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Search Results for " radical-scavenging "

ターゲット

阻害剤

129

天然化合物

カタログ番号	製品名	別名	ターゲット
T8794	4-MMPB	15-Lipoxygenase Inhibitor 1	Apoptosis , Others , Lipoxygenase
	15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB (15-Lipoxygenase Inhibitor 1) has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxyg...		Apoptosis , Others , Lipoxygenase
T17111	Todralazine hydrochloride	Ecarazine hydrochloride	Adrenergic Receptor
	Todralazine hydrochloride (Ecarazine hydrochloride) is a β2AR blocker and has antioxidant and free radical scavenging activities. Todralazine hydrochloride can be used in anti-hypertensive research.		Adrenergic Receptor
T3289	Amifostine	Ethyol,WR2721,Gammaphos	Others , HIF/HIF Prolyl-Hydroxylase
	Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.		Others , HIF/HIF Prolyl-Hydroxylase
T41345	AFMK	Formyl-N-acetyl-5-methoxykynurenamine,Acetyl-N-formyl-5-methoxykynurenamine	Apoptosis , Free radical scavengers , Antioxidant , Endogenous Metabolite
	AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity. AFMK is a modulator of apoptosis and improves the anti-tumor effect of Gemcitabine ...
T1229	Erdosteine	RV 144,KW-9144	NF-κB , Antibacterial , Adenosine deaminase
	Erdosteine (RV 144) is a homocysteine-derived thiol derivative with mucolytic and free radical scavenging properties. Erdosteine and its metabolites modulate mucus production and viscosity, by which facilitating mucocili...		NF-κB , Antibacterial , Adenosine deaminase
T78554	Tyrosinase-IN-12		Tyrosinase
	Tyrosinase-IN-12(Non-competitive tyrosinase inhibitor) is a potent non-competitive tyrosinase inhibitor with an IC50 of 49.33 ± 2.64 µM and a Ki of 31.25 ± 0.25 µM. Tyrosinase-IN-12 has significant antioxidant and free r...		Tyrosinase
T12781	RV01		Others
	RV01 is a novel quinoline-substituted analogue of resveratrol that inhibits DNA damage, reduces ethanol-induced acetaldehyde dehydrogenase (ALDH2) mRNA expression, and has hydroxyl radical scavenging activity. rV01 reduc...		Others
T17112	Todralazine	Ecarazine	Others
	Todralazine is an anti-hypertensive agent and acts as a β2AR blocker. It also has an antioxidant and free radical scavenging activity.		Others
T40979	XJB-5-131
	XJB-5-131 is a synthetic, bi-functional antioxidant specifically designed to target mitochondria for the scavenging of reactive oxygen species (ROS) and electrons, thereby acting as a radical scavenger. Additionally, it ...
T35964	MitoTEMPO hydrate
	MitoTEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties.[1] This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophili...
T78067	Stobadine	(-)-Stobadine	Reactive Oxygen Species
	Stobadine, a potent antioxidant, safeguards endoplasmic reticulum (ER) membrane fluidity against free radical-induced changes. It shows promise in the development of cardio- and neuroprotective agents owing to its mechan...		Reactive Oxygen Species
T61579	BuChE-IN-5
	BuChE-IN-5 (compound 25b) is a highly potent BuChE inhibitor, displaying an IC50 value of 1.94 μM. It effectively inhibits aggregation of Aβ and tau protein in Escherichia coli. Furthermore, BuChE-IN-5 exhibits considera...
T81828	MDYYFEER
	MDYYFEER, an antioxidant peptide derived from pancreatin hydrolysate of C-phycocyanin, exhibits strong DPPH and ABTS radical scavenging activities. It has been demonstrated to protect zebrafish larvae against oxidative d...
T81800	MHLWAAK
	MHLWAAK, an antioxidant peptide derived from pancreatin hydrolysate of C-phycocyanin, exhibits potent DPPH and ABTS radical scavenging capabilities. It effectively shields zebrafish larvae against H2O2-induced oxidative ...
T81799	MHLWAAK TFA
	MHLWAAK TFA, an antioxidant peptide derived from the pancreatin hydrolysate of C-phycocyanin, exhibits potent DPPH and ABTS radical scavenging properties. It effectively shields zebrafish larvae against oxidative damage ...
T81827	MDYYFEER TFA
	MDYYFEER TFA, an antioxidant peptide derived from pancreatin hydrolysate of C-phycocyanin, exhibits potent DPPH and ABTS radical scavenging capability. This compound effectively shields zebrafish larvae against oxidative...
T81863	MAQAAEYYR TFA
	MAQAAEYYR TFA, an antioxidant peptide derived from the pancreatin hydrolysate of C-phycocyanin, exhibits potent DPPH and ABTS radical scavenging properties. It confers protection to zebrafish larvae against oxidative dam...
T82408	Ferroptosis-IN-3		Ferroptosis
	Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM). It exhibits radical scavenging abilities against DPPH and ABTS...		Ferroptosis
T35975	6,9-Dichloro-1,2,3,4-tetrahydroacridine
	6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1It is also an intermediate in the synthesis of multifunctional tacrine hybrids...
T83357	3-Hydroxy-2-(palmitoyloxy)propyl stearat
	3-Hydroxy-2-(palmitoyloxy)propyl stearate is a non-volatile compound isolated from the less polar fractions of the brown macroalga Fucus virsoides J. Agardh. It exhibits significant free radical scavenging activity and i...
T76598	H-Ser-Tyr-OH
	H-Ser-Tyr-OH, a dipeptide comprising serine and tyrosine (incorrectly described as consisting of glutamic acid, glycine, and histidine), exhibits a significant capability to form a copper(II) complex with copper ions, en...
T60421	Antitumor agent-68
	Antitumor agent-68 is a potent tubulin inhibitor that exhibits good antitumor activity with IC 50 s of 3.6 and 3.8 μM for cervical cancer cells line HeLa and breast cancer cells line MCF-7 cells, respectively. Antitumor ...
T78781	TrxR1-IN-1
	Compound 5j, also known as TrxR1-IN-1, is a TrxR1 inhibitor with an IC50 of 8.8 μM. It exhibits anticancer activity, demonstrating IC50 values of 1.5 μM in MCF-7, 1.7 μM in HeLa, 2.4 μM in BGC-823, 2.8 μM in SW-480, and ...
T60447	α-Amylase-IN-3
	α-Amylase-IN-3 (Compound 4) is a non-competitive inhibitor of α-Amylase with an IC50 value of 18.04 μM. α-Amylase-IN-3 has radical scavenging activities with IC50 values of 16.04 μM for DPPH and 16.99 μM for ABTS, respec...
T72763	AChE/BuChE-IN-1
	AChE/BuChE-IN-1, a selective butyrylcholinesterase (BuChE) inhibitor derived from chrysin, exhibits a potent efficacy with an IC50 of 0.48 μM against BuChE and a lesser inhibitory effect on acetylcholinesterase (AChE) wi...

Compounds

4-MMPB

T8794

Synonym: 15-Lipoxygenase Inhibitor 1

Target: Apoptosis, Others, Lipoxygenase

Todralazine hydrochloride

T17111

Synonym: Ecarazine hydrochloride

Target: Adrenergic Receptor

Amifostine

T3289

Synonym: Ethyol,WR2721,Gammaphos

Target: Others, HIF/HIF Prolyl-Hydroxylase

AFMK

T41345

Synonym: Formyl-N-acetyl-5-methoxykynurenamine,Acetyl-N-formyl-5-methoxykynurenamine

Target: Apoptosis, Free radical scavengers, Antioxidant, Endogenous Metabolite

Erdosteine

T1229

Synonym: RV 144,KW-9144

Target: NF-κB, Antibacterial, Adenosine deaminase

Synonym: (-)-Stobadine

Target: Reactive Oxygen Species

6,9-Dichloro-1,2,3,4-tetrahydroacridine

T35975

Synonym:

Target:

3-Hydroxy-2-(palmitoyloxy)propyl stearat

カタログ番号	製品名	別名	ターゲット
T9057	Norbergenin		IL Receptor , TNF , Reactive Oxygen Species
	Norbergenin is a chemical compound. It is the O-demethylated derivative of bergenin. It can be isolated from rhizomes of Bergenia stracheyi.		IL Receptor , TNF , Reactive Oxygen Species
T6S1440	Loganic acid	Loganate	Others
	1. Loganic acid (Loganate) and geniposide exhibit both sides effect on superoxide generation.		Others
T9135	Epirosmanol		Others
	Epirosmanol is a diterpenoid containing a lactone moiety. Epirosmanol is a very weakly basic (essentially neutral) compound (based on its pKa).		Others
T2S1181	Aloenin	Aloenin A,Aloearbonaside	Beta-Secretase , AChR
	1. Aloenin (Aloenin A) and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.		Beta-Secretase , AChR
T22308	Dimboa	2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one	Others , Antibacterial , Antibiotic , Antifungal
	Dimboa (2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one) is an antifungal compound used in crops.		Others , Antibacterial , Antibiotic , Antifungal
TN6706	3-demethylcolchicine		Reactive Oxygen Species
	3-demethylcolchicine is a natural product isolated from Gloriosa superba.Inhibitory effect on the polymerization of purified bovine brain tubulin.		Reactive Oxygen Species
TN2165	Rubrofusarin gentiobioside	Rubrofusarin-6-O-beta-D-gentiobioside	ERK , NF-κB , TGF-beta/Smad
	Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that it has potential as a preventive...		ERK , NF-κB , TGF-beta/Smad
T37710	5-Hydroxyoxindole		Reactive Oxygen Species
	5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria [1]. 5-Hydroxyoxindole has lipid peroxidation inhibition activit...		Reactive Oxygen Species
TN6909	Polyporusterone B	(1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one	Others
	Polyporusterone B ((1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one) is a triterpene carboxylic aci...		Others
T5S0281	Tubuloside A		NOS
	Tubuloside A ( 8.6 microM) can inhibit D-galactosamine-induced death of hepatocytes. Tubuloside A has NO radical-scavenging activity, which possibly contributes to its anti-inflammatory effects.Tubuloside A shows stronge...		NOS
T2936	Antiarol	3,4,5-trimethoxyphenol	Others
	Antiarol (3,4,5-trimethoxyphenol) is a member of aromatic phenols and exhibits moderate DPPH free radical scavenging activity.		Others
T7781	Reynoutrin	Reinutrin,Quercetin-3-D-xyloside	Reactive Oxygen Species
	Reynoutrin (Reinutrin) with antioxidant and radical-scavenging activity.		Reactive Oxygen Species
T3845	(+)-Gallocatechin	Gallocatechol,D-Gallocatechin	Others
	(+)-Gallocatechin (Gallocatechol) possesses free radical scavenging ability. (+)-Gallocatechin has moderate affinity to the human cannabinoid receptor.		Others
T2S1086	Nepitrin	Nepetin-7-glucoside	Antioxidant
	1. Nepitrin (Nepetin-7-glucoside) has antioxidant activity in human HL6 cells assessed as reduction of cytochrome-c release, DPPH free radical scavenging activity, and inhibition of TPA-induced free radical formation.		Antioxidant
TN1002	Blumeatin		ROS
	Blumeatin has antioxidant properties, free radical scavenging activity,and has xanthine oxidase (XO) inhibitory activity.		ROS
TN1513	Clitorin		PKC , Antifection
	Clitorin has free radical scavenging property. It shows significant interactions with CD38, it may have anti-hyperglycemic potential.		PKC , Antifection
TN1137	Isobutylshikonin		Others
	Isobutylshikonin exhibits obvious antioxidant activities , it exerts very good radical scavenging activities toward ABTS+ but shows moderate inhibition of DPPH·.		Others
T3828	(-)-Gallocatechin	(2S,3R)-gallocatechin,(−)-GC	Others
	(-)-Gallocatechin ((−)-GC) has free radical scavenging ability and moderate affinity to the human cannabinoid receptor.		Others
TN2008	Okanin		NF-κB , TLR
	Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.		NF-κB , TLR
TN1916	Matairesinol		ATPase , p38 MAPK , ROS
	Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells.		ATPase , p38 MAPK , ROS
T2S1434	Bergaptol	5-Hydroxyfuranocoumarin,4-Hydroxybergapten,5-Hydroxypsoralen	P450
	1. Bergaptol (4-Hydroxybergapten) shows very good radical scavenging activity. 2. Bergaptol is a potent inhibitor of debenzylation activity of CYP3A4 enzyme.		P450
T3905	Isomangiferin		Free radical scavengers , Antiviral , Influenza Virus
	Isomangiferin has an antiviral effect, may due to their capability of inhibiting virus replication within cells. It also has antioxidant and radical-scavenging activities.		Free radical scavengers , Antiviral , Influenza Virus
TN1490	Chrysoeriol		ERK , p38 MAPK , Akt
	Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selective bronchodilator effect.		ERK , p38 MAPK , Akt
TN1274	4-Allylcatechol	4-Allylpyrocatechol,Hydroxychavicol	Others
	4-Allylcatechol (Hydroxychavicol) has antioxidant activity, it has protective activity against the photosensitization-induced damage to lipids and proteins of rat liver mitochondria, which attributes to its free radical ...		Others
T8087	Tropolone		Tyrosinase
	Tropolone, a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion		Tyrosinase
TN1816	Kadsurin		Antioxidant
	Kadsurin has anti-oxidant activity, it induces enzymes capable of scavenging oxygen radical species in the liver. Kadsurin may be valuable antitumor promoters or chemopreventors.		Antioxidant
T2759	Loganin	Loganoside	Apoptosis , NF-κB , BACE , AChR , AChE
	Loganin (Loganoside), an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent free-radical-scavenging activity and inhibitor...		Apoptosis , NF-κB , BACE , AChR , AChE
TN6489	Regaloside A		Others
	Regaloside A is a phenylpropane derived from lily of the valley that shows DPPH free radical scavenging activity at 160 ppm.Regaloside A has anti-inflammatory activity and antidepressant activity.		Others
T3383	Cimifugin	Cimitin	Others
	Cimifugin (Cimitin) inhibits NO production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and for 1, 1-diphenyl-2-picrylhydrazyl free-radical scavenging activity in cell-free bioassay system.		Others
TN1644	Flavanomarein		Others
	Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells trea...		Others
T1716	Echinacoside		Reactive Oxygen Species , Wnt/beta-catenin
	Echinacoside is a natural polyphenolic compound with various kinds of pharmacological activities, such as anti-inflammatory, antioxidative, hepatoprotective, neuroprotective, nitric oxide radical-scavenging and vasodilat...		Reactive Oxygen Species , Wnt/beta-catenin
TN1788	Isookanin		Amylase
	Isookanin shows strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity with the IC50 value of 7.9 ± 0.53 μM. Isookanin is a potent inhibitor of α-amylase (IC50=0.447 mg/ml).		Amylase
TN2031	γ-Terpinene	Moslene,p-Mentha-1,4-diene,Crithmene	Antioxidant
	γ-Terpinene (p-Mentha-1,4-diene) is a monoterpene compound with high antioxidant properties suitable for oral consumption. It displays direct radical scavenging abilities and is known to be a potent antinociceptive agent...		Antioxidant
T3S0218	Thonningianin A		Apoptosis , Others
	1. Thonningianin A has anti-cancer activities.2. Thonningianin A represents a new potent glutathione S-transferase in vitro inhibitor.3. Thonningianin A has antioxidant property, involves radical scavenging, anti-superox...		Apoptosis , Others
T39887	(S)-3-(4-Hydroxyphenyl)lactic acid	(S)-3-(4-Hydroxyphenyl)lactic acid,(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid	Others
	(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid ((S)-3-(4-Hydroxyphenyl)lactic acid) (compound 1) is a metabolite found in the culture medium of Leuconostoc mesenteroides . (S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid...		Others
TJS2190	Nordihydroguaiaretic acid	NDGA,Dihydronorguaiaretic Acid	Antioxidant , Ferroptosis , Lipoxygenase , Autophagy
	Nordihydroguaiaretic acid (NDGA) (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibito...		Antioxidant , Ferroptosis , Lipoxygenase , Autophagy
TN1420	Bacopaside I		Others
	Bacopaside I is a saponin isolated from Bacopa monniera. Bacopaside I is a modulator of Aquaporin-1 channel, has neuroprotective functions, it has anti-Alzheimer's disease, it ameliorates cognitive impairment in APP/PS1 ...		Others
T2996	Tetrandrine	NSC-77037,d-Tetrandrine,Hanfangchin A,Fanchinine,Sinomenine A	Potassium Channel , Calcium Channel
	Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the c...		Potassium Channel , Calcium Channel
T0926	Azelaic acid	Finacea,Azelex,Nonanedioic acid,Anchoic acid	Others , DNA/RNA Synthesis , Endogenous Metabolite
	Azelaic acid (Anchoic acid) is a component of hair and skin conditioners and is produced by the ozonolysis of oleic acid. Azelaic acid has bacteriostatic activity against Propionibacterium acnes and Staphylococcus epider...		Others , DNA/RNA Synthesis , Endogenous Metabolite
T2S1635	3-Isomangostin		MTH1
	3-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has free radical scavenging activity; it shows antiplasmodial ac...		MTH1
T3834	8-Epideoxyloganic acid		ROS , Immunology/Inflammation related
	8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibl...		ROS , Immunology/Inflammation related
T40615	N,N'-Dimethylthiourea	DMTU	Antioxidant
	N,N'-Dimethylthiourea (DMTU) (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical ( OH) and blocks OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects a...		Antioxidant
T4S1637	Gamma-Mangostin	Normangostin	Others , 5-HT Receptor
	1. gamma-Mangostin (Normangostin) as a preventive agent of the metabolic syndrome. 2. Gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells. 3. Gamma-Mangostin ...		Others , 5-HT Receptor
T3926	Echinatin	Retrochalcone	Free radical scavengers
	Echinatin (Retrochalcone) disturb the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liv...		Free radical scavengers
TN7229	Baihuaqianhuoside	Praeroside	Others
	Baihuaqianhuoside (Praeroside) is a coumarin glycoside. Baihuaqianhuoside can be isolated from the roots of Passiflora and Hindenia solanacea and was first isolated from P. japonicum. Baihuaqianhuoside has anti-inflammat...		Others
TN3972	Epimedokoreanin B		Apoptosis , Others , Antibacterial
	Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.Epimedokoreanin B also possesses anti-...		Apoptosis , Others , Antibacterial
TN2211	Silybin B	Silibinin B	Apoptosis , Beta Amyloid , Bcr-Abl
	Silybin B (Silibinin B) is an effective inhibitor of raloxifene 4 '- and 6-glucosalylation, an effective anti-fibrinogenic and anti-oligomeric component of Silymarin, with free radical scavenging activity of 1, 1-dipheny...		Apoptosis , Beta Amyloid , Bcr-Abl
TN1236	3',4',7-Trihydroxyisoflavone		MAPK , JNK
	3',4',7-Trihydroxyisoflavone is a soy isoflavone soy glycoside derivative and Cot (Tpl2/MAP3K8) and MKK4 inhibitor with anticancer, antiangiogenic and free radical scavenging properties.3',4',7-Trihydroxyisoflavone enhan...		MAPK , JNK
T0877	Gallic acid	3,4,5-Trihydroxybenzoic acid,Gallate,Benzoic acid	Apoptosis , Ferroptosis , Reactive Oxygen Species , ROS , COX , Endogenous Metabolite
	Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
TN3448	Arjunglucoside II		Others
	Arjunglucoside II exhibits a moderate free radical scavenging activity.		Others
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