|
T9648 |
SIRT1-IN-1
|
|
Antiviral
,
Sirtuin
|
|
SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM. SIRT1-IN-1 is an inhibitor of cytomegalovirus (CMV) with antiviral activity. |
|
T24792 |
SIRT1-I5
|
SIRT1-Inhibitor-I5,SIRT1 Inhibitor I5 |
|
|
SIRT1-I5 is a SIRT1 inhibitor. It shows a potent effect on the prostate cancer cell line. |
|
T24791 |
SIRT1-A2
|
SIRT1-Activator-A2,SIRT1A2,SIRT1 Activator A2 |
|
|
SIRT1-A2 is a SIRT1 activator. |
|
T4019 |
Cambinol
|
SIRT1/2 Inhibitor IV,NSC 112546 |
Apoptosis
,
Phospholipase
,
Sirtuin
|
|
Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Ca... |
|
T23357 |
SIRT1/2 Inhibitor IV
|
|
Others
|
|
SIRT1/2 Inhibitor IV (cannabinol) is a small-molecule inhibitor of SIRT1 and SIRT2 with IC50 values of 56 μM and 59 μM, respectively. |
|
T81154 |
SIRT1 activator 1
|
|
Sirtuin
|
|
SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp. mangrove fungus, exhibits angiogenic effects in zebrafish and protects human endothelial progenitor cells (hEPCs) from AngI... |
|
T60373 |
SIRT1-IN-2
|
|
|
|
SIRT1-IN-2 (compound 3h) is a potent and selective inhibitor of SIRT1 (silent information regulator 1) with an IC 50 of 1.6 μM [1]. |
|
T60631 |
SIRT1-IN-3
|
|
|
|
SIRT1-IN-3 (compound 3j) is a potent and selective inhibitor of silent information regulator 1 (SIRT1) with an IC 50 of 4.2 μM [1]. |
|
T79565 |
Sirt1/2-IN-4
|
|
Sirtuin
|
|
Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respectively. It effectively inhibits p53 deacetylation,... |
|
T24394 |
LDN-0028574
|
SIRT1-I1,SIRT1-Inhibitor-I1,LDN-28574,LDN 0028574 |
|
|
LDN-0028574 is a SIRT1 inhibitor that also acts as an inhibitor of the human MDM2-p53 interaction. |
|
T79564 |
Sirt1/2-IN-3
|
|
Sirtuin
|
|
Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respectively. This compound effectively inhibits p53 deacetylation while simultaneously elev... |
|
T62240 |
Sirt1/2-IN-1
|
|
|
|
Sirt1/2-IN-1 (Compound 7) is an inhibitor of SIRT1 and SIRT2 and is capable of acting on SIRT1 (IC50: 1.81 μg/mL), SIRT2 (IC50: 2.10 μg/mL) and SIRT3 (IC50: 20.5 μg/mL) and has α-microtubulin hyperacetylation activity ( ... |
|
T79563 |
Sirt1/2-IN-2
|
|
Sirtuin
|
|
Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM, respectively. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 a... |
|
T74894 |
SIRT1/2/3-IN-1
|
|
|
|
SIRT1/2/3-IN-1 (compound 10) is a potent, selective, and cell-permeable inhibitor targeting SIRT1, SIRT2, and SIRT3, demonstrating inhibitory concentrations (IC50s) of 0.54 μM, 0.253 μM, and 0.72 μM, respectively. It is ... |
|
T10035 |
10,12-Tricosadiynoic acid
|
TDA,TCDA |
Acyltransferase
|
|
10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1). It can treat the high-fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS me... |
|
T0459 |
Sulindac
|
Arthrocine,MK-231,Clinoril,Sulindac sulfoxide |
COX
,
Autophagy
|
|
Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl... |
|
T15263 |
Selisistat R-enantiomer
|
EX-527 (R-enantiomer) |
Sirtuin
|
|
Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM). |
|
T8346 |
SRT 1460
|
SRT1460 |
Sirtuin
|
|
SRT 1460 is a SIRT1 activator. |
|
T12922 |
Sirtuin modulator 1
|
SRT3025 Hydrochloride |
Sirtuin
|
|
Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM. |
|
T7058 |
Selisistat S-enantiomer
|
EX-527 S-enantiomer,EX-527 (S-enantiomer) |
Sirtuin
|
|
Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3. |
|
T12919 |
SIRT-IN-2
|
|
Sirtuin
|
|
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively). |
|
T2412 |
SRT1720 hydrochloride
|
SRT1720 HCl,SRT 1720 Hydrochloride |
Sirtuin
|
|
SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM). |
|
T6671 |
Sirtinol
|
|
Apoptosis
,
Sirtuin
,
Autophagy
|
|
Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM). |
|
T5124 |
SRT 1720 dihydrochloride[925434-55-5(free base)]
|
|
Sirtuin
|
|
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM). |
|
T8480 |
Tenovin-6 Hydrochloride
|
|
Dehydrogenase
,
Sirtuin
,
HDAC
,
p53
,
Autophagy
|
|
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator . |
|
T1887 |
Inauhzin
|
INZ |
Sirtuin
|
|
Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A54... |
|
T12918 |
SIRT-IN-1
|
|
Sirtuin
|
|
|
|
TN7093 |
N-Caffeoyltryptophan
|
trans-Caffeoyl-L-tryptophan |
Sirtuin
|
|
N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM). |
|
T6111 |
Selisistat
|
EX-527,SEN0014196 |
Sirtuin
|
|
Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM). Selisistat can be used in the study of neurological disorders such as Huntington's chorea. |
|
T5096 |
SRT 1720
|
|
Sirtuin
,
Autophagy
|
|
SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3. |
|
T16932 |
SRT 2183
|
|
Apoptosis
,
Sirtuin
|
|
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM). |
|
T4328 |
OSS_128167
|
SIRT6-IN-1 |
HBV
,
Sirtuin
|
|
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM). |
|
T50080 |
MC2184
|
|
Sirtuin
|
|
MC2184 is the inhibitor of human recombinant SIRT1. |
|
T3953 |
Salermide
|
|
Apoptosis
,
Sirtuin
|
|
Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death. |
|
T9106 |
E1231
|
|
Sirtuin
|
|
E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression. |
|
T4062 |
CAY10602
|
|
Sirtuin
|
|
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-depende... |
|
T6679 |
SRT 2104
|
SRT2104,sirtuin modulator,GSK2245840 |
Sirtuin
|
|
SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator. |
|
T1919 |
Tenovin-1
|
Tenovin 1 |
Mdm2
,
Dehydrogenase
,
Sirtuin
,
p53
,
Autophagy
|
|
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination. |
|
T22026 |
AGK7
|
|
Others
,
Sirtuin
|
|
AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively). |
|
T77697 |
BML-278
|
BML278,BML 278 |
Sirtuin
,
Histone Methyltransferase
|
|
BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can be used to improve early embryonic development.BML-278 ind... |
|
T3447 |
Thiomyristoyl
|
|
Sirtuin
|
|
Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM. |
|
T22094 |
JGB1741
|
ILS-JGB-1741 |
Sirtuin
|
|
JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleavage and increases the acetylated p53 levels leading to p53-m... |
|
T1818 |
Tenovin-6
|
Tenovin 6 |
Dehydrogenase
,
Sirtuin
,
Autophagy
|
|
Tenovin-6 is a p53 transcriptional activity agonist. |
|
T21679 |
4'-bromo-Resveratrol
|
|
Sirtuin
|
|
4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3) |
|
T4108 |
3-TYP
|
3-(1H-1,2,3-triazol-4-yl) pyridine |
Sirtuin
|
|
3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor. |
|
T6371 |
AGK2
|
|
Apoptosis
,
Sirtuin
|
|
AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor. |
|
T16342 |
KL1333
|
NQO1 activator 1 |
NADPH
,
Mitochondrial Metabolism
|
|
KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 ... |
|
T9320 |
YK-3-237
|
B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid |
Sirtuin
|
|
YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells ca... |
|
T27004 |
CHIC35
|
CHIC-35,CHIC 35 |
|
|
CHIC-35 is a selective deacetylase SIRT1 inhibitor. |
|
T79601 |
SPC-180002
|
|
Sirtuin
|
|
SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively. It disrupts redox homeostasis through ROS generation, consequently enhancing p21 protein stability and ind... |
