| TMPH-01081
|
CHMP7 Protein, Human, Recombinant (His)
|
Human |
E. coli |
|
ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly ... |
| TMPH-00886
|
ATF7IP2 Protein, Human, Recombinant (His)
|
Human |
E. coli |
|
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the conte... |
| TMPH-02580
|
CHRAC1 Protein, Mouse, Recombinant (His & Myc)
|
Mouse |
E. coli |
|
Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sl... |
| TMPY-00117
|
FGF-16 Protein, Human, Cynomolgus, Recombinant
|
Human,Cynomolgus |
Baculovirus-Insect Cells |
|
Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the ME... |
| TMPY-02580
|
Histone H1 Protein, Human, Recombinant (His)
|
Human |
E. coli |
|
H1 histone family, member 0 (H1F0) is a member of the H1 histone family of nuclear proteins which are a component of chromatin in eukaryotic cells. It's involved in maintaining the structure of chromatin by packing the "... |
| TMPY-00005
|
FGF-8a Protein, Human, Recombinant
|
Human |
E. coli |
|
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment... |
| TMPY-06986
|
FGF-8b Protein, Human, Recombinant
|
Human |
E. coli |
|
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment... |
| TMPY-02521
|
HIST3H2A Protein, Human, Recombinant
|
Human |
E. coli |
|
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident ... |
| TMPY-05449
|
IL-33 Protein, Cynomolgus, Recombinant
|
Cynomolgus |
E. coli |
|
Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural... |
| TMPY-02789
|
IL-33 Protein, Canine, Recombinant
|
Canine |
E. coli |
|
Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural... |
| TMPY-00861
|
IL-33 Protein, Human, Recombinant
|
Human |
E. coli |
|
Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural... |
| TMPY-03650
|
BirA Protein, E. coli, Recombinant (His & MBP)
|
E. coli |
E. coli |
|
The enzyme BirA is a key reagent because of its ability to biotinylate proteins at a specific residue in a recognition sequence. This enzyme is used to biotinylate the C termini of membrane proteins, allowing these prote... |
| TMPY-01478
|
HSP90 alpha Protein, Human, Recombinant
|
Human |
E. coli |
|
Heat shock protein 90 (90 kDa heat-shock protein, HSP90) is a molecular chaperone involved in the trafficking of proteins in the cell. It is a remarkably versatile protein involved in the stress response and normal homoe... |
| TMPY-01188
|
PARP Protein, Human, Recombinant (His)
|
Human |
Baculovirus-Insect Cells |
|
Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of N... |
| TMPH-02849
|
DEK Protein, Mouse, Recombinant (His)
|
Mouse |
Baculovirus |
|
Involved in chromatin organization. |
| TMPJ-01399
|
ASF1A Protein, Human, Recombinant (His, T7)
|
Human |
E. coli |
|
Human Histone Chaperone ASF1A (ASF1A) belongs to the H3/H4 family of histone chaperone proteins. ASF1A is ubiquitously expressed in many cells and tissues, interacting with histones H3 and H4. ASF1A cooperates with Chrom... |
| TMPH-02159
|
SMARCC1 Protein, Human, Recombinant (His & SUMO)
|
Human |
E. coli |
|
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic acti... |
| TMPJ-00694
|
BRD4 Protein, Human, Recombinant (His & Flag)
|
Human |
E. coli |
|
Bromodomain-containing protein 4 (BRD4) is a member of the BET class chromatin reader proteins that bind acetylated histones and play a key role in transcriptional regulation and transmission of epigenetic memory. Remain... |
| TMPH-01800
|
Nucleolin Protein, Human, Recombinant (His)
|
Human |
Yeast |
|
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is ... |
| TMPH-01090
|
CBX8 Protein, Human, Recombinant (His)
|
Human |
E. coli |
|
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex... |
| TMPH-01091
|
CHD1L Protein, Human, Recombinant (His & SUMO)
|
Human |
E. coli |
|
DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catal... |
| TMPY-05251
|
RbAp48 Protein, Mouse, Recombinant (His)
|
Mouse |
Baculovirus-Insect Cells |
|
Histone-binding protein RBBP4, also known as Retinoblastoma-binding protein 4, Retinoblastoma-binding protein p48, Chromatin assembly factor 1 subunit C, Chromatin assembly factor I p48 subunit, Nucleosome-remodeling fac... |
| TMPH-01236
|
DFFB Protein, Human, Recombinant (His)
|
Human |
E. coli |
|
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. |
| TMPH-00769
|
2S albumin Protein, Glycine max, Recombinant (His & SUMO)
|
Glycine max |
E. coli |
|
This is a 2S seed storage protein.; binds to mammalian chromatin, preventing the normal formation of the kinetochore complex in the centromere and leading to the disruption of mitosis. |
| TMPH-02160
|
SMARCB1 Protein, Human, Recombinant (His)
|
Human |
E. coli |
|
Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor form... |
| TMPH-02227
|
ERG Protein, Human, Recombinant (His)
|
Human |
Yeast |
|
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. |
| TMPY-01713
|
RbAp48 Protein, Human, Recombinant (His)
|
Human |
Baculovirus-Insect Cells |
|
Histone-binding protein RBBP4, also known as Retinoblastoma-binding protein 4, Retinoblastoma-binding protein p48, Chromatin assembly factor 1 subunit C, Chromatin assembly factor I p48 subunit, Nucleosome-remodeling fac... |
| TMPH-00770
|
2S albumin Protein, Glycine max, Recombinant (His)
|
Glycine max |
Yeast |
|
This is a 2S seed storage protein.; binds to mammalian chromatin, preventing the normal formation of the kinetochore complex in the centromere and leading to the disruption of mitosis. |
| TMPJ-00918
|
HMGB2 Protein, Human, Recombinant (His)
|
Human |
Human Cells |
|
High Mobility Group Protein B2 (HMGB2) belongs to the non-histone chromosomal high-mobility group protein family. Members of this family are chromatin-associated and widely spread in the nucleus of higher eukaryotic cell... |
| TMPH-01089
|
CBX7 Protein, Human, Recombinant (His)
|
Human |
E. coli |
|
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex... |
| TMPH-01776
|
HMGN2 Protein, Human, Recombinant (GST)
|
Human |
E. coli |
|
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. |
| TMPJ-00986
|
CTCF Protein, Human, Recombinant
|
Human |
E. coli |
|
Transcriptional Repressor CTCF (CTCF) belongs to the CTCF Zinc-Finger Protein family. CTCF contains twelve C2H2-type zinc fingers and interacts with CHD8. CTCF is widely expressed in many tissues, and it is absent in pri... |
| TMPH-01886
|
BMI-1 Protein, Human, Recombinant (GST)
|
Human |
E. coli |
|
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex... |
| TMPH-02217
|
SMARCA4 Protein, Human, Recombinant (His)
|
Human |
Yeast |
|
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic acti... |
| TMPH-00604
|
CDTA Protein, E. coli, Recombinant (His)
|
E. coli |
E. coli |
|
CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells. CdtA, along with CdtC, probably forms a heterodimeric subunit required for ... |
| TMPH-00841
|
SMARCA4 Protein, Human, Recombinant (His)
|
Human |
E. coli |
|
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic acti... |
| TMPY-01332
|
HIST1H3A Protein, Human, Mouse, Recombinant
|
Human,Mouse |
E. coli |
|
Histone H3.1, also known as HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, is a member of the histone H3 family which is a core component of nucleosome. It is expresse... |
| TMPY-03498
|
ING4 Protein, Human, Recombinant (His)
|
Human |
E. coli |
|
ING4 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. ING4 contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling... |
| TMPH-00605
|
CDTB Protein, E. coli, Recombinant (His & Myc & SUMO)
|
E. coli |
E. coli |
|
Part of the tripartite complex that is required for the CDT activity. CdtB exhibits a DNA-nicking endonuclease activity, and very probably causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arres... |
| TMPJ-00675
|
ZNHIT1 Protein, Human, Recombinant (His)
|
Human |
E. coli |
|
ZNHIT1 belongs to the ZNHIT1 family and contains one HIT-type zinc finger. It can be phosphorylated on Thr by MAPK11 or MAPK14. ZNHIT1 is a component of the chromatin-remodeling SRCAP complex, which is composed of at lea... |
| TMPH-01214
|
DNASE1L3 Protein, Human, Recombinant
|
Human |
E. coli |
|
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA... |
| TMPH-01212
|
DNASE1L3 Protein, Human, Recombinant (His & Myc)
|
Human |
E. coli |
|
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA... |
| TMPH-01213
|
DNASE1L3 Protein, Human, Recombinant (His)
|
Human |
Baculovirus |
|
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA... |
| TMPH-03193
|
Alba Protein, Pyrococcus furiosus, Recombinant (His & SUMO)
|
Pyrococcus furiosus |
E. coli |
|
Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DN... |
| TMPH-01526
|
KMT2E Protein, Human, Recombinant (His & Myc)
|
Human |
E. coli |
|
Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4'... |
| TMPH-01677
|
MBD2 Protein, Human, Recombinant (His & KSI)
|
Human |
E. coli |
|
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcrip... |
| TMPH-01880
|
PARP2 Protein, Human, Recombinant (His)
|
Human |
E. coli |
|
Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is t... |
| TMPJ-00483
|
DFF45 Protein, Human, Recombinant (His)
|
Human |
E. coli |
|
DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF... |
| TMPY-04420
|
TLK1 Protein, Human, Recombinant (His & GST)
|
Human |
Baculovirus-Insect Cells |
|
Tousled-like kinase 1 (or protein kinase ubiquitous, PKU-beta/TLK1) is a serine/threonine protein kinase that is implicated in chromatin remodeling, DNA replication and mitosis. TLK1 has a function important for proper c... |
| TMPH-01088
|
CBX5 Protein, Human, Recombinant (His & Myc)
|
Human |
E. coli |
|
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphor... |
