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Search Results for " Adipogenesis "

ターゲット

14

阻害剤

22

天然化合物

22

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T9568 SGC-SMARCA-BRDVIII Epigenetic Reader Domain
SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.
T9266 Fatostatin Lipid , Fatty Acid Synthase
Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs.
T1057 Azilsartan TAK-536 RAAS
Azilsartan (TAK-536) is an Angiotensin 2 Receptor Blocker. The mechanism of action of azilsartan is as an Angiotensin 2 Type 1 Receptor Antagonist. The physiologic effect of azilsartan is by means of Decreased Blood Pres...
T6832 Fatostatin hydrobromide Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin NPC1L1 , Fatty Acid Synthase
Fatostatin hydrobromide (Fatostatin A HBr) ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
T30577 BRD0418 BRD 0418,BRD-0418 Others
BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.
T77788 Palmitic acid sodium Sodium palmitate,Palmitic acid sodium
Palmitic acid sodium (Sodium palmitate) is a type of saturated fatty acid that is formed in fatty acid synthesis.Palmitic acid sodium promotes adipogenesis and cellular lipoatrophy in a variety of cell lines.
T7621 6-​Thioinosine 6-Mercaptopurine riboside,6TI Nucleoside Antimetabolite/Analog
6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.
T6337 RepSox ALK5 Inhibitor II,SJN 2511,E-616452 ALK , TGF-beta/Smad
RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells.
T24182 ISX-1 ISX 1 Others
ISX-1 inhibits adipogenesis and promotes osteoblastogenesis. ISX-1 can be used in studies about osteoporosis and osteopenia.
T13289 EHP-101 VCE-​004.8 Cannabinoid Receptor , HIF/HIF Prolyl-Hydroxylase , PPAR
EHP-101 (VCE-004.8) is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. EHP-101 attenuates adipogenesis and prevents diet-induced obesity.
T61548 Anti-inflammatory agent 22
Anti-inflammatory agent 22 (compound 14a) is a potent orally active compound with anti-inflammatory properties. It effectively inhibits the production of TNF-α induced by LPS, exhibiting an IC50 value of 14.6 μM. Additio...
T36471 Ternatin
Ternatin is a cyclic heptapeptide first isolated from the mushroom C. versicolor that has been shown to have cytotoxic and anti-adipogenic effects in vitro. It inhibits adipogenesis with an IC50 value of 27 nM and become...
T64171 LXR antagonist 2
LXR antagonist 2 (compound 10rr) is a potent LXR (liver X receptor) inverse agonist, acting on LXRβ (IC50: 0.36 μM) and LXRα (IC50: 2.25 μM). LXR antagonist 2 is an adipogenesis inhibitor that downregulates LXR target ge...
T72034 LI-2242 Others
LI-2242 is a potent inositol hexakisphosphate kinase (IP6K) inhibitor with IC50s of 31 nM, 42 nM, 8.7 nM, and 1944 nM for IP6K1, IP6K2, IP6K3, and IPMK, respectively.LI-2242 ameliorated hepatic steatosis by reducing the ...
カタログ番号 製品名 別名 ターゲット
TN1836 Kudinoside D LDL , AMPK , PPAR
Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.
T3836 Eudesmin MAPK , S6 Kinase
Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m...
T2S0712 Sinigrin Allylglucosinolate,2-Propenylglucosinolate Others
Sinigrin (2-Propenylglucosinolate), a glucosinolate, is used as a systrate to identify, differentiate and characterize myrosinase(s)/thioglucoside glucohydrolase(s)/thioglucosidase(s). Sinigrin is used as a reference mat...
T5583 Turanose D-(+)-Turanose Endogenous Metabolite
D(+)-Turanose (D-(+)-Turanose) is a naturally occuring compound. It is a reducing disaccharide.
TN2121 3,5,7,3′,4′-Pentamethoxyflavone Quercetin 3,5,7,3,4-pentamethyl ether Others
3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) is a natural product. It can induce adipogenesis on 3T3-L1 preadipocytes by regulating transcription factors at an early stage of differentiation.
T4S1173 Agrimol B Sirtuin , PPAR
1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
T13803 N-Oleoyl glycine Cannabinoid Receptor , Akt , Endogenous Metabolite , PPAR
N-Oleoyl Glycine, a Lipoamino Acid, Stimulates Adipogenesis Associated With Activation of CB1 Receptor and Akt Signaling Pathway in 3T3-L1 Adipocyte
T4S0227 Sinensetin Pedalitin permethyl ether TNF , PGE Synthase
Sinensetin (Pedalitin permethyl ether) is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.
T3674 Hydroxysafflor yellow A HSYA,Safflomin A TGF-beta/Smad
Hydroxysafflor yellow A (Safflomin A) inhibited adipogenesis by increasing HSL promoter activities. Hydroxysafflor yellow A can effectively protect the liver from long-term alcohol injury by enhancing antioxidant capacit...
T8184 Fucosterol PARP , Endogenous Metabolite , PPAR
Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and C/EBPα expression.
TN5137 Tetramethylkaempferol transporter , PPAR
Tetramethylkaempferol is a PPARγ agonist, it can improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Tetramethylkaempfero...
T3S2312 Poncirin Isosakuranetin-7-neohesperidoside Apoptosis , Others
1. Poncirin (Isosakuranetin-7-neohesperidoside) shows a significant in vitro inhibitory effect on the growth of the human gastric cancer cells, SGC-791, in a dose-dependent manner. 2. Poncirin prevents adipogenesis, enha...
T4S0878 Prunetin Prunusetin ERK , Dehydrogenase , NF-κB
1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesit...
TN3989 Erycibelline LDL , PPAR
Erycibelline has antiobesity activity, it may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis.
T81291 Retrofractamide A
Retrofractamide A, an amide constituent extracted from Piper chaba fruit, enhances adipogenesis in 3T3-L1 cells [1].
TN2228 Soyasaponin Aa PPAR
Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the downregulation of the adipogenesis-related transcription factor...
TN4390 Kihadanin B Akt , PPAR , FOXO1
Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.
T64246 Cinchonine monohydrochloride hydrate
Cinchonine ((8R,9S)-Cinchonine) monohydrochloride hydrate is a natural and potent antimalarial agent and an inhibitor of human platelet aggregation. apoptosis in human hepatocellular carcinoma cells and inhibits adipogen...
TN5369 Dehydroleucodine Dehydroleucodin
Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating a...
TN4213 Hirsutenone ERK , EGFR , IL Receptor , NF-κB , Akt , PI3K , Antifection , mTOR , p53 , Autophagy
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.Hirsutenone exhibits anti-cancer, and anti-filaria...
T79949 Foenumoside B PPAR
Foenumoside B, a triterpene saponin extracted from Lysimachia foenum-graecum, stimulates AMPK signaling, suppresses PPARγ-induced adipogenesis, and promotes lipolysis, shifting lipid metabolism. This compound is utilized...
TN3366 Ailanthoidol IL Receptor , NOS , COX , Prostaglandin Receptor , PPAR
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potential as a chemopreventive agent against tumor promotion. Ailan...

天然物製品

Kudinoside D
TN1836
Synonym:
Target: LDL, AMPK, PPAR
Eudesmin
T3836
Synonym:
Target: MAPK, S6 Kinase
Sinigrin
T2S0712
Synonym: Allylglucosinolate,2-Propenylglucosinolate
Target: Others
Turanose
T5583
Synonym: D-(+)-Turanose
Target: Endogenous Metabolite
3,5,7,3′,4′-Pentamethoxyflavone
TN2121
Synonym: Quercetin 3,5,7,3,4-pentamethyl ether
Target: Others
Agrimol B
T4S1173
Synonym:
Target: Sirtuin, PPAR
N-Oleoyl glycine
T13803
Synonym:
Target: Cannabinoid Receptor, Akt, Endogenous Metabolite, PPAR
Sinensetin
T4S0227
Synonym: Pedalitin permethyl ether
Target: TNF, PGE Synthase
Hydroxysafflor yellow A
T3674
Synonym: HSYA,Safflomin A
Target: TGF-beta/Smad
Fucosterol
T8184
Synonym:
Target: PARP, Endogenous Metabolite, PPAR
Tetramethylkaempferol
TN5137
Synonym:
Target: transporter, PPAR
Poncirin
T3S2312
Synonym: Isosakuranetin-7-neohesperidoside
Target: Apoptosis, Others
Prunetin
T4S0878
Synonym: Prunusetin
Target: ERK, Dehydrogenase, NF-κB
Erycibelline
TN3989
Synonym:
Target: LDL, PPAR
Retrofractamide A
T81291
Synonym:
Target:
Soyasaponin Aa
TN2228
Synonym:
Target: PPAR
Kihadanin B
TN4390
Synonym:
Target: Akt, PPAR, FOXO1
Cinchonine monohydrochloride hydrate
T64246
Synonym:
Target:
Dehydroleucodine
TN5369
Synonym: Dehydroleucodin
Target:
Hirsutenone
TN4213
Synonym:
Target: ERK, EGFR, IL Receptor, NF-κB, Akt, PI3K, Antifection, mTOR, p53, Autophagy
Foenumoside B
T79949
Synonym:
Target: PPAR
Ailanthoidol
TN3366
Synonym:
Target: IL Receptor, NOS, COX, Prostaglandin Receptor, PPAR

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPJ-00080 IL-11 Protein, Human, Recombinant(P. pastoris) Human P. pastoris
Interleukin 11 (IL-11) is a member of a family of human growth factors that includes human growth hormone, granulocyte colony-stimulating factor, and other growth factors. IL-11 is a thrombopoietic growth factor that dir...
TMPK-00089 IL-11 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which tri...
TMPK-00088 IL-11 Protein, Human, Recombinant (His) Human HEK293
Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which tri...
TMPY-05842 IL-11 Protein, Cynomolgus, Recombinant Cynomolgus E. coli
IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 i...
TMPY-04178 IL-11 Protein, Mouse, Recombinant Mouse E. coli
IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 i...
TMPY-03488 IL-11 Protein, Human, Recombinant Human E. coli
IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 i...
TMPH-01016 GDF-10 Protein, Human, Recombinant (His) Human E. coli
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
TMPH-02250 TPP2 Protein, Human, Recombinant (His & Myc) Human Baculovirus
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPH-03757 TPP2 Protein, Human, Recombinant (E. coli, His & Myc) Human E. coli
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPH-01082 CMKLR1 Protein, Human, Recombinant (His) Human in vitro E. coli expression system
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways in...
TMPH-02953 TPP2 Protein, Mouse, Recombinant (His & Myc) Mouse Baculovirus
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPH-03762 TPP2 Protein, Mouse, Recombinant (E. coli, His & Myc) Mouse E. coli
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPY-02135 S100A16 Protein, Human, Recombinant Human E. coli
S100A16 is a member of S100 protein superfamily that carries calcium-binding EF-hand motifs. S100 proteins are cell- and tissue-specific and are involved in many intra- and extracellular processes through interacting wit...
TMPY-00899 GRO gama/CXCL3 Protein, Human, Recombinant (His) Human E. coli
CXCL3 is involved in migration, invasion, proliferation and tubule formation of trophoblasts and may play a key role in the pathogenesis of preeclampsia. CXCL3 autocrine/paracrine pathways are involved in the development...
TMPY-03227 CISD1 Protein, Human, Recombinant (His) Human E. coli
Mitochondrial dysfunction is thought to play a significant role in neurodegeneration observed in Parkinson's disease (PD), the loss of mitoNEET (CISD1), an iron-sulfur containing protein that regulates mitochondrial bioe...
TMPY-04703 GRO gama/CXCL3 Protein, Mouse, Recombinant (His) Mouse Yeast
CXCL3 is involved in migration, invasion, proliferation and tubule formation of trophoblasts and may play a key role in the pathogenesis of preeclampsia. CXCL3 autocrine/paracrine pathways are involved in the development...
TMPY-01427 AACS Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Acetoacetyl-CoA Synthetase (AACS) is a novel cytosolic ketone body (acetoacetate)-specific ligase. The AACS in adipose tissue plays an important role in utilizing ketone body for the fatty acid-synthesis during adipose t...
TMPY-04403 NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Nemo-like kinase contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. It also contains a TQE activation loop motif in which autopho...
TMPH-01791 RORA Protein, Human, Recombinant (His) Human E. coli
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular d...
TMPH-02640 ZC3H12A Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angi...
TMPH-02690 PLA2G10 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatid...
TMPH-01792 RORC Protein, Human, Recombinant (His & SUMO) Human E. coli
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunit...
IL-11 Protein, Human, Recombinant(P. pastoris)
TMPJ-00080
Species: Human
Expression System: P. pastoris
IL-11 Protein, Cynomolgus, Recombinant (His)
TMPK-00089
Species: Cynomolgus
Expression System: HEK293
IL-11 Protein, Human, Recombinant (His)
TMPK-00088
Species: Human
Expression System: HEK293
IL-11 Protein, Cynomolgus, Recombinant
TMPY-05842
Species: Cynomolgus
Expression System: E. coli
IL-11 Protein, Mouse, Recombinant
TMPY-04178
Species: Mouse
Expression System: E. coli
IL-11 Protein, Human, Recombinant
TMPY-03488
Species: Human
Expression System: E. coli
GDF-10 Protein, Human, Recombinant (His)
TMPH-01016
Species: Human
Expression System: E. coli
TPP2 Protein, Human, Recombinant (His & Myc)
TMPH-02250
Species: Human
Expression System: Baculovirus
TPP2 Protein, Human, Recombinant (E. coli, His & Myc)
TMPH-03757
Species: Human
Expression System: E. coli
CMKLR1 Protein, Human, Recombinant (His)
TMPH-01082
Species: Human
Expression System: in vitro E. coli expression system
TPP2 Protein, Mouse, Recombinant (His & Myc)
TMPH-02953
Species: Mouse
Expression System: Baculovirus
TPP2 Protein, Mouse, Recombinant (E. coli, His & Myc)
TMPH-03762
Species: Mouse
Expression System: E. coli
S100A16 Protein, Human, Recombinant
TMPY-02135
Species: Human
Expression System: E. coli
GRO gama/CXCL3 Protein, Human, Recombinant (His)
TMPY-00899
Species: Human
Expression System: E. coli
CISD1 Protein, Human, Recombinant (His)
TMPY-03227
Species: Human
Expression System: E. coli
GRO gama/CXCL3 Protein, Mouse, Recombinant (His)
TMPY-04703
Species: Mouse
Expression System: Yeast
AACS Protein, Human, Recombinant (His)
TMPY-01427
Species: Human
Expression System: Baculovirus-Insect Cells
NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST)
TMPY-04403
Species: Human
Expression System: Baculovirus-Insect Cells
RORA Protein, Human, Recombinant (His)
TMPH-01791
Species: Human
Expression System: E. coli
ZC3H12A Protein, Mouse, Recombinant (His & Myc)
TMPH-02640
Species: Mouse
Expression System: E. coli
PLA2G10 Protein, Mouse, Recombinant (His & Myc)
TMPH-02690
Species: Mouse
Expression System: E. coli
RORC Protein, Human, Recombinant (His & SUMO)
TMPH-01792
Species: Human
Expression System: E. coli