|
T13774 |
ML390
|
|
Others
,
Dehydrogenase
|
|
ML390 exerts its potent differentiation effect on multiple leukemia models. |
|
T7156 |
NIBR189
|
|
EBI2/GPR183
|
|
NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors, respectively) |
|
T5821 |
BC-1215
|
|
Others
,
Ligand for E3 Ligase
|
|
BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). |
|
T8531 |
M-3M3FBS
|
|
Apoptosis
,
Phospholipase
|
|
m-3M3FBS is a phospholipase C (PLC) activator. |
|
T9016 |
AI-10-47
|
1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47 |
Others
|
|
AI-10-47 (1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47) is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM). |
|
T5622 |
BAY-218
|
AHR antagonist 1 |
AhR
,
Aryl Hydrocarbon Receptor
|
|
BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line. |
|
T2036 |
6-OAU
|
GTPL5846 |
GPR
|
|
6-OAU (GTPL5846)(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay. |
|
T63055 |
RIPK1-IN-9
|
|
RIP kinase
|
|
RIPK1-IN-9 is a potent and selective inhibitor of RIPK1, a dihydronaphthone compound, which inhibits U937 and L929 cells with an IC50 of 2 nM and 1.3 nM, respectively. |
|
T77697 |
BML-278
|
BML278,BML 278 |
Sirtuin
,
Histone Methyltransferase
|
|
BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can be used to improve early embryonic development.BML-278 ind... |
|
T78156 |
MC4033
|
|
Apoptosis
|
|
MC4033 exhibits inhibitory concentration 50 (IC50) values of 39.4 µM in HCT116, 52.1 µM in H1299, 41 µM in A549, and 30.1 µM in U937 [1]. Additionally, treatment with MC4033 at concentrations of 25, 50, 100, and 200 µM f... |
|
T22889 |
KF38789
|
KF 38789 |
Others
|
|
KF38789 is a selective inhibitor of P-selectin-mediated cell adhesion and P-selectin immunoglobulin G chimeric protein. |
|
T9034 |
MK2-IN-3
|
MK2 Inhibitor III |
MAPK
|
|
MK2-IN-3 (MK2 Inhibitor III) is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatment of rheumatoid arthritis |
|
T6852 |
GSK481
|
GSK'481 |
RIP kinase
|
|
GSK481 (GSK'481) is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death. |
|
T63854 |
Cathepsin C-IN-3
|
|
|
|
Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM). |
|
T10050 |
1alpha-Hydroxy VD4
|
1α-Hydroxy vitamin D4 |
Others
|
|
1alpha-Hydroxy VD4 can effectively induce the differentiation of monoblastic leukaemia U937, P39/TSU, and P31/FUJ cells. |
|
T62499 |
RIPK1-IN-14
|
|
|
|
RIPK1-IN-14 (Compound 41) is a potent inhibitor of RIPK1 (IC50: 92 nM).RIPK1-IN-14 has a significant anti-necrotic apoptotic effect in a model of necrotic apoptosis in U937 cells. |
|
T62659 |
Cathepsin C-IN-4
|
|
|
|
Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM). |
|
T36319 |
C6 L-erythro Ceramide (d18:1/6:0)
|
C6 L-erythro Ceramide (d18:1/6:0) |
|
|
C6 L-erythro Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is metabolized by ceramide glucosyltransferase to form C6 L-erythro glucosylceramide. C6 L-erythro Ceramide... |
|
T26775 |
Bepafant
|
WEB-2170,WEB2170,STY 2108,STY-2108,WEB 2170 |
|
|
Bepafant is a platelet activating factor (PAF) antagonist. Bepafant may produce significant anti-inflammatory effects. Bepafant triggered apoptosis in NB4, KG1, and NB4-MR4 cells where PTEN was expressed, but not in THP1... |
|
T36322 |
C8 D-threo Ceramide (d18:1/8:0)
|
C8 D-threo Ceramide (d18:1/8:0) |
|
|
C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently th... |
|
T63139 |
Glutaminyl cyclases-IN-1
|
|
|
|
Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent inhibitor of Glutaminyl cyclases (QC), which acts on human QC (IC50: 12 nM) and isoQC (IC 50:73 nM). Glutaminyl cyclases-IN-1 inhibited isoQC and selectively blocked CD47... |
|
T36943 |
Aminopeptidase N Inhibitor
|
|
|
|
Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (... |
|
T78815 |
MOZ-IN-3
|
|
Histone Acetyltransferase
|
|
MOZ-IN-3 (Compound 6j), a potent KAT6A (MOZ) acetyltransferase inhibitor with an IC50 of 30 nM, exhibits antitumor activity against multiple myeloid leukemia cell lines, including HL-60, U937, SKNO-1, and K562. This comp... |
|
T21749 |
4-iodo-SAHA
|
|
|
|
4-Iodo-SAHA (1k), an orally active inhibitor of both class I and class II histone deacetylase (HDAC), exhibits EC50 values of 1.1, 0.95, 0.12, 0.24, 0.85, and 1.3 μM for Skbr3, HT29, U937, JA16, and HL60 cell lines, resp... |
|
T36324 |
C8 L-threo Ceramide (d18:1/8:0)
|
C8 L-threo Ceramide (d18:1/8:0) |
|
|
C8 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 10 μM) and, like C8 D-threo ceramide , induces nuclear DNA fragmentation 5... |
|
T36320 |
C6 L-threo Ceramide (d18:1/6:0)
|
C6 L-threo Ceramide (d18:1/6:0) |
|
|
C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 L-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlik... |
|
T37907 |
DL 175
|
|
|
|
Potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bo... |
|
T35929 |
O-Demethyl Apremilast
|
|
|
|
O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripher... |
|
T60439 |
CAY10789
|
|
|
|
CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist with an IC50 of 2.80 μM. CAY10789 is also a GPBAR1 (G-protein-coupled bile acid receptor 1) agonist with an EC50 of 3 μM. CAY10789 s... |
|
T19674 |
Verlukast
|
MK 0679,MK-679,L 668,019,MK 679,L 668019,L-668,019 |
|
|
Verlukast is an (R)-enantiomer of MK-571 and a potent and selective LTD4 receptor antagonist. Verlukast showed [3H]leukotriene D4 binding in guinea-pig (IC50 = 3.1 +/- 0.5 nM) and human (IC50 = 8.0 +/- 3.0 nM) lung homog... |
|
T4057 |
Hoechst 33258 trihydrochloride
|
Hoechst 33258,Pibenzimol,Bisbenzimide,H 33258 trihydrochloride,bisBenzimide H 33258 trihydrochloride,HOE 33258 |
Parasite
|
|
Hoechst 33258 trihydrochloride (Bisbenzimide) is a benzimidazole anti-filarial agent. it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication. it also interfe... |
|
T68667 |
Oxanosine
|
|
|
|
Oxanosine is an analog of guanosine that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties. It is active against a variety of bacteria, in... |
|
T37565 |
C6 D-threo Ceramide (d18:1/6:0)
|
C6 D-threo Ceramide (d18:1/6:0) |
|
|
C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlik... |
|
T37684 |
CAY10412
|
CAY10412 |
|
|
Anandamide (arachidonoyl ethanolamide; AEA) is an endogenous lipid with cannabinergic activity; along with 2-arachidonoyl glycerol, it forms part of the endocannabinoid system. AEA undergoes reuptake into neurons by a fa... |
|
T35536 |
Tpl2 Kinase Inhibitor (hydrochloride)
|
|
|
|
Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50= 0.05 μM).1It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kina... |
|
T69200 |
CGP74514A
|
|
|
|
CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and t... |
|
T35406 |
α-MSH TFA
|
|
|
|
α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocyt... |
|
T35775 |
HT-2 Toxin-13C22
|
HT-2 Toxin-13C22 |
|
|
HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene... |
