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Search Results for " CDK1 "

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122

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天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T64373	CDK1-IN-2	cdk1 inhibitor 2	CDK
	CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM. A broad-spectrum kinase profiling of CDK1-IN-2 revealed nonselective inhibition of several kinases.		CDK
T14914	Cdk1/2 Inhibitor III		CDK
	Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.		CDK
T63080	CDK1-IN-4
	CDK1-IN-4 (10d) is a selective CDK1 inhibitor that acts on CDK1 (IC50: 44.52 nM), CDK2 (IC50: 624.93 nM) and CDK5 (IC50: 135.22 nM). CDK1-IN-4 affects the cell cycle and thus exhibits inhibitory effects on the growth of ...
T63437	CDK1-IN-5
	CDK1-IN-5 (10h) is a selective CDK1 inhibitor that acts on CDK1 (IC50: 42.19 nM), CDK2 (IC50: 188.71 nM) and CDK5 (IC50: 354.15 nM). CDK1-IN-5 affects the cell cycle and inhibits cancer cell growth and can be used in can...
T63933	CDK1-IN-3
	CDK1-IN-3 (8g) is a selective CDK1 inhibitor that acts on CDK1 (IC50: 36.8 nM), CDK2 (IC50: 305.17 nM) and CDK5 (IC50: 369.37 nM). CDK1-IN-3 can affect the cell cycle and thus inhibit the growth of cancer cells and can b...
T62970	CDK1-IN-1
	CDK1-IN-7 is a potent inhibitor of CDK1 with an IC50 value of 161.2 nM for CDK1/CycB. CDK1-IN-7 induces apoptosis in a p53-dependent manner via the apoptosis-intrinsic pathway. CDK1-IN-7 selectively acts on tumour tissue...
T62405	KDM1/CDK1-IN-1
	KDM1/CDK1-IN-1 (compound 4) is a potent inhibitor of KDM1 (IC50: 0.096 μM) and CDK1 (IC50: 0.078 μM). kDM1/CDK1-IN-1 blocks the cell cycle of HOP-92 cells in G2/M phase and induces apoptosis. KDM1/CDK1-IN-1 is highly cyt...
T61254	CDK1/Cyc B-IN-1
	CDK1/Cyc B-IN-1 (Compound 5) is a potent inhibitor of the CDK1/Cyc B complex, demonstrating selectivity with an IC50 value of 97 nM. This compound induces apoptosis and G2/M cell cycle arrest, effectively halting cancer ...
T60583	CDK1/2/4-IN-1
	CDK1/2/4-IN-1 (compound 3a) is a potent inhibitor of CDK with IC 50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 can be used in cancer research. CDK1/2/4-IN-1 arrests cell cycle a...
T6612	NU6027		ATM/ATR , DNA-PK , CDK
	NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.		ATM/ATR , DNA-PK , CDK
T7426	ALSTERPAULLONE		Apoptosis , GSK-3 , CDK
	Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec		Apoptosis , GSK-3 , CDK
T39752	CDK12-IN-2	CDK12 inhibitor 2,CDK12-IN-2	CDK
	CDK12-IN-2 (CDK12 inhibitor 2) is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CD...		CDK
T40289	CDK12-IN-6	CDK12-IN-6
	CDK12-IN-6, a pyrazolotriazine compound, is a powerful inhibitor of CDK12. Its inhibitory activity is significant with an IC50 value of 1.19 μM when tested at high ATP concentration (2 mM). Notably, CDK12-IN-6 does not e...
T14990	CDK12-IN-3		CDK
	CDK12-IN-3 is a selective CDK12 inhibitor (IC50: 491 nM in an enzymatic assay).		CDK
T40288	CDK12-IN-4	CDK12-IN-4
	CDK12-IN-4, a pyrazolotriazine compound, exhibits potent inhibition of CDK12 by achieving an IC50 value of 0.641 μM, utilizing high ATP levels (2 mM). Notably, CDK12-IN-4 does not impact CDK2/Cyclin E (IC50 > 20 μM) or C...
T14915	CDK12-IN-E9		CDK
	CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak binding ability to CDK7/CyclinH complex (IC50> 1 μM).		CDK
T64284	PROTAC CDK12/13 Degrader-1
	PROTAC CDK12/13 Degrader-1 (7f) is a potent and selective dual degrader of the cell cycle protein-dependent kinases CDK12 (DC50: 2.2 nM) and CDK13 (DC50: 2.1 nM). Breast cancer.
T40290	CDK12-IN-5	CDK12-IN-5
	CDK12-IN-5 is a pyrazolotriazine compound that effectively inhibits CDK12, with an IC50 value of 23.9 nM at a high ATP concentration of 2 mM. However, CDK12-IN-5 does not exhibit inhibitory effects on CDK2/Cyclin E (IC50...
T2356	Ro-3306		Apoptosis , ERK , SGK , PKA , CDK , PKC
	RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases.		Apoptosis , ERK , SGK , PKA , CDK , PKC
T2679	BMS-265246	BMS265246	CDK
	BMS-265246 is a potent and selective CDK1/2 inhibitor.		CDK
T6924	Riviciclib hydrochloride	P276-00	Apoptosis , CDK
	Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Phase 2/3.		Apoptosis , CDK
T6837	Flavopiridol	L868275,Alvocidib,NSC 649890 HCl,HMR-1275	Apoptosis , HIV Protease , CDK , Autophagy
	Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially foun...		Apoptosis , HIV Protease , CDK , Autophagy
T6167	SU9516		Apoptosis , p38 MAPK , CDK , PKC , Autophagy
	SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.		Apoptosis , p38 MAPK , CDK , PKC , Autophagy
T75163	GW297361		VEGFR , CDK , Src
	GW297361 is a potent inhibitor of the cell cycle protein-dependent kinase Cdk1 and also inhibits the Pho85 signaling pathway.The IC50s of GW297361 on yeast Cdk1 and Pho85 were 20 nM and 400 nM, respectively.		VEGFR , CDK , Src
T28218	NU6102	NU-6102,NU 6102	CDK
	NU6102 is a selective and potent ATP-competitive CDK2 inhibitor with antitumor activity against CDK1/cyclinB, CDK2/cyclinA3, CDK1/CDK2, CDK4, DYRK1A , PDK1, and ROCKII, and it can be used to study rectal cancer.		CDK
T21966	MeBIO		GSK-3 , Aryl Hydrocarbon Receptor , CDK
	MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.		GSK-3 , Aryl Hydrocarbon Receptor , CDK
T14916	CDK2-IN-4		CDK
	CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM.		CDK
T6205	AT7519		Apoptosis , GSK-3 , CDK
	AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7.		Apoptosis , GSK-3 , CDK
T2506	AZD-5438	AZD5438	CDK
	AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM).		CDK
T6126	JNJ-7706621	JNJ 7706621	Apoptosis , CDK , Aurora Kinase
	JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.		Apoptosis , CDK , Aurora Kinase
T1917	GSK 3 Inhibitor IX	BIO,GSK 3 IX,6-BIO,6-Bromoindirubin-3'-oxime,MLS 2052,6-bromoindirubin-3-oxime	Apoptosis , GSK-3 , Tyrosine Kinases , CDK
	GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex. It inhibits (GSK-3α/β)/CDK1/CDK5 activity with IC50 values of 5 nM/320 nM/83 nM, respectively.		Apoptosis , GSK-3 , Tyrosine Kinases , CDK
TQ0068	NVP-LCQ195	AT9311,LCQ-195	CDK
	NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).		CDK
T12617	(R)-CR8 trihydrochloride	CR8, (R)-Isomer trihydrochloride	Apoptosis , CDK
	(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis.		Apoptosis , CDK
T6312	R547	Ro 4584820	Apoptosis , GSK-3 , PKA , CDK
	R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.		Apoptosis , GSK-3 , PKA , CDK
T5200	Indirubin-3'-monoxime	Indirubin-3'-oxime	GSK-3 , Lipoxygenase , CDK
	Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).		GSK-3 , Lipoxygenase , CDK
T2247	KenPaullone	9-Bromopaullone,NSC-664704	GSK-3 , CDK
	KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp...		GSK-3 , CDK
T1778	AT7519 Hydrochloride	AT7519 HCl,AT 7519 hydrochloride salt	Apoptosis , GSK-3 , CDK
	AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.		Apoptosis , GSK-3 , CDK
T1912	Dinaciclib	SCH 727965,PS-095760	Apoptosis , CDK
	Dinaciclib (SCH 727965) is a CDK inhibitor that selectively inhibits CDK1, CDK2, CDK5, and CDK9 (IC50 score = 3/1/1/4 nM). Dinaciclib has potential antitumor activity and inhibits the incorporation of thoracic glycan (dT...		Apoptosis , CDK
T6358	1-Azakenpaullone	azakenpaullone	GSK-3
	1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.		GSK-3
T6162	BS-181 hydrochloride	BS-181 HCl	CDK
	BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9.		CDK
T15732	Ribociclib succinate	LEE011 succinate	CDK
	Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent against the cyclin B/CDK1 complex.		CDK
T39403	Avotaciclib	BEY1107,Avotaciclib	CDK
	Avotaciclib (BEY1107) is a potent and orally active cyclin dependent kinase 1 (CDK1) inhibitor.Avotaciclib can be used to study locally advanced or metastatic pancreatic cancer.		CDK
T72057	H1k		CDK
	H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyc...		CDK
T6525	GW 5074	GW5074,Raf1 Kinase Inhibitor I	Apoptosis , Raf
	GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor. It has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms.		Apoptosis , Raf
T2378	RGB-286638 free base		GSK-3 , MEK , JAK , CDK
	RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 a...		GSK-3 , MEK , JAK , CDK
T6787	BIO-acetoxime	BIA,GSK-3 Inhibitor X	Apoptosis , GSK-3 , HSV
	BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.		Apoptosis , GSK-3 , HSV
T16363	NVP-2		Apoptosis , CDK
	NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CD...		Apoptosis , CDK
T6187	TDZD-8	GSK-3β Inhibitor I,NP 01139	GSK-3
	TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.		GSK-3
T9014	SKI-178		Apoptosis , S1P Receptor
	SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ...		Apoptosis , S1P Receptor
T6081	Milciclib	PHA-848125	Trk receptor , CDK , Autophagy
	Milciclib (PHA-848125) (PHA-848125) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7. Phase 2.		Trk receptor , CDK , Autophagy

Compounds

CDK1-IN-2

T64373

Synonym: cdk1 inhibitor 2

Target: CDK

Cdk1/2 Inhibitor III

Target: ATM/ATR, DNA-PK, CDK

ALSTERPAULLONE

T7426

Synonym:

Target: Apoptosis, GSK-3, CDK

CDK12-IN-2

T39752

Synonym: CDK12 inhibitor 2,CDK12-IN-2

Target: CDK

CDK12-IN-6

T40289

Synonym: CDK12-IN-6

Synonym: CDK12-IN-4

PROTAC CDK12/13 Degrader-1

Synonym: CDK12-IN-5

Target: Apoptosis, ERK, SGK, PKA, CDK, PKC

Riviciclib hydrochloride

T6924

Synonym: P276-00

Target: Apoptosis, CDK

Flavopiridol

T6837

Synonym: L868275,Alvocidib,NSC 649890 HCl,HMR-1275

Target: Apoptosis, HIV Protease, CDK, Autophagy

SU9516

T6167

Synonym:

Target: Apoptosis, p38 MAPK, CDK, PKC, Autophagy

GW297361

T75163

Synonym:

Target: VEGFR, CDK, Src

NU6102

T28218

Synonym: NU-6102,NU 6102

Target: GSK-3, Aryl Hydrocarbon Receptor, CDK

Target: Apoptosis, GSK-3, CDK

Target: Apoptosis, CDK, Aurora Kinase

GSK 3 Inhibitor IX

T1917

Synonym: BIO,GSK 3 IX,6-BIO,6-Bromoindirubin-3'-oxime,MLS 2052,6-bromoindirubin-3-oxime

Target: Apoptosis, GSK-3, Tyrosine Kinases, CDK

NVP-LCQ195

TQ0068

Synonym: AT9311,LCQ-195

Target: CDK

(R)-CR8 trihydrochloride

T12617

Synonym: CR8, (R)-Isomer trihydrochloride

Target: Apoptosis, CDK

R547

T6312

Synonym: Ro 4584820

Target: Apoptosis, GSK-3, PKA, CDK

Indirubin-3'-monoxime

T5200

Synonym: Indirubin-3'-oxime

Target: GSK-3, Lipoxygenase, CDK

KenPaullone

T2247

Synonym: 9-Bromopaullone,NSC-664704

Target: GSK-3, CDK

AT7519 Hydrochloride

T1778

Synonym: AT7519 HCl,AT 7519 hydrochloride salt

Target: Apoptosis, GSK-3, CDK

Dinaciclib

T1912

Synonym: SCH 727965,PS-095760

Target: Apoptosis, CDK

1-Azakenpaullone

T6358

Synonym: azakenpaullone

Synonym: LEE011 succinate

Target: CDK

Avotaciclib

T39403

Synonym: BEY1107,Avotaciclib

Synonym: GW5074,Raf1 Kinase Inhibitor I

Target: Apoptosis, Raf

RGB-286638 free base

T2378

Synonym:

Target: GSK-3, MEK, JAK, CDK

BIO-acetoxime

T6787

Synonym: BIA,GSK-3 Inhibitor X

Target: Apoptosis, GSK-3, HSV

NVP-2

T16363

Synonym:

Target: Apoptosis, CDK

TDZD-8

T6187

Synonym: GSK-3β Inhibitor I,NP 01139

Target: Apoptosis, S1P Receptor

Milciclib

T6081

Synonym: PHA-848125

Target: Trk receptor, CDK, Autophagy

カタログ番号	製品名	別名	ターゲット
T3S0737	Flavokawain A	Flavokavain A	Apoptosis , p38 MAPK
	NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significant...		Apoptosis , p38 MAPK
TN1299	Desmethylglycitein	6,7,4'-Trihydroxyisoflavone	PI3K , CDK , PKC
	Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities.		PI3K , CDK , PKC
T75602	Albanol B
	Albanol B, an arylbenzofuran derivative, is extracted from mulberries and demonstrates multifarious biological activities, including anti-Alzheimer's, anti-bacterial, and antioxidant effects. It inhibits the proliferatio...

天然物製品

Flavokawain A

T3S0737

Synonym: Flavokavain A

Target: Apoptosis, p38 MAPK

Desmethylglycitein

TN1299

Synonym: 6,7,4'-Trihydroxyisoflavone

Target: PI3K, CDK, PKC

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04450	CDK1 & CCNE1 Heterodimer Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	CDK1 & CCNE1 Heterodimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus-Insect Cells with His and GST tag. The predicted molecular weight is 109.7 kDa. Accession number: NP_001777.1&NP_001229.1
TMPH-01167	CDK1 Protein, Human, Recombinant (His)	Human	E. coli
	CDK1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPY-04549	CDK1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	CDC2, also known as CDK1, contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. CDC2 is a catalytic subunit of the highly conserved prote...
TMPY-04775	CDK1 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	CDC2, also known as CDK1, contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. CDC2 is a catalytic subunit of the highly conserved prote...
TMPH-01703	CDC25C Protein, Human, Recombinant (His)	Human	E. coli
	Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly de...
TMPH-02884	CTDP1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit...
TMPY-04542	CDK2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinas...
TMPY-03411	ENSA Protein, Human, Recombinant (His)	Human	E. coli
	Endosulfine alpha, also known as ENSA, belongs to the endosulfine family. It is a highly conserved cAMP-regulated phosphoprotein (ARPP) family. Endosulfine alpha is widely expressed with high levels in skeletal muscle ...
TMPY-05654	ENSA Protein, Human, Recombinant (His), Biotinylated	Human	E. coli
	Endosulfine alpha, also known as ENSA, belongs to the endosulfine family. It is a highly conserved cAMP-regulated phosphoprotein (ARPP) family. Endosulfine alpha is widely expressed with high levels in skeletal muscle ...
TMPH-01826	Human Papilloma Virus type 11 (HPV 11) Protein E4 (His)	HPV 11	E. coli
	Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 ph...
TMPH-01831	Human Papilloma Virus type 16 (HPV 16) Protein E4 (His & Myc)	HPV 16	E. coli
	Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 ph...
TMPH-01839	Human Papilloma Virus type 6a (HPV 6a) Protein E4 (His & Myc)	HPV 6a	E. coli
	Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 ph...
TMPY-01401	Cyclin A1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Cyclin A1 is a member of the highly conserved cyclin family that is characterized by a dramatic periodicity in protein abundance, and belongs to the A-type cyclin subfamily. The mammalian A-type cyclin family consists of...
TMPH-01329	FBXW7 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds pho...
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His)	Human	Baculovirus
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections,...
TMPH-01556	EIF2AK2 Protein, Human, Recombinant (His)	Human	Yeast
	IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to v...