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Search Results for " PDGFRβ "

ターゲット

87

阻害剤

2

天然化合物

1

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T2676 PF-04217903 c-Met/HGFR
MET Tyrosine Kinase Inhibitor PF-04217903 is an orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic activity.
T8496 MAZ51 Apoptosis , VEGFR
MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.
T6920 ON123300 FGFR , c-RET , JAK , CDK , PDGFR , Src , AMPK
ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).
T41003 KG5 Raf , FLT , PDGFR , c-Kit
KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 nM and 300 nM for PDGFRβ and PDGFRα. KG5 inhibits FLT3, KIT, and c-Raf with anticancer and antiangiogenic activities.
T13238 Tyrphostin AG1433 SU1433,AG1433 VEGFR , PDGFR
T7861 Flumatinib mesylate HHGV678 mesylate Bcr-Abl , PDGFR , c-Kit
Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.
T6479 Dovitinib lactate hydrate Dovitinib (TKI258) Lactate,Dovitinib Lactate,TKI258 VEGFR , FGFR , FLT , PDGFR , c-Kit
Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) R...
T16947 SU16f 3-substituted indolin-2-one 16f,SU-16F,SU 16F PDGFR
SU16f (3-substituted indolin-2-one 16f) is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively). Neutralization of PDGFRβ receptor by SU16f blocks the promoting...
T0374 Sunitinib Malate Sutent,SU 11248 (Malate),SU 11248,Sunitinib Apoptosis , Mitophagy , VEGFR , FLT , IRE1 , PDGFR , c-Kit , Autophagy
Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-kit.
TQ0235 AC710 FLT , PDGFR , c-Kit
T8976 PD-089828 EGFR , FGFR , PDGFR , Src
PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 ...
T13178 Toceranib PHA 291639E,SU11654 VEGFR , PDGFR , c-Kit
T10157 Regorafénib N-oxyde (M2) Raf , VEGFR , c-RET , PDGFR , c-Kit , Drug Metabolite
Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/4.2/46, 1.5, 22, 7, and 2.5 nM).
T7945 SU14813 VEGFR , PDGFR , c-Kit
SU14813 is a multi-receptor tyrosine kinase inhibitor with potent antiangiogenesis and antitumor activity (IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT).
T0374L Sunitinib SU 11248 Apoptosis , Mitophagy , VEGFR , FLT , IRE1 , PDGFR , c-Kit , Autophagy
Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that inhibits VEGFR2 and PDGFRβ (IC50=80/2 nM). Sunitinib has antitumor activity and can be used for the treatment of kidney cancer and ga...
T1452 Axitinib AG-013736 VEGFR , PDGFR , c-Kit
Axitinib (AG-013736) is an orally bioavailable tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.7, 1.6 nM for VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFRβ, respectively.
T11638 Ilorasertib hydrochloride ABT-348 hydrochloride Aurora Kinase
Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase,...
TQ0059 Ilorasertib ABT-348 VEGFR , FLT , c-RET , PDGFR , Aurora Kinase
Ilorasertib (ABT-348) (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: ...
T8900 Seralutinib GB002 PDGFR
Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.
T6435 CCT129202 Aurora Kinase
CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively. It is less potent to FGFR3, GSK3β, PDGFRβ, etc.
T12145L N-Desethylsunitinib hydrochloride VEGFR , PDGFR , c-Kit
N-Desethylsunitinib hydrochloride is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ, and KIT inhibitor.
T4315 Ki20227 c-Fms , VEGFR , CSF-1R , PDGFR , c-Kit
Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451/217 nM), respectively.
T2500 Cediranib AZD2171,NSC-732208 VEGFR , FLT , PDGFR , c-Kit , Autophagy
Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/≤3 nM), similar activity against PDGFRβ and c-Kit...
T10870L CP-547632 VEGFR , FGFR , PDGFR , BTK
T1777 Nintedanib BIBF 1120,Intedanib VEGFR , FGFR , FLT , PDGFR , Src
Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108 nM), PDGFRα, and PDGFRβ (IC50=59/65 nM). Nintedanib has an...
T2341 KW-2449 KW2449 Apoptosis , FGFR , FLT , JAK , Bcr-Abl , Src , c-Kit , Aurora Kinase
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.
T1792 Regorafenib BAY 73-4506,Fluoro-Sorafenib Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active. Regorafenib has antitumor and anti-angiogenic activity.
T0093L Sorafenib Bay 43-9006 Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy
Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. Sorafenib has antitumor activity...
T6996 SU 5402 SU5402 VEGFR , FGFR , PDGFR
SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.
T2496 (Z)-Semaxinib SU5416 VEGFR
(Z)-Semaxinib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR over PDGFRβ, no inhibition for FGFR, InsR, and EGFR. (Z)-Semaxinib is a quinolone derivative w...
T2668 JNK-IN-8 JNK Inhibitor XVI JNK , c-Kit
JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM). The selectivity is higher 10-fold than MNK2, Fms and no inhibition of Met, c-Kit, PDGFRβ in A375 cell line.
T2514 Linifanib ABT-869,RG3635,AL-39324 Apoptosis , c-Fms , VEGFR , FLT , CSF-1R , PDGFR , c-Kit , Autophagy
Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: 66 nM). Linifanib may exhibit potent antiprolife...
T4320 Flumatinib HHGV678 Bcr-Abl , PDGFR , c-Kit
Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.
T6184 Orantinib SU6668,TSU-68,NSC 702827 Apoptosis , VEGFR , FGFR , PDGFR
Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation. It shows little effect against IGF-1R, Met, Src, Lck, Zap70, A...
T6091 CP-673451 VEGFR , PDGFR , c-Kit
CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than other angiogenic receptors.
T2064 Semaxinib SU5416 VEGFR
Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR than PDGFRβ, lack of activity against InsR, EGFR, and FGFR. Semaxanib reversibly inhibits ATP binding to the...
T7394 Toceranib Phosphate SU11654 phosphate,PHA 291639 phosphate VEGFR , Tyrosinase , PDGFR , c-Kit
Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including Flk-1/KDR, PDGFR
T5001 Nintedanib esylate Intedanib,BIBF 1120 (esylate),Nintedanib Ethanesulfonate Salt,BIBF 1120 VEGFR , FGFR , PDGFR
Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β
T8402 Regorafenib Hydrochloride BAY73-4506 hydrochloride Raf , VEGFR , c-RET , PDGFR , Autophagy
Regorafenib Hydrochloride (BAY73-4506 hydrochloride) is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
T0093 Sorafenib tosylate Bay 43-9006 Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy
Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
T3476 JI-101 CGI-1842,JI 101 VEGFR , PDGFR , Ephrin Receptor
JI-101 (CGI-1842) is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor receptor β (PDGFR-β), and ephrin type-B receptor 4 (EphB4).
T6930 Pazopanib Hydrochloride GW786034,Pazopanib HCl,GW786034 HCl,Votrient HCl,Armala c-Fms , VEGFR , FGFR , PDGFR , c-Kit , Autophagy
Pazopanib Hydrochloride (Votrient HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, resp...
T1792L Regorafenib monohydrate Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respect...
T0097L Pazopanib GW786034 VEGFR , FGFR , PDGFR , c-Kit , Autophagy
Pazopanib (GW786034), a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits VEGFR-1, -2 and -3, c-kit and PDGF-R, which may result i...
T2576 Brivanib (alaninate) BMS-582664,Brivanib Alaninate VEGFR , FGFR , Autophagy
Brivanib Alaninate (BMS-582664) is the alaninate salt of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activity. Brivanib strongly binds to and inhibits VEGFR2, a tyrosi...
T12396 PDGFRα kinase inhibitor 1 PDGFR
PDGFRα kinase inhibitor 1 is a highly selective inhibitor of type II PDGFRα kinase (PDGFRα and PDGFRβ with IC50s of 132 nM and 6115 nM , respectively).
TQ0080 SU14813 maleate VEGFR , PDGFR , c-Kit
SU14813 maleate is an inhibitor of multi-targeted receptor tyrosine kinases (IC50s: 2, 50, 4, 15 nM for VEGFR1, VEGFR2, PDGFRβ, and KIT).
T22740 DMPQ dihydrochloride Others
PDGFRβ inhibitor
T13039 Sunitinib-d10 Sunitinib D10,SU 11248 D10 VEGFR , PDGFR
Sunitinib D10 is a deuterium labeled Sunitinib. Sunitinib is a inhibitor of multi-targeted receptor tyrosine kinase(IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively).
T10228 AC710 Mesylate PDGFR

Compounds

PF-04217903
T2676
Synonym:
Target: c-Met/HGFR
MAZ51
T8496
Synonym:
Target: Apoptosis, VEGFR
ON123300
T6920
Synonym:
Target: FGFR, c-RET, JAK, CDK, PDGFR, Src, AMPK
KG5
T41003
Synonym:
Target: Raf, FLT, PDGFR, c-Kit
Tyrphostin AG1433
T13238
Synonym: SU1433,AG1433
Target: VEGFR, PDGFR
Flumatinib mesylate
T7861
Synonym: HHGV678 mesylate
Target: Bcr-Abl, PDGFR, c-Kit
Dovitinib lactate hydrate
T6479
Synonym: Dovitinib (TKI258) Lactate,Dovitinib Lactate,TKI258
Target: VEGFR, FGFR, FLT, PDGFR, c-Kit
SU16f
T16947
Synonym: 3-substituted indolin-2-one 16f,SU-16F,SU 16F
Target: PDGFR
Sunitinib Malate
T0374
Synonym: Sutent,SU 11248 (Malate),SU 11248,Sunitinib
Target: Apoptosis, Mitophagy, VEGFR, FLT, IRE1, PDGFR, c-Kit, Autophagy
AC710
TQ0235
Synonym:
Target: FLT, PDGFR, c-Kit
PD-089828
T8976
Synonym:
Target: EGFR, FGFR, PDGFR, Src
Toceranib
T13178
Synonym: PHA 291639E,SU11654
Target: VEGFR, PDGFR, c-Kit
Regorafénib N-oxyde (M2)
T10157
Synonym:
Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Drug Metabolite
SU14813
T7945
Synonym:
Target: VEGFR, PDGFR, c-Kit
Sunitinib
T0374L
Synonym: SU 11248
Target: Apoptosis, Mitophagy, VEGFR, FLT, IRE1, PDGFR, c-Kit, Autophagy
Axitinib
T1452
Synonym: AG-013736
Target: VEGFR, PDGFR, c-Kit
Ilorasertib hydrochloride
T11638
Synonym: ABT-348 hydrochloride
Target: Aurora Kinase
Ilorasertib
TQ0059
Synonym: ABT-348
Target: VEGFR, FLT, c-RET, PDGFR, Aurora Kinase
Seralutinib
T8900
Synonym: GB002
Target: PDGFR
CCT129202
T6435
Synonym:
Target: Aurora Kinase
N-Desethylsunitinib hydrochloride
T12145L
Synonym:
Target: VEGFR, PDGFR, c-Kit
Ki20227
T4315
Synonym:
Target: c-Fms, VEGFR, CSF-1R, PDGFR, c-Kit
Cediranib
T2500
Synonym: AZD2171,NSC-732208
Target: VEGFR, FLT, PDGFR, c-Kit, Autophagy
CP-547632
T10870L
Synonym:
Target: VEGFR, FGFR, PDGFR, BTK
Nintedanib
T1777
Synonym: BIBF 1120,Intedanib
Target: VEGFR, FGFR, FLT, PDGFR, Src
KW-2449
T2341
Synonym: KW2449
Target: Apoptosis, FGFR, FLT, JAK, Bcr-Abl, Src, c-Kit, Aurora Kinase
Regorafenib
T1792
Synonym: BAY 73-4506,Fluoro-Sorafenib
Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy
Sorafenib
T0093L
Synonym: Bay 43-9006
Target: Apoptosis, Raf, VEGFR, FLT, Ferroptosis, PDGFR, c-Kit, Autophagy
SU 5402
T6996
Synonym: SU5402
Target: VEGFR, FGFR, PDGFR
(Z)-Semaxinib
T2496
Synonym: SU5416
Target: VEGFR
JNK-IN-8
T2668
Synonym: JNK Inhibitor XVI
Target: JNK, c-Kit
Linifanib
T2514
Synonym: ABT-869,RG3635,AL-39324
Target: Apoptosis, c-Fms, VEGFR, FLT, CSF-1R, PDGFR, c-Kit, Autophagy
Flumatinib
T4320
Synonym: HHGV678
Target: Bcr-Abl, PDGFR, c-Kit
Orantinib
T6184
Synonym: SU6668,TSU-68,NSC 702827
Target: Apoptosis, VEGFR, FGFR, PDGFR
CP-673451
T6091
Synonym:
Target: VEGFR, PDGFR, c-Kit
Semaxinib
T2064
Synonym: SU5416
Target: VEGFR
Toceranib Phosphate
T7394
Synonym: SU11654 phosphate,PHA 291639 phosphate
Target: VEGFR, Tyrosinase, PDGFR, c-Kit
Nintedanib esylate
T5001
Synonym: Intedanib,BIBF 1120 (esylate),Nintedanib Ethanesulfonate Salt,BIBF 1120
Target: VEGFR, FGFR, PDGFR
Regorafenib Hydrochloride
T8402
Synonym: BAY73-4506 hydrochloride
Target: Raf, VEGFR, c-RET, PDGFR, Autophagy
Sorafenib tosylate
T0093
Synonym: Bay 43-9006
Target: Apoptosis, Raf, VEGFR, FLT, Ferroptosis, PDGFR, c-Kit, Autophagy
JI-101
T3476
Synonym: CGI-1842,JI 101
Target: VEGFR, PDGFR, Ephrin Receptor
Pazopanib Hydrochloride
T6930
Synonym: GW786034,Pazopanib HCl,GW786034 HCl,Votrient HCl,Armala
Target: c-Fms, VEGFR, FGFR, PDGFR, c-Kit, Autophagy
Regorafenib monohydrate
T1792L
Synonym:
Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy
Pazopanib
T0097L
Synonym: GW786034
Target: VEGFR, FGFR, PDGFR, c-Kit, Autophagy
Brivanib (alaninate)
T2576
Synonym: BMS-582664,Brivanib Alaninate
Target: VEGFR, FGFR, Autophagy
PDGFRα kinase inhibitor 1
T12396
Synonym:
Target: PDGFR
SU14813 maleate
TQ0080
Synonym:
Target: VEGFR, PDGFR, c-Kit
DMPQ dihydrochloride
T22740
Synonym:
Target: Others
Sunitinib-d10
T13039
Synonym: Sunitinib D10,SU 11248 D10
Target: VEGFR, PDGFR
AC710 Mesylate
T10228
Synonym:
Target: PDGFR
1 2
カタログ番号 製品名 別名 ターゲット
T15542 Hypothemycin Others
T14055 5Z-7-Oxozeaenol FR148083,L783279,LL-Z 1640-2 VEGFR , FLT , MEK , MAPK , PDGFR , Antibiotic , Src
5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is ...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPK-00223 Ephrin B2/EFNB2 Protein, Human, Recombinant (hFc) Human HEK293
Ephrin-B2 controls platelet-derived growth factor receptor β (PDGFRβ) distribution in the VSMC plasma membrane, endocytosis, and signaling in a fashion that is highly distinct from its role in the endothelium. Ephrin-B2 ...