|
T8963 |
CYM2503
|
|
Neuropeptide Y Receptor
|
|
CYM2503 is a positive allosteric modulator (PAM) of the GAL2 receptor that potentiates galanin-induced IP1 production in vitro. It has no affinity for the orthosteric galanin binding site of the receptor (as measured by ... |
|
T8944 |
TTA-A2
|
|
Calcium Channel
|
|
TTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels ... |
|
T4664 |
ML 297
|
ML297 |
Potassium Channel
|
|
ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). ML 297 exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, an... |
|
T0680 |
Lamotrigine
|
LTG,BW430C |
5-HT Receptor
,
Sodium Channel
,
Autophagy
|
|
Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
|
T0028 |
Gamibetal
|
3-Hydroxy-GABA,4-Amino-3-hydroxybutyric Acid |
HIV Protease
|
|
Gamibetal (4-Amino-3-hydroxybutyric Acid) is used as a chiral reagent in the synthesis of antiepileptic and hypotensive drug GABOB and analogues. Also used in the preparation of HIV-1 inhibitors derived from Betulinic Ac... |
|
T0786 |
Clidinium bromide
|
Ro 2-3773 |
AChR
|
|
Clidinium bromide (Ro 2-3773) , a synthetic anticholinergic agent, has been shown in experimental and clinical researchers to have a pronounced antisecretory and antispasmodic effect on the gastrointestinal tract. It can... |
|
T8937 |
Soticlestat
|
TAK-935,OV935 |
P450
|
|
Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research. |
|
T4979 |
Procyclidine hydrochloride
|
(±)-Procyclidine hydrochlorid |
NMDAR
,
iGluR
|
|
Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) is a potent anticholinergic agent and also have NMDA antagonist properties. |
|
T0024 |
Primidone
|
Primaclone,Mysoline,NCI-C56360 |
GABA Receptor
,
Sodium Channel
,
GluR
,
AChR
|
|
Primidone (NCI-C56360) is a potent anticonvulsant agent. It is a neuronal voltage-gated sodium channel blocker and has value in the study of epilepsy, essential tremor, and psychiatric disorders. |
|
T3217 |
PF-CBP1 hydrochloride
|
PF-CBP1 HCl |
Epigenetic Reader Domain
,
Histone Acetyltransferase
|
|
PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively. |
|
T0267 |
Zonisamide
|
AD 810,CI 912 |
Calcium Channel
,
Sodium Channel
,
Carbonic Anhydrase
|
|
Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms... |
|
T1602 |
Valproic acid sodium salt
|
Sodium Valproate |
Mitophagy
,
Gamma-secretase
,
HIV Protease
,
GABA Receptor
,
HDAC
,
Autophagy
|
|
Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mecha... |
|
T7806 |
Licarbazepine
|
10,11-hydroxy-10,11 Dihydrocarbamezer |
Others
|
|
Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial seizures and bipolar disorders. |
|
T6474 |
Divalproex Sodium
|
Valproate semisodium,Epival |
HDAC
|
|
Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme... |
|
T68112 |
Nafimidone
|
|
|
|
Nafimidone shows anticonvulsant activity in a rat model of amygdala epilepsy and can be used in the treatment of chronic intractable epilepsy. |
|
T31614 |
Elpetrigine
|
JZP-4,JZP4,GW-273293,JZP 4,GW 273293,GW273293 |
Sodium Channel
|
|
Elpetrigine (GW273293) is a potential sodium channel blocker with antiepileptic activity that can be used to study epilepsy. |
|
T23301 |
(S)-(+)-Niguldipine hydrochloride
|
|
Adrenergic Receptor
|
|
(S)-(+)-Niguldipine hydrochloride is a selective α1A-AR antagonist used in the study of depression and epilepsy. |
|
T22638 |
CBiPES hydrochloride
|
CBiPES HCl |
GluR
|
|
CBiPES hydrochloride (CBiPES HCl) is a potent orthosteric modulator of the mGlu2 receptor with an EC50 value of 92.8 nM.CBiPES hydrochloride blocks the action of WT and mGlu(3) receptors.CBiPES hydrochloride can be used ... |
|
T8604 |
Fenaclon
|
Fenaclonum |
Others
|
|
Fenaclon (Fenaclonum) is an anticonvulsant. It is indicated for the treatment of epilepsy. |
|
T25813 |
Milenperone
|
R 34009,R-34009,R34009 |
Others
|
|
Milenperone (R 34009) is a novel anti-invasive compound for the control of behavioral disorders in patients with epilepsy and alcoholism. |
|
T8594 |
Pheneturide
|
2-PHENYLBUTYRYLUREA,S-46,Benuride |
Others
|
|
Pheneturide (Benuride) is the ureide class, used to treat epilepsy, and is an anticonvulsant. |
|
T22808 |
GR 46611
|
|
5-HT Receptor
|
|
GR 46611 is a selective 5-HT1B and 5-HT1D receptor agonist and can be used in studies about the treatment of epilepsy. |
|
TNU0685 |
Dipropofol
|
4,4-Bis(2,6-di-isopropylphenol) |
GABA Receptor
|
|
Dipropofol (4,4-Bis(2,6-di-isopropylphenol)) is a small molecule GABAA receptor agonist that can be used to study epilepsy. |
|
T24167 |
Inflachromene
|
ICM |
Others
|
|
Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene reduces seizure severity in a mouse model of epilepsy by inhibiting HMGB1 translocation, inhibits endothelial... |
|
T0598 |
Iminostilbene
|
Dibenzazepine |
Others
|
|
Iminostilbene (Dibenzazepine) (Dibenzazepine) is a chemical precursor of carbamazepine which is used primarily in the treatment of epilepsy and neuropathic pain. |
|
T16427 |
Padsevonil
|
UCB-0942,UCB1415943-000 |
GABA Receptor
|
|
Padsevonil (UCB-0942) is a potential GABA A receptor orthosteric modulator with antiepileptic activity for the treatment of epilepsy. |
|
T23072 |
NNC 05-2090 hydrochloride
|
|
Transaminase
|
|
NNC 05-2090 hydrochloride is a betaine/GABA transporter (BGT-1) inhibitor with an IC50 value of 10.6 μM.NNC 05-2090 hydrochloride can be used for the study of epilepsy and neurological disorders. |
|
T31860 |
Fosdevirine
|
GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A |
HIV Protease
|
|
Fosdevirine (GSK2248761) is a selective and potent non-nucleoside reverse transcriptase (NNRTI) inhibitor with anti-HIV activity for the study of neurological related disorders such as late-onset epilepsy. |
|
T60796 |
Cholesterol 24-hydroxylase-IN-1
|
|
P450
|
|
Cholesterol 24-hydroxylase-IN-1 is an orally active, selective, and potent inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1) that crosses the blood-brain barrier.Cholesterol 24-hydroxylase-IN-1 may be useful in ... |
|
T77596 |
Soretolide
|
D2916,D-2916 |
Others
|
|
Soretolide (D2916) is a small molecule compound that is used to treat epilepsy. |
|
T7612 |
ICA 110381
|
|
Potassium Channel
|
|
ICA 110381 is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy |
|
T67954 |
Endixaprine
|
SR 41378 |
|
|
Endixaprine (SR 41378) is a small molecule compound used to treat neurological disorders and may be used to study anxiety disorders and epilepsy. |
|
T73586 |
Anticonvulsant agent 2
|
|
Others
|
|
Anticonvulsant agent 2 is a potent orally active anticonvulsant that has shown antiepileptic activity in a model of drug-resistant epilepsy. |
|
T0355 |
Valpromide
|
Depamide,Valpramide,Dipropylacetamide,2-propylpentanamide |
Epoxide Hydrolase
,
HSV
|
|
Valpromide (Dipropylacetamide) is a carboxamide derivative of valproic acid, used in the treatment of epilepsy and some affective disorders. |
|
T27405 |
GAT211
|
AZ4,GAT-211,AZ 4,GAT 211,AZ-4 |
cAMP
,
Cannabinoid Receptor
,
Arrestin
|
|
GAT211 (AZ-4) is a selective and potent cannabinoid 1 receptor (CB1R) orthosteric modulator (PAM) with high affinity for cAMP and β-arrestin2.GAT211 has IOP-lowering and antipsychotic effects and can be used in the study... |
|
T31592 |
E6801
|
E 6801,E-6801 |
5-HT Receptor
|
|
E6801 is a novel selective 5-HT6 receptor agonist with a wide range of biological activities.E6801 can be used in the study of dementia, Parkinson's disease, depression, obesity epilepsy, anxiety, and many other diseases... |
|
TD1228 |
ETHOTOIN
|
|
|
|
Ethotoin (Peganone), an orally active anticonvulsant agent utilized in epilepsy research, is a hydantoin derivative analogous to phenytoin [1]. |
|
T31860L |
(Iso)-Fosdevirine
|
(Iso)-Fosdevirine（Iso-1018450-26-4）,(Iso)-GSK2248761 |
HIV Protease
|
|
(Iso)-Fosdevirine ( (Iso)-GSK2248761) is a selective and potent non-nucleoside reverse transcriptase (NNRTI) inhibitor with anti-HIV activity for the study of neurological disorders such as late-onset epilepsy. |
|
T34609 |
Selurampanel
|
BGG-492,BGG 492,BGG492 |
iGluR
|
|
Selurampanel (BGG492) is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in the study of epilepsy, migraine and tinnitus. |
|
T39630 |
Zandatrigine
|
NBI-921352,XEN901 |
Sodium Channel
|
|
Zandatrigine (NBI-921352) is a blocker of sodium channel protein type 8 subunit alpha and can be used in studies about nervous system pathologies of epilepsy treatment. |
|
T72170 |
NaV1.2/1.6 channel blocker-1
|
|
Sodium Channel
|
|
NaV1.2/1.6 channel blocker-1 is a potent NaV1.2/1.6 channel blocker with inhibitory effects on rNaV1.6 and hNaV1.2.NaV1.2 channel blocker-1 can be used in the study of generalised epilepsy and movement disorders. |
|
T3562 |
Valrocemide
|
TV1901,N-Valproylglycinamide |
Others
|
|
Valrocemide (TV1901), also known as TV-1901, is an antiepileptic drug (AED). Valrocemide has a broad spectrum of anticonvulsant activity and promising potential as a new AED. Valrocemide is an anticonvulsant agent under ... |
|
T61745 |
HCAI/II-IN-6
|
|
Carbonic Anhydrase
|
|
hCAI/II-IN-6 is a selective and orally active inhibitor of human carbonic anhydrase (CA). hCAI/II-IN-6 inhibited hCA I, hCA II, hCA VII, and hCA XII with Ki values of 220, 4.9, 6.5, and ＞50,000 nM. hCAI/II-IN-6 showed an... |
|
T0806 |
Flunarizine dihydrochloride
|
Flunarizine 2HCl,KW-3149,R14950 |
Calcium Channel
,
Dopamine Receptor
,
Sodium Channel
|
|
Flunarizine dihydrochloride (R14950) is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. Flunarizine dihydrochloride (R14950) is effective in the prophylaxis of mig... |
|
T50021 |
3-(3,6-dichloro-9H-carbazol-9-yl)propanoic acid
|
|
Others
|
|
3-(3,6-dichloro-9H-carbazol-9-yl)propanoic acid (DCPPA) is an ASIC3 inhibitor that effectively blocks ASIC3-mediated pain and inflammation. It has been shown to have potential applications in the treatment of other disea... |
|
T73447 |
NP10679
|
|
P450
,
HER
,
NMDAR
,
Histamine Receptor
|
|
NP10679 is an orally available, selective, brain-penetrating, potent, and pH-sensitive N-methyl-D-aspartate (NMDA) receptor inhibitor of the GluN2B subunit.NP10679 inhibits histamine H1, hERG channels, and CYP enzymes, a... |
|
T60351 |
Acetazolamide sodium
|
OT-302 sodium |
Carbonic Anhydrase
|
|
Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA)IX inhibitor with diuretic, antigonococcal, and antihypertensive activity and may be used for indications such as epilepsy, glaucoma, edema, and alt... |
|
T16489 |
Darigabat
|
CVL-865,PF-6372865,PF-06372865 |
GABA Receptor
|
|
Darigabat (PF-06372865) is an orally active and selective GABAA receptor modulator that crosses the blood-brain barrier and exhibits anxiolytic activity, with Ki values of 2.9 nM, 21 nM, and 134 nM for α2, α1 PAM, and α2... |
|
T17197 |
UCL 2077
|
|
|
|
UCL 2077 is a subtype-selective blocker of the epilepsy-associated KCNQ channels and it also is a selective slow-afterhyperpolarization channel blocker，with IC50 of 500 nM in hippocampal neurons in culture, having minima... |
|
T50046 |
2-(2-amino-3-methylbutanamido)-3-phenylpropanoic acid hydrochloride
|
|
Others
|
|
2-(2-amino-3-methylbutanamido)-3-phenylpropanoic acid hydrochloride is an amino acid compound that is a synthetic analog of glutamate, an important neurotransmitter in the central nervous system. It has been investigated... |
