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T9582 |
CLEFMA
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NF-κB
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CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects. |
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T8310 |
MMP-9-IN-1
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MMP
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MMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9). |
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T5125 |
LY3200882
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TGF-beta/Smad
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LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). |
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T17255 |
WJ460
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Others
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WJ460 is an effective inhibitor of myoferlin. WJ460 exerts anti-metastatic activity in breast cancer cells. |
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T26969 |
CCT365623
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CCT-365623,CCT 365623 |
Monoamine Oxidase
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CCT365623 is an orally bioavailable Lysyl Oxidase inhibitor with good anti-LOX potency, selectivity, pharmacokinetic properties, as well as anti-metastatic efficacy. |
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T9236 |
WSB1 Degrader 1
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Others
,
E1/E2/E3 Enzyme
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WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects. |
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T62536 |
S100P-IN-1
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Others
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S100P-IN-1 is a potent S100P inhibitor.S100P-IN-1 has anti-metastatic effects on pancreatic cancer (pancreatic) cells. |
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T9075 |
BDP-13176
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Others
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BDP-13176 is a potent inhibitor of fascin 1(Kd of 90 nM and an IC50 of 240 nM). It has potential as an anti-metastatic agent |
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T77374 |
Ontuxizumab
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MORAb-004 |
Others
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Ontuxizumab (MORAb-004) is a monoclonal antibody targeting endomelanic acid with anti-tumor effects.Ontuxizumab is a potent IgG1/κ anti-endothelin (TEM-1 or CD248) monoclonal antibody for the treatment of metastatic mela... |
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T76828 |
Sonepcizumab
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LT 1009 |
LPL Receptor
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Sonepcizumab (LT 1009) is a fully humanized monoclonal antibody against S1P. Sonepcizumab has anti-cancer activity and can be used to study metastatic renal cell carcinoma (mRCC) to prevent eye scarring after glaucoma fi... |
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T76857 |
Anetumab
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Others
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Anetumab is a novel fully human anti-mesothelin IgG1 antibody that is a naked antibody to Anetumab ravtansine.Anetumab can be used to synthesize the antibody-activated molecule coupling, Anetumab ravtansine.Anetumab can ... |
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T76750 |
Cemiplimab
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REGN-2810,SAR-439684 |
Others
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Cemiplimab (Anti-Human PD-1) is a human monoclonal antibody against programmed cell death receptor 1 (PD-1) and a checkpoint inhibitor that blocks PD-1/PD-L1 mediated T-cell inhibition and can be used in metastatic cance... |
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T60616 |
MPT0G211
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HDAC
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MPT0G211 is a highly selective and orally active HDAC6 inhibitor (IC50=0.291 nM) that has neuroprotective effects and has shown anti-metastatic activity in human breast cancer cells. MPT0G211 has 1,000 times more affinit... |
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T77434 |
Vopratelimab
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JTX 2011 |
Others
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Vopratelimab (JTX-2011) is a selective humanized immunoglobulin G1-kappa monoclonal antibody that is a potent ICOS agonist. Vopratelimab has a high affinity for inducible T cell CO stimulating factors (ICOS), with an aff... |
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T70226 |
Amentoflavone hexaacetate
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|
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Amentoflavone hexaacetate is a 3,5-cyclic nucleotide phosphodiesterase inhibitor. It has anti-angiogenic and anti-metastatic effects. |
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T25593 |
Labetuzumab govitecan
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IMMU-130,Labetuzumab-SN38,hMN14-SN38,IMMU130,IMMU 130 |
Others
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Labetuzumab govitecan is an anti-CEACAM5/SN-38 antibody-drug conjugate for therapy of refractory or relapsing metastatic colorectal cancer. |
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T9901A-009 |
Anti-MAGEA3
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Anti-HIP8 |
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Anti-MAGEA3 is an antibody that targets MAGE-A for the study of metastatic and melanoma cancers. |
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T72740 |
N-Octyl caffeate
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|
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n-Octyl caffeate demonstrates anti-cancer and apoptosis-inducing properties in highly liver-metastatic murine colon 26-L5 carcinoma cell lines. |
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T75058 |
RLA-5331
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|
|
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RLA-5331 is an anti-androgen compound with iron-activating properties, demonstrating anti-proliferative effects on the metastatic castration-resistant prostate cancer (mCRPC) cell line [1]. |
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T62833 |
Myoferlin inhibitor 1
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|
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Myoferlin inhibitor 1 is a novel anti-metastatic agent against pancreatic cancer that acts on myosin. |
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T37037 |
Vinflunine ditartrate
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|
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Vinflunine ditartrate, a fluorinated microtubule inhibitor and member of the Vinca alkaloids family, exhibits anti-angiogenic, vascular-disrupting, and anti-metastatic properties. It presents a potential avenue for study... |
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T34632 |
SH-5
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SH5 PIA5. LchiroInositol 1deoxy6Omethyl 5(2R)2methoxy3(octadecyloxy)propyl hydrogen phosphate. Akt inhibitor II |
|
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SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IκBα kinase activation. |
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T75057 |
RLA-4842
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|
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RLA-4842, an iron activator with anti-androgen properties, exhibits anti-proliferative effects on the metastatic castration-resistant prostate cancer (mCRPC) cell line [1]. |
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T76918 |
Barecetamab
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|
|
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Barecetamab (ISU-104), a fully human anti-ErbB3 monoclonal antibody, is utilized in researching recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) [1]. |
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T77996 |
IRGD peptide 1 TFA
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|
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iRGD Peptide 1 TFA is a prototypic tumor-homing peptide with tissue-penetrating capabilities, facilitating deep delivery of therapeutic agents into extravascular tumor tissue. Additionally, it possesses anti-metastatic a... |
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T70957 |
NMac1
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|
|
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NMac1is a small molecule phenylbutenoid dimer that has novel anti-proliferative effect only under glucose starvation in metastatic breast cancer cells. NMac1 causes significant activation of AMPK by decreasing ATP synthe... |
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T76689 |
Margetuximab
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|
|
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Margetuximab (MGAH22) is a chimeric anti-HER2 monoclonal antibody with an optimized Fc domain, exhibiting an EC50 value of 39.33 ng/mL. It is utilized in the research of metastatic HER2-positive breast cancer [1]. |
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T78796 |
MHJ-627
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ERK
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MHJ-627, a potent inhibitor of ERK5 (MAPK7) with an IC50 value of 0.91 μM, enhances the mRNA expression of tumor suppressors and anti-metastatic genes, leading to the promotion of cancer cell death [1]. |
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T76970 |
Tagitanlimab
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|
|
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Tagitanlimab (HBM-9167), a humanized anti-PD-L1 antibody (IgG1κ type), selectively inhibits the PD-L1 and PD-1 interaction. It shows promise for investigation in recurrent or metastatic nasopharyngeal carcinoma (NPC) [1]... |
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T80067 |
Uroguanylin (human)
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|
Guanylate cyclase
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Uroguanylin (human) serves as a natural ligand for the Guanylyl Cyclase C (GCC) receptor in metastatic colorectal cancer tumors and exhibits anti-tumor effects in an animal model of human colon cancer [1] [2]. |
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T76879 |
Vesencumab
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|
|
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Vesencumab (MNRP-1685A), an IG1 antibody targeting neuropilin-1 (NRP-1), inhibits the interaction between NRP-1 and VEGFR-2. This action confers anti-angiogenic and anti-neoplastic properties to Vesencumab. It is utilize... |
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T62945 |
Aurora A/PKC-IN-1
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Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, θ), acting on AurA (IC50: 6.9 nM) and PKCα (IC50: 16.9 nM). Aurora A/PKC-IN-1 showed anti-proliferative and anti-metastati... |
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T70344 |
BJ-2302
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|
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BJ-2302 is a SRC inhibitor. BJ-2302 effectively suppressed MDA-MB-231 cell invasion (Matrigel invasion assay) and metastasis (chorioallantoic membrane assay xenografted with MDA-MB-231-luc2-tdTomato cancer cells). Additi... |
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T61753 |
MPT0G211 mesylate
|
|
|
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MPT0G211 mesylate is a powerful and selective HDAC6 inhibitor (IC50 = 0.291 nM), with high oral bioavailability. It exhibits remarkable selectivity for HDAC6 over other HDAC isoforms (>1000-fold selectivity). Additionall... |
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T79599 |
Anti-inflammatory agent 53
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COX
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Anti-inflammatory agent 52 (compound 7c) is an orally active, selective COX-2 inhibitor with demonstrated anti-HT29 metastatic activity, causing periodic arrest in the S phase and G2/M phase. This agent exhibits moderate... |
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T79919 |
S-Adenosyl-L-methionine (1,4-butanedisulfonate)
|
Ademetionine (1,4-butanedisulfonate),S-Adenosyl methionine (1,4-butanedisulfonate),AdoMet (1,4-butanedisulfonate) |
Endogenous Metabolite
|
|
S-Adenosyl-L-methionine (SAMe) 1,4-butanedisulfonate functions as an orally active methyl group donor and serves as a dietary supplement known for its significant antidepressant properties. Additionally, it plays anti-pr... |
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T76997 |
Socazolimab
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|
|
|
Socazolimab (ZKAB001), an anti-PD-L1 monoclonal antibody, demonstrates enduring safety and efficacy in treating recurrent or metastatic cervical cancer. Additionally, it shows promise for treating small cell lung cancer,... |
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T73547 |
CPUL1
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|
|
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CPUL1, a TrxR inhibitor, exhibits proliferation-inhibitory and anti-metastatic effects on A549 cells by modulating epithelial-mesenchymal transition (EMT) through the induction of ROS-mediated ERK/JNK signaling, achieved... |
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T62090 |
(Rac)-Tanomastat
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|
|
|
Rac)-Tanomastat ((Rac)-BAY 12-9566) is a racemate of Tanomastat. Tanomastat (BAY 12-9566) is an orally active, zinc carboxy-containing inhibitor of non-peptide biphenyl matrix metalloproteinases (MMPs) that inhibits MMP-... |
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T64022 |
Antitumor agent-37
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|
|
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Antitumor agent-37 exhibits potent anti-proliferative and anti-metastatic effects. antitumor agent-37 induces severe DNA damage, leading to high expression of γ-H2AX and p53. antitumor agent-37 induces apoptosis by explo... |
