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T21955 |
GQ-16
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PPAR
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GQ-16 is a partial agonist of PPARγ with a Ki of 160 nM. GQ-16 reduces adipogenic actions and promotes insulin Sensitization without weight gain. |
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T4628 |
Seladelpar
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MBX 8025 |
PPAR
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Seladelpar (MBX 8025) has been used in trials studying the treatment of Hyperlipidemia. |
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T7656 |
Apelin-13
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|
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Apelin-13 is a 13-amino acid peptide sequence found in the central and peripheral nervous system that is an endogenous ligand for the G protein-coupled receptor angiotensin II protein J (APJ), with an EC50 value of 0.37 ... |
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T7714 |
Temocapil
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Tyrosinase
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Temocapril is an inhibitor of tyrosine kinase. |
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T10353 |
APX-115 free base
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Ewha-18278 free base |
NADPH-oxidase
,
NADPH
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APX-115 free base (Ewha-18278 free base) (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kid... |
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T6698 |
Temocapril hydrochloride
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CS-622 HCl,Acecol,Temocapril HCl,CS-622 |
RAAS
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Temocapril hydrochloride (CS-622 HCl), the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension. |
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T76664 |
Adropin (34-76) (human, mouse, rat)
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Adropin (34-76) (human, mouse, rat) is a peptide that attenuates liver fibrosis and insulin resistance independent of obesity or food intake. |
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T38715 |
MSDC-0602K
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MSDC-0602K,Azemiglitazone potassium |
PPAR
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MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (... |
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T30579 |
BRD4097
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HDAC
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BRD4097, a negative control in the HDAC1/2/3/8 assay, is a selective histone deacetylase (HDAC3) inhibitor that can be used to protect b-cells and improve insulin resistance, help promote cognitive function and enhance l... |
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T62656 |
GPR81 agonist 1
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GPR
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GPR81 agonist 1 is a potent and selective GPR81 agonist with high affinity for human and mouse GPR81.GPR81 agonist 1 inhibits lipolysis of differentiated 3T3-L1 adipocytes, improves insulin sensitivity and glycaemic cont... |
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T78169 |
Enpp-1-IN-16
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PDE
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Enpp-1-IN-16 is an inhibitor targeting ENPP1 with potential anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance in relation to type II diabetes mellitus and various ENPP1-mediated diseases in the ch... |
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T72617 |
Nampt activator-2
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P450
,
NAMPT
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Nampt activator-2 is a NAMPT activator (EC50: 0.023 μM). Nampt activator-2 has an affinity for CYP2C9, 2D6, and 2C19 with affinity values of 0.060 μM, 0.41 μM, and 0.59 μM, respectively.Nampt activator-2 can be used in t... |
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T62238 |
AMPK activator 4
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AMPK
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AMPK activator 4 is a potent and selective AMPK activator that does not inhibit mitochondrial complex I. AMPK activator 4 selectively activates AMPK in muscle tissue and dose-dependently improves glucose tolerance in nor... |
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T3170 |
Troglitazone
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CS-045,Romozin,Rezulin,Romglizone,Noscal,Prelay |
Apoptosis
,
Ferroptosis
,
PPAR
,
Autophagy
|
|
Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity. |
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T25780 |
MDK-4823
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LMPTP-IN-23,LMPTP-IN 23,MDK4823,LMPTP-IN23,MDK 4823 |
Others
|
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MDK-4823, also known as LMPTP inhibitor1, is a potent low-molecular-weight tyrosine phosphatase (LMPTP) inhibitor. LMPTP is highly expressed in insulin-target tissues. LMPTP promotes diabetes and insulin resistance in ob... |
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T68132 |
Quercetin-3'-o-phosphate
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Others
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Quercetin-3'-O-phosphate belongs to the class of organic compounds known as flavonols,has been used in trials studying the treatment of Insulin Resistance and Impaired Glucose Tolerance. |
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T70141 |
MDK80908
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Others
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MDK80908, also known as PPARalpha/gamma agonist N15, is a dual PPARα/γ agonist, ameliorating insulin resistance and gluconeogenesis in vivo and vitro. MDK80908 has CAS#1821380-90-8. |
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T31732 |
Evogliptin HCl
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Evogliptin hydrochloride,DA 1229,DA1229,Evogliptin,DA-1229 |
Others
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Evogliptin(DA-1229) is a potent and selective DPP4 inhibitor (dipeptidyl peptidase 4 inhibitor) that can improve insulin resistance and delays the onset of diabetes. Evogliptin delays the onset of diabetes in young db/db... |
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TP1183 |
Amylin, amide, human
|
DAP amide, human |
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Amylin, a 37-amino acid polypeptide that is structurally related to calcitonin, is secreted from the B cells of the pancreas. Amylin has anoretic effects in rats. Amylin may be responsible for the etiology of insulin res... |
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T60696 |
CXCR2 antagonist 8
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Others
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CXCR2 antagonist 8 is a potent and selective antagonist of CXCR2 that can be used for the researching of insulin resistance [1]. |
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T71251 |
DS-1558
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Others
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DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyp... |
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T38764 |
Amylin (8-37), human
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Amylin (8-37), human, derived from human Amylin, possesses direct vasodilator effects in isolated mesenteric resistance arteries of rats. Human Amylin is a small pancreatic β-cell hormone that forms aggregates in the abs... |
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T80915 |
Tyr0-Neurokinin A
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|
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Tyr0-Neurokinin A, a member of the tachykinin peptide family, acts as an agonist for the Tacr2 receptor. It is utilized in research focused on insulin resistance, obesity, and diabetes [1] [2]. |
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T35588 |
Ganglioside GM3 Mixture (sodium salt)
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Others
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Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation. It suppresses angiogenesis and reduce... |
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T74716 |
Curcumin 5-8
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Others
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Curcumin 5-8 (CUR5-8), a naturally active analog of curcumin (CUR), exhibits potent oral activity. It effectively inhibits lipid droplet formation, enhances autophagy, and reduces apoptosis. Additionally, Curcumin 5-8 ha... |
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T15043 |
D5D-IN-326
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Others
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T39490 |
Aclimostat
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ZGN-1061,Aclimostat |
Others
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Aclimostat (ZGN-1061) is a highly potent inhibitor of the MetAP2 enzyme that demonstrates promising efficacy and safety profiles in preclinical trials. In a mouse model of obesity and insulin resistance, ZGN-1061 exhibit... |
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T76310 |
Acetyl Gastric Inhibitory Peptide (human)
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|
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Acetyl Gastric Inhibitory Peptide (human), a fatty acid-derivatized analog of glucose-dependent insulinotropic polypeptide, exhibits enhanced antihyperglycemic and insulinotropic characteristics. This compound is utilize... |
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T35809 |
C20 Sphingomyelin (d18:1/20:0)
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Others
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C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlate... |
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T68808 |
11-Dehydrocorticosterone
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Others
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11-Dehydrocorticosterone is an endogenous mineralocorticoid. It increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration... |
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T72889 |
FXR agonist 4
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Others
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FXR agonist 4 with an EC 50 value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of ... |
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T78543 |
Acetyl Gastric Inhibitory Peptide (human) TFA
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Human N-acetyl GIP TFA |
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Acetyl Gastric Inhibitory Peptide (human) TFA, a fatty acid-derivatized analog of the glucose-dependent insulinotropic polypeptide, exhibits enhanced antihyperglycemic and insulinotropic properties. It is utilized in the... |
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TP2019 |
[D-Ala2]-GIP (human)
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|
|
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Highly potent GIP receptor agonist (EC50 = 630 ± 119 pM). Displays equivalent cAMP stimulating properties and improved resistance to enzymatic degradation compared to native GIP in cells expressing wild type GIP receptor... |
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T85300 |
Palmitoleic Acid sodium
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C16:1(9Z),cis-Palmitoleic Acid,(9Z)-Hexadecenoic Acid,C16:1 n-7 |
Others
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Palmitoleic acid, an ω-7 monounsaturated fatty acid found in macadamia and sea buckthorn oils, enhances both basal and insulin-stimulated glucose uptake, as well as Glut4 protein levels in 3T3-L1 adipocytes at a 200 µM c... |
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T36582 |
Glucocerebrosides (Gaucher's spleen)
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Others
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Glucocerebrosides are formed by the tethering of glucose to a ceramide by glucosylceramide synthase. They are present in neuronal and non-neuronal mammalian tissues and are found at low quantities in a large number of pl... |
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T84415 |
9-PAHSA 13C4
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Others
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Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are a class of endogenous lipids whose levels are modulated by fasting and high-fat diets, and they play a role in insulin sensitivity. These compounds consist o... |
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T35799 |
MBX-8025 (sodium salt)
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Others
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MBX-8025 is an agonist of peroxisome proliferator-activated receptor δ (PPARδ).1 It is greater than 750- and 2,500-fold selective for PPARδ over PPARα and PPARγ. MBX-8025 (10 mg/kg per day for eight weeks) reduces increa... |
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T35634 |
Platensimycin
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Others
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Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM). It targets the β-ketoacyl-acyl-carrier-protein synt... |
