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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T40659L | γ-Acetylenic GABA hydrochloride | γ-Acetylenic GABA hydrochloride(57659-38-8 Free base) | Transaminase , GABA Receptor |
γ-Acetylenic GABA hydrochloride is a GABA transaminase inhibitor. | |||
T17649 | Boc-GABA-OH | Others , PROTAC Linker | |
Boc-GABA-OH serves as a PROTAC linker essential for synthesizing UNC6852, an EED-targeted PROTAC[1]. | |||
T40659 | γ-Acetylenic GABA | 4-Aminohex-5-ynoic acid,γ-Acetylenic GABA | |
γ-Acetylenic GABA (4-Aminohex-5-ynoic acid) is a potent, irreversible inhibitor of GABA-transaminase. This compound effectively raises the concentration of γ-Aminobutyric acid (GABA) in the brain of rats. | |||
T21409 | GABOB (beta-hydroxy-GABA) | β-hydroxy-GABA,beta-hydroxy-GABA,GABOB | |
GABOB is an anticonvulsant used to treat epilepsy. GABOB is an endogenous active metabolite, it is analogue to the neurotransmitter γ-aminobutyric acid (GABA), therefore may function as a neurotransmitter. | |||
T3290 | Pikamilone | Picamilon,Nicotinoyl-GABA | Others |
Pikamilone (Picamilon) is an intelligent medicine. | |||
T23277 | RuBi-GABA | Others | |
Ruthenium-bipyridine-triphenylphosphine caged GABA | |||
T23276 | RuBi GABA trimethylphosphine | Others | |
GABAB receptor agonist | |||
T22509 | 3-Methyl-GABA | Others | |
3-Methyl-GABA, an anticonvulsant agent [1] [2], acts as a potent activator of GABA aminotransferase, fits the binding pocket of the GABA A receptor (GABAaR), and activates L-glutamic acid decarboxylase (GAD). | |||
T0028 | Gamibetal | 3-Hydroxy-GABA,4-Amino-3-hydroxybutyric Acid | HIV Protease |
Gamibetal (4-Amino-3-hydroxybutyric Acid) is used as a chiral reagent in the synthesis of antiepileptic and hypotensive drug GABOB and analogues. Also used in the preparation of HIV-1 inhibitors derived from Betulinic Ac... | |||
T22364 | Methyl 4-aminobutyrate HCl | Methyl 4-aminobutyrate hydrochloride,GABA methyl ester | Others |
Methyl 4-aminobutyrate HCl (GABA methyl ester) is a methyl ester compound derived from the condensation of aminobutyric acid and methanol. | |||
T82356 | GABA-IN-1 | ||
GABA-IN-1 (Compound 6), a GABA inhibitor, exhibits larvicidal and insecticidal properties, achieving a mortality rate of 93% at a concentration of 50 mg/L [1]. | |||
T82355 | GABA-IN-2 | ||
GABA-IN-2 (Compound 5), a GABA inhibitor, exhibits both larvicidal and insecticidal properties, achieving an 87% mortality rate at a concentration of 50 mg/L [1]. | |||
T62185 | GABA-AT-IN-1 | ||
GABA-AT-IN-1 (Compound 6) is an inhibitor of γ-aminobutyric acid transaminase (GABA-AT) that crosses the blood-brain barrier. | |||
T82357 | GABA receptor Antagonist 1 | GABA Receptor | |
GABA receptor Antagonist 1 (compound 7w) effectively inhibits the Px RDL1 GABAR at an IC50 of 7.08 nmol/L and demonstrates insecticidal efficacy against P. xylostella, S. frugiperda, S. exigua, and S. litura with respect... | |||
T3290L | Pikamilone Sodium | GABA-NG,Nicotinoyl-GABA sodium salt,GABA NG,GABANG,Pikamilone Na | |
Pikamilone Sodium is a prodrug of GABA used for therapy of neurogenic bladder in spinal and benign prostatic hyperplasia. | |||
T0128L | Vigabatrin Hydrochloride | γ-Vinyl-GABA hydrochloride | GABA Receptor |
Vigabatrin Hydrochloride (γ-Vinyl-GABA hydrochloride) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), which irreversibly inhibits the catabolism of GABA by GABA transaminase. | |||
T4176 | Rac-BHFF | (R,S)-BHFF | GABA Receptor |
rac-BHFF ((R,S)-BHFF) is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). It exhibits anxiolytic activity in vivo an... | |||
T1065 | Baclofen | Lioresal | GABA Receptor |
Baclofen (Lioresal) is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist sp... | |||
T14571 | Bifenazate | GABA Receptor | |
Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm[1] and it also is a positive allosteric modulator of GABA receptor[2]. | |||
T4440 | Saclofen | GABA Receptor | |
Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50: 7.8 μM).1 This compound can be used to determine the function... | |||
T10618 | Broflanilide | GABA Receptor | |
Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR (IC50: 1.3 nM). | |||
TQ0023 | Lorediplon | GABA Receptor | |
Lorediplon is a novel hypnotic drug acting as a GABAA receptor modulator, differentially active at the α1-subunit, associated with promoting sleep. | |||
T7794 | Zuranolone | GABA Receptor | |
Zuranolone is an agonist of GABAA receptor. | |||
T15775 | Lotilaner | GABA Receptor , Parasite | |
Lotilaner is a parasiticide. It is used as a potent non-competitive antagonist of insects GABACl receptors (IC50 of 23.84 nM for Drosophila melanogaster GABA receptor). It also has no effect on a dog GABAA receptor. | |||
T26834 | BL-1020 Mesylate | CYP-1020 Mesylate | Dopamine Receptor , GABA Receptor |
BL-1020 Mesylate (CYP-1020 Mesylate) is an orally available GABA A receptor agonist and D2 antagonist that decreases dopamine activity and enhances GABAA activity.BL-1020 Mesylate has been used in the study of schizophre... | |||
T16539 | Piperazine citrate | GABA Receptor | |
Piperazine citrate, an organic compound, consists of a six-membered ring, containing two nitrogen atoms at opposite positions in the ring. It used as an Anthelmintic. | |||
T5375 | Loreclezole | GABA Receptor | |
Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors. | |||
T8630 | Baclofen hydrochloride | 4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride | GABA Receptor |
Baclofen hydrochloride (4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride) is a GAMMA-AMINOBUTYRIC ACID derivative that is a specific GABA-B RECEPTORS agonist. It is used in the treatment of MUSCLE SPASTICITY, espe... | |||
T26600 | Alpidem | Ananxyl | GABA Receptor |
Alpidem (Ananxyl) is an anxiolytic drug from the imidazopyridine family. Alpidem does not produce sedative effects at normal doses, and is instead used specifically for the treatment of anxiety. Alpidem has nanomolar bin... | |||
T11822 | LAU159 | GABA Receptor | |
LAU159 is a functionally selective positive α1β3 GABA(A) receptor modulator(EC50 : 2.2 μM). | |||
T9424 | Temgicoluril | Tetramethylglycoluril,mebikar | GABA Receptor |
Temgicoluril (mebikar) acts on GABA Receptor. | |||
T7136 | AZD-6280 | GABA Receptor | |
AZD6280 is a novel, subtype-selective GABAAα2/3 receptor positive modulators, used for treatment of generalized anxiety disorder. | |||
T3644 | U93631 | GABA Receptor | |
GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude... | |||
T8572 | CL 218872 | GABA Receptor | |
CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptor... | |||
T17144 | TPA 023 | GABA Receptor | |
TPA 023 is an agonist of the GABAA α2/α3 subtype-selective (Ki: 0.19-0.41 nM). | |||
T7622 | Gabazine | SR95531 | GABA Receptor |
Gabazine (SR95531) is an antagonist of GABAA receptors (Ki : 74-150 nM) | |||
T0715 | Chlormezanone | Trancopal | Others , GABA Receptor |
Chlormezanone (Trancopal) is a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. | |||
T3173 | DAA-1106 | DAA1106 | Others , GABA Receptor |
DAA-1106 is a potent and selective ligand for peripheral benzodiazepine receptor (PBR), acting as a potent and selective agonist at the peripheral benzodiazepine receptor. | |||
T36520 | COR659 | Cannabinoid Receptor , GABA Receptor | |
COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effects via a composite mechanism, including positive allosteri... | |||
T1240 | Flumazenil | Ro 15-1788 | GABA Receptor |
Flumazenil (Ro 15-1788) antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel openi... | |||
T2196 | Fipronil | Fluocyanobenpyrazole,Termidor | P450 , GluCls , GABA Receptor |
Fipronil (Fluocyanobenpyrazole) is a broad-use insecticide that belongs to the phenylpyrazole chemical family. Fipronil is a broad-spectrum insecticide that disrupts the insect central nervous system by blocking GABA-gat... | |||
T13536 | Afoxolaner | Chloride channel , GABA Receptor , Parasite | |
Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting i... | |||
T11349 | GABAA receptor agent 1 | GABA Receptor | |
GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor. | |||
T1128 | Oxiracetam | ISF2522 | GABA Receptor |
Oxiracetam (ISF2522), a cyclic derivative of gamma-aminobutyric acid (GABA), is utilized for the treatment of cognitive impairments. | |||
T8887 | 2'MeO6MF | GABA Receptor | |
2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors.It offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response... | |||
T23104 | Ocinaplon | DOV 273547 | GABA Receptor |
Ocinaplon (DOV 273547) is a GABAA receptors modulator. | |||
TQ0040 | ONO-8590580 | CS-2894 | GABA Receptor |
ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5. | |||
T21793 | CGP 35348 | GABA Receptor | |
CGP 35348 is a selective antagonist of GABAB receptor (EC50 = 34 μM). CGP 35348 can be used in studies of neuromuscular coordination and spatial learning after neonatal brain damage in albino mice. | |||
T11684 | Isoguvacine hydrochloride | 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride | GABA Receptor |
Isoguvacine hydrochloride (1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride) is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2... | |||
T2067 | NS11394 | NS 11394 | GABA Receptor |
NS11394 is a effective and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of α(5) > α(3) > α(2) > α(1) at GABA(A) alpha subunit-containing receptors. |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T4728 | 4-Acetamidobutanoic acid | N-acetyl GABA,4-ACETAMIDOBUTYRIC ACID | GABA Receptor , Endogenous Metabolite , Antibacterial |
4-Acetamidobutanoic acid (4-ACETAMIDOBUTYRIC ACID) can be found in blood, feces, and urine, as well as in human prostate tissue. 4-Acetamidobutanoic acid exists in all eukaryotes, ranging from yeast to humans. 4-Acetamid... | |||
T0508 | γ-Aminobutyric acid | Gamma-aminobutyric acid,4-Aminobutyric acid,GABA,4-Aminobutanoic acid,Piperidic acid | GABA Receptor , Endogenous Metabolite |
γ-Aminobutyric acid (4-Aminobutyric acid) is the most common inhibitory neurotransmitter in the central nervous system. | |||
TN1023 | Miltirone | P450 , GABA Receptor | |
Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central benzodiazepine receptors. | |||
TQ0119 | Cirsimaritin | GABA Receptor | |
T5754 | Kavain | NF-κB , GABA Receptor | |
Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of transcriptional factors such as NF-kB and LITAF. | |||
T7557 | Guvacine hydrochloride | GABA Receptor | |
Guvacine hydrochloride is an inhibits of GABA uptake (IC50 : 10 μM) | |||
T3782 | Jujuboside A | transporter , GABA Receptor | |
Jujuboside A is a glycoside extracted from Semen Ziziphi Spinosae, having neurophysiological inhibitory effects, used as a potential therapeutic agent for the treatment of Alzheimer s disease. | |||
T8036 | 6-Methylflavone | GABA Receptor | |
6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. | |||
T3S2100 | (-)-Securinine | Securinine | GABA Receptor |
(-)-Securinine (Securinine) is plant-derived alkaloid and also a GABAA receptor antagonist. | |||
T5799 | Arecaidine hydrochloride | Others | |
Arecaidine hydrochloride may have carcinogenesis. | |||
TN1217 | 2'-O-Methylisoliquiritigenin | Dopamine Receptor , 5-HT Receptor , GABA Receptor | |
2'-O-Methylisoliquiritigenin, a compound synthesized by enzymes specifically induced in NR.2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA and GABA pathways, but does not put a ... | |||
T2979 | DL-Menthol | Hexahydrothymol,(±)-Menthol | GABA Receptor , AChE |
DL-Menthol ((±)-Menthol) is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (+)-menthol in nature and exhibits analgesic, anti... | |||
T2749 | Ginkgolide A | BN-52020 | GABA Receptor , Endogenous Metabolite |
Ginkgolide A (BN-52020) is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and immunological disorders. | |||
T8268 | 6,2'-Dihydroxyflavone | GABA Receptor | |
6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor. | |||
T2850 | Bicuculline | (+)-Bicuculline,d-Bicuculline | GABA Receptor |
Bicuculline ((+)-Bicuculline) is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungos... | |||
T1396 | Bemegride | Bemegrid,3-Ethyl-3-methylglutarimide,Agipnon | GABA Receptor |
Bemegride (3-Ethyl-3-methylglutarimide), a central nervous system stimulant, serves as an antidote for barbiturate poisoning. | |||
T3698 | Alpha-Asarone | α-Asarone,trans-Asarone | P450 , GABA Receptor , HMG-CoA Reductase |
alpha-Asarone (trans-Asarone) is a psychoactive compound with antidepressant-like activity in mice. | |||
T2720 | Ginsenoside Rc | Panaxoside Rc | Others , TNF , GABA Receptor , Interleukin |
Ginsenoside Rc (Panaxoside Rc) is one of the ginsenosides from Panax ginseng, inhibits the expression of TNF-α and IL-1β. | |||
TMS0418 | Dihydroergotoxine mesylate | Ergoloid mesylates | GABA Receptor |
Dihydroergotoxine mesylate (Ergoloid mesylates) is mainly used to improve symptoms and physical symptoms of mental degeneration related to aging. | |||
T5S1882 | Songorine | Napellonine,Zongorine,Bullatine G | Others , GABA Receptor |
Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays. | |||
TN1202 | (-)-α-Pinene | (1S)-(-)-Alpha-Pinene | Virus Protease , GABA Receptor , Endogenous Metabolite , Antibacterial |
(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directl... | |||
T4590 | (+)-Kavain | Kavain,L-KAWAIN,(R)-KAWAIN | Calcium Channel , GABA Receptor , Sodium Channel , Monoamine Transporter |
(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B. | |||
TN1325 | (2S)-6-Prenylnaringenin | 6-Prenylnaringenin,6-PN | GABA Receptor |
(2S)-6-Prenylnaringenin (6-Prenylnaringenin) is an isomer of the potent phytoestrogen, 8-prenylnaringenin. (2S)-6-Prenylnaringenin is the most potent compound in the forebrain and acts as a positive allosteric modulator ... | |||
T7595 | L-DABA | L-2,4-Diaminobutyric acid,L-DAB HBR | GABA Receptor , Endogenous Metabolite |
L-DABA (L-2,4-Diaminobutyric acid) is an inhibitor of GABA transaminase (IC50 > 500 μM). | |||
T8040 | Cholesterol myristate | Cholesteryl myristate,Cholesteryl tetradecanoate | Others , Potassium Channel , GABA Receptor , Endogenous Metabolite , AChR |
Cholesterol Myristate (Cholesteryl Myristate) is a natural steroid found in traditional Chinese medicine that interacts with various ion channels, including the GABAA receptor, nicotinic acetylcholine receptor, and the i... | |||
T2983 | 3,4,5-Trimethoxycinnamic acid | 3-(3,4,5-Trimethoxyphenyl)acrylic Acid,O-Methylsinapic acid | GABA Receptor , Endogenous Metabolite |
3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex. | |||
T0710 | L-Cycloserine | Levcycloserine,Levcicloserina,(-)-Cycloserine,(S)-Cycloserine,Levcycloserinum,(S)-4-Amino-3-isoxazolidone | HIV Protease , GABA Receptor |
L-Cycloserine ((-)-Cycloserine) irreversibly inhibits GABA pyridoxal 5′-phosphate-dependent aminotransferase in E. coli, as well in the brains of various animals, results in increased levels of gamma-aminobutyric acid (G... | |||
T8193 | α-Thujone | Thujone,ALPHA-(-)-THUJONE | Apoptosis , Reactive Oxygen Species , GABA Receptor , AChR , Parasite , Autophagy |
α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM. | |||
T2S1814 | P-Hydroxybenzaldehyde | 4-Formylphenol,4-hydroxybenzaldehyde,p-Oxybenzaldehyde | Transaminase , GABA Receptor , Endogenous Metabolite |
1. p-Hydroxybenzaldehyde (p-Oxybenzaldehyde) shows an inhibitory effect on the GABA transaminase to contribute to an antiepileptic and anticonvulsive activity, and its inhibitory activity was higher than that of valproic... | |||
T2S1464 | Thiocolchicoside | Thiocolchicine 2-glucoside analog,Coltramyl | Others , GABA Receptor |
Thiocolchicoside (Thiocolchicine 2-glucoside analog) (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine rece... | |||
T3417 | Amentoflavone | Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin | Apoptosis , P450 , Phospholipase , Reactive Oxygen Species , Opioid Receptor , COX , Antibacterial , RSV , Antifungal |
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhib... | |||
TJS0123 | Guvacine ethyl ester | PT00442-2 | Others |
Guvacine ethyl ester (Arecoline) is an alkaloid found in betel nut that is used in the synthesis of GABA uptake inhibitors. | |||
TN2865 | (E)-3,4,5-Trimethoxycinnamic acid | O-Methylsinapic acid,3,4,5-Trimethoxy-trans-cinnamic acid,3,4,5-Trimethoxyphenylacrylic acid | Others |
(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) is a natural product from the roots and rhizomes of Notopterygium incisum. | |||
T5734 | (+)-BORNEOL | d-Borneol | GABA Receptor |
(+)-BORNEOL (d-Borneol) is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM. | |||
T3741 | (-)-borneol | L-Borneol | GABA Receptor |
(-)-borneol (L-Borneol) has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM. | |||
TN3174 | 6-Methoxyflavanone | NSC50184 | GABA Receptor |
6-Methoxyflavanone (6-MeOF) is A positive allosteric modulator of the GABA response of human recombinant GABA A receptor, with antianxiety and anti-inflammatory activity, and can be used to reduce cisplatin induced neuro... | |||
T5776 | Pimpinellin | Apoptosis , Anti-infection | |
Pimpinellin is a natural product that acts as antagonist of proteins with GABA receptor activity. | |||
T0627 | β-Alanine | beta-Alanine,3-Aminopropanoic acid,2-Carboxyethylamine | GABA Receptor , Endogenous Metabolite |
β-Alanine (3-Aminopropanoic acid) is a naturally occurring beta amino acid formed in vivo by the degradation of dihydrouracil and carnosine. It acts as a neurotransmitter by activating glycine and GABA receptors. | |||
T39359 | γ-Glu-Gly | gamma-Glutamylglycine | Amino Acids and Derivatives |
γ-Glu-Gly (gamma-Glutamylglycine), a γ-glutamyl dipeptide, is a human lipid metabolite with a structure resembling that of GABA (γ-aminobutyric acid). It functions as an antagonist of excitatory amino acids. | |||
T0883 | Tramiprosate | Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed | Beta Amyloid , GABA Receptor |
Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble Aβ and maintains it in a non-protofibrillar form.It is a GAB... | |||
TN1308 | 6-Hydroxyflavanone | Others , Lipoxygenase , COX , GABA Receptor | |
6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A r... | |||
T4814 | (R)-5-Oxopyrrolidine-2-carboxylic acid | D-Pyroglutamic acid,(R)-(+)-2-Pyrrolidone-5-carboxylic acid | Others , Endogenous Metabolite |
(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of glutamic acid, physiologically present in mammalian tissues. It has been shown that PCA releases GABA from the cerebral cortex and di... | |||
T3578 | Pyridoxal phosphate | PLP,PAL-P,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate | Reverse Transcriptase , Endogenous Metabolite |
Pyridoxal phosphate (Vitamin B6 phosphate) is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and d... | |||
T4881 | Phosphorylethanolamine | O-Phosphorylethanolamine | Others , Endogenous Metabolite |
Phosphorylethanolamine (O-Phosphorylethanolamine) is a phosphomonoester metabolite of the phospholipid metabolism. Phosphorylethanolamine is a precursor of phospholipid synthesis and a product of phospholipid breakdown. ... | |||
T5089 | 5-Aminovaleric acid | Others , Endogenous Metabolite | |
5-aminovalerate (or 5-aminopentanoic acid) is a lysine degradation product. It can be produced both endogenously or through bacterial catabolism of lysine. 5-aminovalerate is formed via the following multi-step reaction:... | |||
T3S2259 | Methyl eugenol | 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether | GABA Receptor |
1. Methyl eugenol (4-allylveratrole) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carcinogenic potential of ME, the need to check its... | |||
TN3702 | (-)-Corlumine | GABA Receptor | |
Corlumine exhibits spasmolytic and GABA antagonist activity. | |||
TN1717 | Guvacine | GABA Receptor | |
Guvacine can enhance the inhibition of spinal neurones by GABA. | |||
T80014 | Guvacine hydrobromide | GABA Receptor | |
Guvacine hydrobromide, an alkaloid derived from the Areca catechu nut, serves as a potent inhibitor of GABA (GABA uptakp) uptake. It effectively inhibits rat GABA transporter isoforms GAT-1, GAT-2, and GAT-3, with respec... | |||
TN4298 | Isohyenanchin | GABA Receptor | |
Isohyenanchin is the potent antagonist of RDLac homo-oligomers, it is also a weak antagonist of ionotropic GABA receptors. | |||
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カタログ番号 | 製品名 | Species | Expression System |
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TMPH-00857 | ABAT Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli |
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. ABAT Protein, Hu... | |||
TMPY-00587 | GABARAP Protein, Human, Recombinant (His & MBP) | Human | E. coli |
The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). GABARAP in tumorigenesis in... | |||
TMPJ-00016 | GABARAP Protein, Human, Recombinant (GST) | Human | E. coli |
GABARAP Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 37 KDa and the accession number is Q6IAW1. | |||
TMPJ-00015 | GABARAP Protein, Human, Recombinant (His & hFc) | Human | E. coli |
GABARAP Protein, Human, Recombinant (His & hFc) is expressed in E. coli expression system with N-6xHis and C-Fc tag. The predicted molecular weight is 50 KDa and the accession number is Q6IAW1. | |||
TMPY-03268 | GABARAPL1 Protein, Human, Recombinant (His) | Human | E. coli |
ATG8, also known as GABARAPL1, is a ubiquitin-like protein that has a crystal structure. ATG8 consists of a 5-stranded β-sheet, which is enclosed by two α-helices at one side and one α-helix at the other side and exhibit... | |||
TMPY-03461 | GABARAPL2 Protein, Human, Recombinant (His) | Human | E. coli |
GATE-16, also known as ATG8, belongs to the MAP1 LC3 family. It is expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. GATE-16 is expressed at very low levels in lung, thymus and... | |||
TMPY-03991 | DBI Protein, Human, Recombinant (His) | Human | E. coli |
The diazepam binding inhibitor (DBI), alternatively known as the acyl-CoA binding protein (ACBP), is involved in multiple biological actions. The polypeptide binds to the peripheral, or mitochondrial, benzodiazepine rece... | |||
TMPH-01368 | GABRP Protein, Human, Recombinant (His) | Human | E. coli |
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of th... | |||
TMPH-02149 | ALDH5A1 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). | |||
TMPH-02492 | DBI Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site lo... | |||
TMPH-00890 | DBI Protein, Human, Recombinant (aa 2-104, His) | Human | E. coli |
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site lo... | |||
TMPH-03235 | DBI Protein, Rat, Recombinant (His & Myc) | Rat | E. coli |
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site lo... | |||
TMPY-00186 | GHRH Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
The role of hypothalamic growth hormone-releasing hormone (GHRH) in the release of growth hormone (GH) from the pituitary is well established. Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important... | |||
TMPH-02564 | CARNMT1 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of ... | |||
TMPH-00627 | GAD-alpha Protein, E. coli, Recombinant (His) | E. coli | E. coli |
Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions... | |||
TMPK-01233 | LAMP5 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesi... | |||
TMPK-01161 | LAMP5 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesi... | |||
TMPY-02091 | GAD67 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Glutamate decarboxylase 1, also known as 67 kDa glutamic acid decarboxylase, Glutamate decarboxylase 67 kDa isoform and GAD1, is a member of thegroup II decarboxylase family. GAD1 is expressed in benign and malignant ... | |||
TMPK-00659 | LAMP5 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesi... | |||
TMPK-01234 | LAMP5 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesi... | |||
TMPH-03037 | Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc) | Naja kaouthia | E. coli |
Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=... | |||
TMPY-00286 | Neuropeptide Y Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
NPY (Neuropeptide Y) is a Protein Coding gene. This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress ... | |||
TMPH-01248 | ADAR Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translatio... |
カタログ番号 | 製品名 | ||
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L2610 | Neurotransmitter Receptor Compound Library | 1513 compounds | |
A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening; |