|
T8808L |
LYN-1604 dihydrochloride
|
LYN-1604 2HCl（2216753-86-3 free base) |
Apoptosis
,
Autophagy
|
|
LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. |
|
TP2008L |
Lyn peptide inhibitor acetate
|
Lyn peptide inhibitor acetate(222018-18-0 free base) |
IL Receptor
|
|
Lyn peptide inhibitor acetate is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the bind... |
|
T4123 |
LYN-1604
|
LYN1604 |
Apoptosis
,
Autophagy
|
|
LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. |
|
T11916 |
Lyn-IN-1
|
Bafetinib analog |
Bcr-Abl
,
Src
|
|
Lyn-IN-1 (Bafetinib analog) is a selective and potent dual inhibitor of Bcr-Abl and Lyn |
|
T39687 |
LYN-1604 hydrochloride
|
|
|
|
LYN-1604 hydrochloride, a powerful activator of UNC-51-like kinase 1 (ULK1) with an EC50 value of 18.94 nM, has significant implications in the study of triple-negative breast cancer (TNBC). |
|
TP2008 |
Lyn peptide inhibitor
|
|
|
|
Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinoph... |
|
T75806 |
Lyn peptide inhibitor TFA
|
|
|
|
Lyn Peptide Inhibitor TFA is a powerful, cell-permeable inhibitor specifically targeting the Lyn-coupled IL-5 receptor signaling pathway, without affecting alternative signaling pathways. It effectively prevents Lyn acti... |
|
T13186 |
TL02-59
|
|
Apoptosis
,
Src
,
Hck
|
|
|
|
T1260 |
Cromolyn sodium
|
Disodium Cromoglycate,FPL 670 (Cromolyn) Disodium,FPL-670,Sodium cromoglycate |
Others
,
Potassium Channel
,
GSK-3
,
Calcium Channel
|
|
Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. |
|
T31011 |
Coralyne chloride
|
|
Topoisomerase
|
|
Coralyne chloride is a protoberberine with strong anticancer activity. It can be used to prepare Coralyne derivatives, a fluorescent DNA-based molecular rectifier built into DNA duplexes through site-specific insertion. ... |
|
TP2450 |
Argipressin, des-glynh2(9)-
|
9-Deglycinamide-argipressin,(Arg8,de-Gly9)-vasopressin,DEAVP,DGAVP,9-Des-glynh2-argipressin |
|
|
Argipressin, des-glynh2(9)-, can effect on aggregation of blood platelets. |
|
T80274 |
Lynronne-1
|
|
|
|
Lynronne-1, an antimicrobial peptide, exhibits activity against Gram-positive bacteria, including multi-drug resistant (MDR) strains, with a minimal inhibitory concentration (MIC) of 8-32 μg/mL for methicillin-resistant ... |
|
T38326 |
Cromolyn (sodium salt hydrate)
|
|
|
|
Cromolyn is a chromone complex that acts as a mast cell stabilizer, preventing the release of histamine. Its mechanism of action is thought to involve an interference with the antigen-stimulated calcium transport across ... |
|
T40961 |
Lynamicin B
|
|
|
|
Lynamicin B, a promising pesticide, functions as a selective chitinase inhibitor exclusive to lepidoptera. It exhibits a Ki value of 8.76 μM, indicating its potential efficacy. |
|
T20188 |
Polynoxylin
|
Formaldehyde, urea polymer,Gabrite,Hygromull,HSDB 7203 |
|
|
Polynoxylin is an antiseptic. It is used for local treatment of the skin and the mouth. |
|
T33034 |
Lyngbyatoxin B
|
|
|
|
Lyngbyatoxin B is an irritant form Lyngbya majuscula. |
|
T80276 |
Lynronne-3
|
|
|
|
Lynronne-3, an antimicrobial peptide, demonstrates activity against Gram-positive bacteria, including multi-drug resistant (MDR) strains, with a minimum inhibitory concentration (MIC) ranging from 32-128 μg/mL for methic... |
|
T31715 |
Ethynylestradiol mixture with lynestrenol
|
|
|
|
Ethynylestradiol mixture with lynestrenol is a drug/ therapeutic agent with reproductive effect. |
|
T33032 |
Lynestrenol mixture with mestranol
|
|
|
|
Lynestrenol mixture with mestranol is a bioactive chemical. |
|
T19656 |
Pyrazolynate
|
SW-751,BRN 0860937,Pyrazolate |
|
|
Pyrazolynate is a herbicide. It is used to evaluate the hydrolyzation to destosyl pyrazolynate (DTP). |
|
T7974L |
Lynestrenol acetate
|
|
|
|
Lynestrenol acetate is a bioactive chemical. |
|
T31977 |
GLYN
|
NSC 137875,NSC137875,Glycidyl nitrate,NSC-137875 |
|
|
GLYN, a nitric oxide donor, acts by enhancing the therapeutic efficacy of chemotherapy and radiotherapy. |
|
T80275 |
Lynronne-2
|
|
|
|
Lynronne-2, an antimicrobial peptide, exhibits activity against Gram-positive bacteria, including methicillin-resistant MRSA strains (MIC: 32-256 μg/mL), and demonstrates effectiveness in combating P. aeruginosa infectio... |
|
T23959 |
Dactylyne
|
|
|
|
Dactylyne is a new drug metabolism inhibitor of marine origin. It was isolated from the sea hare Aplysia dactylomela and characterized pharmacologically. |
|
TQ0132 |
A 419259 trihydrochloride
|
RK 20449 trihydrochloride |
Src
|
|
A 419259 trihydrochloride (RK 20449 trihydrochloride) is an Src family kinases inhibitor (IC50s: 9 nM, 3 nM and 3 nM for Src, Lck and Lyn). |
|
T6311 |
Bafetinib
|
NS-187,INNO-406 |
Bcr-Abl
,
Src
,
Autophagy
|
|
Bafetinib (INNO-406) (INNO-406) is an effective and specific dual Bcr-Abl/Lyn inhibitor (IC50: 5.8/19 nM), and no inhibition of the phosphorylation of the T315I mutant and less effective to c-Kit and PDGFR. |
|
T6997 |
SU6656
|
|
FAK
,
Akt
,
Src
|
|
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively. |
|
T6078 |
Saracatinib
|
AZD0530 |
EGFR
,
Src
,
BTK
,
Autophagy
|
|
Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes. |
|
T6896 |
Tolimidone
|
NSC 314335,MLR-1023,CP-26154 |
Src
|
|
Tolimidone (NSC 314335) is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals. |
|
T6115 |
Fostamatinib
|
R788 |
FLT
,
Syk
,
Monoamine Transporter
,
Adenosine Receptor
|
|
Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn. |
|
T17267 |
XL228
|
|
IGF-1R
,
Bcr-Abl
,
Src
,
Aurora Kinase
|
|
XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively). |
|
T6174 |
R406
|
R-406 besylate |
Apoptosis
,
FLT
,
Syk
|
|
R406 (R-406 besylate) is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn. |
|
T6093 |
AZD-7762
|
AZD7762 |
Chk
|
|
AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. |
|
T6318 |
AZ 628
|
|
Apoptosis
,
Raf
|
|
AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc. |
|
T2640 |
Rebastinib
|
DCC2036,DCC 2036,DCC-2036 |
Apoptosis
,
FLT
,
Bcr-Abl
,
Src
|
|
DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT3, KDR, and Tie-2, and low activity to c-Kit. Re... |
|
T2600 |
AG490
|
Zinc02557947,Tyrphostin AG 490,AG 490,AG-490,Tyrphostin B42 |
EGFR
,
JAK
,
STAT
,
Autophagy
|
|
AG490 (Tyrphostin B42) is an inhibitor of EGFR (IC50: 0.1 μM). It is 135-fold more selective for EGFR than ErbB2, also inhibits JAK2 with no effect to Lyn, Lck, Syk, Btk, and Src. |
|
T4263 |
BAY 61-3606
|
Syk inhibitor IV |
Apoptosis
,
Syk
|
|
BAY 61-3606 (Syk inhibitor IV) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. |
|
T2467 |
R406 free base
|
R406 (free base) |
Apoptosis
,
FLT
,
Syk
|
|
R406 free base (R406 (free base)) is a potent Syk inhibitor. |
|
T4337 |
PCI 29732
|
PCI29732,PCI-29732 |
Others
,
BCRP
,
BTK
|
|
PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay. |
|
T2605 |
Fostamatinib Disodium
|
Tamatinib Fosdium,R788(Disodium),R788 Disodium,R788 (Fostamatinib) Disodium |
FLT
,
Syk
|
|
Fostamatinib Disodium (R788 Disodium) is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities. |
|
T16364 |
Infigratinib phosphate
|
NVP-BGJ398 phosphate,BGJ-398 phosphate |
FGFR
|
|
Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively). |
|
T2609 |
Masitinib
|
AB1010 |
Apoptosis
,
FAK
,
c-Fms
,
FGFR
,
Bcr-Abl
,
PDGFR
,
Src
,
c-Kit
,
Hck
|
|
Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has been distributed under the commercial name Masivet... |
|
T10206 |
A 419259
|
RK-20449 |
Src
|
|
A 419259 is a pyrrolo-pyrimidine inhibitor, designed to enhance selectivity towards the Src family (IC50s: 9 nM, <3 nM and <3 nM for Src, Lck and Lyn). |
|
T15725 |
Lck inhibitor 2
|
|
Others
|
|
Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK (IC50s: 13nM, 9nM, 3nM, 26nM, and 2nM for Lck, Btk, Lyn, Btk, and Txk respectively). |
|
T71819 |
RK-20448
|
|
|
|
RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2. It also inhibits BLK, Csk, Fyn, and Lyn. RK-20448 is the cis isomer of A-419259 |
|
T22597 |
Bafetinib (INNO-406)
|
|
Others
|
|
Bafetinib is a potent and selective dual inhibitor of Bcr-Abl/Lyn tyrosine kinase (IC50: 5.8nM and 19nM, respectively). |
|
T13157L |
TG 100801 Hydrochloride
|
|
VEGFR
|
|
TG 100801 Hydrochloride is a prodrug to treat age-related macular degeneration. TG 100572 is a inhibitor of multi-targeted kinase(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 for VEGFR1, VEGFR2, FGFR1, FGFR2, PD... |
|
T13156 |
TG 100572
|
|
VEGFR
|
|
|
|
T16583 |
Propargyl-PEG1-acid
|
|
Others
|
|
Propargyl-PEG1-acid, a PEG-based PROTAC linker, enables the synthesis of BTK-CRBN PROTACs, specifically Ibrutinib-based PROTAC 4 and PROTAC 5. At a concentration of 10 μM, PROTAC 5 facilitates the degradation of BTK and ... |
|
T35804 |
C16 Lactosylceramide (d18:1/16:0)
|
|
|
|
C16 Lactosylceramide is an endogenous bioactive sphingolipid. It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Pla... |
