|
T39567 |
HDAC1/2-IN-3
|
HDAC1/2-IN-3 |
|
|
HDAC1/2-IN-3 is an inhibitor of both HDAC1 and HDAC2, demonstrating IC50 values of 0-5 nM and 5-10 nM, respectively. |
|
T11625 |
IDO1 and HDAC1 Inhibitor
|
|
Others
|
|
IDO1 and HDAC1 Inhibitor is a dual IDO1 and HDAC1 inhibitor (IC50s: 69.0 nM and 66.5 nM). |
|
T62786 |
HDAC1-IN-3
|
|
|
|
HDAC1-IN-3 is a potent inhibitor of Pf HDAC1. HDAC1-IN-3 is antimalarial in both wild-type and multidrug-resistant strains of the parasite. HDAC1-IN-3 exhibits a significant in vivo killing effect on all life cycles of t... |
|
T63482 |
HDAC1-IN-4
|
|
|
|
HDAC1-IN-4 is a potent inhibitor of Plasmodium falciparum HDAC1 (PfHDAC1) with low cytotoxicity and antimalarial effects (IC50<5 nM). |
|
T61433 |
HDAC1-IN-5
|
|
|
|
HDAC1-IN-5, a potent inhibitor of HDAC1 with an IC50 value of 15 nM, also exhibits inhibitory activity towards HDAC6 with an IC50 value of 20 nM. In cancer cells, HDAC1-IN-5 enhances the acetylation of both histone H3 an... |
|
T82227 |
HDAC1/CDK7-IN-1
|
|
HDAC
|
|
HDAC1/CDK7-IN-1 (compound 8e) serves as a dual inhibitor targeting both CDK7 and HDAC1, with IC50 values of 893 nM and 248 nM , respectively. This compound effectively suppresses the proliferation of various cancer cell... |
|
T64187 |
HDAC1/6-IN-1
|
|
|
|
HDAC1/6-IN-1 is a potent multi-target inhibitor of GLP (IC50: 1.3 nM), HDAC6 (IC50: 13 nM) and HDAC1 (IC50: 89 nM). HDAC1/6-IN-1 inhibits the methylation and deacetylation of H3K9 at the protein level. HDAC1/6-IN-1 can b... |
|
T80873 |
VEGFR2/HDAC1-IN-1
|
|
VEGFR
|
|
VEGFR2/HDAC1-IN-1 (compound 13) is a potent dual inhibitor of VEGFR-2 and HDAC, with IC50 values of 57.83 nM for VEGFR-2 and 9.82 nM for HDAC. It arrests the cell cycle at the S and G2 phases and induces apoptosis in H... |
|
T60947 |
HDAC1/MAO-B-IN-1
|
|
|
|
HDAC1/MAO-B-IN-1 has the potential to be used in the Alzheimer’s disease research. HDAC1/MAO-B-IN-1 is a potent and selective inhibitor of HDAC1/MAO-B that can cross the blood-brain barrier. The IC50 values of HDAC1/MAO-... |
|
T7664 |
Pyroxamide
|
|
Apoptosis
,
HDAC
|
|
Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM). |
|
T63209 |
HDAC1/2 and CDK2-IN-1
|
|
|
|
HDAC1/2 and CDK2-IN-1 (compound 14d) are potent inhibitors of HDAC1, HDAC2 and CDK2 with IC50 values of 70.7, 23.1 and 0.80 μM, respectively. HDAC1/2 and CDK2-IN-1 are able to block the cell cycle and induce apoptosis. T... |
|
T5347 |
CXD101
|
CXD-101 |
HDAC
|
|
CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101(CXD-101) has no activity against HDAC class II |
|
T60794 |
HDAC10-IN-1
|
|
|
|
HDAC10-IN-1 (compound 13b) is a potent and highly selective inhibitor of HDAC10 (IC 50 = 58 nM) that regulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells [1]. |
|
T78145 |
HDAC10-IN-2 hydrochloride
|
|
Autophagy
|
|
HDAC10-IN-2 hydrochloride (compound 10c) is an HDAC10 inhibitor with high potency and selectivity, exhibiting an IC50 of 20 nM. It influences autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells [1]. |
|
T60760 |
HDAC10-IN-2
|
|
|
|
HDAC10-IN-2 (compound 10c) regulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells. HDAC10-IN-2 is a potent and highly selective inhibitor of HDAC10 (IC50 = 20 nM) [1]. |
|
T10603 |
BRD-6929
|
|
HIV Protease
,
HDAC
|
|
BRD-6929 is a selective, brain-penetrant HDAC1 and HDAC2 inhibitor (IC50: 1 and 8 nM). BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 (Kis: 0.2 and 1.5 nM) [2]. BRD-6929 potentiates the efficacy of gnidimacrin... |
|
T10245 |
ACY-957
|
HDAC Inhibitor C001 |
HDAC
|
|
ACY-957 (HDAC Inhibitor C001) is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/7/8/9. |
|
T3516 |
EDO-S101
|
Tinostamustine,Minomustine |
HDAC
|
|
EDO-S101 (Tinostamustine) is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively. |
|
T6639 |
RG2833
|
RGFP109 |
HDAC
|
|
RG2833 (RGFP109) (RGFP109), a brain-penetrant HDAC inhibitor, is with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. |
|
T10864 |
Corin
|
|
Histone Demethylase
,
HDAC
|
|
Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM). |
|
T4389 |
SR-4370
|
SR 4370 |
HDAC
|
|
SR-4370 is an HDAC inhibitor. SR- 4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. |
|
T6233 |
Entinostat
|
SNDX-275,MS-275 |
Apoptosis
,
HDAC
,
Autophagy
|
|
Entinostat (MS-275) (MS-275) is an inhibitor of HDACs that inhibits HDAC1 and HDAC3 (IC50s: 0.18/0.74 μM). |
|
T26897 |
BRD2492
|
|
HDAC
|
|
BRD2492 is a selective and potent dual inhibitor of HDAC1 and HDAC2 with potential anticancer, antitumour and antiproliferative activities, inhibiting HDAC1/2, HDAC3 and HDAC6.BRD2492 inhibits the growth of breast cancer... |
|
T0431 |
Abexinostat
|
CRA 24781,PCI24781,PCI-24781,PCI 24781,CRA 024781 |
HDAC
|
|
PCI-24781 (Abexinostat (PCI24781)) is a new pan-HDAC inhibitor mainly targeting HDAC1 (Ki: 7 nM), also have moderate inhibitory for HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2. |
|
T2025 |
HDAC-IN-7
|
HBI-8000,CS055,Chidamide impurity |
HDAC
|
|
HDAC-IN-7 (HBI-8000) (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable inhibitor of HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10). |
|
T6055 |
Quisinostat
|
JNJ-26481585 |
Apoptosis
,
HDAC
,
Autophagy
|
|
Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against... |
|
T20080 |
Exifone
|
NSC 680919,NSC680919,NSC-680919 |
HDAC
|
|
Exifone (NSC-680919) is a mixed, nonessential activator of HDAC1 that is capable of binding to both free and substrate-bound enzyme, resulting in an increased relative maximal rate of HDAC1-catalyzed deacetylation. |
|
T6362 |
Domatinostat
|
4SC202,4SC 202,4SC-202 (free base),4SC-202 |
Apoptosis
,
HDAC
|
|
Domatinostat (4SC202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (L... |
|
T6865 |
Quisinostat dihydrochloride
|
Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl |
Apoptosis
,
HDAC
,
Autophagy
|
|
Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; g... |
|
T4370 |
Resminostat hydrochloride
|
4SC-201 hydrochloride,RAS2410 hydrochloride |
HDAC
|
|
Resminostat hydrochloride (RAS2410 hydrochloride) is an effective inhibitor of HDAC1/HDAC3/HDAC6 (IC50: 42.5/50.1/71.8 nM), respectively, and shows less potent activities against HDAC8 (IC50: 877 nM). |
|
T6006 |
Romidepsin
|
FR 901228,FK 228,Depsipeptide,NSC 630176 |
Apoptosis
,
HDAC
|
|
Romidepsin (FR 901228) is an HDAC inhibitor that inhibits HDAC1/2/4/6 (IC50=36/47/510/1400 nM). Romidepsin has antitumor activity and can be used for the treatment of peripheral T-cell lymphoma and cutaneous T-cell lymph... |
|
T4477 |
Domatinostat tosylate
|
4SC-202 tosylate,4SC-202 |
Apoptosis
,
HDAC
|
|
Domatinostat tosylate (4SC-202) is a selective inhibitor of class I HDAC for HDAC1/2/3 (IC50: 1.20/1.12/0.57 μM). It also displays inhibitory activity against Lysine-specific demethylase 1 (LSD1). |
|
T2512 |
Mocetinostat
|
MGCD0103,MG0103 |
Apoptosis
,
HDAC
,
Autophagy
|
|
Mocetinostat (MG0103) is an orally available HDAC inhibitor with most potency for HDAC1 (IC50: 0.15 μM), 2- to 10- fold selectivity against HDAC2/3/11. |
|
T67878 |
HDAC-IN-52
|
|
HDAC
|
|
HDAC-IN-52 is a pyridine-containing HDAC inhibitor that inhibits HDAC1, HDAC2, HDAC3 and HDAC10 with IC50s of 0.189, 0.227, 0.440 and 0.446 μM, respectively. HDAC-IN-52 can be used in cancer research. |
|
T73515 |
MC2590
|
|
Apoptosis
,
HDAC
|
|
MC2590 is a potent and selective histone deacetylase (HDAC) inhibitor that inhibits HDAC1-3, -6, -8, and -10 activities, induces cell cycle arrest, and promotes apoptosis. |
|
T6279L |
Givinostat hydrochloride
|
ITF2357 hydrochloride,Givinostat HCl,ITF2357,ITF 2357,ITF-2357,ITF2357 HCl |
HDAC
|
|
Givinostat hydrochloride (ITF2357 hydrochloride) is an inhibitor of HDAC with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride exhibits anti-inflammatory, anti-angiogenic, and antineopla... |
|
T4481 |
Tucidinostat
|
HBI-8000,Chidamide,CS 055 |
HDAC
|
|
Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and sho... |
|
T5332 |
TH34
|
|
HDAC
|
|
TH34 is an HDAC6/8/10 inhibitor (IC50s: 4.6/1.9/7.7 μM). It shows high selectivity over HDAC1/2/3. |
|
T10883 |
CRA-026440
|
PCI-34051 |
HDAC
|
|
|
|
T13996 |
1-Naphthohydroxamic acid
|
|
HDAC
|
|
1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid d... |
|
T6327 |
Tubacin
|
|
Virus Protease
,
HDAC
|
|
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1. |
|
T10841 |
CM-675
|
|
HDAC
,
PDE
|
|
CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to treat Alzheimer’s disease. |
|
T30579 |
BRD4097
|
|
HDAC
|
|
BRD4097, a negative control in the HDAC1/2/3/8 assay, is a selective histone deacetylase (HDAC3) inhibitor that can be used to protect b-cells and improve insulin resistance, help promote cognitive function and enhance l... |
|
T77334 |
HDAC-IN-57
|
|
Apoptosis
,
HDAC
|
|
HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4 nM, and 107 nM, respectively. HDAC-IN-57 inhibits LSD1 with ... |
|
T77664 |
KH16
|
|
Apoptosis
,
HDAC
|
|
KH16 is a potent HDAC inhibitor that specifically targets class I HDACs (HDAC1, HDAC2 and HDAC3) with IC50 values between 6 and 34 nM. KH16 is able to stimulate apoptosis and can inhibit gene expression patterns in a wid... |
|
T2489 |
Ricolinostat
|
ACY-1215,Rocilinostat |
Apoptosis
,
HDAC
|
|
Ricolinostat (Rocilinostat) is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. |
|
T10883L |
CRA-026440 hydrochloride
|
CRA-026440 hydrochloride（847460-34-8 Free base） |
HDAC
|
|
CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor. CRA-026440 hydrochloride exhibits Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM... |
|
T1583 |
Vorinostat
|
MK0683,suberoylanilide hydroxamic acid,SAHA |
Apoptosis
,
Mitophagy
,
Virus Protease
,
HDAC
,
Autophagy
|
|
Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and i... |
|
T6481 |
Droxinostat
|
NS 41080 |
Apoptosis
,
HDAC
|
|
Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10. |
|
T27083 |
Crebinostat
|
|
Epigenetic Reader Domain
,
Histone Acetyltransferase
,
HDAC
|
|
Crebinostat is a potent histone deacetylase (HDAC) inhibitor, inhibiting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively.Crebinostat increases the density of synapsin-1 punct... |
