|
T2331 |
Solithromycin
|
OP-1068,CEM-101 |
Antibacterial
,
Antibiotic
|
|
Solithromycin (OP-1068) is an orally bioavailable antimicrobial agent that inhibits cell viability, protein synthesis, and growth rate of Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus aureus, and Haemop... |
|
T39810 |
CEM114
|
|
|
|
CEM114 is a potent chemical compound known as a chemical epigenetic modifier (CEM). It functions by employing CRISPR-Cas9 systems to harness endogenous chromatin machinery, thereby exerting its epigenetic modifying effec... |
|
T9104 |
TJ191
|
|
Apoptosis
|
|
TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells. |
|
T20038 |
2-Fluoroadenine
|
NSC-27364,NSC 27364,NSC27364 |
DNA/RNA Synthesis
|
|
2-Fluoroadenine (NSC-27364) has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for anticancer studies. |
|
T6018 |
Zosuquidar trihydrochloride
|
Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride |
P-gp
|
|
Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3. |
|
T0370 |
Pheniramine maleate
|
Daneral,Inhiston,Trimetose |
5-HT Receptor
,
Histamine Receptor
|
|
Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re... |
|
T5858 |
Sertindole
|
Lu 23-174 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Autophagy
|
|
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively) |
|
T50055 |
Milacemide
|
|
MAO
|
|
Milacemide is a glycine prodrug and MAO-B inhibitor. Milacemide has been studied for its effects on human memory and as a potential treatment for the symptoms of Alzheimer's disease. |
|
T6809 |
CPI-169 racemate
|
CPI 169,CPI-169,CPI169 |
Epigenetic Reader Domain
,
Histone Methyltransferase
|
|
CPI-169 racemate (CPI 169) is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively. |
|
T22253 |
AG-120 (racemic)
|
|
Dehydrogenase
|
|
AG-120 (racemic), the racemic mixture of AG-120, is an orally available isocitrate dehydrogenase type 1 (IDH1) inhibitor, and shows potential antineoplastic activity. |
|
T16731 |
Rentiapril racemate
|
(Rac)-SA-446,SA-446 racemate,(Rac)-Rentiapril |
Angiotensin-converting Enzyme (ACE)
|
|
Rentiapril racemate (SA-446 racemate) is the racemate of Rentiapril.Rentiapril racemate has anti-inflammatory activity and may be used in glaucoma research. |
|
T13331 |
WAY127093B racemate
|
|
PDE
|
|
WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs. |
|
T4345 |
CeMMEC1
|
CeMMEC1 HCl |
Epigenetic Reader Domain
,
Carboxypeptidase
,
DNA/RNA Synthesis
|
|
CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM). |
|
T9005 |
VPC-80051 racemate
|
|
Others
|
|
VPC-80051 is the first small molecule inhibitor of hnRNP A1 splicing activity by using a computer-aided drug discovery approach. |
|
T20700 |
Racemetirosine
|
|
Others
|
|
Racemetirosine is an inhibitor of Tyrosine 3-monooxygenase, and consequently it inhibits the synthesis of catecholamines. |
|
T22988 |
MK-4827 Racemate
|
Niraparib Racemate,2-(4-piperidin-3-ylphenyl)indazole-7-carboxamide |
PARP
|
|
MK-4827 Racemate (Niraparib Racemate) is a selective PARP1 and PARP2 inhibitor with IC50s of 3.8 nM and 2.1 nM, respectively, over 330-fold selectivity for PARP3, V-PARP and Tank1. |
|
T11178L |
ELN318463 racemate
|
ELN318463 (racemate),ELN 318463 racemate |
Gamma-secretase
|
|
ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor. |
|
T70407 |
cemadotin free base
|
LU103793 free base |
Microtubule Associated
|
|
Cemadotin free base(LU103793 free base) is a novel anti-limiting peptide , an analog of Dolastatin 15, a naturally occurring cytotoxic peptide that blocks mitosis and inhibits microtubules (tubulin) with a Ki of 1 μM. Ce... |
|
T67778 |
DCeMM1
|
|
Molecular Glues
|
|
dCeMM1 is a RBM39 glue degrader. dCeMM1 can re-direct the activity of the CRL4DCAF15 ligase. dCeMM1 can decrease the expression levels of RBM39 in WT KBM7 cells. |
|
T6425 |
BTZ043 Racemate
|
BTZ044,BTZ10526038,Benzothiazinone 10526038 |
Antibacterial
,
DprE1
|
|
BTZ043 Racemate (Benzothiazinone 10526038) is a decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) inhibitor, used as a new antimycobacterial agent. |
|
T3534 |
Tetrabenazine Racemate
|
Nitoman,Ro 1-9569 Racemate,Rubigen,TETRABENAZINE |
Monoamine Transporter
|
|
Tetrabenazine Racemate (Rubigen) is a selective and reversible inhibitor of vesicular monoamine transporter-2 (VMAT-2). Tetrabenazine Racemate blocks neurotransmitter uptake into adrenergic storage vesicles and has been ... |
|
T3562 |
Valrocemide
|
TV1901,N-Valproylglycinamide |
Others
|
|
Valrocemide (TV1901), also known as TV-1901, is an antiepileptic drug (AED). Valrocemide has a broad spectrum of anticonvulsant activity and promising potential as a new AED. Valrocemide is an anticonvulsant agent under ... |
|
T7504 |
Necrostatin 2 racemate
|
Necrostatin-2 racemate |
RIP kinase
|
|
Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1. |
|
T7359 |
CAY10471 Racemate
|
TM30089 Racemate |
GPR
,
Prostaglandin Receptor
|
|
CAY10471 Racemate (TM30089 Racemate) is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 Racemate binds to the human CRTH2/DP2, DP1, and TP receptors( Ki values of 0.6, 1200, and >10,000 nM,respectivel... |
|
T9758 |
DCeMM3
|
2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide |
Others
|
|
dCeMM3 (2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide) is a glue degrader. dCeMM3 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, result in inducing ubiquitination and degradati... |
|
T12215 |
Nexopamil racemate
|
(Rac)-Nexopamil |
Calcium Channel
,
5-HT Receptor
|
|
|
|
T27143 |
Delucemine Hydrochloride
|
NPS 1506,Delucemine,Delucemine HCl,NPS1506,NPS-1506 |
NMDAR
|
|
Delucemine Hydrochloride (Delucemine) is a polyamine NMDA receptor antagonist used in the study of neurological disorders such as depression and Alzheimer's disease. |
|
T76750 |
Cemiplimab
|
REGN-2810,SAR-439684 |
Others
|
|
Cemiplimab (Anti-Human PD-1) is a human monoclonal antibody against programmed cell death receptor 1 (PD-1) and a checkpoint inhibitor that blocks PD-1/PD-L1 mediated T-cell inhibition and can be used in metastatic cance... |
|
T10464L |
Atuveciclib Racemate
|
BAY-1143572 Racemate |
CDK
|
|
Atuveciclib Racemate (BAY-1143572 Racemate) is the racemate mixture of Atuveciclib, which is a potent and highly selective, oral P-TEFb/CDK9 inhibitor which supresses CDK9/CycT1 with an IC50 of 13 nM. |
|
T14864 |
Caracemide
|
NSC-253272 |
Others
,
DNA/RNA Synthesis
,
Antibacterial
|
|
Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies. |
|
T12400 |
Peliglitazar racemate
|
(Rac)-Peliglitazar,(Rac)-BMS 426707-01,BMS 426707-01 racemate |
PPAR
|
|
|
|
T3120 |
K858 (Racemic)
|
K858 Racemic,K858 |
Apoptosis
,
Kinesin
|
|
K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner. |
|
T1467 |
Acemetacin
|
K-708,TVX 1322 |
COX
|
|
Acemetacin (TVX 1322) is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metaboli... |
|
T6801 |
CeMMEC13
|
|
Carboxypeptidase
,
DNA/RNA Synthesis
|
|
CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 μM). |
|
T10591 |
BPO-27 racemate
|
BPO-27 (racemate) |
CFTR
,
Autophagy
|
|
|
|
T3449 |
Bay 41-4109 racemate
|
|
HBV
|
|
BAY 41-4109 racemate is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM. |
|
T2344L |
LY 344864 racemate
|
|
5-HT Receptor
|
|
LY 344864 racemate is a 5-HT1F receptor agonist. |
|
T61477 |
DCeMM2
|
|
Molecular Glues
|
|
dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K. |
|
T70109 |
Delucemine Free Base
|
|
|
|
Delucemine Free Base is an NMDA Receptor Antagonist |
|
T11859 |
Litronesib Racemate
|
LY-2523355 Racemate,KF-89617 Racemate |
Others
|
|
Litronesib is a selective, allosteric inhibitor of kinesin Eg5.Litronesib (Racemate) is the racemate of litronesib. |
|
T13081 |
Taranabant racemate
|
MK-0364 racemate |
Cannabinoid Receptor
|
|
Taranabant racemate is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor. |
|
T13700 |
GDC-0927 Racemate
|
SRN-927 Racemate |
Others
|
|
GDC-0927 Racemate is a degrader of estrogen receptor, is used in the research of ER-related diseases, potently inhibits ER-α activity, with an IC50 of 0.2 nM. |
|
T12583 |
PX20606 trans racemate
|
PX-102 trans racemate |
Others
|
|
PX20606 trans racemate is an agonist of FXR (EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively). |
|
T77188 |
Tifcemalimab
|
|
|
|
Tifcemalimab (JS004), a humanized monoclonal antibody targeting BTLA (B and T lymphocyte attenuation factor), inhibits the HVEM-BTLA interaction by binding to BTLA. This action prevents the BTLA-mediated inhibitory signa... |
|
T11786 |
KUL-7211 racemate
|
KUL 7211 racemate |
Adrenergic Receptor
|
|
KUL 7211, a selective β-adrenoceptor agonist, exists as a racemate, referred to as KUL 7211 racemate, which is the mixture of its enantiomers. |
|
T74431 |
Cemdisiran
|
|
|
|
Cemdisiran, a conjugated siRNA with N-acetylgalactosamine (GalNAc), targets the liver to inhibit the production of complement 5 (C5) protein, serving as a potential therapeutic agent for the study of complement-mediated ... |
|
T71910 |
Racemic rasagiline
|
|
|
|
Racemic rasagiline, also known as AGN-1135, is a Monoamine Oxidase type-B inhibitor (MAOI). However, application of this drug can lead to fatal hypertensive crisis in patients who consume tyramine-rich foods. TVP-102... |
|
T27421 |
GNE-140 racemic
|
GNE-140,GNE 140,GNE140 |
|
|
GNE-140 racemic is a potent lactate dehydrogenase (LDHA) inhibitor. |
|
T11951 |
Mavoglurant racemate
|
AFQ-056 racemate |
Others
|
|
Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. Mavoglurant (racemate) is the racemate of mavoglurant. |
|
T20667 |
Racemic Naproxen
|
DL-Naproxen,DL Naproxen |
|
|
Racemic Naproxen is a biochemical substance. |
