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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T1819 | Nexturastat A | HDAC | |
Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs. | |||
T6327 | Tubacin | Virus Protease , HDAC | |
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1. | |||
T7664 | Pyroxamide | Apoptosis , HDAC | |
Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM). | |||
T16129 | MPI_5a | HDAC | |
MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation in cells (IC50: 210 nM). | |||
T9745 | Elevenostat | HDAC | |
Elevenostat is an HDAC11-selective inhibitor with an IC50 value of 0.235 µM. | |||
T5830 | SKLB-23bb | HDAC | |
SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability. | |||
T5631 | SIS17 | HDAC | |
SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhib... | |||
T1857 | TMP269 | HDAC | |
TMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respectively. | |||
T3205 | UF010 | HDAC | |
UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. | |||
T5332 | TH34 | HDAC | |
TH34 is an HDAC6/8/10 inhibitor (IC50s: 4.6/1.9/7.7 μM). It shows high selectivity over HDAC1/2/3. | |||
T7082 | HDAC8-IN-1 | HDAC | |
MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5). HDAC8-IN-1 exhibits ... | |||
T2430 | HPOB | Apoptosis , HDAC | |
T7385 | WT-161 | Apoptosis , HDAC | |
WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM). | |||
T3206 | NKL 22 | Histone Deacetylase Inhibitor IV,PAOA | HDAC |
NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor. | |||
T16962 | SW-100 | HDAC | |
SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the... | |||
T1762 | RGFP966 | RGFP 966 | HDAC |
RGFP966 is an HDAC3 inhibitor (IC50: 0.08 μM) and does not affect other HDACs at concentrations up to 15 µM. | |||
T3358 | ITSA-1 | ITSA1 | HDAC |
ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but shows no activity towards other HDAC inhibitors. | |||
T6061 | LMK-235 | LMK235 | HDAC |
LMK-235 is a potent HDAC inhibitor, and is used in cancer research. | |||
T2023 | MC1568 | HDAC | |
MC1568 is a specific HDAC inhibitor for maize HD1-A (IC50: 100 nM, in a cell-free assay). It is 34-fold more selective for HD1-A than HD1-B. | |||
T8508 | HDAC-IN-3 | GSK3117391A | HDAC |
HDAC-IN-3 (GSK3117391A) is a potent histone deacetylase (HDAC) inhibitor, and treatment chronic inflammatory disorders. | |||
T10602L | BRD 4354 | HDAC | |
BRD 4354 is an inhibitor of HDAC5 and HDAC9. For HDAC5 and HDAC9, the IC50s values are 0.85 and 1.88 μM, respectively. | |||
TQ0074 | ACY-775 | HDAC | |
ACY-775 is an effective and specific inhibitor of HDAC6 (IC50: 7.5 nM). | |||
T21715 | BRD6688 | HDAC | |
BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes | |||
T4389 | SR-4370 | SR 4370 | HDAC |
SR-4370 is an HDAC inhibitor. SR- 4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. | |||
T3509 | ACY-738 | ACY 738 | HDAC |
ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold. | |||
T2294 | BG45 | Apoptosis , HDAC | |
BG45 is an HDAC I type inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3/1/2/6 in cell-free assays, respectively. | |||
T16729 | Remetinostat | SHP-141 | HDAC |
Remetinostat (SHP-141), a hydroxamic acid-based inhibitor of histone deacetylase enzymes, is currently being developed for the treatment of cutaneous T-cell lymphoma. | |||
T0867 | Bufexamac | Bufexamic acid | COX , HDAC |
Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action. | |||
T10777 | CG347B | HDAC | |
CG347B is a selective inhibitor of HDAC6. | |||
T1890 | Pracinostat | SB939 | Apoptosis , HDAC |
Pracinostat (SB939) is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in Clinicalal trials, allowing oral dosing. Data demonstrate that Pracinostat is a potent and eff... | |||
T1966 | Tubastatin A | Tubastatin A BASE | Apoptosis , HDAC , Autophagy |
Tubastatin A (Tubastatin A BASE) is an effective and specific HDAC6 inhibitor (IC50: 15 nM, in a cell-free assay). Its selectivity is 1000-fold against all the other isozymes except HDAC8. | |||
T9041 | AES-350 | Apoptosis , HDAC | |
AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, ... | |||
T10255 | AES-135 | HDAC | |
AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity. | |||
T9148 | KA2507 | HDAC | |
KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM. | |||
T6678 | Splitomicin | 1-Naphthalenepropanoic Acid | Sirtuin , HDAC |
Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay. | |||
T10603 | BRD-6929 | HIV Protease , HDAC | |
BRD-6929 is a selective, brain-penetrant HDAC1 and HDAC2 inhibitor (IC50: 1 and 8 nM). BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 (Kis: 0.2 and 1.5 nM) [2]. BRD-6929 potentiates the efficacy of gnidimacrin... | |||
T6695 | Tasquinimod | ABR-215050 | HDAC |
Tasquinimod (ABR-215050) is a quinoline-3-carboxamide linomide analog with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease blood vessel density but the exact mechanism of ac... | |||
T2489 | Ricolinostat | ACY-1215,Rocilinostat | Apoptosis , HDAC |
Ricolinostat (Rocilinostat) is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. | |||
T9963 | MPT0B390 | HDAC | |
MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis. | |||
T3204 | BML-210 | CAY10433 | Apoptosis , HDAC |
BML-210 (CAY10433) is a new-type HDAC inhibitor. | |||
T6421 | BRD73954 | HDAC | |
BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively. | |||
T5347 | CXD101 | CXD-101 | HDAC |
CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101(CXD-101) has no activity against HDAC class II | |||
T13996 | 1-Naphthohydroxamic acid | HDAC | |
1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid d... | |||
T6639 | RG2833 | RGFP109 | HDAC |
RG2833 (RGFP109) (RGFP109), a brain-penetrant HDAC inhibitor, is with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. | |||
T6980 | Scriptaid | GCK1026,Scriptide | Apoptosis , Influenza Virus , HDAC , Autophagy |
Scriptaid (GCK1026) is an inhibitor of HDAC, and has a greater effect on acetylated H4 than H3. | |||
T6362 | Domatinostat | 4SC202,4SC 202,4SC-202 (free base),4SC-202 | Apoptosis , HDAC |
Domatinostat (4SC202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (L... | |||
T3516 | EDO-S101 | Tinostamustine,Minomustine | HDAC |
EDO-S101 (Tinostamustine) is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively. | |||
T3983 | TMP195 | TFMO 2,TMP 195 | HDAC |
TMP195 (TFMO 2) is a selective class IIa histone deacetylase (HDAC) inhibitor. | |||
T3108 | CUDC-101 | CUDC 101,CUDC101 | EGFR , HER , HDAC |
CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively. | |||
T21551 | 2-hexyl-4-Pentynoic Acid | HDAC | |
2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM. |
カタログ番号 | 製品名 | 別名 | ターゲット |
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TQ0207 | Sulforaphane | Apoptosis , Nrf2 , HDAC | |
Sulforaphane is derived from the consumption of cruciferous vegetables, such as broccoli. It has shown anticancer and cardioprotective activities. | |||
T7052 | Gnetol | Tyrosinase , COX , HDAC , AChR | |
Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. ... | |||
T2266 | SantacruzaMate A | CAY-10683 | HDAC |
SantacruzaMate A (CAY-10683) is a potent and selective HDAC inhibitor. | |||
T6270 | Trichostatin A | TSA | HDAC |
Trichostatin A (TSA) is a natural derivative of diene isohydroxamic acids. Trichostatin A is a histone deacetylase inhibitor (IC50=1.8 nM) that is reversible and specific. Trichostatin A leads to the hyperacetylation of ... | |||
TN1911 | Marein | transporter , Akt , HDAC , AMPK | |
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for ... | |||
T3753 | Sinapinic Acid | Sinapic acid,Synapoic acid | Apoptosis , RAAS , Reactive Oxygen Species , HDAC |
Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinap... | |||
T6S0033 | Crotonoside | Isoguanosine,2-HYDROXYADENOSINE | Others , FLT , HDAC |
1. Crotonoside (Isoguanosine) has much more active than adenosine in reducing the blood pressure in rabbits and cats, in decreasing the tone of isolated intestinal strips of the rabbit, guinea pig and hamster and in stim... | |||
T7064 | Valproic Acid | Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid | Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , Sodium Channel , HDAC , Autophagy |
Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research. | |||
T3878 | Raddeanin A | NSC382873,Anemodeanin A,Raddeanin R3 | Apoptosis , HDAC |
Raddeanin A (NSC-382873) has moderate inhibitory activity against histone deacetylases (HDACs). Raddeanin A has high antiangiogenic potency, antitumor activity. | |||
T36797 | 1-Alaninechlamydocin | ||
1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. and an inhibitor of histone deacetylases (HDACs). It reduces total HDAC activity in HeLa cell lysates in a conc... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPH-01472 | HDAC11 Protein, Human, Recombinant (GST) | Human | E. coli |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcrip... | |||
TMPH-01677 | MBD2 Protein, Human, Recombinant (His & KSI) | Human | E. coli |
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcrip... | |||
TMPJ-01068 | FKBP25/FKBP3 Protein, Human, Recombinant (His) | Human | E. coli |
FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell prolif... | |||
TMPH-01512 | HIF1AN Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coa... | |||
TMPY-02844 | EBP1 Protein, Human, Recombinant (His) | Human | E. coli |
EBP1, also known as PA2G4, is an RNA-binding protein that belongs to the peptidase M24 family. It can be detected n several cell lines tested, including primary and transformed cell lines. EBP1 also present in pre-riboso... | |||
TMPY-03431 | HDAC4 Protein, Human, Recombinant (aa 612-1084) | Human | Baculovirus Insect Cells |
HDAC4 (histone deacetylase 4), belongs to class II of the histone deacetylase/AcuC/APhA family. Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups ... |
カタログ番号 | 製品名 | ||
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L8300 | Chromatin Modification Compound Library | 250 compounds | |
A unique collection of 250 compounds targeting chromatin remodeling pathway for high throughput screening (HTS) and high content screening (HCS); |