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141

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T8767	PfDHODH-IN-2		Dehydrogenase , Parasite
	PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor . It is used an antimalarial agent and can be used for the research of m...		Dehydrogenase , Parasite
T12438	PfDHODH-IN-1		Dehydrogenase , Parasite
	PfDHODH-IN-1 is an analogue of the active Leflunomide metabolite, has antimalarial activity.		Dehydrogenase , Parasite
T5421	KDU691		Parasite , PI4K
	KDU691 is a PI4K inhibitor.		Parasite , PI4K
T9984	Antimalarial agent 13	N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine	Parasite
	Antimalarial agent 13 (N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine) is a potent antimalarial agent.		Parasite
T7167	Purvalanol B	NG 95	CDK , Parasite
	Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)		CDK , Parasite
T22381	Antimalarial agent 14	4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone	Others
	Antimalarial agent 14 (NSC-102533) is a bioactive chemical.		Others
T16269	Nanaomycin A		DNA Methyltransferase , Dehydrogenase , Parasite
	Nanaomycin A is the first selective DNMT3B inhibitor (IC50: 500 nM). Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum (IC80: 33.1 nM). Nanaomycin A is quinone antibiotics, reactiv...		DNA Methyltransferase , Dehydrogenase , Parasite
T16697	Pyronaridine tetraphosphate		Topoisomerase
	Pyronaridine tetraphosphate is an orally active, mannitol-containing inhibitor of DNA topoisomerase 2 and erythrocyte cytokine with antimalarial and antitumour activity.Pyronaridine tetraphosphate treats P. falciparum an...		Topoisomerase
T9591	YCN47284		Parasite
	YCN47284 is an antimalarial compound with an IC50 of 1 μM for P. falciparum.		Parasite
T14324	Artemisone	BAY 44-9585,Artemifone	Others , Parasite
	Artemisone (BAY 44-9585) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains (IC50: 0.83 nM). It also is a potent inhibitor of human CMV.		Others , Parasite
T16326	Cipargamin	KAE609,NITD609	Parasite
	Cipargamin (NITD609) is an effective antimalarial compound. It has an IC50 of appr 1 nM against P. falciparum.		Parasite
T40417	Ethylhydrocupreine hydrochloride	Optochin hydrochloride	Antibacterial , Parasite
	Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a derivative of quinine with antimicrobial activity against Streptococcus pneumoniae.Ethylhydrocupreine hydrochloride has antimalarial activity with an IC50 of...		Antibacterial , Parasite
T9858	5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole		Parasite
	Antileishmanial agent-2 is a 3-Br-isoxazoline-Based Inhibitors against Plasmodium falciparum (D10 and W2 strains) and Leishmania spp. (L. infantum and L. tropica) Promastigotes with IC50s of 0.035, 0.058, 3.5 and 7.5 μM.		Parasite
T11030	DHODH-IN-8		Dehydrogenase
	DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively.		Dehydrogenase
T10356	AQ-13 dihydrochloride		Parasite
	AQ-13 dihydrochloride is an antimalarial drug. It is effective against drug-resistant strains of Plasmodium falciparum.		Parasite
T14766	BPH-715		Others , Parasite
	BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth. With an IC50 of 10 μM for Plasmodium exoerythrocytic forms in HepG2 cells[1].		Others , Parasite
T13246	UCT943		Parasite , PI4K
			Parasite , PI4K
T16125	MMV390048		Parasite , PI4K
	MMV390048 is an antimalarial agent and is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. fal...		Parasite , PI4K
T10378	Artelinic acid		Parasite
	Artelinic acid is a water-soluble artemisinin analog with antimalarial activity and is used for the treatment of multi-drug resistant strains of Plasmodium falciparum.		Parasite
T11027	DHODH-IN-4		Dehydrogenase
	DHODH-IN-4 is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor. The IC50 values of PfDHODH and HsDHODH are 4 μM and 0.18 μM, respectively. DHODH-IN-4 has antimalarial activity.		Dehydrogenase
T21022	Deacylketoconazole	Deacyl ketoconazole	Antifungal
	Deacylketoconazole (Deacyl ketoconazole) is a Ketoconazole derivative and is also an antifungal agent. Deacylketoconazole was 15- to 50-fold more active against Plasmodium falciparum than was ketoconazole.		Antifungal
T10903	CWHM-1552		Parasite
	CWHM-1552 is an effective Plasmodium falciparum inhibitor. For the 3D7 and Dd2 strains, the IC50s are 51 nM and 53 nM.		Parasite
T0860	Mefloquine hydrochloride	Mefloquin hydrochloride,Mefloquine HCl	Potassium Channel , SARS-CoV , Reactive Oxygen Species , Parasite , Autophagy
	Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.
T12909	SID 26681509		Cysteine Protease , Parasite
			Cysteine Protease , Parasite
T5493	Pyronaridine		Others
	Pyronaridine is an orally active, mannitol-containing anti-malarial compound that acts by interfering with the replication of the malaria parasite (Plasmodium) within red blood cells. Pyronaridine is often used in combin...		Others
T11558	Hexyl gallate	Gallic acid hexyl ester,Hexyl 3,4,5-trihydroxybenzoate	Antibacterial
	Hexyl gallate (Gallic acid hexyl ester), an alkyl ester derivative of gallic acid, exhibits potent antimalarial activity against Plasmodium falciparum (IC50: 0.11 mM).		Antibacterial
T67694	ZY-19489		Parasite
	ZY-19489 is an antimalarial compound that is a potential single-dose cure for Plasmodium falciparum and Plasmodium vivax malaria. It has received orphan drug designation from the FDA.		Parasite
T74696	SpdSyn binder-1		Parasite
	SpdSyn binder-1 is a weak binding agent that binds to the active site of Plasmodium falciparum spermidine synthase, which is partially inhibitory to malaria and can be used to study malaria.		Parasite
T17257L	WR99210 hydrochloride(47326-86-3 free base)	WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine	Others
	WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target. It has subnanomolar potency for the wild type, double mutant and quadruple mut...		Others
T27214	DSM421	DSM 421,DSM-421	Dehydrogenase
	DSM421 (DSM-421) is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shown activity against field isolates of both P. falciparum and P. vivax...		Dehydrogenase
T9741	INE963		Others
	INE963 demonstrates potent cellular activity against Pf 3D7 (EC50 = 6 nM) and achieves "artemisinin-like" kill kinetics in vitro with a parasite clearance time of <24 h. INE963 is also potent against P. falciparum and P....		Others
T1491	Atovaquone	Atavaquone	Others , P450 , Dehydrogenase , Antibiotic , Parasite
	Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.		Others , P450 , Dehydrogenase , Antibiotic , Parasite
T3266	Lumefantrine	Benflumetol,dl-Benflumelol	Others , Parasite , Autophagy
	Lumefantrine (dl-Benflumelol) is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects again...		Others , Parasite , Autophagy
T0049	Azlocillin sodium salt	Sodium azlocillin,Azlocillin sodium	Antibacterial , Antibiotic , Parasite
	Azlocillin sodium, an acylampicillin, is a broad-spectrum antibiotics		Antibacterial , Antibiotic , Parasite
T11039	Didesethyl chloroquine	Bisdesethylchloroquine	Drug Metabolite
	Didesethyl chloroquine (Bisdesethylchloroquine) is an effective myocardial inhibitor. Didesethyl chloroquine (Bisdesethylchloroquine) is the main metabolite of the antimalarial drug chloroquine.		Drug Metabolite
Fr13587	7-Chloro-4-(piperazin-1-yl)quinoline
	7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. It exhibited either alone or as hybrid with other active pharmacophores diverse pharmacological profiles. 7-Chloro-4-(piperazin-1-yl)q...
T4220	BQR-695	BQR695,NVP-BQR695	PI3K , Parasite , PI4K
	BQR-695 (NVP-BQR695) is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.		PI3K , Parasite , PI4K
T15173	DSM265	PfSPZ	Dehydrogenase , Parasite
	DSM265 (PfSPZ) is a dihydroorotic acid dehydrogenase inhibitor with antimalarial activity (IC50: 8.9 nM).DSM265 inhibits the growth of Pf3D7 parasites and can be used for the treatment and prophylaxis of malaria infectio...		Dehydrogenase , Parasite
T14325	Arterolane	OZ 277,RBx 11160	Others
			Others
T10902	CWHM-1008		Others
	CWHM-1008 is an effective oral antimalarial drug. The EC50 values of the drug-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains are 46 and 21 nM, respectively.		Others
T11331	FTI 276 TFA		Others
	FTI 276 TFA is effective against plasmodium falciparum and humans.It is a protein-based nikyltransferase (PFT) inhibitor with an IC50s of 0.9 nM and 0.5 nM, respectively.		Others
T20910	Dibemethine	Dibemetina,DBMA,AI3-26795,Dibemethinum
	Dibemethine is active against chloroquinone-resistant Plasmodium falciparum by the inhibition of P. falciparum chloroquine-resistance transporter (PfCRT).
T71841	MMV085203
	MMV08520 is a novel inhibitor of Plasmodium falciparum, killing both blood- and sexual-stage P. falciparum parasites.
T68421	MMV019662
	MMV019662 is a novel inhibitor of Plasmodium falciparum.
T12084	MMV008138		Others
	MMV008138 inhibits the growth of P. falciparum Dd2 strain (IC50 of 250 nM).		Others
T71061	DSM267
	DSM267 is a novel Plasmodium falciparum Dihydroorotate Dehydrogenase (PfDHODH) Inhibitor.
T25524	IDI-3783
	IDI-3783 is a mutant-selective inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).
T25448	Genz-669178
	Genz-669178 is a wild-type inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).
T36649	AN3661
	AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3). AN3661 inhibits Plasmodium falciparum laboratory-adapted strains...
T27516	GW844520
	GW844520 is a potent and selective inhibitor of the cytochrome bc1 complex of mitochondrial electron transport in P. falciparum.

Compounds

PfDHODH-IN-2

T8767

Synonym:

Target: Dehydrogenase, Parasite

PfDHODH-IN-1

T12438

Synonym:

Target: Dehydrogenase, Parasite

KDU691

T5421

Synonym:

Target: Parasite, PI4K

Antimalarial agent 13

T9984

Synonym: N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine

Target: CDK, Parasite

Antimalarial agent 14

T22381

Synonym: 4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone

Target: DNA Methyltransferase, Dehydrogenase, Parasite

Pyronaridine tetraphosphate

T16697

Synonym:

Target: Topoisomerase

Synonym: BAY 44-9585,Artemifone

Target: Others, Parasite

Cipargamin

T16326

Synonym: KAE609,NITD609

Target: Parasite

Ethylhydrocupreine hydrochloride

T40417

Synonym: Optochin hydrochloride

Target: Antibacterial, Parasite

5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole

Target: Dehydrogenase

AQ-13 dihydrochloride

Target: Others, Parasite

UCT943

T13246

Synonym:

Target: Parasite, PI4K

MMV390048

T16125

Synonym:

Target: Parasite, PI4K

Target: Dehydrogenase

Deacylketoconazole

T21022

Synonym: Deacyl ketoconazole

Mefloquine hydrochloride

T0860

Synonym: Mefloquin hydrochloride,Mefloquine HCl

Target: Potassium Channel, SARS-CoV, Reactive Oxygen Species, Parasite, Autophagy

SID 26681509

T12909

Synonym:

Target: Cysteine Protease, Parasite

Synonym: Gallic acid hexyl ester,Hexyl 3,4,5-trihydroxybenzoate

Target: Antibacterial

WR99210 hydrochloride(47326-86-3 free base)

T17257L

Synonym: WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine

Target: Others

DSM421

T27214

Synonym: DSM 421,DSM-421

Target: Dehydrogenase

Target: Others, P450, Dehydrogenase, Antibiotic, Parasite

Lumefantrine

T3266

Synonym: Benflumetol,dl-Benflumelol

Target: Others, Parasite, Autophagy

Azlocillin sodium salt

T0049

Synonym: Sodium azlocillin,Azlocillin sodium

Target: Antibacterial, Antibiotic, Parasite

Didesethyl chloroquine

T11039

Synonym: Bisdesethylchloroquine

Target: Drug Metabolite

7-Chloro-4-(piperazin-1-yl)quinoline

Synonym: BQR695,NVP-BQR695

Target: PI3K, Parasite, PI4K

DSM265

T15173

Synonym: PfSPZ

Target: Dehydrogenase, Parasite

Arterolane

T14325

Synonym: OZ 277,RBx 11160

Synonym: Dibemetina,DBMA,AI3-26795,Dibemethinum

カタログ番号	製品名	別名	ターゲット
TN7103	13,21-Dihydroeurycomanone	Pasakbumin C	Anti-infection , Parasite
	13,21-Dihydroeurycomanone (Pasakbumin C) is a natural product isolated from the root of Eurycoma longifolia with antiparasitic activity such as Plasmodium falciparum and Toxoplasma gondii.		Anti-infection , Parasite
T6S0084	Tuberostemonine	Tuberstemonine	Parasite
	1. Tuberostemonine (Tuberstemonine) exhibits relatively higher intestinal permeabilities. 2. Tuberostemonine acts in part as an open-channel blocker at the crayfish neuromuscular junction.		Parasite
TN2027	Oxysanguinarine	8-Oxosanguinarine,Hydroxysanguinarine	Parasite
	Oxysanguinarine (Hydroxysanguinarine) possesses antiplatelet aggregation activity, it has potential inhibitory properties against the dengue virus.		Parasite
T3933	Jatrorrhizine	Yatrorizine,neprotin	MAO , 5-HT Receptor , Antibacterial , AChE
	Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo...		MAO , 5-HT Receptor , Antibacterial , AChE
T4912	Jatrorrhizine chloride	Yatrorhizine chloride,Neprotine chloride	Others , 5-HT Receptor , OCT , Antibacterial , AChE
	Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h...		Others , 5-HT Receptor , OCT , Antibacterial , AChE
T3327	Artemotil	SM-227,β-Arteether,Beta-Arteether,Arteether,(+)-Arteether	CXCR , CCR , Parasite
	Artemotil (SM-227) is a new, fast-acting antimalarial drug.		CXCR , CCR , Parasite
T3682	(-)-Catechin gallate	(-)-Catechin 3-O-gallate,(-)-Catechin 3-gallate	Others , COX
	(-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of 6PGD, IDH. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of human Beta-secretase. (-)-Catechin gallate ((-)-Catechin 3-O-gallat...		Others , COX
TN3790	Dehydroabietinol	Pomiferin A,Dehydroabietyl alcohol	Antifection
	Dehydroabietinol (Pomiferin A) inhibits growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM).		Antifection
T0392	Artemisinin	Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,Artemisinine	HCV Protease , Ferroptosis , Akt , Parasite
	Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organisms, including chloroquine-resistant Plasmodium ...		HCV Protease , Ferroptosis , Akt , Parasite
TN1905	Magnolioside		Antifection
	Magnolioside has anti-plasmodial activity, shows notable growth inhibitory activity against chloroquine-sensitive strains of P. falciparum. It also shows a moderate antibacterial activity against Staphylococcus aureus CI...		Antifection
TCS2070	Homogentisic acid	2,5-dihydroxyphenylacetic acid,Homogentisinic Acid,Melanic acid	Antioxidant , Endogenous Metabolite
	1. Homogentisic acid (2,5-dihydroxyphenylacetic acid) shows interesting antioxidant and antiradical activities, and protective effect against thermal-cholesterol degradation, comparable to those of well known antioxidant...		Antioxidant , Endogenous Metabolite
TN1019	Beta-mangostin	β-Mangostin	Apoptosis , Antibacterial , Parasite
	Beta-mangostin (β-Mangostin) is a xanthone compound with antibacterial and antimalarial activities. Beta-mangostin present in Cratoxylum arborescens and exhibits antimycobacterial activity against Mycobacterium tuberculo...		Apoptosis , Antibacterial , Parasite
T35749	Thymohydroquinone	Thymoquinol	Antioxidant , Reactive Oxygen Species
	Thymohydroquinone (Thymoquinol) is a monoterpenoid phenolic compound found in thyme, oregano, and other plants in the labiaceae family. Thymohydroquinone inhibits cancer cell growth, reduces oxidative stress and modulate...		Antioxidant , Reactive Oxygen Species
T2S2362	Dehydrocorydaline nitrate		BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a...
TN4883	Quinine sulfate dihydrate		Others
	Quinine sulfate dihydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassiu...		Others
TN3466	Atherosperminine		cAMP , Calcium Channel , AChR , Parasite
	Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong anti-plasmodial activity against Plasmodium falciparum, with t...		cAMP , Calcium Channel , AChR , Parasite
T11802	L-Canaline		Others
	L-Canaline, a nonprotein amino acid found in many leguminous plants, exhibits potent anticancer and antiproliferative effects. It effectively inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50...		Others
TN4314	Isonardoperoxide		Antifection
	Isonardoperoxide shows strong antimalarial activity against Plasmodium falciparum malaria (6.0 × 10-7 M).		Antifection
T11681	Isochondrodendrine	Isochondrodendrin	Others
	Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum. Isochondrodendrine is a class of bisbenzylisoquinoline alkaloid isolated from Isolona ghesquiereina.		Others
TN4717	Oplopanone		Antifection
	Oplopanone exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strain.		Antifection
TN4933	Sahandol		Antifection
	Sahandol shows antiprotozoal activity against P. falciparum and T. brucei rhodesiense.		Antifection
TN3583	Canophyllal		Antifection
	Canophyllal shows antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs.		Antifection
TN2485	1,2-Dihydrotanshinone	1,2-Dihydrotanshinquinone	Antifection
	1,2 Dihydrotanshinquinone is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.		Antifection
TN3563	Caesalmin B		Antifection
	Caesalmin B shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.		Antifection
T11509	Guanfu base H	Atisinium chloride	Others
	Guanfu base H is a diterpenoid alkaloid isolated from Aconitum coreanum. It has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 (IC50s: 4 μM and 3.6 μM).		Others
TN2747	2-Acetoxy-3-deacetoxycaesaldekarin E		Antifection
	2-Acetoxy-3-deacetoxycaesaldekarin E shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.		Antifection
TN1930	Methylenetanshinquinone		Antifection
	Methylenetanshinquinone shows antiplasmodial and antitrypanosomal activity, it is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.		Antifection
TN3987	Eriodictyol chalcone		Anti-infection , Aromatase
	Eriodictyol chalcone has anti-plasmodial effects on P. falciparum growth.		Anti-infection , Aromatase
TN1442	Betulinic acid methyl ester		Antifection
	Betulinic acid methyl ester showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro.It also inhibited B16 2F2 cell proliferation by induction of apoptosis.		Antifection
TN4666	Norcaesalpinin E		Antifection
	Norcaesalpinin E shows antimalarial activity against the malaria parasite Plasmodium falciparum FCR-3/A2 clone in vitro, with an IC50 value of 0.090 microM.		Antifection
TN4202	(-)-Heraclenol		Antifection
	(-)-Heraclenol shows in vitro anti-plasmodial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.(-)-Heraclenol has moderate antibacterial and antifungal activities.		Antifection
T16719	Radicicol	Monorden	HSP
	Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: 1 μM). Radicicol binds to the ATPase domain of Hsp90 and pr...		HSP
TN5657	Goniotriol
	Goniotriol shows antimycobacterial activity against Mycobacterium tuberculosis (MIC =100 microg/mL). It exhibits antiplasmodial activity against Plasmodium falciparum (IC50=2.6 microg/mL). Goniotriol shows cytotoxicity a...
T79984	Chaparrinone		Parasite
	Chaparrinone, a quassinoid derived from the root of Eurycoma harmandiana, exhibits antimalarial and cytotoxic properties, with IC50 values of 0.037 μg/mL against Plasmodium falciparum and 0.34 μg/mL against P-388 cells [...		Parasite
TN3124	5-Hydroxysophoranone		Antibacterial , Parasite , Antifection
			Antibacterial , Parasite , Antifection
T71896	Brevicompanine B
	Brevicompanine B is a fungal metabolite that has plant growth and circadian rhythm regulatory activity. Brevicompanine B inhibits primary root growth in Arabidopsis seedlings and disrupts the transcription of various gen...
TN2738	2,6-Dimethoxy-1-acetonylquinol		Antifection
	2,6-Dimethoxy-1-acetonylquinol shows varying degrees of in vitro antimalarial activity against Plasmodium falciparum. It is devoid of significant cytotoxicity to the human oral epidermoid KB cancer cell line.		Antifection
TN4716	Oplodiol		Influenza Virus
	Oplodiol exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strains. Oplodiol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts; it also shows mode...		Influenza Virus
T75450	P-orlandin
	P-orlandin, a fungal metabolite, effectively impedes Plasmodium falciparum infection in mosquitoes by preventing FREP1 from binding to gametocytes or ookinetes [1].
T75568	Z-Antiepilepsirine
	Z-Antiepilepsirine, an amide alkaloid present in Piper capense L.f., exhibits antiplasmodial properties, demonstrating an IC50 value of 27 µM against the W2 strain of Plasmodium falciparum [1].
T75676	Orotidine 5′-monophosphate trisodium
	Orotidine 5'-monophosphate trisodium, a pyrimidine nucleotide, is synthesized through the de novo DNA synthesis pathway by various microorganisms, including M. tuberculosis, S. cerevisiae, S. typhimurium, and P. falcipar...
T75447	Asperaculane B
	Asperaculane B, a fungal metabolite, exhibits anti-malarial activity by inhibiting Plasmodium falciparum transmission and its asexual development, with IC50 values of 7.89 µM and 3 µM, respectively. Additionally, it is n...
TN4113	Garcinone E		Antifection
	Garcinone E is active constituents in the anticomplement assay used. Garcinone E exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM. It has potent...		Antifection
T35483	19,20-Epoxycytochalasin D
	19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for...
T35754	Aszonapyrone A
	Aszonapyrone A is a meroditerpene fungal metabolite that has been found in Neosartorya and has diverse biological activities.1,2,3 It inhibits the growth of MCF-7, NCI H460, and A375-C5 cancer cells (GI50s = 13.6, 11.6, ...
TN4449	Longistylin C		Antifection
	Longistylin A and longistylin C show some cytotoxic effects, with IC(50) values of 0.7-14.7 microM against the range of cancer cell lines. Longistylin A and longistylin C, and betulinic acid show a moderately high in vit...		Antifection
T35758	Butyrolactone V
	Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.1,2,3 It is active against the P. falciparum strain K1 (IC50 = 7.9 μg/ml) and L. amaz...
TN5474	Bonducellin
	Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bon...
TN4683	Nyasol		ERK , IL Receptor , IκB/IKK , NOS , NF-κB , Akt , Antifection
	Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhibiting iNOS expression; it also has antif...
T35751	Violacein
	Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.[1] [2] It is produced by C. violaceum as a purple pigment in response to N-hexanoyl homoserin...
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天然物製品

13,21-Dihydroeurycomanone

TN7103

Synonym: Pasakbumin C

Target: Anti-infection, Parasite

Tuberostemonine

T6S0084

Synonym: Tuberstemonine

Target: Parasite

Oxysanguinarine

TN2027

Synonym: 8-Oxosanguinarine,Hydroxysanguinarine

Target: Parasite

Jatrorrhizine

T3933

Synonym: Yatrorizine,neprotin

Target: MAO, 5-HT Receptor, Antibacterial, AChE

Jatrorrhizine chloride

T4912

Synonym: Yatrorhizine chloride,Neprotine chloride

Target: Others, 5-HT Receptor, OCT, Antibacterial, AChE

Artemotil

T3327

Synonym: SM-227,β-Arteether,Beta-Arteether,Arteether,(+)-Arteether

Target: CXCR, CCR, Parasite

(-)-Catechin gallate

T3682

Synonym: (-)-Catechin 3-O-gallate,(-)-Catechin 3-gallate

Target: Others, COX

Dehydroabietinol

TN3790

Synonym: Pomiferin A,Dehydroabietyl alcohol

Target: Antifection

Artemisinin

T0392

Synonym: Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,Artemisinine

Target: HCV Protease, Ferroptosis, Akt, Parasite

Synonym: 2,5-dihydroxyphenylacetic acid,Homogentisinic Acid,Melanic acid

Target: Antioxidant, Endogenous Metabolite

Beta-mangostin

TN1019

Synonym: β-Mangostin

Target: Apoptosis, Antibacterial, Parasite

Thymohydroquinone

T35749

Synonym: Thymoquinol

Target: Antioxidant, Reactive Oxygen Species

Dehydrocorydaline nitrate

T2S2362

Synonym:

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Quinine sulfate dihydrate

Target: cAMP, Calcium Channel, AChR, Parasite

Synonym: Isochondrodendrin

1,2-Dihydrotanshinone

TN2485

Synonym: 1,2-Dihydrotanshinquinone

Synonym: Atisinium chloride

Target: Others

2-Acetoxy-3-deacetoxycaesaldekarin E

TN2747

Synonym:

Target: Antifection

Methylenetanshinquinone

Target: Anti-infection, Aromatase

Betulinic acid methyl ester

Target: Antibacterial, Parasite, Antifection

2,6-Dimethoxy-1-acetonylquinol

Target: Influenza Virus

Orotidine 5′-monophosphate trisodium

19,20-Epoxycytochalasin D

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt, Antifection

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Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04180	PfLDH Protein, P. falciparum, Recombinant (His)	P. falciparum	E. coli
	Plasmodium falciparum lactate dehydrogenase (PfLDH) is a key enzyme for energy generation of malarial parasites and is considered to be a potential antimalarial target. The ability of PfLDH- or PfIDEh-based immuno-PCR as...
TMPH-03140	Plasmepsin-1 Protein, Plasmodium falciparum, Recombinant (His)	Plasmodium falciparum	E. coli
	During the asexual blood stage, catalyzes the initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation; specifically cleaves between Phe-33 and Leu-34 of Hb alpha-chain. Digestion of host Hb is an ess...
TMPH-03143	PFD0110w Protein, Plasmodium falciparum, Recombinant	Plasmodium falciparum	E. coli
	PFD0110w Protein, Plasmodium falciparum, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 30.1 kDa and the accession number is P86148.
TMPH-03137	PFS230 Protein, Plasmodium falciparum, Recombinant	Plasmodium falciparum	E. coli
	Gametocyte surface protein required for male/female gamete fusion. Also required for male gamete exflagellation and interaction with erythrocytes. PFS230 Protein, Plasmodium falciparum, Recombinant is expressed in E. col...
TMPH-03141	Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (His & Myc)	Plasmodium falciparum	Baculovirus Insect Cells
	During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation. May cleave preferentially denatured hemoglobin that has been cleaved by PMI. Digestion of host...
TMPY-04181	PfHPRT Protein, P. falciparum, Recombinant (His)	P. falciparum	E. coli
	pfHPRT Protein, P. falciparum, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 28.6 kDa and the accession number is Q76NM3.
TMPH-03138	GST Protein, Plasmodium falciparum, Recombinant (His)	Plasmodium falciparum	P. pastoris (Yeast)
	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin IX (hemin). GST Protein,...
TMPH-03139	MDR1 Protein, Plasmodium falciparum, Recombinant (His & SUMO)	Plasmodium falciparum	E. coli
	Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. MDR1 Protein, Plasmodium falciparum, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-...
TMPH-03142	Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (E. coli, His & Myc)	Plasmodium falciparum	E. coli
	During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation. May cleave preferentially denatured hemoglobin that has been cleaved by PMI. Digestion of host...