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阻害剤 血管新生 アポトーシス オートファジー 細胞周期・チェックポイント クロマチン・エピジェネティック 細胞骨格シグナル DNA損傷・DNA修復 内分泌・ホルモン GPCR/Gタンパク質 免疫・炎症 JAK・STATシグナル MAPK
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シグナル伝達経路 血管新生 アポトーシス オートファジー 細胞周期・チェックポイント クロマチン・エピジェネティック 細胞骨格シグナル
DNA損傷・DNA修復 内分泌・ホルモン GPCR/Gタンパク質 免疫・炎症 JAK・STATシグナル MAPK 膜輸送体・イオンチャネル
代謝 微生物学・ウィルス学 神経科学 NF-Κb 酸化還元 PI3K/Akt/mTORシグナル プロテアーゼ・プロテアソーム
幹細胞 チロシンキナーゼ・アダプター ユビキチン その他 PROTAC
生物活性化合物ライブラリー ゼネラルバイオウアクティヴライブラリー 承認/再開発 医薬品ライブラリー 疾患別 化合物ライブラリー 標的/経路別 化合物ライブラリー 特徴的な生物活性化合物ライブラリー
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ドラッグライク 化合物ライブラリー ドラッグライクライブラリー
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Search Results for " proteases "

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天然化合物

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TargetMolキット

カタログ番号 製品名 別名 ターゲット
T82386 Fluorescent Substrate for Glu-Specific Proteases
Fluorescent Substrate for Glu-Specific Proteases is a chromogenic substrate specifically recognized by V8 protease [1].
T82387 Fluorescent Substrate for Asp-Specific Proteases
Fluorescent Substrate for Asp-Specific Proteases selectively cleaves the Asp-Val bond [1].
TP1277 Bradykinin Endogenous Metabolite , Bradykinin Receptor
Bradykinin is an inflammatory mediator. It is a peptide that causes blood vessels to dilate (enlarge) via the release of prostacyclin, nitric oxide, and Endothelium-Derived Hyperpolarizing Factor. Bradykinin is a physiol...
T7017 WNK463 Serine/threonin kinase
WNK463 is a pan-WNK-kinase inhibitor. It effectively inhibits the in vitro kinase activity of all four WNK family members (WNK1/2/3/4).
T11666 IPR-803 Serine/threonin kinase
IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity. IPR-803 binds directly to uPAR with a Ki of 0.2 μM.
T4058 R-IMPP Others , Serine/threonin kinase
R-IMPP is an inhibitor of PCSK9 translation. R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin.
T10547 BioE-1115 Serine/threonin kinase , Casein Kinase
T8362 Benzamidine hydrochloride Benzamidine HCl Serine/threonin kinase , Serine Protease
Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively).
T13257 Upamostat PAI-1 , Serine/threonin kinase , Serine Protease
Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.
T11885 LSP-249 Others
LSP-249 is a plasma kallikrein inhibitor under the study for angioedema, with an EC50 less than 100 nM in cell.
T9920 Evolocumab Others
Evolocumab is a human IgG2 monoclonal antibody that binds to human PCSK9 Proprotein Convertase Subtilisin Kexin Type 9).
T4524 SBC-110736 SBC110736 Others , Serine/threonin kinase
SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor
T8350 TPCK Proteasome
TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis
T9276 SBC-115337 Others , Serine/threonin kinase
SBC-115337 is a PCSK9 inhibitor.
T14358 Avoralstat BCX4161 Others
Avoralstat (BCX4161) is an oral plasma kallikrein (PKK) inhibitor. Which is used for the treatment of hereditary angioedema.
T8676 FOY 251 Others , Serine/threonin kinase , SARS-CoV
FOY 251 is a proteinase inhibitor, and is an anti-proteolytic active metabolite camostate.
T5456 WNK-IN-11 Allosteric WNK Kinase Inhibitor Serine/threonin kinase
WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)
T8645 PF-06446846 Others
PF 06446846 is a potent and selective PCSK9 inhibitor
T2626 SBC-115076 SBC115076 Others , Serine/threonin kinase
SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.
T6370 AEBSF hydrochloride AEBSF HCl,Pefabloc SC Thrombin , Serine Protease , Influenza Virus
AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.
T13408 ZK824190 Others , Serine Protease
ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively).
T3359 Aprotinin Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin Others , Serine Protease , Influenza Virus , Proteasome
Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activat...
T31206 Darexaban YM 150,Darexaban, Tanexaban,YM150 Factor Xa
Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati...
T2392 Nafamostat mesylate FUT-175 Apoptosis , Serine/threonin kinase , SARS-CoV , Serine Protease
Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
T19763 Cetraxate hydrochloride DV-1006,DV 1006,Cetraxate HCl,DV1006 Serine/threonin kinase
Cetraxate hydrochloride (DV10062) is an oral gastrointestinal medication. It has a cytoprotective effect.
T8936 Proteinase K proteinase K for tritirachium album,Protease K Others
Proteinase K (proteinase K for tritirachium album) is a nonspecific serine protease that is useful for general digestion of proteins. It is active in the presence of SDS or urea and over a wide range of pH (4-12), salt c...
T2391 Camostat mesylate FOY-S980,FOY305,Camostat mesilate Serine/threonin kinase , SARS-CoV , Sodium Channel
Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.
T70840 Osemozotan Free Base
Osemozotan Free Base is a 5-HT(1A) receptor agonist.
T3695 Pepstatin Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C Amino Acids and Derivatives , Proteasome , HIV Protease , Autophagy
Pepstatin (Pepsin Inhibitor S 735A) is a specific aspartic proteases inhibitor produced by actinomycetes, and inhibits the aspartic proteases cathepsin D, pepsin and renin.
T5188 GC376 sodium SARS-CoV
GC376 is an inhibitor of 3C-like proteases (3CLpro) with IC50 values range from 0.49~4.35 μM.
T1525 Ritonavir RTV,Abbott 84538,A 84538,ABT 538 Apoptosis , SARS-CoV , HIV Protease
Ritonavir (ABT 538) is a peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other HIV proteases by blocking their degradation by cy...
TP1309 Gastric mucin Antibacterial , Antibiotic
Gastric mucin is a large glycoprotein which is thought to play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma.
T6583 MG-101 ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101 Cysteine Protease , Proteasome
MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
T2639 LY2811376 Beta Amyloid , Beta-Secretase , BACE
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition...
T4317 PF 429242 NPC1L1 , Lipid
PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). It is selective for site 1 protease against a panel of serine proteases. PF-429242 inhibits rat...
T1902 BAY 11-7082 BAY 11-7821 Apoptosis , Others , IκB/IKK , DUB , Autophagy
BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM). BAY 11-7082 is also an inhibitor of the ubiquitin-specific proteases USP7 and USP21 (IC50=0.19/0.96 μM).
T6040 Aloxistatin E64d,Loxistatin,E64c ethyl ester SARS-CoV , Cysteine Protease
Aloxistatin (E64d) is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with...
T12188 NB-360 BACE
T37885 1-Dodecylimidazole Antifungal
1-Dodecylimidazole (N-Dodecylimidazole) is a chemical compound that serves as a cytotoxic agent and lysosomotropic detergent. It induces cell death through acid-dependent accumulation in lysosomes, which disrupts the lys...
T10925 Cysteine Protease inhibitor Others
Cysteine protease inhibitors are inhibitors of cysteine proteases. Target: Cysteine Protease
T27660 JNJ-10311795
JNJ-10311795, a dual inhibitor of the leukocyte Proteases Cathepsin G and Chymase, has therapeutic efficacy in animals models of inflammation.
T26128 Rpi 856 C Rpi-856 C,Rpi856 C,Rpi-856 D,Rpi856 D,Rpi 856 D
Rpi 856 C is a retrovirus protease inhibitor from Streptomyces that is effective against HIV-1 and HTLV-1 proteases.
T25218 CE-2072 CE2072,CE 2072
CE-2072 is a synthetic host serine proteases inhibitor.
T13011 Statine (S,S)-Statine,(3S,4S)-Statine Others
Statine is a protease inhibitor that is active against pepsin and other acid proteases.
T10125 (3R,4R)-A2-32-01 Others
(3R,4R)-A2-32-01 (compound 2) is a specific caseinolytic protein proteases (ClpP) inhibitor (EC50: 4.5 μM).
T24737 Rpi 856 A Rpi856 A,Rpi 856 B,Rpi-856 A,Rpi-856 B,Rpi856 B
Rpi 856 A is a retrovirus protease inhibitor. It is effective against HIV-1 and HTLV-1 proteases.
T78409 Boc-Val-Pro-Arg-MCA hydrochloride Boc-Val-Pro-Arg-MCA HCl
Boc-Val-Pro-Arg-MCA hydrochloride (Boc-Val-Pro-Arg-MCA HCl) is a sensitive fluorescent substrate for the determination of trypsin-like serine proteases activity.
T37019 P-APMSF (hydrochloride)
p-APMSF is an irreversible inhibitor of serine proteases with Ki values of 1.02, 1.18, 1.5, and 1.54 μM for bovine trypsin, human thrombin, bovine plasmin, and bovine Factor Xa, respectively. It is selective for these pr...
T40320 Antiviral agent 5
Antiviral agent 5 is a crucial intermediate utilized in the development of antiviral agents that specifically target 3C and 3CL proteases, which includes the SARS-CoV-2 M pro enzyme.
TP1308 Suc-Leu-Leu-Val-Tyr-AMC
Suc-Leu-Leu-Val-Tyr-AMC is a fluorescent substrate for the 20S proteasome, other chymotrypsin-like proteases.

Compounds

Fluorescent Substrate for Glu-Specific Proteases
T82386
Synonym:
Target:
Fluorescent Substrate for Asp-Specific Proteases
T82387
Synonym:
Target:
Bradykinin
TP1277
Synonym:
Target: Endogenous Metabolite, Bradykinin Receptor
WNK463
T7017
Synonym:
Target: Serine/threonin kinase
IPR-803
T11666
Synonym:
Target: Serine/threonin kinase
R-IMPP
T4058
Synonym:
Target: Others, Serine/threonin kinase
BioE-1115
T10547
Synonym:
Target: Serine/threonin kinase, Casein Kinase
Benzamidine hydrochloride
T8362
Synonym: Benzamidine HCl
Target: Serine/threonin kinase, Serine Protease
Upamostat
T13257
Synonym:
Target: PAI-1, Serine/threonin kinase, Serine Protease
LSP-249
T11885
Synonym:
Target: Others
Evolocumab
T9920
Synonym:
Target: Others
SBC-110736
T4524
Synonym: SBC110736
Target: Others, Serine/threonin kinase
TPCK
T8350
Synonym:
Target: Proteasome
SBC-115337
T9276
Synonym:
Target: Others, Serine/threonin kinase
Avoralstat
T14358
Synonym: BCX4161
Target: Others
FOY 251
T8676
Synonym:
Target: Others, Serine/threonin kinase, SARS-CoV
WNK-IN-11
T5456
Synonym: Allosteric WNK Kinase Inhibitor
Target: Serine/threonin kinase
PF-06446846
T8645
Synonym:
Target: Others
SBC-115076
T2626
Synonym: SBC115076
Target: Others, Serine/threonin kinase
AEBSF hydrochloride
T6370
Synonym: AEBSF HCl,Pefabloc SC
Target: Thrombin, Serine Protease, Influenza Virus
ZK824190
T13408
Synonym:
Target: Others, Serine Protease
Aprotinin
T3359
Synonym: Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin
Target: Others, Serine Protease, Influenza Virus, Proteasome
Darexaban
T31206
Synonym: YM 150,Darexaban, Tanexaban,YM150
Target: Factor Xa
Nafamostat mesylate
T2392
Synonym: FUT-175
Target: Apoptosis, Serine/threonin kinase, SARS-CoV, Serine Protease
Cetraxate hydrochloride
T19763
Synonym: DV-1006,DV 1006,Cetraxate HCl,DV1006
Target: Serine/threonin kinase
Proteinase K
T8936
Synonym: proteinase K for tritirachium album,Protease K
Target: Others
Camostat mesylate
T2391
Synonym: FOY-S980,FOY305,Camostat mesilate
Target: Serine/threonin kinase, SARS-CoV, Sodium Channel
Osemozotan Free Base
T70840
Synonym:
Target:
Pepstatin
T3695
Synonym: Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C
Target: Amino Acids and Derivatives, Proteasome, HIV Protease, Autophagy
GC376 sodium
T5188
Synonym:
Target: SARS-CoV
Ritonavir
T1525
Synonym: RTV,Abbott 84538,A 84538,ABT 538
Target: Apoptosis, SARS-CoV, HIV Protease
Gastric mucin
TP1309
Synonym:
Target: Antibacterial, Antibiotic
MG-101
T6583
Synonym: ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101
Target: Cysteine Protease, Proteasome
LY2811376
T2639
Synonym:
Target: Beta Amyloid, Beta-Secretase, BACE
PF 429242
T4317
Synonym:
Target: NPC1L1, Lipid
BAY 11-7082
T1902
Synonym: BAY 11-7821
Target: Apoptosis, Others, IκB/IKK, DUB, Autophagy
Aloxistatin
T6040
Synonym: E64d,Loxistatin,E64c ethyl ester
Target: SARS-CoV, Cysteine Protease
NB-360
T12188
Synonym:
Target: BACE
1-Dodecylimidazole
T37885
Synonym:
Target: Antifungal
Cysteine Protease inhibitor
T10925
Synonym:
Target: Others
JNJ-10311795
T27660
Synonym:
Target:
Rpi 856 C
T26128
Synonym: Rpi-856 C,Rpi856 C,Rpi-856 D,Rpi856 D,Rpi 856 D
Target:
CE-2072
T25218
Synonym: CE2072,CE 2072
Target:
Statine
T13011
Synonym: (S,S)-Statine,(3S,4S)-Statine
Target: Others
(3R,4R)-A2-32-01
T10125
Synonym:
Target: Others
Rpi 856 A
T24737
Synonym: Rpi856 A,Rpi 856 B,Rpi-856 A,Rpi-856 B,Rpi856 B
Target:
Boc-Val-Pro-Arg-MCA hydrochloride
T78409
Synonym: Boc-Val-Pro-Arg-MCA HCl
Target:
p-APMSF (hydrochloride)
T37019
Synonym:
Target:
Antiviral agent 5
T40320
Synonym:
Target:
Suc-Leu-Leu-Val-Tyr-AMC
TP1308
Synonym:
Target:
1 2
カタログ番号 製品名 別名 ターゲット
TN2082 Pinostrobin Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppress...
T5S0689 Demethylwedelolactone Serine Protease
Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells.
T23664 Agathisflavone 6,8'-Biapigenin
Agathisflavone is a NS2B-NS3 proteases inhibitor of the Dengue virus serotypes 2 and 3.
T38649 Lyciumin A
Lyciumin A, a cyclic octapeptide, possesses inhibitory properties against proteases, renin, and angiotensin-converting enzyme. It holds potential for hypertension research.
T79978 6,6′-Dihydroxythiobinupharidine
6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold and 3-fold, respectively [1] [2].
T75705 Pepstatin Trifluoroacetate
Pepstatin Trifluoroacetate (Pepstatin A), a specific and orally active aspartic protease inhibitor produced by actinomycetes, demonstrates inhibition efficacy with IC50 values of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM, a...

天然物製品

Pinostrobin
TN2082
Synonym:
Target: Beta Amyloid, IL Receptor, Serine/threonin kinase, TNF
Demethylwedelolactone
T5S0689
Synonym:
Target: Serine Protease
Agathisflavone
T23664
Synonym: 6,8'-Biapigenin
Target:
Lyciumin A
T38649
Synonym:
Target:
6,6′-Dihydroxythiobinupharidine
T79978
Synonym:
Target:
Pepstatin Trifluoroacetate
T75705
Synonym:
Target:

Recombinant Proteins

Species：
Human (44)
Mouse (18)
SARS (2)
Bovine (1)
Cynomolgus (1)
E. coli (1)
HCV (1)
Macaca mulatta (1)
Rat (1)
SARS-CoV-2 (1)
Expression System：
HEK293 Cells (45)
E. coli (18)
Baculovirus Insect Cells (6)
P. pastoris (Yeast) (2)
Tag：
C-His (29)
C-6xHis (15)
N-His (6)
C-His-Avi (3)
C-hFc (3)
N-6xHis (3)
Tag Free (3)
N-10xHis, C-Myc (2)
C-10xHis (1)
C-Avi (1)
カタログ番号 製品名 Species Expression System
TMPY-00817 Granzyme B/GZMB Protein, Human, Recombinant (His) Human HEK293 Cells
Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the ...
TMPY-01897 PRSS3 Protein, Human, Recombinant (His) Human HEK293 Cells
Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains on...
TMPY-01104 Coagulation factor XI/F11 Protein, Human, Recombinant (His) Human HEK293 Cells
Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the p...
TMPY-02258 Kallikrein 3/KLK3 Protein, Human, Recombinant (His) Human HEK293 Cells
KLK3 (Kallikrein Related Peptidase 3) is a Protein Coding gene. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease that i...
TMPJ-01204 TPSAB1 Protein, Human, Recombinant (His) Human HEK293 Cells
Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(T...
TMPY-01101 Coagulation factor X/F10 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the...
TMPH-00661 Ecotin Protein, E. coli O127:H6, Recombinant (His & Myc) E. coli E. coli
General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases.
TMPH-02895 Serpin A3K Protein, Mouse, Recombinant (His) Mouse P. pastoris (Yeast)
Contrapsin inhibits trypsin-like proteases. Serpin A3K Protein, Mouse, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 45.7 kDa and the accession number is P07759.
TMPK-00918 ADAM8/CD156a Protein, Human, Recombinant (aa 17-655, His) Human HEK293 Cells
A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essent...
TMPY-01363 Serpin A11 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesi...
TMPY-01855 Serpin A10 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Protein Z-dependent protease inhibitor, also known as PZ-dependent protease inhibitor, SERPINA1 and ZPI, is a secreted protein that belongs to the serpin family. It is expressed by the liver and secreted in plasma. SERPI...
TMPK-00933 ADAM8/CD156a Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essent...
TMPY-01893 Serpin A12 Protein, Human, Recombinant (His) Human HEK293 Cells
Serpins are the largest and most diverse family of protease inhibitors. Most serpins control proteolytic cascades, certain serpins do not inhibit enzymes, but instead perform diverse functions such as storage (ovalbumin,...
TMPY-01841 Serpin I2 Protein, Human, Recombinant (His) Human HEK293 Cells
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, infl...
TMPK-00276 TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting d...
TMPH-02832 Serpin A5 Protein, Mouse, Recombinant (His) Mouse Baculovirus Insect Cells
Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extr...
TMPY-00732 Cathepsin C Protein, Human, Recombinant (His) Human HEK293 Cells
Cathepsins are proteases found in many types of cells conserved in all animals, which have a vital role in mammalian cellular turnover such as bone resorption. The lysosomal cysteine protease Cathepsin C (CTSC), also kno...
TMPY-04934 Serpin A3n Protein, Rat, Recombinant (His) Rat HEK293 Cells
Serpina3n may represent a circulating biomarker of muscle atrophy associated with GC and, broadly, a reflection of dynamic changes in muscle mass. Serpina3n blocks endogenous increases in the activity of select skeletal ...
TMPJ-01431 SARS-CoV-2 Papain-Like Protease Protein SARS-CoV-2 E. coli
Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a pap...
TMPH-02898 SPINK2 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defe...
TMPK-00870 AREG Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine...
TMPY-06585 C1s Protein, Human, Recombinant (His) Human HEK293 Cells
Complement is an integral component of the adaptive and innate immune systems and represents one of the major effector systems for the immune responses. The classical complement pathway is triggered by C1, a complex comp...
TMPJ-00542 TPSB2 Protein, Human, Recombinant (His) Human HEK293 Cells
Tryptases are Trypsin-like Serine Proteases. β-Tryptases are the main isoenzymes in mast cells. Βtryptases form active tetramers with heparin proteoglycan. In the tetramer, the unique arrangement of the active sites faci...
TMPK-00277 TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc) Human HEK293 Cells
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter mol...
TMPY-02712 Serpin B3 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
SERPINB3, also known as SCCA-1, belongs to the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was orig...
TMPY-01589 Serpin B10 Protein, Mouse, Recombinant (His) Mouse Baculovirus Insect Cells
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesi...
TMPK-00636 BID Protein, Mouse, Recombinant (His) Mouse E. coli
Bid, BH3-interacting domain death agonist, was initially cloned based in its ability to interact with both Bcl-2 and Bax. Bid contains only the BH3 domain, which is required for its interaction with the Bcl-2 family prot...
TMPY-02128 Serpin B1 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
SerpinB1 is an endogenous inhibitor of serine proteases recognized for its anti-inflammatory and host-protective properties. Serum SerpinB1 levels are elevated in patients with type 2 diabetes compared with that in healt...
TMPH-02430 SNCG Protein, Cynomolgus, Recombinant Cynomolgus E. coli
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent prote...
TMPK-01043 VEGFC Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
the lymphangiogenic factors vascular endothelial growth factor C (VEGFC) and VEGFD are cleaved by thrombin and plasmin, serine proteases generated during hemostasis and wound healing. Genetic studies reveal that platelet...
TMPJ-00770 Granzyme B/GZMB Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an...
TMPH-01370 SNCG Protein, Human, Recombinant (His & SUMO) Human E. coli
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent prote...
TMPJ-00149 Complement Factor D/CFD Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement a...
TMPY-01632 Serpin B4 Protein, Mouse, Recombinant (His) Mouse Baculovirus Insect Cells
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesi...
TMPK-01352 SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi) SARS E. coli
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro ...
TMPJ-01174 Cystatin B Protein, Mouse, Recombinant (His) Mouse E. coli
Cystatin B, also called stefin B or liver thiol proteinase inhibitor, is a member of family 1 of the cystatin superfamily. Like Cystatin A, it is an intracellular inhibitor regulating the activities of cysteine proteases...
TMPY-03496 EBAG9 Protein, Human, Recombinant (His) Human E. coli
RCAS1, also known as EBAG9, is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. RCAS1 gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen ...
TMPK-01384 SARS PLpro/papain-like protease Protein (His) SARS E. coli
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro ...
TMPK-01044 VEGFC Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
the lymphangiogenic factors vascular endothelial growth factor C (VEGFC) and VEGFD are cleaved by thrombin and plasmin, serine proteases generated during hemostasis and wound healing. Genetic studies reveal that platelet...
TMPJ-01358 DPP3 Protein, Human, Recombinant (His) Human E. coli
Dipeptidyl peptidase 3(DPP3), is a member of the S9B family in clan SC of the serine proteases. DPP3 has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. This c...
TMPJ-00481 CELA3A Protein, Human, Recombinant (His) Human HEK293 Cells
Chymotrypsin-Like Elastase Family Member 3A (CELA3A) is an enzyme that contains one peptidase S1 domain. ELA3A belongs to the peptidase S1 family of the Elastase subfamily. ELA3A is secreted from the pancreas as a zymoge...
TMPY-04626 Enterokinase/EK Protein, Bovine, Recombinant Bovine P. pastoris (Yeast)
Enterokinase is a member of the trypsin family of serine proteases. The precursor protein is cleaved into two chains which then forms a heterodimer linked by a disulfide bond. The heavy chain anchors enterokinase in the ...
TMPJ-00832 Granzyme D/GZMD Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Granzyme D is a member of the granzyme family of the serine proteases which plays a role in the induction of apoptosis. T cells, lymphohematopoietic stromal cells, and granulated metrial gland cells express granzyme D, b...
TMPJ-00508 CTSL Protein, Human, Recombinant (His) Human HEK293 Cells
Cathepsin L is an enzyme. Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain-like family of cysteine proteinases. Cathepsin L plays a major role in antigen processing, tu...
TMPY-03653 CTRL Protein, Human, Recombinant (His) Human HEK293 Cells
CTRL-1, also known as chymotrypsin-like protease, belongs to thepeptidase S1 family. CTRL-1 contains 1peptidase S1 domain. Its expression is increased in preeclampsia (PE). Placental-derived chymotrypsin-like protease is...
TMPJ-00497 CTSB Protein, Human, Recombinant (His) Human HEK293 Cells
Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, bot...
TMPY-01249 Cathepsin V Protein, Human, Recombinant (His) Human HEK293 Cells
Cathepsin V (CTSV), also known as Cathepsin L2, CTSL2, and CATL2, is a member of the peptidase C1 family. It is predominantly expressed in the thymus and testis. Cathepsin V is also expressed in corneal epithelium, and t...
TMPY-00163 SPINK2 Protein, Human, Recombinant (hFc) Human HEK293 Cells
Human serine proteinase inhibitor Kazal-type 2 (SPINK2) functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. The SPINK2 protein ...
TMPJ-00437 Fetuin A Protein, Macaca mulatta, Recombinant (His) Macaca mulatta HEK293 Cells
Alpha-2-HS-glycoprotein (AHSG) is a glycoprotein that is composed of two subunits, the A and B chains, belongs to the Cystatin family of proteases inhibitors. It is highly expressed in embryonic cells and adult hepatocyt...
TMPJ-00544 Kallikrein 7/KLK7 Protein, Human, Recombinant (aa 23-252, His) Human HEK293 Cells
Human Kallikrein 7 is a member of the tissue kallikrein family of extracellular serine proteases that is made up of 15 members. It is predominantly expressed in the skin. A major physiological function of Kallikrein 7 is...
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Granzyme B/GZMB Protein, Human, Recombinant (His)
TMPY-00817
Species: Human
Expression System: HEK293 Cells
PRSS3 Protein, Human, Recombinant (His)
TMPY-01897
Species: Human
Expression System: HEK293 Cells
Coagulation factor XI/F11 Protein, Human, Recombinant (His)
TMPY-01104
Species: Human
Expression System: HEK293 Cells
Kallikrein 3/KLK3 Protein, Human, Recombinant (His)
TMPY-02258
Species: Human
Expression System: HEK293 Cells
TPSAB1 Protein, Human, Recombinant (His)
TMPJ-01204
Species: Human
Expression System: HEK293 Cells
Coagulation factor X/F10 Protein, Human, Recombinant (His)
TMPY-01101
Species: Human
Expression System: Baculovirus Insect Cells
Ecotin Protein, E. coli O127:H6, Recombinant (His & Myc)
TMPH-00661
Species: E. coli
Expression System: E. coli
Serpin A3K Protein, Mouse, Recombinant (His)
TMPH-02895
Species: Mouse
Expression System: P. pastoris (Yeast)
ADAM8/CD156a Protein, Human, Recombinant (aa 17-655, His)
TMPK-00918
Species: Human
Expression System: HEK293 Cells
Serpin A11 Protein, Mouse, Recombinant (His)
TMPY-01363
Species: Mouse
Expression System: HEK293 Cells
Serpin A10 Protein, Mouse, Recombinant (His)
TMPY-01855
Species: Mouse
Expression System: HEK293 Cells
ADAM8/CD156a Protein, Mouse, Recombinant (His)
TMPK-00933
Species: Mouse
Expression System: HEK293 Cells
Serpin A12 Protein, Human, Recombinant (His)
TMPY-01893
Species: Human
Expression System: HEK293 Cells
Serpin I2 Protein, Human, Recombinant (His)
TMPY-01841
Species: Human
Expression System: HEK293 Cells
TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi)
TMPK-00276
Species: Human
Expression System: HEK293 Cells
Serpin A5 Protein, Mouse, Recombinant (His)
TMPH-02832
Species: Mouse
Expression System: Baculovirus Insect Cells
Cathepsin C Protein, Human, Recombinant (His)
TMPY-00732
Species: Human
Expression System: HEK293 Cells
Serpin A3n Protein, Rat, Recombinant (His)
TMPY-04934
Species: Rat
Expression System: HEK293 Cells
SARS-CoV-2 Papain-Like Protease Protein
TMPJ-01431
Species: SARS-CoV-2
Expression System: E. coli
SPINK2 Protein, Mouse, Recombinant (His & Myc)
TMPH-02898
Species: Mouse
Expression System: E. coli
AREG Protein, Mouse, Recombinant (hFc)
TMPK-00870
Species: Mouse
Expression System: HEK293 Cells
C1s Protein, Human, Recombinant (His)
TMPY-06585
Species: Human
Expression System: HEK293 Cells
TPSB2 Protein, Human, Recombinant (His)
TMPJ-00542
Species: Human
Expression System: HEK293 Cells
TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)
TMPK-00277
Species: Human
Expression System: HEK293 Cells
Serpin B3 Protein, Human, Recombinant (His)
TMPY-02712
Species: Human
Expression System: Baculovirus Insect Cells
Serpin B10 Protein, Mouse, Recombinant (His)
TMPY-01589
Species: Mouse
Expression System: Baculovirus Insect Cells
BID Protein, Mouse, Recombinant (His)
TMPK-00636
Species: Mouse
Expression System: E. coli
Serpin B1 Protein, Human, Recombinant (His)
TMPY-02128
Species: Human
Expression System: Baculovirus Insect Cells
SNCG Protein, Cynomolgus, Recombinant
TMPH-02430
Species: Cynomolgus
Expression System: E. coli
VEGFC Protein, Human, Recombinant (His & Avi)
TMPK-01043
Species: Human
Expression System: HEK293 Cells
Granzyme B/GZMB Protein, Mouse, Recombinant (His)
TMPJ-00770
Species: Mouse
Expression System: HEK293 Cells
SNCG Protein, Human, Recombinant (His & SUMO)
TMPH-01370
Species: Human
Expression System: E. coli
Complement Factor D/CFD Protein, Mouse, Recombinant (His)
TMPJ-00149
Species: Mouse
Expression System: HEK293 Cells
Serpin B4 Protein, Mouse, Recombinant (His)
TMPY-01632
Species: Mouse
Expression System: Baculovirus Insect Cells
SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi)
TMPK-01352
Species: SARS
Expression System: E. coli
Cystatin B Protein, Mouse, Recombinant (His)
TMPJ-01174
Species: Mouse
Expression System: E. coli
EBAG9 Protein, Human, Recombinant (His)
TMPY-03496
Species: Human
Expression System: E. coli
SARS PLpro/papain-like protease Protein (His)
TMPK-01384
Species: SARS
Expression System: E. coli
VEGFC Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-01044
Species: Human
Expression System: HEK293 Cells
DPP3 Protein, Human, Recombinant (His)
TMPJ-01358
Species: Human
Expression System: E. coli
CELA3A Protein, Human, Recombinant (His)
TMPJ-00481
Species: Human
Expression System: HEK293 Cells
Enterokinase/EK Protein, Bovine, Recombinant
TMPY-04626
Species: Bovine
Expression System: P. pastoris (Yeast)
Granzyme D/GZMD Protein, Mouse, Recombinant (His)
TMPJ-00832
Species: Mouse
Expression System: HEK293 Cells
CTSL Protein, Human, Recombinant (His)
TMPJ-00508
Species: Human
Expression System: HEK293 Cells
CTRL Protein, Human, Recombinant (His)
TMPY-03653
Species: Human
Expression System: HEK293 Cells
CTSB Protein, Human, Recombinant (His)
TMPJ-00497
Species: Human
Expression System: HEK293 Cells
Cathepsin V Protein, Human, Recombinant (His)
TMPY-01249
Species: Human
Expression System: HEK293 Cells
SPINK2 Protein, Human, Recombinant (hFc)
TMPY-00163
Species: Human
Expression System: HEK293 Cells
Fetuin A Protein, Macaca mulatta, Recombinant (His)
TMPJ-00437
Species: Macaca mulatta
Expression System: HEK293 Cells
Kallikrein 7/KLK7 Protein, Human, Recombinant (aa 23-252, His)
TMPJ-00544
Species: Human
Expression System: HEK293 Cells
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カタログ番号 製品名
L1100 Protease Inhibitor Library

343 compounds
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;

ライブラリー

Protease Inhibitor Library
L1100
Compounds: 343

Reagents


Protease Inhibitor Cocktail
(EDTA-Free, 100× in DMSO)
カタログ番号 C0001
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