|
T12979 |
BI-3406
|
|
p38 MAPK
,
MAPK
,
Ras
|
|
BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity. |
|
T5314 |
Pyridoxal isonicotinoyl hydrazone
|
PIH |
Others
|
|
pyridoxal isonicotinoyl hydrazone (PIH) is a cell-permeable and relatively non-toxic iron (Fe3+) chelator that shows high iron chelation efficacy both in vitro and in vivo. |
|
T15102 |
Dexamethasone palmitate
|
DXP |
Glucocorticoid Receptor
|
|
Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone, shows a 47-fold lower affinity for the glucocorticoid receptor than Dexamethasone. Dexamethasone palmitate is a glucocorticoid receptor agonist and an... |
|
T26955 |
Cavosonstat
|
N91115,N 91115,N-91115 |
GSNOR
,
CFTR
|
|
Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor that promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturation and plasma membrane stabilization.Cavosonstat ... |
|
T68087 |
Inaperisone
|
|
Others
|
|
Inaperisone is a novel centrally acting muscle relaxant that inhibits the voiding reflex. Inaperisone may inhibit the voiding reflex by acting indirectly on GABAB receptors in the brainstem. |
|
T10991 |
Dehydronitrosonisoldipine
|
|
Calcium Channel
|
|
|
|
T31731 |
Evodenoson
|
DE 112,DE-112,ATL 313,DE112,ATL313,ATL-313 |
Adenosine Receptor
|
|
Evodenoson (ATL313) is a potent and selective adenosine A2a receptor (A2aR) agonist for the treatment of eye diseases, tumors, and immune system disorders, and may be used in studies of open-angle glaucoma and blood tumo... |
|
T4275 |
Fluanisone
|
Sedalande,Haloanison |
Others
|
|
Fluanisone (Haloanison) is a butyrophenone derivative with sedative properties. It is a typical antipsychotic and is used in the treatment of schizophrenia. |
|
T50086 |
Clomesone
|
|
Others
|
|
Clomesone is a synthetic non-steroidal drug that can be used as a molecular structural unit. It is a drug commonly used to treat female infertility and works by blocking the action of estrogen in the brain. It has been s... |
|
T1127 |
Beclometasone dipropionate
|
Beclovent,Beclomethasone dipropionate,Beconase,Vancenase |
Glucocorticoid Receptor
|
|
Beclometasone dipropionate (Vancenase) is the dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, beclomethasone... |
|
T23380 |
Sonepiprazole
|
|
Dopamine Receptor
|
|
Sonepiprazole (PNU-101387G) is a chemical compound known for its selective antagonistic properties toward D4 dopamine receptors, exhibiting dissociation constants (Kis) of 3.6 nM and 10.1 nM for rat D4 (rD4) and human D4... |
|
T8396 |
Prednisone acetate
|
Prednisone 21-acetate |
Glucocorticoid Receptor
|
|
Prednisone acetate (Prednisone 21-acetate) is a glucocorticoid receptor agonist with immunomodulating properties and anti-inflammatory. |
|
T4572 |
Desoximetasone
|
Desoximetasonum,Topicort,Desoxymethasone,Desoximetasona |
Others
|
|
Desoximetasone (Desoximetasona)(Topicort), a topical corticosteroid, is employed for the alleviation of diverse skin conditions, including rashes. |
|
T1926 |
Sonidegib
|
Erismodegib,NVP-LDE225,LDE225 |
Hedgehog/Smoothened
,
Smo
|
|
Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. |
|
T38013 |
Sonlicromanol hydrochloride
|
KH176 hydrochloride |
ROS
|
|
Sonlicromanol hydrochloride (KH176 hydrochloride) is a ROS-redox modulator that crosses the blood-brain barrier and has potential anticancer activity, ameliorates neuronal network dysfunction and transcriptomic changes i... |
|
T0947L |
Dexamethasone Phosphate disodium
|
EGP-437,EGP437. Dex-Phos,EGP 437 |
Glucocorticoid Receptor
|
|
Dexamethasone Phosphate disodium (EGP437. Dex-Phos) is a water-soluble form of the synthetic glucocorticoid dexamethasone. |
|
T21899 |
Misonidazole
|
SR-1354,SR1354,Ro 7-0582 |
GPX
|
|
Misonidazole as a novel GPX inhibitors to cause oxidative stress in chemotherapy-resistant tumors. |
|
T34914 |
Trabodenoson
|
INNO-8875,INO-8875,PJ875,PJ-875,INNO 8875,INNO8875,PJ 875 |
Adenosine Receptor
|
|
Trabodenoson (INO-8875) is a selective and potent adenosine A1 receptor agonist, an adenosine analog, for the study of primary open-angle glaucoma. |
|
T20763 |
Betamethasone disodium phosphate
|
Vista-Methasone,NSC90616,Betamethasone 21-phosphate disodium salt,NSC-90616 |
Others
|
|
Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) is a corticosteroid with anti-inflammatory activity that promotes the polarization of M1 to M2 macrophages by decreasing the secretion of pro-in... |
|
T14981 |
Clobetasone butyrate
|
|
Glucocorticoid Receptor
|
|
Clobetasone butyrate, a synthetic glucocorticoid with topical anti-inflammatory activity, is effective in treating corticosteroid-responsive dermatoses, such as atopic dermatitis and psoriasis, especially within skin tis... |
|
T0972 |
Isoniazid
|
INH,Isonicotinic acid hydrazide,Isonicotinic hydrazide |
Mitophagy
,
Dehydrogenase
,
CAT
,
Antibacterial
,
Autophagy
|
|
Isoniazid (Isonicotinic hydrazide) is an antibacterial agent used primarily as a tuberculostatic. |
|
T76828 |
Sonepcizumab
|
LT 1009 |
LPL Receptor
|
|
Sonepcizumab (LT 1009) is a fully humanized monoclonal antibody against S1P. Sonepcizumab has anti-cancer activity and can be used to study metastatic renal cell carcinoma (mRCC) to prevent eye scarring after glaucoma fi... |
|
T0552 |
Isonicotinamide
|
|
Others
|
|
Isonicotinamide is used as pharmaceutical intermediate to synthesis Cefalonium, etc. |
|
T14324 |
Artemisone
|
BAY 44-9585,Artemifone |
Others
,
Parasite
|
|
Artemisone (BAY 44-9585) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains (IC50: 0.83 nM). It also is a potent inhibitor of human CMV. |
|
T26641L |
Apadenoson TFA
|
BAY 68-4986 TFA,Apadenoson TFA(250386-15-3 Free base),Discontinued TFA |
Adenosine Receptor
|
|
Apadenoson TFA is a potent adenosine A2A receptor (A2AR) agonist that can be used to improve survival in patients infected with SARS. |
|
T0891 |
Dapsone
|
DDS,4,4‘-Sulfonyldianiline,Bis(4-aminophenyl) sulfone,Sulphadione,4,4'-Diaminodiphenylsulfone,4-Aminophenyl sulfone |
Reactive Oxygen Species
,
Antibacterial
,
Antibiotic
,
Parasite
|
|
Dapsone (Sulphadione) has activity against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. |
|
T0188 |
Fluticasone (propionate)
|
CCI-187881,Fluticasone propionate |
Glucocorticoid Receptor
,
Virus Protease
,
Estrogen/progestogen Receptor
,
Phospholipase
,
Endogenous Metabolite
|
|
Fluticasone propionate (CCI-187881), derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist. |
|
T6884 |
Namodenoson
|
2-Cl-IB-MECA,CF-102 |
Adenosine Receptor
|
|
Namodenoson (2-Cl-IB-MECA) is an adenosine A3 receptor agonist. |
|
T17023 |
Tecadenoson
|
CVT-510 |
Adenosine Receptor
|
|
Tecadenoson (CVT-510) is a selective agonist of A1 adenosine receptor. |
|
T9516 |
Binodenoson
|
WRC 0470,MRE-0470,2-(cyclohexylmethylidenehydrazino)adenos |
Adenosine Receptor
|
|
Binodenoson (WRC 0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stres... |
|
T7188 |
Piclidenoson
|
CF-101,IB-MECA |
Apoptosis
,
Adenosine Receptor
|
|
Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients. |
|
T0270 |
Hydrocortisone 17-butyrate
|
Cortisol 17-butyrate,Hydrocortisone butyrate |
Glucocorticoid Receptor
,
Annexin A
,
Adrenergic Receptor
|
|
Hydrocortisone 17-butyrate (Cortisol 17-butyrate) is a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects. |
|
T1666L |
Fludrocortisone
|
9α-fluorocortisol,9α-Fludrocortisone,Florinef,9α-fluorohydrocortisone,Fludrocortisone acetate,Astonin,9α-Fluorcortisol |
Others
|
|
Fludrocortisone (Florinef) is a synthetic corticosteroid with moderate glucocorticoid potency and much greater mineralocorticoid potency. Fludrocortisone can be used to studies on treating low blood pressure. |
|
T1666 |
Fludrocortisone acetate
|
9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,9α-fluorocortisol acetate |
Glucocorticoid Receptor
,
Autophagy
|
|
Fludrocortisone acetate (9α-Fludrocortisone acetate) , a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-respon... |
|
T35903 |
N-acetyl Dapsone
|
|
Antibacterial
,
Parasite
|
|
N-acetyl Dapsone is an anti-inflammatory and antimicrobial compound widely used in the treatment of leprosy, malaria, acne and various immune disorders. |
|
T0511 |
Tolperisone hydrochloride
|
Muscalm,Midocalm,Tolperisone HCl |
Sodium Channel
|
|
Tolperisone hydrochloride (Muscalm), a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by neurological diseases (damage of the encephalomyel... |
|
T5005 |
Eperisone hydrochloride
|
|
Others
|
|
Eperisone is a skeletal muscle relaxant and a spasmolytic agent related structurally to Tolperisone. |
|
T4602 |
Hydrocortisone hemisuccinate
|
Hydrocortisone 21-he,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate |
Glucocorticoid Receptor
,
Others
,
Interleukin
|
|
Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) is a corticosteroid used as an analytical and chromatography reagent. |
|
T15727 |
Sonidegib diphosphate
|
NVP-LDE 225 diphosphate,Erismodegib diphosphate,LDE225 diphosphate |
Smo
|
|
Sonidegib diphosphate (LDE225 diphosphate) is an effective and selective Smo antagonist (IC50: 1.3 nM and 2.5 nM for mouse and human Smo in a binding assay, respectively). |
|
T0276 |
Hydrocortisone Valerate
|
Westcort |
Glucocorticoid Receptor
|
|
Hydrocortisone Valerate (Westcort) has anti-inflammatory, antipruritic and vasoconstrictive properties. |
|
T0977 |
Medrysone
|
Gimeracil,6α-Methyl-11β-hydroxyprogesterone |
Glucocorticoid Receptor
,
Others
|
|
Medrysone (6α-Methyl-11β-hydroxyprogesterone) is a topical, synthetic glucocorticoid with metabolic, anti-inflammatory and anti-allergic properties. Medrysone exerts its effect by interacting with specific intracellular ... |
|
T34685 |
Sonedenoson
|
MRE 0094,MRE0094,MRE-0094 |
SARS-CoV
,
Adenosine Receptor
|
|
Sonedenoson (MRE0094) is an adenosine A(2A) receptor agonist and potential inhibitor potentially targeting SARS-CoV-2 coronavirus 2;-O-ribose methyltransferase, and may be used in the study of diabetic foot ulcers. |
|
T4279 |
Esonarimod
|
KE-298 |
IL Receptor
|
|
Esonarimod (KE-298) is an antirheumatic drug. |
|
T32114 |
Hydrocortisone aceponate
|
Suniderma,Efficort,Hydrocortisone 17-propionate 21-acetate |
Glucocorticoid Receptor
|
|
Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is an effective topical glucocorticoid used in the form of a cream to treat various skin diseases. |
|
T21361 |
Alclometasone dipropionate
|
Vaderm,Sch 22219,Aclovate,Delonal |
Others
|
|
Alclometasone dipropionate （Sch 22219） is a synthetic glucocorticoid, a steroidal compound with antiproliferative, anti-inflammatory, anti-allergic, antipruritic, and vasoconstrictive properties, which is used in the stu... |
|
T22348 |
Isonipecotic acid
|
4-Piperidinecarboxylic acid,Hexahydroisonicotinic acid,4-Carboxypiperidine |
GABA Receptor
|
|
Isonipecotic acid (4-Piperidinecarboxylic acid) is a heterocyclic compound. Isonipecotic acid mainly characterized as a GABAA receptor partial agonist. |
|
T19277 |
Dexamethasone 9,11-epoxide
|
|
Others
|
|
Dexamethasone 9,11-epoxide is a compound obtained by extraction and is an intermediate in the preparation of dexamethasone. |
|
T20802 |
Flumethasone pivalate
|
Locacorten,NSC-107680,Lorinden,NSC 107680,NSC107680,Locorten |
Others
|
|
Flumethasone pivalate (Locorten) has antipruritic, anti-inflammatory, and vasoconstrictive properties and can be used in studies about adrenocortical suppression, cutaneous atrophy, plasma transcortin binding, and telang... |
|
T1365 |
Thioisonicotinamide
|
Pyridine-4-carbothioamide,Isothionicotinamide,4-Pyridylthiocarboxamide |
Antibiotic
|
|
Thioisonicotinamide (Isothionicotinamide) is a chemical based on the nicotinamide structure, but in which the amide is in the 4-position and not the 3-position. |
|
T71356 |
Lanperisone HCl
|
|
|
|
Lanperisone, also known as NK433, is a muscle relaxant. NK433 inhibited the facilitation of the flexor reflex mediated by group II afferent fibers that was induced by intrathecal administration of noradrenaline-HCl. NK43... |
