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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T80964 | Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) | ||
Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) acts as a T cell proliferation activator by promoting the in vitro proliferation of human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner and is utilized... | |||
T4378 | MS049 | Histone Methyltransferase | |
MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively. | |||
T25492 | Hepln-13 | Hepln 13,Hepln13 | c-Met/HGFR |
Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis. | |||
TP1253 | Argireline | Acetyl hexapeptide-3 | Others |
Argireline (Acetyl hexapeptide-3) is composed of chains of amino acids known as peptides. Argireline significantly inhibits Ca2+ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argirelin... | |||
T1643 | Penciclovir | BRL 39123,VSA 671 | HCV Protease , Antifection , HSV |
Penciclovir (BRL 39123) is a Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the ... | |||
T0640 | Benzyl butyl phthalate | BBP,1,2-benzenedicarboxylic acid,butyl phenylmethyl ester,Butyl benzyl phthalate | Others , Aryl Hydrocarbon Receptor |
Benzyl butyl phthalate (1,2-benzenedicarboxylic acid) is used as a plasticizer for PVC. | |||
T6456 | CRT0044876 | NSC 69877,7-NO2-ICA,NSC 69877,7-Nitroindole-2-Carboxylic Acid | DNA/RNA Synthesis |
CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM. | |||
T60750 | Neuronotoxicity-IN-1 | ||
Neuronotoxicity-IN-1 is a pyridothiazine derivative. Neuronotoxicity-IN-1 is an inhibitor of kainic acid neurotoxicity with neuroprotective activity[1]. | |||
T20721 | Isoxaflutole | RP 201772,Merlin,RP-201772,RP201772 | Others |
Isoxaflutole (RP-201772) is a low toxic herbicide and has been marketed as a substitute for atrazine. | |||
T19423 | Methyl cellulose | Others | |
Methylcellulose is not toxic. Methylcellulose is a natural polymer which gels on heating. | |||
T8391 | Cesium chloride | CsCl | Potassium Channel |
Cesium chloride (CsCl) is considered to be the most toxic of the alkali chlorides, inhibiting fungal growth. | |||
T63992 | KS100 | ||
KS100 is a potent inhibitor of ALDH, acting on ALDH1A1 (IC50: 334 nM), ALDH2 (IC50: 2137 nM) and ALDH3A1 (IC50: 360 nM). KS100 significantly increases ROS activity, lipid peroxidation and the accumulation of toxic aldehy... | |||
T38410 | Phosphoramide mustard | DNA Alkylation , Drug Metabolite | |
Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage. | |||
T5314 | Pyridoxal isonicotinoyl hydrazone | PIH | Others |
pyridoxal isonicotinoyl hydrazone (PIH) is a cell-permeable and relatively non-toxic iron (Fe3+) chelator that shows high iron chelation efficacy both in vitro and in vivo. | |||
TQ0133 | Amifostine thiol dihydrochloride | WR 1065 | p53 |
Amifostine thiol dihydrochloride (WR 1065) can activate p53 through a JNK-dependent signaling pathway. It also protects normal tissues from the toxic effects of certain cancer drugs. | |||
T19232 | CMC-Na (Viscosity:800-1200 mPa.s) | CMC-Na (Viscosity:800-1200 mPa.s) | Others |
Sodium carboxymethyl cellulose (CMC-Na) (Viscosity:800-1200 mPa.s) is a water-soluble cellulose, commonly used as a co-solvent in animal experiments, and is essentially non-toxic to animals. | |||
T64771 | Amido Black 10B | Amido Black Staining Solution 2X,Naphthol Blue Black | |
Amido Black 10B (Naphthol Blue Black) is a highly toxic azo dye for staining proteins and is commonly used to stain proteins on polyacrylamide gels and agarose gels. | |||
T8669 | 3,3',4,4'-Benzophenonetetracarboxylic dianhydride | Others | |
3,3',4,4'-Benzophenonetetracarboxylic dianhydride is a compound used as a polyimide precursor in the production of polyimide films and adhesives. It is a non-toxic material with no known adverse effects on human health. | |||
T0914 | Metacetamol | 3-Acetamidophenol | Others |
Metacetamol (3-Acetamidophenol) is a derivative of acetaminophen, a non-toxic regional isomer of acetaminophen. It is an over-the-counter analgesic and antipyretic and is also used as an organic synthesis intermediate. | |||
T10393 | AT-007 | Reductase | |
AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats. | |||
T50013 | 4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoic acid | Others | |
4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoic acid is a synthetic compound with potent antitumor activity, high efficiency and selectivity against tumor cells. However, it has poor solubility in water and is pot... | |||
TP1095 | Elamipretide | MTP-131,RX-31,SS-31 | Others |
Elamipretide (MTP-131) is a mitochondria-targeted antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that reduces toxic reactive oxygen species (ROS) production and stabilizes cardiolipin, with blood-brain-barrier ... | |||
T9720 | T3Inh-1 | Others | |
T3Inh-1 is an effective and selective inhibitor of ppGalNAc-T3 with an IC50 of 7 µM. T3Inh-1 prevents breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic sid... | |||
T14319 | Aripiprazole Lauroxil | Dopamine Receptor , 5-HT Receptor | |
Aripiprazole lauroxil, the N-acyloxymethyl prodrug form of aripiprazole, a long-acting injectable (LAI) antipsychotic. Aripiprazole lauroxil is cleaved by esterases in vivo to N-hydroxymethyl aripiprazole (lauric acid), ... | |||
T4081 | MPTP hydrochloride | MPTP-hydrochloride | Apoptosis , Dopamine Receptor |
MPTP hydrochloride is a precursor of MPP+, a dopamine neurotoxin with blood-brain barrier permeability. MPTP hydrochloride is toxic to dopaminergic neurons, which can lead to Parkinson's disease, and is widely used in th... | |||
T16949 | Sucrose octaacetate | Others | |
Sucrose octaacetate is an acetylated derivative of sucrose. Sucrose octaacetate can be used as food additive and also used as an adhesive and plasticizer. Sucrose octaacetate also used in many pesticides, insecticides, a... | |||
T14922 | Cefodizime | Antibacterial , Antibiotic | |
TP1299L | Melittin TFA(20449-79-0(free base)) | Phospholipase | |
Melittin TFA is a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not ... | |||
T10782 | CGP52411 | DAPH | EGFR , Beta Amyloid |
CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM). CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells and dramatically inhibits and reverses the formation of β-amyloid Aβ42... | |||
T0765 | Fomepizole | Antizol-Vet,4-Methylpyrazole,Antizol | P450 , CAT , AChR |
Fomepizole (4-Methylpyrazole) is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole(4-Methylpyrazole) is a competitive inhibitor of alcohol dehydrogenase, the enzyme that cata... | |||
T9727 | 2'-Fluoro-2'-Deoxyadenosine | Nucleoside Antimetabolite/Analog | |
2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors ex... | |||
T38585 | Tetrachlorocatechol | Others | |
Tetrachlorocatechol (TCC) is a chlorinated catechol compound that serves as a metabolite of pentachlorophenol. It is prominently generated during the chlorobleaching process in pulp production and is commonly detected in... | |||
T31011 | Coralyne chloride | Topoisomerase | |
Coralyne chloride is a protoberberine with strong anticancer activity. It can be used to prepare Coralyne derivatives, a fluorescent DNA-based molecular rectifier built into DNA duplexes through site-specific insertion. ... | |||
T15602 | ITX3 | Others , Rho | |
ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange on RhoG and Rac1, inhibits NGF-mediated neurite growth in P... | |||
T22297 | Clindamycin hydrochloride monohydrate | Clindamycin alcoholate | Antibiotic |
Clindamycin hydrochloride monohydrate (Clindamycin alcoholate) is a protein synthesis inhibitor used orally, capable of diminishing virulence factor expression in Staphylococcus aureus at sub-minimum inhibitory concentra... | |||
T67791 | BMS-903452 | GPR | |
BMS-903452 is a potent and selective GPR119 agonist with EC50 of 14 nM. BMS-903452 is indicated for the treatment of acute and chronic rodent diabetes. GPR119 was mainly expressed in pancreatic b cells and gastrointestin... | |||
T14884 | CBR-5884 | Others , Dehydrogenase | |
CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with h... | |||
T38063 | N-Acetyl lysyltyrosylcysteine amide | Glutathione Peroxidase | |
N-Acetyl lysyltyrosylcysteine amide is a non-toxic myeloperoxidase (MPO) tripeptide inhibitor that is potent, reversible, and specific.N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO production in vivo. N-Ac... | |||
TF0106 | Cholesteryl Hemisuccinate Tris Salt | Apoptosis | |
Cholesteryl Hemisuccinate Tris Salt is an acidic cholesteryl ester with hepatoprotective and anticancer activity.Cholesteryl hemisuccinate is a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing C... | |||
T12009 | Telomerase-IN-1 | Telomerase | |
Telomerase-IN-1 is a telomerase inhibitor (IC50: 0.19 μM). telomerase-IN-1 activates hTERT expression through the endoplasmic reticulum stress (ERS) of the ER overreaction (EOR), which then induces ERS, leading to apopto... | |||
T38272 | Thiacloprid | AChR , Parasite | |
Thiacloprid is a neonicotinoid insecticide that acts as a selective agonist at insect nicotinic acetylcholine receptors (nAChRs) with IC50values of 2.7 and 860 nM forDrosophilanAChRs and M10 mouse fibroblast cells expres... | |||
T32095 | Holothurinogenin | Nobilisidenol A | |
Holothurinogenin, as a lanosterol derivative, has toxic to nerve tissue. | |||
T34563 | Scaritoxin | ||
Scaritoxin is a potent toxic substance isolated from poisonous fish. | |||
T33073 | Lysinoalanine, (S,S)- | N6-Lysino-L-alanine | |
Lysinoalanine, (S, S)- is a toxic compound from processed proteinaceous foods. | |||
T31991 | Grandiflorine | Ribasine,Deoxyhimalayamine,Limogine | |
Grandiflorine is a toxic dorditerpenoid alkaloid. | |||
T19537 | Quizalofop-p-ethyl | (R)-Quizalofop ethyl,Quinofop-ethyl | Others |
Quizalofop-P-ethyl is a selective,slightly toxic, postemergence phenoxy herbicide. | |||
TP2453 | Conotoxin GII | alpha-Conotoxin G II | |
Conotoxin GII is a highly toxic peptide. | |||
T34391 | Rosmarinine | ||
Rosmarinine is a non-toxic pyrrolizidine alkaloid. | |||
T16082 | Mivotilate | YH439 | Others |
Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent. | |||
T33037 | Lyoniol-A | ||
Lyoniol-A is a toxic component from poisonous tree in Japan(Lyonia ovalifolia var. elliptica). |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T3S0895 | Spirostan-3-ol | Sarsaponin | Others |
Spirostan-3-ol (Sarsaponin) is a stereoisomer of Sarsasapogenin (S142505), a steroid glycoside isolated from plant materials. A saponin with with potential anti-tumor activity via apoptosis. | |||
TN1078 | Seneciphylline | P450 , GST | |
Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutat... | |||
T20754 | Deltamethrin | Butoss,RU-22974,Esbecythrin,K-Othrin,Decamethrin,RU 22974 | Others |
Deltamethrin (RU 22974), a neurotoxic pyrethroid insecticide, produces a reversible sequence of motor symptoms in rats involving hind limb rigidity and choreoathetosis.Deltamethrin is globally used in crop protection, co... | |||
T3748 | Orcinol | 5-Methylresorcinol,3,5-Dihydroxytoluene,5-Methylresorcin,3,5-ToluenediolOrcin,5-Methyl-1,3-benzenediol,Orcin | Others |
orcinol (5-Methylresorcin) is anxiolytic agent without sedative effect. | |||
TN1113 | Vincetoxicoside B | Anti-infection , Antifungal | |
Vincetoxicoside B, isolated from Polygonum paleaceum Wall. Vincetoxicoside B , quercetin, kaempferol , and (-)-epicatechin show synergistic antifungal activities with the FICI values <0.5. | |||
T13531 | Aflatoxicol | Aflatoxin R0 | Others |
Aflatoxin (Aflatoxin R0) is a mutagenic and carcinogenic mycotoxin derived from aflatoxin B1 through metabolic processes facilitated by Rhizopus spp. | |||
TN3392 | Alpha-Toxicarol | Others | |
Alpha-Toxicarol exhibits a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. | |||
TN3811 | Dehydrotoxicarol | Others | |
Dehydrotoxicarol is a natural product of Derris, Fabaceae. The catalog number is TN3811 and the CAS number is 59086-93-0. Dehydrotoxicarol can be used as a reference standard. | |||
T13934 | Toxicarol isoflavone | Others | |
Toxicarol isoflavone, an iso avone, is extracted from Millettia brandisiana. | |||
T5757 | Loganetin | Antibacterial | |
Loganetin, a non-toxic natural product, shows antibacterial activity against multidrug-resistant Gram-negative infections. | |||
T9600 | 2,4-Di-tert-butylphenol | Endogenous Metabolite | |
2,4-Di-tert-butylphenol is a common toxic secondary metabolite produced by various groups of organisms. | |||
T6S0630 | Hypaconitine | P450 , TNF | |
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism. | |||
TN6928 | L-Azetidine-2-carboxylic acid | (2S)-azetidine-2-carboxylic acid | Endogenous Metabolite |
L-Azetidine-2-carboxylic acid ((2S)-azetidine-2-carboxylic acid) is a toxic proline analogue produced by members of the Liliaceae and Agavaciae families. | |||
T8161 | Vicine | Others | |
Vicine, an alkaloid found in fava beans, is toxic in individuals and may cause haemolytic anaemia. | |||
T2S0663 | Humantenmine | P450 | |
1. Humantenmine is a toxic compound isolated from Gelsemium elegans Benth . 2. Humantenmine and koumine may inhibit several CYP450 enzyme activities. | |||
T4S1521 | 1,4-Dicaffeoylquinic acid | HIV Protease | |
1,4-Dicaffeoylquinic acid has antioxidant activity.1,4-Dicaffeoylquinic acid is a potent and highly selective class of HIV-1 integrase inhibitors, inhibitsHIV-1 replication in MT-2 cell culture at non-toxic concentration... | |||
T20091 | Stearamide | Stearic acid amide,NSC 66462,NSC66462,NSC-66462 | |
Stearamide(Stearic acid amide) is a primary fatty acid amide that is cytotoxic and fish toxic and can be used to increase the properties of nanoparticles. | |||
T5718 | L-(+)-Abrine | L-N-Methyltryptophan,N-α-Methyl-L-tryptophan,L-ABRINE | Others |
L-(+)-Abrine (L-N-Methyltryptophan) is a toxic protein found in the jequirity seed.,can be used as a biomarker for abrin exposure. | |||
T3321 | Oleanonic acid | 3-Oxooleanolic acid,3-Oxoolean-12-en-28-oic Acid,Oleanonic Acid,3-Ketooleanolic Acid | HIV Protease |
Oleanonic acid (3-Ketooleanolic Acid) is relatively non-toxic, hepatoprotective, and exhibits antitumor and andantiviral properties. | |||
T3154 | Citral | Geranialdehyde,alpha-Citral,geranial | Others |
Citral (alpha-Citral) is a clear yellow colored liquid with a lemon-like odor. Less dense than water and insoluble in water. Toxic by ingestion. Used to make other chemicals. | |||
T10164 | 5,6-Dihydroxyindole | Dopamine lutine | Endogenous Metabolite |
5,6-Dihydroxyindole (Dopamine lutine) is a melanin precursor and has a broad-spectrum antibacterial, antiviral, antifungal, antiparasitic activity. It has cytotoxic effects and is strongly toxic against various pathogens... | |||
T5068 | D-Glucuronic acid sodium salt monohydrate | Sodium D-glucuronate,D(+)-Glucuronic acid sodium salt monohydrate | Others , Endogenous Metabolite |
D-Glucuronic acid sodium salt monohydrate (Sodium D-glucuronate) is a carboxylic acid and highly soluble in water. In humans, glucuronic acid is often linked to toxic or poisonous substances to allow for subsequent elimi... | |||
T4S1869 | 12-Epinapelline | Others | |
12- Epinapelline is a diterpene alkaloid which displays anaesthetic activity as toxic neurological agents. Similar to aconitine, its suggested that modulation of voltage gated Na+ channels are responsible for these obser... | |||
T0012 | Cinchonine | LA40221,(8R,9S)-Cinchonine | Apoptosis , P-gp , Parasite |
Cinchonine (LA40221), a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narcotics and its parenteral use is restricted to spi... | |||
T8100 | Azetidine-2-carboxylic acid | Others | |
Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including hu... | |||
T0461 | Berberine chloride | Berberine hydrochloride,Benzodioxide,Natural Yellow 18 | Reactive Oxygen Species , Topoisomerase , Antibacterial , Antibiotic , Autophagy |
Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae and also found in many other plants. It is relatively toxic to parenterally but has been used orally for various fungal an... | |||
T5222 | N-(5-Aminopentyl)acetamide | Monoacetylcadaverine,N-Acetylcadaverine,N-Acetyl-1,5-pentanediamine | Others , Endogenous Metabolite |
N-(5-Aminopentyl)acetamide (N-Acetylcadaverine) is the acetylated form of the polyamine cadaverine. Cadaverine is produced by the breakdown of amino acids in living and dead organisms and is toxic in large doses. N-(5-Am... | |||
T2803 | Monocrotaline | Crotaline | TGF-beta/Smad |
Monocrotaline (Crotaline) is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hyp... | |||
T1507 | Streptozocin | STZ,Streptozotocin,NSC-85998,U 9889 | DNA Alkylator/Crosslinker , DNA Alkylation , DNA/RNA Synthesis , Antibacterial , Antibiotic , Autophagy |
Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used in the construction of animal models of type 1 diabetes. Th... | |||
TN1216 | 2-O-Acetyl-20-hydroxyecdysone | 20-Hydroxyeedysone 2-acetate | Beta Amyloid , Others |
2-O-Acetyl-20-hydroxyecdysone is an ecdysone present in insects and terrestrial plants. 2-O-Acetyl-20-hydroxyecdysone inhibits amyloid-β42-induced cytotoxicity and is able to reduce the formation of Aβ oligomers by promo... | |||
T3S1227 | Aristolactam I | Aristolactam,Aristololactam I,Aristololactum | Apoptosis , Caspase |
1.Aristolactam I (Aristololactum) has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I may be mediated by different mechanisms except TGF... | |||
T5279 | Ethylmalonic acid | alpha-Carboxybutyrate,2-Ethylmalonic acid | Others , Endogenous Metabolite |
Ethylmalonic acid (alpha-Carboxybutyrate) can be found in blood, cerebrospinal fluid (CSF), and urine, as well as in human fibroblasts, prostate, and skeletal muscle tissues. Moreover, ethylmalonic acid is found to be as... | |||
T1121 | Podofilox | Podophyllotoxin,(+)-Shikonin | Microtubule Associated , Topoisomerase |
Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irrit... | |||
T5S0018 | Betulonic acid | (+)-Betulonic acid,Betunolic acid,Liquidambaric acid | Parasite , HSV |
1. Betulonic acid (Liquidambaric acid) amide stimulated the regenerative response in hepatocytes under conditions of combined toxic exposure and promoted recovery of their qualitative and quantitative characteristics, wh... | |||
T3779 | Crocin II | Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B | Caspase , COX , NO Synthase |
Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expres... | |||
T4776 | Glycerol | Glycerin | Endogenous Metabolite |
Glycerol or glycerin is a colourless, odourless, viscous liquid that is sweet-tasting and mostly non-toxic. It is widely used in the food industry as a sweetener and humectant and in pharmaceutical formulations. Glycerol... | |||
T10045 | 15-Acetyl-deoxynivalenol | Others | |
15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals and exhibits toxicity to HepG2 cells. | |||
T33775 | Ochratoxin C | HSDB 3439 | |
Ochratoxin C is a toxic metabolite from Aspergillus orchraceus. | |||
TN5112 | Taxin B | Others | |
Taxin B has toxic effects. | |||
TN3507 | Beta-Yohimbine | Adrenergic Receptor , Antifection | |
Beta-Yohimbine has approximately twice as toxic as yohimbine and corynanthine about one fifth as toxic. Beta-yohimbine has alpha-1 and alpha-2 adrenoceptor blocking activities, it has cardiovascular effects. Beta-Yohimbi... | |||
TN3574 | Canadine | P450 | |
Canadine has antioxidant activity with low-toxic effect. | |||
TN3872 | Diosbulbin D | ROS | |
Diosbulbin D shows direct toxic effect on hepatocytes, the mechanism could be associated with oxidative stress. | |||
T13630 | Cytochalasin C | Others | |
Cytochalasin C is a cell-permeable fungal toxin that can induce the formation of nuclear sticks. Cytochalasin C is 10 times less toxic than cytochalasin D in mice. | |||
TN1971 | Nagarine | Others | |
Nagarine has toxic and analgesic effects. | |||
TN5232 | Victoxinine | Others | |
Victoxinine, the toxic metabolite, considered previously to be a unique product of Helminthosporium victoriae. | |||
T10825 | Citrinin | NSC 186 | Others |
Citrinin is a mycotoxin that causes contamination in the food and is associated with different toxic effects. Citrinin also possesses a broad spectrum of bioactivities, including antifungal, antibacterial, and potential ... | |||
T15356 | Fumonisin B1 | Others | |
Fumonisin B1 is the most abundant and toxic fumonisin and is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is also a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de no... | |||
T82897 | Benzo[e]pyrene | ||
Benzo[e]pyrene, a highly toxic polyaromatic hydrocarbon (PAH), is found in fossil fuels [1]. | |||
TN4219 | Homobaldrinal | Others | |
Homobaldrinal has low toxic activity. It has genotoxic activity in the Salmonella/microsome test and the SOS-chromotest. | |||
TN3133 | 5-O-Methylgenistein | Others | |
5-O-Methylgenistein may show free radical scavenging activity, it also may have hepatoprotective property on the model of toxic hepatitis induced by carbon tetrachloride damage. | |||
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カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPH-03709 | Viscotoxin-A3 Protein, Viscum album, Recombinant (His) | Viscum album | P. pastoris (Yeast) |
Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known. Viscotoxin-A3 Protein, Viscum album, Recomb... | |||
TMPH-03710 | Viscotoxin-A3 Protein, Viscum album, Recombinant (His & SUMO) | Viscum album | E. coli |
Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known. Viscotoxin-A3 Protein, Viscum album, Recomb... | |||
TMPH-03378 | SOD1 Protein, Rat, Recombinant (His) | Rat | P. pastoris (Yeast) |
Destroys radicals which are normally produced within the cells and which are toxic to biological systems. SOD1 Protein, Rat, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 17.... | |||
TMPH-02918 | SOD1 Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) |
Destroys radicals which are normally produced within the cells and which are toxic to biological systems. SOD1 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 1... | |||
TMPH-03579 | TSST-1 Protein, S. aureus, Recombinant (His & SUMO) | Staphylococcus aureus | E. coli |
Responsible for the symptoms of toxic shock syndrome. TSST-1 Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 37.9 kDa and th... | |||
TMPH-00771 | Ferritin-2 Protein, Glycine max, Recombinant (His & SUMO) | Glycine max | E. coli |
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | |||
TMPJ-00104 | SOD2 Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms to... | |||
TMPH-01318 | SOD3 Protein, Human, Recombinant | Human | E. coli |
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. SOD3 Protein, Human, Recombinant is expressed in E. coli expression ... | |||
TMPH-02917 | SOD1 Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli |
Destroys radicals which are normally produced within the cells and which are toxic to biological systems. SOD1 Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The pr... | |||
TMPH-00345 | Catalase Protein, Capsicum annuum, Recombinant (His) | Capsicum annuum | E. coli |
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Catalase Protein, Capsicum annuum, Recombinant (His) is expressed in E. coli expression system... | |||
TMPH-00783 | YafQ Protein, Haemophilus influenzae, Recombinant (His & Myc) | Haemophilus influenzae | E. coli |
Toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin is RelB. YafQ Protein, Haemophilus influenzae, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag... | |||
TMPY-02420 | HEMK2 Protein, Human, Recombinant (His) | Human | E. coli |
N6AMT1 (N-6 Adenine-Specific DNA Methyltransferase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes an N(6)-adenine-specific DNA methyltransferase. It belongs to t... | |||
TMPH-00080 | Catalase-2 Protein, Arabidopsis thaliana, Recombinant (His & SUMO) | Arabidopsis thaliana | E. coli |
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Catalase-2 Protein, Arabidopsis thaliana, Recombinant (His & SUMO) is expressed in E. coli exp... | |||
TMPH-00052 | Superoxide dismutase [Fe] Protein, Anabaena sp., Recombinant (His & KSI) | Anabaena | E. coli |
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Superoxide dismutase [Fe] Protein, Anabaena sp., Recombinant (His & KSI) is expressed in E. coli ... | |||
TMPH-01317 | SOD3 Protein, Human, Recombinant (His) | Human | E. coli |
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. SOD3 Protein, Human, Recombinant (His) is expressed in E. coli expre... | |||
TMPH-03612 | SodC Protein, Mycobacterium tuberculosis, Recombinant (His & Myc) | Mycobacterium tuberculosis | E. coli |
Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes. SodC Protein, Mycobacterium tuberculosis, Recomb... | |||
TMPH-02102 | PON1 Protein, Human, Recombinant (GST) | Human | E. coli |
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediate... | |||
TMPH-02903 | PON1 Protein, Mouse, Recombinant | Mouse | E. coli |
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediate... | |||
TMPH-03448 | EHT1 Protein, S. cerevisiae, Recombinant (His) | Saccharomyces cerevisiae | E. coli |
Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by est... | |||
TMPH-03594 | Exotoxin type A Protein, S. pyogenes, Recombinant (His & SUMO) | Streptococcus pyogenes | E. coli |
Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever. Exotoxin type A Protein, S. pyog... | |||
TMPY-00320 | APOA1BP Protein, Human, Recombinant (His) | Human | HEK293 Cells |
APOA1BP, now renamed NAXE, encodes an epimerase essential in the cellular metabolite repair for NADHX and NADPHX. The enzyme catalyzes the epimerization of NAD(P)HX, thereby avoiding the accumulation of toxic metabolites... | |||
TMPH-00120 | Ribonuclease clavin Protein, Aspergillus clavatus, Recombinant (His & Myc) | Aspergillus clavatus | E. coli |
Clavin has the same substrate specificity as alpha-sarcin. It is specific for purines in both single- and double-stranded RNA. Its toxic action on eukaryotic cells is the result of cleavage of a single phosphodiester bon... | |||
TMPH-03582 | MazF Protein, S. epidermidis, Recombinant (His) | Staphylococcus epidermidis | E. coli |
Toxic component of a type II toxin-antitoxin (TA) system. Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis. It cuts between the f... | |||
TMPH-02404 | LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO) | Yellow scorpion | E. coli |
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin... | |||
TMPH-03565 | MazF Protein, S. aureus, Recombinant (His) | Staphylococcus aureus | E. coli |
Toxic component of a type II toxin-antitoxin (TA) system. Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis. It cuts between the f... | |||
TMPJ-00744 | Toxin B Protein, Vibriocholerae, Recombinant | Vibrio cholerae | E. coli |
Cholera toxin is protein complex secreted by the bacterium Vibrio cholerae. It is responsible for the massive, watery diarrhea characteristic of cholera infection. Cholera enterotoxin subunit B (CTXB) pentameric ring dir... | |||
TMPH-00013 | Abrin-a Protein, Abrus precatorius, Recombinant (Yeast, His) | Abrus precatorius | P. pastoris (Yeast) |
The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. Abrin-a is more toxic than ricin.; The B chain... | |||
TMPH-00014 | Abrin-c Protein, Abrus precatorius, Recombinant (His & Myc) | Abrus precatorius | E. coli |
The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. Abrin-a is more toxic than ricin.; The B chain... | |||
TMPK-00249 | TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL... | |||
TMPH-02615 | CBS Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cystei... | |||
TMPH-00012 | Abrin-a Protein, Abrus precatorius, Recombinant (E. coli, His) | Abrus precatorius | E. coli |
The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. Abrin-a is more toxic than ricin.; The B chain... | |||
TMPH-03702 | MTA/SAH nucleosidase Protein, Vibrio cholerae serotype O1, Recombinant (His & Myc) | Vibrio cholerae | E. coli |
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocy... | |||
TMPK-00248 | TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL... | |||
TMPH-00692 | MTA/SAH nucleosidase Protein, E. coli O9:H4, Recombinant (His & Myc) | E. coli | E. coli |
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocy... | |||
TMPJ-00105 | SOD2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Superoxide Dismutase (SOD2) belongs to the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 transforms toxic super... | |||
TMPK-00545 | HPX Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Hemopexin (HPX) serves as scavenger and transporter of toxic plasma heme to the liver. HPX is formed by two four-bladed beta-propeller domains, resembling two thick disks that lock together at a 90 degrees angle. The hem... | |||
TMPH-03586 | Toxin zeta Protein, S. agalactiae, Recombinant (His) | Streptococcus agalactiae | P. pastoris (Yeast) |
Toxic component of a type II toxin-antitoxin (TA) system. Phosphorylates UDP-N-acetyl-D-glucosamine (UNAG) on the 3'-hydroxyl group of the N-acetyl-D-glucosamine moiety, yielding UNAG-3P. UNAG-3P inhibits MurA, the first... | |||
TMPJ-00764 | Catalase/CAT Protein, Human, Recombinant | Human | E. coli |
Catalase (CAT) is a member of the catalase family. It exists as a homotetramer that occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Catalase ... | |||
TMPJ-00871 | BAR Protein, S. hygroscopicus, Recombinant | Streptomyces hygroscopicus | E. coli |
Phosphinothricin N-acetyltransferase (PAT) is an enzyme that acetylates the free NH2 group of L-phosphinothricin (L-PPT) in the presence of acetyl-CoA as a co-substrate. It is highly specific for L-PPT and does not acety... | |||
TMPY-03450 | GSTK1 Protein, Human, Recombinant | Human | E. coli |
GSTK1 gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. Glutathione S-transferases (GSTs) are a family of enzymes that catalyze a var... | |||
TMPY-03406 | NMNAT1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
NMNAT, also known as NMNAT1, is a member of the Nicotinamide-nucleotide adenylyltransferases. It is widely expressed with high levels in skeletal muscle, heart, liver, and kidney. NMNAT appears to have the ability to pro... | |||
TMPJ-00761 | FTH Protein, Human, Recombinant (His) | Human | E. coli |
Ferritin heavy polypeptide 1(FTH1), is a ubiquitous intracellular protein which stores iron in a soluble, non-toxic, readily available form. FTH1 has ferroxidase activity and is important for iron homeostasis. Iron is ta... | |||
TMPY-02393 | Thimet Oligopeptidase/THOP1 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus Insect Cells |
THOP1, also known as Thimet oligopeptidase 1, Thimet oligopeptidase, EC 3.4.24.15, or EP24.15, is a zinc(II) endopeptidase implicated in the processing of numerous physiological peptides. As an intracellular enzyme, high... | |||
TMPY-03849 | NUDT5 Protein, Human, Recombinant (His) | Human | E. coli |
NUDT5 (Nudix Hydrolase 5) is a Protein Coding gene. This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphos... | |||
TMPY-03985 | Adenosine Deaminase Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Adenosine Desaminase (ADA) deficiency, is a purine metabolic disorder that cause severe combined immunodeficiency (SCID) due to the accumulation of toxic metabolites that primarily affects development, differentiation a... | |||
TMPY-01588 | ALDH7A1 Protein, Human, Recombinant (His) | Human | E. coli |
ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol... | |||
TMPY-02622 | Aldolase B Protein, Human, Recombinant (GST) | Human | E. coli |
The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed... | |||
TMPY-03491 | Lysozyme 2 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
The lysozyme 2 gene is a member of a family of lysozyme-like genes. Lysozymes, especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective ... | |||
TMPY-02711 | Ferritin heavy chain 1/FTH1 Protein, Human, Recombinant | Human | E. coli |
FTH1 (ferritin, heavy polypeptide 1) is the heavy subunit of ferritin which is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin cha... | |||
TMPY-04122 | ATOX1 Protein, Human, Recombinant (His) | Human | E. coli |
ATOX1 is a cytoplasmic copper chaperone that interacts with the copper-binding domain of the membrane copper transporters ATP7A and ATP7B. ATOX1 has also been suggested to have a potential anti-oxidant activity. As the t... | |||
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カタログ番号 | 製品名 | ||
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L5500 | Toxic Compound Library | 262 compounds | |
A unique collection of 262 toxic substances for high throughput screening (HTS) and high content screening (HCS); | |||
L4900 | Cardiotoxicity Compound Library | 131 compounds | |
A unique collection of 131 cardiotoxicity inducing compounds for toxicological study; | |||
L3100 | Hematopoietic Toxicity Compound Library | 101 compounds | |
A unique collection of 101 compounds with defined hematopoietic toxicity for high throughput and high content drug screening; | |||
L9850 | Orally Active Compound Library | 2427 compounds | |
A unique collection of 2427 of orally active compounds for high-throughput screening and high-content screening. | |||
L2910 | Antioxidant Compound Library | 1314 compounds | |
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species (ROS) and a biological system's ability to readily detoxify the reactive intermediates or repair the resulting damage. ... | |||
L2152 | Targeted Therapy Drug Library | 119 compounds | |
119 tumor-targeted drugs that can be used for high-throughput and high-content screening. | |||
L8710 | Cuproptosis Compound Library | 400 compounds | |
TargetMol’s Cuproptosis Compound Library is a collection of 400 compounds related to copper-dependent death that can be used to study its mechanism and related diseases. | |||
L9300 | Macrocyclic Compound Library | 210 compounds | |
210 macrocyclic compounds of known activity for high-throughput, high-content screening; |