|
T2008 |
LY294002
|
LY 294002,NSC 697286,SF 1101 |
Apoptosis
,
DNA-PK
,
Casein Kinase
,
PI3K
,
Autophagy
|
|
LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 ... |
|
T4079 |
LY-294002 hydrochloride
|
SF 1101,LY 294002,NSC 697286 |
PI3K
|
|
LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation... |
|
T2404 |
Vonoprazan fumarate
|
TAK-438 |
ATPase
|
|
Vonoprazan fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase. |
|
T6617 |
Optovin
|
|
TRP/TRPV Channel
|
|
Optovin is a TRPA1 activator, which is reversibly photoactivated. |
|
T21839L |
10Panx Acetate
|
10Panx Acetate(955091-53-9 Free base) |
Others
|
|
10Panx Acetate is a mimetic inhibitory peptide that readily and reversibly inhibits the panx1 currents. |
|
T1473 |
Trilostane
|
Win 24540 |
Dehydrogenase
|
|
Trilostane (Win 24540) is a synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex. |
|
T4348 |
Syk Inhibitor II
|
|
5-HT Receptor
,
Syk
|
|
Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM). |
|
T12437 |
PF429242 dihydrochloride
|
|
S1P Receptor
|
|
PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P (IC50 of 175 nM). |
|
T5410 |
PD158780
|
|
EGFR
|
|
PD 158780 reversibly inhibits auto and transphosphorylation of all four members of the ErbB receptor superfamily: EGFR, ErbB2, ErbB3, and ErbB4 (IC50s: 8μM, 49 nM, 52 nM, and 52 nM in cell assay). |
|
T4093 |
Fabomotizole hydrochloride
|
Afobazole hydrochloride,CM346 hydrochloride |
MAO
|
|
Fabomotizole hydrochloride (CM346 hydrochloride), an anxiolytic drug, produces anxiolytic and neuroprotective effects. The mechanism of Afobazole remains poorly defined, however, with GABAergic, NGF, and BDNF release pro... |
|
T3052 |
Sancycline
|
Bonomycin,Norcycline,Sancyclinum,6-Demethyl-6-deoxytetracycline |
Antibacterial
|
|
Sancycline (Bonomycin) is a rare semi-synthetic tetracycline, acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site. |
|
T1535 |
Sodium 4-phenylbutyrate
|
Sodium Phenylbutyrate,Buphenyl,TriButyrate |
Apoptosis
,
HDAC
,
Autophagy
|
|
Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, inc... |
|
T4680L |
HC067047 Hydrochloride(883031-03-6 free base)
|
|
TRP/TRPV Channel
|
|
HC-067047 hydrochloride is a potent and selective TRPV4 antagonist. HC-067047 hydrochloride reversibly inhibited currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 486 nM, 133nM, and 17 nM, re... |
|
T10142L |
P-Ethynylphenylalanine hydrochloride
|
4-Ethynyl-L-phenylalanine HCL,p-Ethynylphenylalanine hydrochloride(278605-15-5 free base) |
Hydroxylase
|
|
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selectively and reversibly the b... |
|
T1848 |
Dynasore
|
Dynamin Inhibitor I |
Dynamin
,
Virus Protease
,
Autophagy
,
HSV
|
|
Dynasore (Dynamin Inhibitor I), a cell-permeable chemical, can reversibly and non-competitivity inhibit GTPase activity of dynamin 1/2 (IC50: 15 μM in a cell-free assay). It also inhibits the mitochondrial dynamin Drp1, ... |
|
T6651 |
Safinamide mesylate
|
PNU-151774E,FCE28073,PNU-151774E,NW-1015,EMD 1195686 mesylate |
MAO
,
Monoamine Oxidase
|
|
Safinamide mesylate (EMD 1195686 mesylate) , a mesylate salt of Safinamide, can reversibly and specifically inhibit MAO-B (IC50: 98 nM), has 5918-fold selectivity against MAO-A. |
|
T6645 |
Ropivacaine hydrochloride monohydrate
|
Ropivacaine HCl,Ropivacaine HCl monohydrate,LEA 103,LEA-103 HCl |
Potassium Channel
,
Sodium Channel
|
|
Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly. |
|
T3689 |
Ruboxistaurin hydrochloride
|
Ruboxistaurin,LY333531 HCl,LY 333531 hydrochloride |
PKC
|
|
Ruboxistaurin hydrochloride (LY 333531 hydrochloride) is an Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Sel... |
|
T3637 |
Pifithrin-β hydrobromide
|
Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide) |
Ferroptosis
,
p53
|
|
Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorder... |
|
T8799 |
(E/Z)-IT-603
|
IT603 |
Others
,
NF-κB
|
|
(E/Z)-IT-603 is a cell-permeable c-Rel inhibitor (IC50: 3μM). IT-603 directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding and transcriptional activity. |
|
T0030 |
Bupivacaine hydrochloride
|
Vivacaine,Bupivacaine HCl |
Sodium Channel
|
|
Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the vol... |
|
T0018 |
Procainamide hydrochloride
|
Procapan,Procainamide HCl,Pronestyl,Procanbid |
DNA Methyltransferase
,
Sodium Channel
,
AChR
,
Autophagy
|
|
Procainamide Hydrochloride (Procapan) is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to... |
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T2064 |
Semaxinib
|
SU5416 |
VEGFR
|
|
Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR than PDGFRβ, lack of activity against InsR, EGFR, and FGFR. Semaxanib reversibly inhibits ATP binding to the... |
|
T12908 |
SIBA
|
5'-Deoxy-5'-isobutylthioadenosine,5'-Isobutylthioadenosine |
Nucleoside Antimetabolite/Analog
,
HSV
|
|
SIBA (5'-Deoxy-5'-isobutylthioadenosine) is a synthetic analogue of SAH, acts as an inhibitor of S-adenosylmethionine-mediated transmethylation. SIBA can interfere with a variety of enzymatic activities in vitro, such as... |
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T39463 |
Asundexian
|
BAY 2433334,Asundexian,BAY2433334,BAY-2433334 |
Factor Xa
|
|
Asundexian (BAY-2433334) is a potent and orally active inhibitor of the coagulation factor FXIa that directly and reversibly binds to the active site of FXIa, thereby inhibiting its activity.Asundexian has an IC50 of 1 n... |
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T15411 |
GPNA hydrochloride
|
|
Apoptosis
,
Others
|
|
GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT).... |
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T15183 |
Dynarrestin
|
|
Hedgehog/Smoothened
|
|
Dynarrestin is an inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells. It inhibits dynein 1-driven microtubule gliding in vitro pl... |
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T40652 |
Meclizine
|
Meclozine |
Histamine Receptor
|
|
Meclizine, also known as Meclozine, is a piperazine class H1 antagonist with antihistamine properties that inhibits the interaction of histamine at H1 receptors reversibly. It serves as an effective anti-motion sickness ... |
|
T3979 |
Emedastine
|
LY188695,Emadine |
Histamine Receptor
|
|
Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its... |
|
T4391 |
Syk Inhibitor II dihydrochloride
|
Syk Inhibitor II (hydrochloride) |
Others
,
Tyrosine Kinases
,
Syk
,
PKC
,
BTK
|
|
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet fun... |
|
T36816 |
S-trityl-L-Cysteine
|
STLC |
Kinesin
|
|
S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in ... |
|
T3226 |
Paritaprevir free base
|
ABT-450,Veruprevir |
HCV Protease
|
|
Paritaprevir free base(ABT-450) is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with potential acti... |
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T22405 |
Pravastatin
|
|
Others
|
|
Pravastatin is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins. |
|
T19181 |
Afegostat
|
D-Isofagomine,Isofagomine |
Others
|
|
|
|
T16327 |
Nitracrine
|
|
Others
|
|
Nitracrine is a 1-nitroacridine derivative and is an effective hypoxia-selective agent in vitro and antitumor drugs. Nitracrine suppresses RNA synthesis and covalently, reversibly binds to DNA but also forms covalent add... |
|
T20660 |
Revaprazan
|
SB-641257,SB 641257,SB641257 |
|
|
Revaprazan is a novel, selective potassium-competitive acid blocker, to be specific, it reversibly inhibits gastric H(+)/K(+)-ATPase and shows effective acid suppression comparable to PPIs. |
|
T19182 |
Afegostat D-Tartrate
|
Isofagomine D-Tartrate,D-Isofagomine D-Tartrate |
Others
|
|
|
|
T20694 |
DIDS
|
|
|
|
DIDS, an anion exchange inhibitor, acts by blocking reversibly and later irreversibly, exchangers such as chloride-bicarbonate exchanger. It is also a RAD51 inhibitor. |
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T39223 |
Milvexian
|
JNJ-70033093,BMS-986177 |
|
|
Milvexian (BMS-986177) is a potent antithrombotic compound that inhibits human and rabbit factor XIa (FXIa) directly and reversibly. It is orally-bioavailable and exhibits a K i of 0.11 nM and 0.38 nM against human and r... |
|
T28223 |
OB-1
|
|
|
|
OB-1 is an inhibitor of stomatin-like protein-3 (STOML3) oligomerization. OB-1 reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo. |
|
T21464 |
Methiocarb
|
Mercaptodimethur,Mesurol |
|
|
Methiocarb, a carbamate pesticide, is used as an insecticide, acaricide, bird repellent, and molluscicide. Methiocarb stimulates cholinergic by inhibiting reversibly acetylcholinesterase activity, making methiocarb a pot... |
|
T28224 |
OB-2
|
|
|
|
OB-2 is an inhibitor of stomatin-like protein-3 (STOML3) oligomerization. OB-2 reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo. |
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T73536 |
QM295
|
|
|
|
QM295 is a selective, reversibly reactive thiol inhibitor of endoplasmic reticulum oxidation 1 (ERO1), utilized in research related to endoplasmic reticulum stress. |
|
T16112 |
ML67-33
|
|
HIV Protease
|
|
ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. |
|
T0378L |
Oxybuprocaine
|
Butoxyprocaine,BNX,Benoxinate,Novescine,Novesin |
|
|
Oxybuprocaine is an ester-type local anesthetic that is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its perm... |
|
T28227 |
Oe-9000
|
Oe 9000 |
|
|
Oe-9000 is a blocker of voltage-gated Na(+) currents in neurons. It reversibly reduces rapidly activating and inactivating TTX-sensitive (TTX-S) Na(+) currents as well as slowly activating and inactivating tetrodotoxin-r... |
|
TP1902 |
G-Protein antagonist peptide
|
|
|
|
Substance P-related peptide that inhibits binding of G proteins to their receptors. Competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors. |
|
TP2062 |
ω-Conotoxin GVIA
|
|
|
|
Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo. |
|
T38004 |
ML-309 (hydrochloride)
|
|
|
|
ML-309 is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). It reversibly and selective inhibits IDH1R132H over wild-type IDH1 (IC50s = 96 and 36,500 nM, respectively). ML-309 reduces 2-hydroxyglutarate productio... |
|
TP1968 |
ProTx-I
|
ProTx I |
|
|
Selective CaV3.1 channel blocker (IC50 values are 0.2 and 31.8 μM for hCaV3.1 and hCaV3.2 respectively). Also reversibly inhibits NaV1.8 and blocks KV2.1 channels. |
