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T37260 |
14,15-dehydro Leukotriene B4
|
14,15-dehydro Leukotriene B4 |
|
|
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement ... |
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T37261 |
14,15-Leukotriene D4
|
14,15-Leukotriene D4 |
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|
14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 ... |
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T37262 |
14,15-Leukotriene E4
|
14,15-Leukotriene E4 |
|
|
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metaboli... |
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T38128 |
Leukotriene D4
|
Leukotriene D4 MaxSpec® Standard,LTD4 |
|
|
Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. It is the first cysteinyl-leukotriene metabolite of LTC4... |
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T37493 |
11-trans Leukotriene D4
|
11-trans Leukotriene D4 |
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11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency fo... |
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T37970 |
12-epi Leukotriene B4
|
12-epi Leukotriene B4 |
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|
Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis pr... |
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T38087 |
20-hydroxy Leukotriene B4
|
20-hydroxy Leukotriene B4 |
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20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing deg... |
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T37492 |
11-trans Leukotriene C4
|
11-trans Leukotriene C4 |
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11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative... |
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T37256 |
12-oxo Leukotriene B4
|
12-oxo Leukotriene B4 |
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Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosom... |
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T37494 |
11-trans Leukotriene E4
|
11-trans Leukotriene E4 |
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Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum. |
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T37980 |
N-methyl Leukotriene C4
|
N-methyl Leukotriene C4 |
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Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione t... |
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T38062 |
N-acetyl Leukotriene E4
|
N-acetyl Leukotriene E4 |
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N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. This route of metabolism is prominent in the rat, but of minor importance in humans. N-acetyl LTE4 is 100 times less potent than LTC4 as a vasoconstri... |
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T37616 |
Leukotriene A4 methyl ester
|
Leukotriene A4 methyl ester |
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Leukotriene A4 methyl ester can be converted into leukotriene C4 monomethyl ester catalyzed by the major alkaline cytosolic glutathione transferase in rat liver, which can be used in metabolism-related studies. |
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T37618 |
Leukotriene B4 dimethyl amide
|
Leukotriene B4 dimethyl amide |
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LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL. LTB4 dimethyl amide appears to be an antagonist of the LTB4 receptor on gui... |
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T37619 |
Leukotriene B4 Ethanolamide
|
|
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The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2. LTB4 is a high affinity ligand for BLT1, and many of its pro-inflammatory effects are believed to be transduced through this recept... |
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T36423 |
Leukotriene B5
|
|
|
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Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities. It is a metabolite of eicosapentaenoic acid formed through the 5-lipoxygenase (5-LO) pathway. LTB5 increases contraction of bullfrog lung strips ... |
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T37617 |
Leukotriene B3
|
|
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LTB3 is the LTA hydrolase metabolite of LTA3 in the leukotriene biosynthetic pathway. LTB3 and LTB4 are equipotent in their pro-inflammatory effects. However, LTB3 is five times less potent than LTB4 in eliciting chemota... |
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T38129 |
Leukotriene F4
|
LTF4 |
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LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contrac... |
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T37615 |
Leukotriene A3 methyl ester
|
|
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Biosynthesis of LTA3 occurs from 5,8,11-eicosatrienoic acid via the 5-LO pathway and it is the putative intermediate in the biosynthesis of 3-series leukotrienes. LTA3 as a free acid is highly unstable. The methyl ester ... |
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T40870 |
Leukotriene E4
|
LTE4 |
Endogenous Metabolite
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Leukotriene E4 (LTE4) (LTE4) is produced by the action of dipeptidyl peptidase on LTD4 and is a component of the Slow Reactive Substance of Anaphylaxis (SRS-A).LTE4 is present in plasma and urine and can be used to detec... |
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T37620 |
Leukotriene C4 methyl ester
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Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular met... |
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T32680 |
Leukotriene E-4 sulfone
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Leukotriene E-4 sulfone is a synthetic leukotriene. |
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T14045 |
Leukotriene B4
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LTB4,5(S),12(R)-DiHETE |
Others
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Leukotriene B4 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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T32681 |
Leukotriene F-4 sulfone
|
Ltf4 sulfone |
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Leukotriene F-4 sulfone induces vascular permeability changes. |
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T73793 |
20-Carboxy-Leukotriene B4
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20-Carboxy-Leukotriene B4 (20-COOH LTB4), a metabolite of Leukotriene B4 (LTB4), exhibits high affinity binding to the BLT1 receptor. It notably inhibits LTB4-mediated neutrophil responses, including migration, degranula... |
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T72144 |
6-trans-12-epi-Leukotriene B4
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6-trans-12-epi-Leukotriene B4, a metabolite of arachidonic acid, serves as a potent anti-inflammatory agent. |
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T1677 |
Montelukast
|
Singular |
Leukotriene Receptor
,
Lipoxygenase
,
LTR
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Montelukast (Singular) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury... |
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T1677L |
Montelukast sodium
|
MK0476 |
Leukotriene Receptor
,
LTR
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Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver i... |
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T6893 |
MK-886
|
MK886,L 663536 |
Apoptosis
,
Leukotriene Receptor
,
COX
,
PPAR
,
FLAP
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MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist. |
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T26519 |
Ablukast
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Ro 23-3544 |
Leukotriene Receptor
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Ablukast (Ro 23-3544) is a leuktriene receptor antagonist. Ablukast acts as an anti-asthmatic. |
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T22946 |
LY255283
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LY 255283 |
Leukotriene Receptor
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LY255283 is a specific antagonit of leukotriene B4 (LTB4) receptor. It inhibits the production of LTB(4) in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A2318... |
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T0694 |
Pranlukast
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ONO-1078 |
Leukotriene Receptor
,
IL Receptor
,
Others
,
TNF
,
NF-κB
,
LTR
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Pranlukast (ONO-1078) is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered aller... |
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T6736 |
Zafirlukast
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Vanticon,ICI 204219,Accolate |
Leukotriene Receptor
|
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Zafirlukast (ICI 204219) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma. |
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T20615 |
Olsalazine
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Dipentium,Salicylic acid |
Others
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Olsalazine (Dipentium), an anti-inflammatory drug, is used in the treatment of inflammatory bowel disease. It is also a novel DNA hypomethylating agent. |
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T16280 |
Nedocromil
|
FPL 59002 |
Leukotriene Receptor
,
Prostaglandin Receptor
,
Histamine Receptor
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Nedocromil (FPL 59002) inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2). |
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T22358 |
Etalocib
|
LY293111,VML295 |
Apoptosis
,
Leukotriene Receptor
,
LTR
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|
Etalocib (LY293111) is a novel diaryl ether carboxylic acid derivative, is a selective and potent inhibitor of the lipoxygenase pathway either via antagonism of the leukotriene B4 (LTB4) receptor or directly through 5'-l... |
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T21696 |
SC-57461A
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Aminopeptidase
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SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor. |
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T3148 |
MK-571 sodium
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L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid |
Leukotriene Receptor
,
LTR
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MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ... |
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T22787 |
FPL 55712
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|
Others
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Leukotriene receptor antagonist |
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T24327 |
L 674573
|
L 674,573,L674,573,L-674,573,L674573,L-674573 |
Leukotriene Receptor
|
|
L 674573 is an inhibitor of leukotriene biosynthesis. |
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T26524 |
ABT-080
|
VML530,VML-530,VML 530,ABT080 |
Leukotriene Receptor
|
|
ABT-080 (VML 530), a leukotriene synthesis inhibitor, is used potentially for treatment of asthma. |
|
T2583 |
Cilastatin
|
MK0791 |
Proteasome
,
Antibacterial
,
Antibiotic
|
|
Cilastatin (MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cila... |
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T77638 |
BIRM 271
|
|
Phospholipase
,
LTR
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BIRM 271 is a novel arachidonic acid release inhibitor that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils. BIRM 271 and BIRM 270 are enantiomers that inhibit the production of leu... |
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T27979 |
Masilukast
|
ICI-D-3523,ZD-3523,ICI D-3523,MCC-847,SA-09012,D-3523 |
Leukotriene Receptor
|
|
Masilukast(MCC-847) is an oral leukotriene D4 (LTD4) receptor antagonist for the study of diseases associated with inflammation. |
|
T28529 |
RG 7152
|
RG7152,RG-7152 |
Leukotriene Receptor
|
|
RG 7152 is a leukotriene D4 antagonist with anti-asthmatic properties and can be used in the study of asthma. |
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T16395 |
ONO4057
|
ONO-LB457 |
Leukotriene Receptor
|
|
ONO4057 is a potent and orally active Leukotriene B4 receptor antagonist with an IC50 value of 0.7±0.3 μM. Immunosuppressive effect of ONO4057 on rat allografts. |
|
TQ0047 |
DG051
|
|
Aminopeptidase
|
|
DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor (IC50: 47 nM). |
|
T15002 |
CP-105696
|
Pfizer 105696 |
LTR
|
|
CP-105696 is a potent and selective leukotriene B4 (LTB4) receptor antagonist for the study of allograft rejection. |
|
T12771 |
RS-601
|
|
Leukotriene Receptor
,
Thrombin
|
|
RS-601 is a potent dual leukotriene D4/thromboxane A2 inhibitor that inhibits antigen-induced airway hyperresponsiveness (AHR) and shows asthmatic effects in a guinea pig model of asthma. |
|
T15647 |
Tipelukast
|
MN 001,KCA 757 |
Leukotriene Receptor
|
|
Tipelukast (KCA 757) is a novel orally available leukotriene receptor antagonist with anti-inflammatory activity that reduces fibrosis and down-regulates TIMP-1, type 1 collagen.Tipelukast is used in the study of asthma. |
