|
T2550 |
Tolmetin
|
Tolectin |
COX
|
|
Tolmetin (Tolectin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of tolmetin is as a Cyclooxygenase Inhibitor. The chemical classification of tolmetin is Nonsteroidal Anti-inflammatory Compounds. |
|
T36964 |
BML-259
|
CAY10554 |
CDK
|
|
BML-259 is an inhibitor of CDK5 and CDK2 with IC50s of 64 and 98 nM, respectively. BML-259 can be used in studies about the treatment of cancer and neurodegenerative diseases. |
|
T0412 |
Idebenone
|
CV-2619 |
Apoptosis
,
Antioxidant
,
Mitochondrial Metabolism
|
|
Idebenone (CV-2619) is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC). |
|
T6500 |
Ferrostatin-1
|
Ferrostatin 1,Ferrostatin-1 (Fer-1) |
Ferroptosis
,
Antifungal
|
|
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of iron death. Ferrostatin-1 potently inhibits Erastin-induced iron death in HT-1080 cells with an EC50 of 60 nM. Ferrostatin-1 also exhibits antioxidant and anti... |
|
T2264 |
AM281
|
|
Cannabinoid Receptor
|
|
AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats. |
|
T12352L |
Oxidopamine hydrobromide
|
6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide |
Mitophagy
,
Dopamine Receptor
,
Autophagy
|
|
Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist. |
|
T12352 |
Oxidopamine hydrochloride
|
6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride |
Mitophagy
,
Dopamine Receptor
,
Autophagy
|
|
Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist. |
|
T25384 |
Erbulozole
|
R-55104,R55104,R 55104 |
Microtubule Associated
|
|
Erbulozole (R 55104) is a potent synthetic microtubule inhibitor with anti-invasive, anti-tumour and radiosensitising activity that induces Wernicke's encephalopathy-like neurotoxicity. |
|
T6411 |
Biapenem
|
CLI 86815,Biapenern,Omegacin,L 627,LJC 10627 |
Antibacterial
,
Antibiotic
|
|
Biapenem (CLI 86815) is a 1-beta-methylcarbapenem antibiotic with a wide range of antibacterial activity. Biapenem has similar antibacterial activity to that of imipenem, but is more stable against human renal dehydropep... |
|
T15055 |
DB04760
|
MMP-13 Inhibitor |
MMP
|
|
DB04760 is a highly selective, non-zinc-chelating inhibitor of MMP-13 (IC50: 8 nM). DB04760 obviously decreases paclitaxel neurotoxicity and has anticancer activity. |
|
T21470L |
Davunetide acetate
|
Davunetide acetate(211439-12-2 Free base) |
Beta Amyloid
,
Microtubule Associated
|
|
Davunetide acetate is derived from activity-dependent neuroprotective protein existing in the mammalian CNS. Davunetide acetate is a microtubule-stabilizing peptide and inhibits Aβ aggregation and Aβ-induced neurotoxicit... |
|
T3570 |
SU4312
|
SU 4312,NSC 86429 |
VEGFR
,
PDGFR
|
|
SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). SU4312 (SU 4312) unexpectedly protects against MPP(+) -induced neurotox... |
|
T72059 |
S1R agonist 2
|
|
Sigma receptor
,
ROS
,
NMDAR
|
|
S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity. |
|
T67981 |
Copper histidine
|
|
|
|
Copper histidine inhibited Ctr1-mediated cellular uptake of oxaliplatin in vitro without altering oxaliplatin accumulation of platinum or neurotoxicity in DRG tissues in vivo. Copper histidine is administered orally for ... |
|
T14138 |
AG-825
|
Tyrphostin AG-825 |
Apoptosis
,
EGFR
|
|
AG-825（Tyrphostin C15） is a selective and competitive ErbB2 inhibitor that inhibits tyrosine phosphorylation with an IC50 value of 0.35 μM.AG-825 (Tyrphostin C15) inhibits HER2 and shows anticancer activity in a mouse xe... |
|
T12532 |
PQM130
|
|
Beta Amyloid
|
|
|
|
T15576 |
Indibulin
|
ZIO 301,D 24851 |
Apoptosis
,
Microtubule Associated
|
|
Indibulin (D 24851) is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neu... |
|
T68599 |
Orphenadrine
|
Orphenadrine (free base) |
Sodium Channel
,
NMDAR
,
AChR
|
|
Orphenadrine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that inhibits clonal HERG channels in a concentration-dependent manner, producing an IC of 0.85 μM in HEK cells.Orphenadrine is an antagoni... |
|
T26947 |
Caprospinol
|
SP 233,SP233,SP-233 |
|
|
Caprospinol inhibits β-Amyloid (Aβ) protein neurotoxicity. |
|
T71611 |
αSyn-IN-576755
|
|
|
|
αSyn-IN-576755 is a novel inhibitor of αSyn fibrillization, blocking fibril growth and suppressing A53T αSyn neurotoxicity. |
|
T19838 |
Brilliant Blue R250
|
Acid Blue 83,Brilliant Blue R,Coomassie Brilliant Blue R250,CBBR,Coomassie Brilliant Blue R |
|
|
CBBR is an inhibitor of wild type and mutant alpha-synuclein aggregation. CBBR also a modulator of neurotoxicity. |
|
T14963 |
CI-943
|
(±)-CI-943 |
Others
|
|
CI-943 is a novel potential antipsychotic drug that does not bind to dopamine (DA) receptors and has some developmental neurotoxicity. |
|
TP2284 |
Prion Protein 106-126 (human)
|
|
Others
|
|
Prion peptide fragment that exhibits neurotoxicity |
|
T36092 |
Fenobucarb
|
|
|
|
Fenobucarb, a widely employed carbamate insecticide, poses potential risks to the cardiovascular and cerebrovascular systems in animals[1][2]. It triggers developmental neurotoxicity in zebrafish by engaging pathways rel... |
|
T33858 |
PACA
|
N-Propargyl Caffeamide |
|
|
PACA, (N-propargyl Caffeamide)enhances NGF-induced neurite growth and reduces 6-hydroxydopamine neurotoxicity in neuron cultures. Parkinson's disease (PD) is associated with insufficient production of nerve growth factor... |
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T75592 |
Odonthobuthus Doriae Venom
|
|
|
|
Odonthobuthus Doriae Venom, extracted from the scorpion Odonthobuthus Doriae, exhibits neurotoxicity through the modulation of ion channels. |
|
T61178 |
Aβ-IN-5
|
|
|
|
Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor that also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Furthermore, Aβ-IN-5 exhibits remarkable neuroprotective effec... |
|
T60750 |
Neuronotoxicity-IN-1
|
|
|
|
Neuronotoxicity-IN-1 is a pyridothiazine derivative. Neuronotoxicity-IN-1 is an inhibitor of kainic acid neurotoxicity with neuroprotective activity[1]. |
|
TP1225 |
β-Amyloid (22-35)
|
β-Amyloid 22-35,Amyloid β-Protein (22-35) |
|
|
β-Amyloid (22-35) is a 14-aa peptide, shows aggregates and induces neurotoxicity in the hippocampal cells. Beta amyloid (22-35) is a synthetic truncated fragment of beta-amyloid peptide. |
|
T41179 |
CL 82198 hydrochloride
|
|
|
|
CL 82198 hydrochloride is a selective inhibitor of MMP-13 (89% inhibition at 10μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibitsin vitroinvasion by the human pituitary adenoma cell line HP75. Rescues pac... |
|
T72642 |
Cefepime chloride
|
BMY-28142 chloride |
|
|
Cefepime chloride (BMY-28142) is a broad-spectrum cephalosporin capable of crossing the blood-brain barrier, exhibiting antibacterial activity against both Gram-positive and Gram-negative aerobic bacteria. It also induce... |
|
T81638 |
NSC363998 free base
|
|
|
|
NSC363998 (free base), an orally active compound, suppresses rCGG90-induced neurotoxicity and is utilized in researching neurodegenerative disorders, including Fragile X associated tremor/ataxia syndrome (FXTAS) [1]. |
|
T78086 |
S1R agonist 1 hydrochloride
|
|
Sigma receptor
|
|
S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstrated neuroprotective effects against ROS and NMDA-induced neurotoxicity [1... |
|
T71554 |
ARN 14494
|
|
|
|
ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound preven... |
|
T78171 |
QR-0217
|
|
|
|
QR-0217 is a potent inhibitor of both Aβ1-40 and α-synuclein aggregation, exhibiting an IC50 of 7.5 µM for Aβ1-40. Additionally, QR-0217 has been shown to alleviate memory impairments attributed to Aβ neurotoxicity [1]. |
|
T78087 |
S1R agonist 2 hydrochloride
|
|
Sigma receptor
|
|
Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R. It demonstrates neuroprotective effects against ROS and NMDA-induced neurotoxicity [1]. |
|
T61052 |
GABAA receptor agent 7
|
|
|
|
GABAA receptor agent 7 (compoud 5c) has anticonvulsant activity both in vitro and in vivo with low neurotoxicity which can be used in epilepsy research. GABAA receptor agent 7 is a potent positive modulator of GABAA rece... |
|
T74822 |
S1R agonist 1
|
|
|
|
Compound 6b, also known as S1R agonist 1, is a selective agonist for S1R with dissociation constants (Ki) of 0.93 nM for S1R and 72 nM for S2R. This compound demonstrates neuroprotective effects against reactive oxygen s... |
|
T60826 |
GABAA receptor agent 8
|
|
|
|
GABAA receptor agent 8 (compoud 5e) has the potential in epilepsy research. GABAA receptor agent 8 is a potent positive modulator of GABAA receptor with anticonvulsant activity both in vitro and in vivo as well as low ne... |
|
T79342 |
BChE-IN-17
|
|
|
|
BChE-IN-17 (compound 6n) is a potent, selective inhibitor of butyrylcholinesterase (BChE), demonstrating inhibitory half-maximal inhibitory concentrations (IC50s) of 10.5 nM for equine BChE (eqBChE) and 32.5 nM for human... |
|
T62115 |
HBV-IN-24
|
|
|
|
HBV-IN-24 (compound (2 S, 6S)-1a) is a potent inhibitor of HBV. HBV-IN-24 is a strong inhibitor of HBV DNA (EC50: 0.6 nM), HBsAg (EC50: 0.6 nM) and HBeAg (EC50: 4.6 nM). antiviral effect and was able to improve neurotoxi... |
|
T73575 |
SD-6
|
|
|
|
SD-6, an orally active inhibitor targeting both hAChE and hBChE, demonstrates IC50 values of 0.907 µM and 1.579 µM, respectively. With its excellent blood-brain barrier (BBB) permeability and lack of neurotoxicity, SD-6 ... |
|
T62046 |
HDAC6-IN-5
|
|
|
|
HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated inhibitor of HDAC6 (IC50= 0.025 μM). HDAC6-IN-5 inhibits Aβ 1-42 self-aggregation and AChE, with IC 50s of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowt... |
|
T60954 |
HDAC6-IN-6
|
|
|
|
HDAC6-IN-6 (compound 6a) is a potent inhibitor of HDAC6 that can penetrate BBB with an IC50 value of 0.025 μM. HDAC6-IN-6 has potent inhibitory activity against AChE and Aβ 1-42 self-aggregation with IC50 values of 0.72 ... |
|
T78874 |
GSK-3β inhibitor 15
|
|
|
|
GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-induced iNOS expression. It demonstrates neuroprotective propert... |
|
T76033 |
Humanin
|
|
|
|
Humanin, a 24-amino acid anti-apoptotic peptide and Bax inhibitor, prevents Bax translocation from the cytosol to mitochondria and obstructs its activation. This mitochondria-associated peptide has neuroprotective proper... |
|
T83509 |
[Arg6]-β-Amyloid (1-40), england mutation
|
|
|
|
β-Amyloid (1-40), England mutation, is a biologically active peptide with a histidine (His) to arginine (Arg) substitution at position 6, known to enhance oligomerization kinetics that serve as fibril seeds and increase ... |
|
T82243 |
HAChE-IN-5
|
|
GSK-3
|
|
hAChE-IN-5 (compound 49) is a dual inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE), exhibiting inhibitory potency with IC50 values of 0.17 μM for both enzymes. Additionally, it de... |
|
T65396 |
Piperazine 2HCl
|
|
|
|
Piperazine (2HCl) is gamma-aminobutyric acid (GABA) agonists and its major effects appear to be on the central nervous system. Piperazine was the anthelmintic with the greatest number of reports of toxicoses and suspecte... |
|
T37605 |
D-DOPA
|
|
|
|
D-DOPA is an enantiomer of the dopamine precursor L-DOPA . It can be converted to L-DOPAviasequential oxidation and transamination, which are mediated by D-amino acid oxidase (DAAO) and DOPA transaminase, respectively, i... |
