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天然化合物

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T4306	CCG-203971	CCG203971	Rho , Ras
	CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This compound also inhibits PC-3 cell migration (IC50: 4.2 μM),...		Rho , Ras
T8310	MMP-9-IN-1		MMP
	MMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9).		MMP
T77059	Leronlimab	PRO 140	CCR
	Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. leronlimumab has both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronl...		CCR
T77743	TT-012		Others
	TT-012 has anti-tumor activity, selectively binds dynamic MITF and disrupts the dimer formation and DNA binding of the latter. TT-012 can inhibit the transcription of MITF in B16F10 melanoma cells. TT-012 inhibited the g...		Others
T11325	Frondoside A		Others
	possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety.Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa,		Others
T12650	R916562		TAM Receptor
			TAM Receptor
T10273	AhR modulator-1		Others
	AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. It inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. It also possesses anti-estrog...		Others
T79410	anti-TNBC agent-3
	Anti-TNBC agent-3 (compound 3g) is a compound that induces apoptosis and possesses anti-cancer cell proliferation properties. It effectively inhibits tumor growth and metastasis in xenograft models of triple-negative bre...
T62119	Lasofoxifene
	Lasofoxifene (CP-336156) is a selective, orally active estrogen receptor modulator (SERM) that inhibits the growth and metastasis of primary tumours and is also anti-osteoporotic.
T70344	BJ-2302
	BJ-2302 is a SRC inhibitor. BJ-2302 effectively suppressed MDA-MB-231 cell invasion (Matrigel invasion assay) and metastasis (chorioallantoic membrane assay xenografted with MDA-MB-231-luc2-tdTomato cancer cells). Additi...
T79699	anti-TNBC agent-2		Apoptosis
	Anti-TNBC agent-2 (3j), a purine derivative, acts as an anti-triple negative breast cancer (TNBC) therapeutic. It promotes apoptosis in MDA-MB-231 cells, while also inhibiting their migration and angiogenesis. Moreover, ...		Apoptosis
T74859	SLC7A11-IN-1
	SLC7A11-IN-1 is a potent inhibitor of the solute carrier family 7 member 11 (SLC7A11, xCT), exhibiting antiproliferative, anti-tumor activities, and the ability to inhibit cell invasion and metastasis. It induces apoptos...
T63648	EGFR kinase inhibitor 1
	EGFR kinase inhibitor 1 is a potent inhibitor of EGFR that acts on WT (IC50: 37 nM), l885R/T790M (IC50: 1.7 nM), and L858R/T790M/C797S (IC50>300 nM). EGFR kinase inhibitor 1 is capable of blocking the cell cycle in G0/G1...
T74393	Antitumor agent-36
	Antitumor agent-36 exhibits strong anti-proliferative and anti-metastasis capabilities, causing significant DNA damage that results in elevated levels of γ-H2AX and p53. It promotes tumor cell apoptosis via the mitochond...
T79647	VEGFR/PARP-IN-1		PARP
	VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively. It impairs DNA damage repair pathways, promotes apoptosis, and halts cells in the G2/M phase. Thi...		PARP
T35993	Epitalon (acetate)
	Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalo...

Compounds

EGFR kinase inhibitor 1

カタログ番号	製品名	別名	ターゲット
T2982	Xanthone	Genicide,Xanthenone,Benzophenone oxide	Apoptosis , Others , Influenza Virus , Antibacterial , Antifungal
	Xanthone (Xanthenone) is currently used as ovicide for codling moth eggs and as a larvicide.
T2786	Oxysophocarpine		Prostaglandin Receptor
	Oxysophocarpine is extracted from Sophra flavescens Ait.		Prostaglandin Receptor
T8169	Decursinol		Others
	Decursinol is isolated from the roots of Angelica Gigas with an antinociceptive effect. It also has anti-tumor and anti-metastasis activity.		Others
T4S1383	Escin IA	Aescin IA,Escin IA;Aescin IA,Escin IA	HIV Protease
	Escin IA (Escin IA;Aescin IA) is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved ...		HIV Protease
T3402	20(S)-Ginsenoside Rg3	20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3	EGFR , Beta Amyloid , Potassium Channel , NF-κB , COX , Sodium Channel , Endogenous Metabolite
	20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial c...
T3403	Glabridin	Q-100692,KB-289522,LS-176045	Reactive Oxygen Species , Tyrosinase , GABA Receptor , Antibacterial , PPAR
	Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on...
T6S1699	Shogaol	[6]-Shogaol,6-Shogaol	Lipoxygenase , Autophagy
	1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory response and protected the f...		Lipoxygenase , Autophagy
T4S0969	Obtusifolin		Antioxidant , NF-κB
	1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be...		Antioxidant , NF-κB
TN5901	Cudratricusxanthone A
	Cudratricusxanthone A has potent anti-proliferative, antioxidative, and monoamine oxidase inhibitory effects, it also possesses anti-cancer activities and provide a basis for developing effective therapeutic agents to in...
TN3587	Capillarisin		MMP , ERK , IL Receptor , BCL , VEGFR , TNF , NOS , NF-κB , TLR , MAPK , COX , DNA/RNA Synthesis , Prostaglandin Receptor , JNK , STAT
	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by ...

天然物製品

Xanthone

T2982

Synonym: Genicide,Xanthenone,Benzophenone oxide

Target: Apoptosis, Others, Influenza Virus, Antibacterial, Antifungal

Oxysophocarpine

T2786

Synonym:

Target: Prostaglandin Receptor

Synonym: Aescin IA,Escin IA;Aescin IA,Escin IA

Target: HIV Protease

20(S)-Ginsenoside Rg3

T3402

Synonym: 20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3

Target: EGFR, Beta Amyloid, Potassium Channel, NF-κB, COX, Sodium Channel, Endogenous Metabolite

Glabridin

T3403

Synonym: Q-100692,KB-289522,LS-176045

Target: Reactive Oxygen Species, Tyrosinase, GABA Receptor, Antibacterial, PPAR

Shogaol

T6S1699

Synonym: [6]-Shogaol,6-Shogaol

Target: Lipoxygenase, Autophagy

Obtusifolin

T4S0969

Synonym:

Target: Antioxidant, NF-κB

Cudratricusxanthone A

Target: MMP, ERK, IL Receptor, BCL, VEGFR, TNF, NOS, NF-κB, TLR, MAPK, COX, DNA/RNA Synthesis, Prostaglandin Receptor, JNK, STAT

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00566	CCL18 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Proof showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its...
TMPK-00658	IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, prot...
TMPK-00456	IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated	Human	HEK293 Cells
	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, prot...
TMPK-00455	IGF1R/CD221 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, prot...
TMPY-02965	MMP-19 Protein, Human, Recombinant	Human	E. coli
	MMP19, also known as RASI-1, is a member of the peptidase M1A family. It contains 4 hemopexin-like domains and is expressed in the mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate...
TMPY-04203	RAB1B Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	RAB1B, a member of the RAS oncogene family, was significantly down-regulated in highly metastatic breast cancer cells. Moreover, down-regulation of RAB1B was also found to promote the proliferation and migration of TNBC ...
TMPH-03753	MYLK Protein, Human, Recombinant (His)	Human	E. coli
	Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phos...

CCL18 Protein, Human, Recombinant (His)

TMPY-00566

Species: Human

Expression System: P. pastoris (Yeast)

IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)

TMPK-00658

Species: Cynomolgus

Expression System: HEK293 Cells

IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated

TMPK-00456

Species: Human

Expression System: HEK293 Cells

IGF1R/CD221 Protein, Human, Recombinant (His & Avi)

TMPK-00455

Species: Human

Expression System: HEK293 Cells

MMP-19 Protein, Human, Recombinant

TMPY-02965

Species: Human

Expression System: E. coli

RAB1B Protein, Human, Recombinant (hFc)

TMPY-04203

Species: Human

Expression System: HEK293 Cells

MYLK Protein, Human, Recombinant (His)

TMPH-03753

Species: Human

Expression System: E. coli

カタログ番号	製品名
L2100	Anti-Cancer Compound Library		7234 compounds
	A unique collection of 7234 compounds with anti-cancer activity for high throughput screening (HTS) and high content screening (HCS);

ライブラリー

Anti-Cancer Compound Library

L2100

Compounds: 7234