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T72322 |
R 59-022 hydrochloride
|
DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride |
5-HT Receptor
,
PKC
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R 59-022 hydrochloride (DKGI-I hydrochloride) is a 5-HT Receptor antagonist that activates protein kinase C (PKC).R 59-022 hydrochloride is a DGK inhibitor (IC50:2.8 µM) that inhibits the phosphorylation of OAG to OAPA.R... |
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T16709 |
R 59-022
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Diacylglycerol kinase inhibitor I,DKGI-I |
Others
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R 59-022 is a 5-HTR antagonist and activates protein kinase C (PKC). R 59-022 is a diacylglycerol kinase inhibitor (IC50=2.8 μM). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits ... |
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T8476 |
RSVA405
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RSVA 405 |
AMPK
,
STAT
,
Autophagy
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RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor |
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T6547 |
Ipratropium Bromide
|
Sch 1000,Itrop,Atrovent |
AChR
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Ipratropium Bromide (Sch 1000) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema. |
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T19930 |
Nitrosoglutathione
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S-Nitrosoglutathione,SNOG,Glutathione thionitrite,GSNO |
RAAS
,
NO Synthase
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Nitrosoglutathione (GSNO) is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, i... |
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T0098 |
Ipratropium bromide monohydrate
|
Ipratropium bromide hydrate |
AChR
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Ipratropium bromide monohydrate (Ipratropium bromide hydrate) is a muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial... |
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TD0001 |
SYBR GREEN 1
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SYBR(R) GREEN I NUCLEIC ACID GEL STAIN *10,000× concentrate in DMSO |
Others
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SYBR Green I is an asymmetrical cyanine dye, which is used to detect nucleic acids. It consists of a N-alkylated benzothiazolium or benzoxazolium ring system, that is joined by a monomethine bridge to a pyridinium or qui... |
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T16708 |
R-268712
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|
ALK
,
TGF-beta/Smad
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R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor. |
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T27335 |
Floctafenine
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RU 15750,R-4318,R 4318,RU-15750,R4318 |
COX
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Floctafenine (R-4318) is an orally available nonsteroidal anti-inflammatory compound that is a COX-I and COX-2 inhibitor and interferes with the antiplatelet effects of aspirin.Floctafenine has analgesic activity and is ... |
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T4191 |
Multi-kinase inhibitor 1
|
Multi-kinase inhibitor I |
Others
,
Bcr-Abl
,
PDGFR
,
c-Kit
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Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor. |
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T30981 |
Clometocillin
|
Penicilline 356 |
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Clometocillin is a penicillin that can active penicillin to pen-I or pen-R pneumococci. |
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T15672 |
KU14R
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|
Others
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KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines. |
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T33451 |
ML 7
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ML7,ML-7 |
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ML 7 is an inhibitor of myosin light chain kinase that protects cardiac function from ischemia/reperfusion (I/R) injury. |
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T61491 |
(R)-ND-336
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|
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(R)-ND-336 is a highly potent and selective MMP-9 inhibitor, displaying a K i value of 19 nM. It also exhibits inhibitory activity against MMP-2 (K i = 127 nM) and MMP-14 (K i =119 nM). With its significant potential, (R... |
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T22140 |
(R)-SLV 319
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|
|
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(R)-SLV 319 is a potent and selective antagonist of cannabinoid receptor 1 (CB1), with a K i value of 894 nM. (R)-SLV 319 is a dextrorotatory counterpart of SLV 319 [1] |
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T61980 |
Carbonic anhydrase inhibitor 8
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|
|
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Carbonic anhydrase inhibitor 8 (compound R-13) is a potent human carbonic anhydrase (hCA). Carbonic anhydrase inhibitor 8 shows K i values of 60.7 nM, 320.7 nM, 2298 nM for hCA I, hCA II, hCA IV, respectively. |
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T39795 |
Tricarbonyldichlororuthenium(II) dimer
|
CORM-2 |
|
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Tricarbonyldichlororuthenium(II) dimer, a pharmacological CO donor, prevents ischemia/reperfusion (I/R)-induced oxidative damage to the gastric mucosa by enhancing gastric blood flow (GBF) and reducing DNA oxidation and ... |
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T39870 |
5-HT7R antagonist 1 free base
|
5-HT7R antagonist 1 free base |
|
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5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM. |
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T61982 |
Human carbonic anhydrase II-IN-2
|
|
|
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Human carbonic anhydrase II-IN-24 (Compound R-13) is a potent human carbonic anhydrase (hCA) inhibitor. Human carbonic anhydrase II-IN-24 shows K i s of 60.7, 320.7, 2298, and 35.2 nM for hCA I, II, IV and IX, respective... |
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T74723 |
MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan
|
|
|
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MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan is an agent-linker conjugate for antibody-drug conjugates (ADCs), incorporating Exatecan, a DNA Topoisomerase I inhibitor (IC 50 = 2.2 μM) [1]. |
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T71001 |
GSK-598809
|
|
|
|
GSK598809 is a selective D(3)R antagonist recently progressed in Phase I trials. GSK-598809 may decrease the rewarding effects of contextual cues associated with drug intake preclinically, which may reduce drug craving i... |
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T74331 |
HCAII-IN-7
|
|
|
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Compound R-13, also known as hCAII-IN-7, is a powerful inhibitor of human carbonic anhydrase (hCA), exhibiting inhibition constants (Ki) of 60.7 nM for hCA I, 320.7 nM for hCA II, 2298 nM for hCA IV, and 35.2 nM for hCA ... |
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T37680 |
3-hydroxy Palmitic Acid methyl ester
|
|
|
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3-hydroxy Palmitic acid methyl ester (3-hydroxy PAME) is an esterized long-chain fatty acid involved in quorum sensing in R. solanacearum, a bacteria that causes lethal wilting in plants. 3-hydroxy-PAME (175 nM) increase... |
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T83043 |
Anti-MI/R injury agent 1
|
|
|
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Anti-MI/R injury agent 1 (compound 18), derived from Panaxatriol, represents an orally administered, potent agent against myocardial ischemia/reperfusion (MI/R) injury. It improves cell viability in cardiomyocytes subjec... |
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T81267 |
RIPK3-IN-4
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|
RIP kinase
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RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor that mitigates necroptosis, inflammatory responses, and HK-2 cell damage. It alleviates acute kidney injury by attenuating Cisplatin- and I/R-induced kidney damage, along wit... |
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T74724 |
MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan
|
|
|
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MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan is a agent-linker conjugates for ADC , consisting Exatecan . Exatecan is a DNA Topoisomerase I inhibitor (IC 50 =2.2 μM) [1] . |
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T76223 |
NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal)
|
|
|
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Compound 39 (NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal)) is a potent agonist of the APJ receptor, possessing a K i value of 0.6 nM. It is capable of activating Gαi1, with an EC 50 of 0.8 nM, and of recruiting β-arrestin2, with an E... |
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T80138 |
(D-Arg8)-Inotocin
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|
Vasopressin Receptor
|
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'(D-Arg8)-Inotocin is a potent, selective, and competitive antagonist of the vasopressin receptor (V 1a R), exhibiting a binding affinity (K i) of 1.3 nM. It demonstrates over 3000-fold selectivity for the human V1aR com... |
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T37887 |
1-Heptadecanoyl-rac-glycerol
|
|
|
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1-Heptadecanoyl-rac-glycerol is a monoacylglycerol that contains heptadecanoic acid at the sn-1 position. It is active against the bacteria E. aerogens, E. cloacae, P. mirabilis, and S. faecalis (MIC = 78 μg/ml for all).... |
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T38329 |
CU-76
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|
|
|
CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50= 0.24 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sens... |
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T38328 |
CU-32
|
|
|
|
CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS ... |
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T72091 |
ADRA1D receptor antagonist 1 free base
|
|
|
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ADRA1D receptor antagonist 1 (free base) antagonist ( K i =1.6 nM). ADRA1D receptor antagonist 1 (free base) dose-dependently inhibits bladder contraction with an IC 30 value of 15 nM. ADRA1D receptor antagonist 1 (free... |
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T35762 |
MC1742
|
|
|
|
MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).1 ... |
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T37536 |
Carbazomycin A
|
|
|
|
Carbazomycin A is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2It is active againstS. aureus,T. asteroides, andT. mentagrophytes(MIC = 12.5 μg/ml for all), as well a... |
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T36929 |
Pal-KTTKS (acetate)
|
|
|
|
Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid .1 It increases collagen production in human corneal and dermal fibroblasts when use... |
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T36679 |
Rp-cAMPS sodium salt
|
|
|
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Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis b... |
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T38284 |
C24 dihydro 1-Deoxyceramide (m18:0/24:0)
|
C24 dihydro 1-Deoxyceramide (m18:0/24:0) |
|
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C24 dihydro 1-Deoxyceramide (m18:0/24:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alan... |
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T38280 |
C22 dihydro 1-Deoxyceramide (m18:0/22:0)
|
C22 dihydro 1-Deoxyceramide (m18:0/22:0) |
|
|
C22 dihydro 1-Deoxyceramide (m18:0/22:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alan... |
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T83765 |
Dendrogenin A
|
DDA |
|
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Dendrogenin A (DDA) is a compound acting as a selective liver X receptor (LXR) modulator, cholesterol epoxide hydrolase inhibitor (Ki = 120 nM), and a metabolic product of cholesterol, originating from 5,6α-epoxy cholest... |
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T38214 |
1-Deoxysphingosine (m18:1(4E))
|
1-Deoxysphingosine (m18:1(4E)) |
|
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1-Deoxysphingosine (m18:1(4E)) is an atypical sphingolipid that contains a double bond at the 4E native position and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine durin... |
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T36892 |
4'-Acetyl Chrysomycin A
|
|
|
|
4'-Acetyl chrysomycin A is a bacterial metabolite and derivative of chrysomycin A that has been found inStreptomycesand has antibacterial and anticancer activities.1It is active against strains of methicillin-resistantS.... |
