: Apoptosis, Calcium Channel, Reactive Oxygen Species, IGF-1R, Endogenous Metabolite

Synonym: Floridzin,NSC 2833,Phloridzin

Target: ATPase, SGLT

Kaempferitrin

T3386

Synonym: Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside

Target: cell cycle arrest, Glucokinase, IGF-1R

Pentagalloylglucose

T3794

Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose

Target: Influenza Virus

(2S,3R,4S)-4-Hydroxyisoleucine

T2P2919

Synonym: (4S)-4-Hydroxy-L-isoleucine,Hydroxyisoleucine

Target: PI3K

Propane-1,2,3-triyl tripalmitate

TWO2727

Synonym: Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate

Target: Others, Endogenous Metabolite

Dracorhodin perchlorate

T2S2043

Synonym: Dracorhodin perochlorate,Dracohodin perochlorate

Target: Apoptosis, Others

Neferine

T5S1097

Synonym: (R)-1,2-Dimethoxyaporphine,(-)-Neferine

Target: Apoptosis, NF-κB, Autophagy

5,7-Dihydroxychromone

T5S1805

Synonym: 5,7-Dihydroxy-4H-Chromen-4-One

Target: Others, Virus Protease, PARP, Caspase, Nrf2

Barlerin

T5S1632

Synonym: 8-O-Acetylshanzhiside methyl ester,ND01

Target: VEGFR, TNF, NF-κB, Akt, Caspase

Synonym: Leachianone E

Target: GABA Receptor, Antifection

Target: ERK, MEK, Akt

Kushenol C

TN4399

Synonym:

Target: SGLT, NF-κB, ROS, BACE, Antifection

Target: IL Receptor, TNF, NOS, LTR

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00395	Insulin Protein, Human, Recombinant	Human	P. pastoris (Yeast)
	INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsul...
TMPH-02119	SLC5A2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.; Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affini...
TMPY-06864	GLP1R Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Glucagon-like peptide (GLP)-1 receptor is encoded by GLP1R. GLP1R plays a critical role in mediating the biological actions of GLP1 in mammals and fish. The neuronal GLP1Rs mediate body weight and anorectic effects of li...
TMPY-00319	GIP Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Glucose-dependent insulinotropic polypeptide (GIP) is an incretin that plays an important role in fat accumulation. GIP is involved in fat accumulation and insulin resistance with aging. Glucose-dependent insulinotropic ...
TMPH-00776	Griffithsin Protein, Griffithsia sp., Recombinant (X31S, His & Myc)	Griffithsia	Baculovirus Insect Cells
	Mixed specificity lectin with anti-HIV activity. Binds to HIV envelope glycoproteins, including exterior membrane glycoprotein gp120, and inhibits viral entry into cells. Binding to gp120 is dependent on gp120 being glyc...
TMPH-00777	Griffithsin Protein, Griffithsia sp., Recombinant (X31S, His)	Griffithsia	E. coli
	Mixed specificity lectin with anti-HIV activity. Binds to HIV envelope glycoproteins, including exterior membrane glycoprotein gp120, and inhibits viral entry into cells. Binding to gp120 is dependent on gp120 being glyc...
TMPY-04771	CARKL Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	CARKL, also known as SHPK, is a nonprotein kinase of glucose metabolism. CARKL has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibi...
TMPK-00036	GIP Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial. Initial interest in the therapeutic...
TMPK-00890	GIP Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial. Initial interest in the therapeutic...
TMPY-04394	Glucokinase Protein, Human, Recombinant	Human	E. coli
	Glucokinase belongs to the bacterial glucokinase family. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in ...
TMPK-00891	GIP Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial. Initial interest in the therapeutic...
TMPH-01540	Intelectin-1/ITLN1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-G...
TMPY-03460	DCXR Protein, Human, Recombinant (His)	Human	E. coli
	DCXR, also known as HCR2, belongs to the short-chain dehydrogenases/reductases (SDR) family. It is highly expressed in kidney, liver and epididymis. In the epididymis, DCXR is mainly expressed in the proximal and dist...
TMPY-02438	AKR1B1 Protein, Human, Recombinant (His)	Human	E. coli
	Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest...
TMPH-01676	Meteorin-like/METRNL Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. A...
TMPY-02461	AKR1A1 Protein, Human, Recombinant (His)	Human	E. coli
	Aldehyde reductase (AKR1A1) is a member of the aldo-keto reductase superfamily, which consists of more than 40 known enzymes and proteins that includes variety of monomeric NADPH-dependent oxidoreductases, such as aldehy...
TMPY-01960	Munc18c/STXBP3 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Syntaxin-binding protein 3, also known as Platelet Sec1 protein, Protein unc-18 homolog 3, Protein unc-18 homolog C, Unc-18C, Unc18-3 and STXBP3, is a cytoplasm protein which belongs to the STXBP/unc-18/SEC1 family. STXB...
TMPY-01869	SIRT1 Protein, Human, Recombinant (His)	Human	E. coli
	SIRT1 belongs to the sirtuin family. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT1 is included in class I of the sirtuin family. It is a NAD-dependent prote...
TMPY-01099	GPT Protein, Rat, Recombinant (His)	Rat	Baculovirus Insect Cells
	Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (GPT), is a pyridoxal enzyme that belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfa...
TMPH-01282	ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in th...