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天然化合物

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カタログ番号	製品名	別名	ターゲット
T21727	Ivermectin B1a		SARS-CoV , Parasite
	Ivermectin B1a is the major (80%) component of commercially available ivermectin and a derivative of Avermectin B1a.		SARS-CoV , Parasite
T8381	Amodiaquine		Others , Histone Methyltransferase , Parasite
	Amodiaquine is a synthetic aminoquinoline, used to treat malaria.		Others , Histone Methyltransferase , Parasite
T10339	Antitrypanosomal agent 1		Parasite
	Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor (IC50: 3.3 μM). Antitrypanosomal agent 1 inhibits glutathione reductase (IC50: 64.8 μM) and T. brucei (EC50: 1 μM).		Parasite
T10423	AWZ1066S		Parasite
	AWZ1066S is a highly specific anti-Wolbachia drug candidate for the short-course treatment of filariasis (EC50: 2.5 nM in cell assay).		Parasite
T8146	Imidocarb dipropionate		Antibiotic , Parasite
	Imidocarb dipropionate is an antigenic insecticide, is active against the protozoan parasite B. bovis (IC50 : 0.87 µg/ml).		Antibiotic , Parasite
T1647	Ronidazole	Ronidazol,Ridzol	Antibacterial , Antibiotic , Parasite
	Ronidazole (Ronidazol) is an antiprotozoal and antimicrobial agent used mainly in veterinary practice.		Antibacterial , Antibiotic , Parasite
T3467	Miransertib	ARQ-092,AKT inhibitor 2	Akt , Parasite
	Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor.		Akt , Parasite
T15507	Hycanthone	Etrenol(mesylate),Win 249-33	DNA/RNA Synthesis , Topoisomerase , Parasite
	Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibit...		DNA/RNA Synthesis , Topoisomerase , Parasite
T31482	Diloxanide	Diloxanid,RD 3803,RD3803,RD-3803,Diloxanida	Parasite
	Diloxanide (RD3803) is an endomoeba insecticide. It is considered to be the luminal agent of choice for patients with mild enteroamoebiasis or asymptomatic cysts.		Parasite
T0314	Hexylresorcinol	4-Hexylresorcinol	Apoptosis , Tyrosinase , Antibacterial , Parasite
	Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.		Apoptosis , Tyrosinase , Antibacterial , Parasite
T6275	Obatoclax Mesylate	Obatoclax,GX15-070	BCL , Parasite , Autophagy
	Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3.		BCL , Parasite , Autophagy
T2160	Suramin Sodium Salt	BAY-205,Suramin hexasodium salt,NF-060	Apoptosis , Phosphatase , SARS-CoV , Sirtuin , Reverse Transcriptase , Topoisomerase , Parasite
	Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth f...
T0381	Amodiaquine dihydrochloride dihydrate	Amodiaquine hydrochloride,Amodiaquin dihydrochloride dihydrate	Histone Methyltransferase , Parasite , Histamine Receptor
	Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.		Histone Methyltransferase , Parasite , Histamine Receptor
T10785	Chalcone 4 hydrate		Others , Parasite
	Chalcone 4 hydrate, an anti-parasite compound, inhibits the growth of Theileria and Babesia.		Others , Parasite
T69567	UCB7362	GLXC-26743	Parasite
	UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction.		Parasite
T38400	Triclabendazole sulfoxide	TCBZ-SO	BCRP , Parasite
	Triclabendazole sulfoxide (TCBZ-SO) is a main plasma metabolite of Triclabendazole. Triclabendazole sulfoxide inhibits membrane transporter ABCG2/BCRP and exhibits anti-parasite effects.		BCRP , Parasite
T4382	Proguanil hydrochloride	Paludrine hydrochloride,Chlorguanide hydrochloride,Chloroquanil	Others , Dehydrogenase , DNA/RNA Synthesis , Antifolate , Parasite
	Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine ...
T79535	Antimalarial agent 30		Parasite
	Antimalarial agent 30 has anti-Plasmodium berghei liver stage parasite activity and antimalarial activity for the study of malarial infections.		Parasite
T5493	Pyronaridine		Others
	Pyronaridine is an orally active, mannitol-containing anti-malarial compound that acts by interfering with the replication of the malaria parasite (Plasmodium) within red blood cells. Pyronaridine is often used in combin...		Others
T15110	DHQZ 36		Others
	DHQZ 36 is a potent retrograde trafficking inhibitor. It has potent anti-parasite activity. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages (EC50: 13.63 μM).		Others
T61158	Anti-infective agent 5
	Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi exhibiting an IC50 value of 0.10 μM. In addition to its potent inhibitory effect, anti-infective agent 5 demonstrates efficacy in re...
T72134	Anti-Trypanosoma cruzi agent-4
	Anti-Trypanosoma cruzi Agent-4 is a Trypanosoma cruzi inhibitor utilized for the investigation of infections caused by this parasite.
T11711	Jaspamycin	7-CN-7-C-Ino	JAK
	Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity. Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in T...		JAK
T62401	Anti-infective agent 4
	Anti-infective agent 4 (compound 73) is an orally active Trypanosoma cruzi inhibitor (IC50: 0.016 μM). anti-infective agent 4 is effective in reducing parasite burden in vivo and can be used to study infections.
T78184	MMV009085
	MMV009085 is a potent inhibitor of the Plasmodium falciparum hexose transporter (Pf HT1), with potential as an anti-malarial agent. It also inhibits the human glucose transporter, demonstrating high potency with an IC50 ...
T60836	PT4
	PT4 is a treatment agent for Cutaneous leishmaniasis (CL). PT4 decreases of mitochondrial membrane potential and increases reactive oxygen species production, therefore leads to parasite death. PT4 is effective against b...
T35904	O-11
	O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the pr...

Compounds

Ivermectin B1a

T21727

Synonym:

Target: SARS-CoV, Parasite

Amodiaquine

T8381

Synonym:

Target: Others, Histone Methyltransferase, Parasite

Antitrypanosomal agent 1

Imidocarb dipropionate

T8146

Synonym:

Target: Antibiotic, Parasite

Ronidazole

T1647

Synonym: Ronidazol,Ridzol

Target: Antibacterial, Antibiotic, Parasite

Miransertib

T3467

Synonym: ARQ-092,AKT inhibitor 2

Target: Akt, Parasite

Hycanthone

T15507

Synonym: Etrenol(mesylate),Win 249-33

Target: DNA/RNA Synthesis, Topoisomerase, Parasite

Diloxanide

T31482

Synonym: Diloxanid,RD 3803,RD3803,RD-3803,Diloxanida

Target: Parasite

Hexylresorcinol

T0314

Synonym: 4-Hexylresorcinol

Target: Apoptosis, Tyrosinase, Antibacterial, Parasite

Obatoclax Mesylate

T6275

Synonym: Obatoclax,GX15-070

Target: BCL, Parasite, Autophagy

Suramin Sodium Salt

T2160

Synonym: BAY-205,Suramin hexasodium salt,NF-060

Target: Apoptosis, Phosphatase, SARS-CoV, Sirtuin, Reverse Transcriptase, Topoisomerase, Parasite

Amodiaquine dihydrochloride dihydrate

T0381

Synonym: Amodiaquine hydrochloride,Amodiaquin dihydrochloride dihydrate

Target: Histone Methyltransferase, Parasite, Histamine Receptor

Chalcone 4 hydrate

T10785

Synonym:

Target: Others, Parasite

Triclabendazole sulfoxide

T38400

Synonym: TCBZ-SO

Target: BCRP, Parasite

Proguanil hydrochloride

T4382

Synonym: Paludrine hydrochloride,Chlorguanide hydrochloride,Chloroquanil

Target: Others, Dehydrogenase, DNA/RNA Synthesis, Antifolate, Parasite

Antimalarial agent 30

Anti-infective agent 5

T61158

Synonym:

Target:

Anti-Trypanosoma cruzi agent-4

Synonym: 7-CN-7-C-Ino

Target: JAK

Anti-infective agent 4

カタログ番号	製品名	別名	ターゲット
T5660	Menthone		IL Receptor , TNF , NF-κB , Parasite
	Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha),as well as nuclear factor k...		IL Receptor , TNF , NF-κB , Parasite
T4S0590	Columbin		Phospholipase , COX , Parasite
	1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion.		Phospholipase , COX , Parasite
TN4660	Niranthin		Anti-infection , HBV , PAFR , Topoisomerase
	Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. N...		Anti-infection , HBV , PAFR , Topoisomerase
T0690	Quinine		Potassium Channel , Platelet aggregation , Parasite
	Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cramps. Quinine therapy has been associated with rare instances...		Potassium Channel , Platelet aggregation , Parasite
TN6512	Tectol		Transferase , Parasite
	Tectol has anti-plasmodial activity, it as a moderately active growth inhibitor with an IC50 3.44±0.20μM. It exhibited significant activity against human leukemia cell lines HL60 and CEM. Tectol may cause itchy dermatiti...		Transferase , Parasite
TN2239	Strictosamide		ATPase , Potassium Channel , Sodium Channel , Parasite , Antifungal
	Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.
T5S0018	Betulonic acid	(+)-Betulonic acid,Betunolic acid,Liquidambaric acid	Parasite , HSV
	1. Betulonic acid (Liquidambaric acid) amide stimulated the regenerative response in hepatocytes under conditions of combined toxic exposure and promoted recovery of their qualitative and quantitative characteristics, wh...		Parasite , HSV
T3254	PHYTOL	trans-Phytol,(E)-Phytol	Antibacterial , PPAR , Parasite
	PHYTOL (trans-Phytol) , a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects....		Antibacterial , PPAR , Parasite
T4333	Quinine dihydrochloride	Quinine bimuriate	Others
	Quinine dihydrochloride (Quinine bimuriate) is a primary alkaloid of various species of Cinchona (Rubiaceae). It is also an antimalarial and muscle relaxant (skeletal).		Others
T2481	Ascomycin	FK520,Immunomycin,FR-900520	Phosphatase , Others , Antibiotic , Parasite , Antifungal
	Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
T3739	2,6-Dimethoxyquinone	2,6-Dimethoxy-1,4-benzoquinone,2,6-Dimethoxy-p-benzoquinone,2,6-Dimethoxybenzoquinone	Others
	2,6-Dimethoxyquinone (2,6-Dimethoxy-p-benzoquinone) is a member of the class of compounds known as P-benzoquinones. 2,6-Dimethoxyquinone is slightly soluble (in water) and an extremely weak basic (essentially neutral) co...		Others
TN4893	Rapanone	2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone,2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione	Apoptosis , Phospholipase , Antibacterial , Parasite
	Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.		Apoptosis , Phospholipase , Antibacterial , Parasite
T8193	α-Thujone	Thujone,ALPHA-(-)-THUJONE	Apoptosis , Reactive Oxygen Species , GABA Receptor , AChR , Parasite , Autophagy
	α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
T0956	Avermectin B1	Avermectin B1a-Avermectin B1b mixt.,Abamectin	Antibiotic , Parasite , Autophagy
	Avermectin B1 is served as anthelmintic and insecticide.		Antibiotic , Parasite , Autophagy
T6631	Quinine hydrochloride dihydrate	Quinine HCl Dihydrate	Potassium Channel , Parasite
	Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria.		Potassium Channel , Parasite
T3376	Cynaroside	Luteoloside,Luteolin 7-β-D-Glucopyranoside,Luteolin 7-O-Glucoside,Luteolin 7-O-β-D-glucoside,Luteolin 7-glucoside	Others , Influenza Virus , DNA/RNA Synthesis
	Cynaroside (Luteolin 7-O-Glucoside) is a flavone, a flavonoid-like chemical compound. It has an anti-oxidant effect, inhibiting lipid and protein oxidation.		Others , Influenza Virus , DNA/RNA Synthesis
T9279	Nerolidol acetate		Others
	Nerolidol acetate is a natural sesquiterpene with anti-cancer, anti-inflammatory, antibacterial and anti-insect activities. Nerolidol acetate can inhibit parasite activity and inhibit schistosomiasis, nematodes, malaria,...		Others
T2P2806	Hederacolchiside A1	Raddeanoside R13	Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR
	Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacol...		Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR
TQ0072	Warangalone	Scandenolone	PKA
	Warangalone is an anti-malarial compound that can inhibit the growth of both strains of parasite 3D7 (chloroquine-sensitive) and K1 (chloroquine-resistant) with IC50s of 4.8 μg/mL and 3.7 μg/mL, respectively.		PKA
TN5228	Vestitol		Antifection
	Vestitol is a phytoalexin with insect feeding-deterrent activity, it has antioxidant, anti-inflammatory and antimicrobial activities, it can inhibit neutrophil migration at a dose of 10 mg/kg, and shows MICs ranging from...		Antifection

天然物製品

Menthone

T5660

Synonym:

Target: IL Receptor, TNF, NF-κB, Parasite

Columbin

T4S0590

Synonym:

Target: Phospholipase, COX, Parasite

Niranthin

TN4660

Synonym:

Target: Anti-infection, HBV, PAFR, Topoisomerase

Quinine

T0690

Synonym:

Target: Potassium Channel, Platelet aggregation, Parasite

Tectol

TN6512

Synonym:

Target: Transferase, Parasite

Strictosamide

TN2239

Synonym:

Target: ATPase, Potassium Channel, Sodium Channel, Parasite, Antifungal

Betulonic acid

T5S0018

Synonym: (+)-Betulonic acid,Betunolic acid,Liquidambaric acid

Target: Parasite, HSV

PHYTOL

T3254

Synonym: trans-Phytol,(E)-Phytol

Target: Antibacterial, PPAR, Parasite

Quinine dihydrochloride

T4333

Synonym: Quinine bimuriate

Target: Others

Ascomycin

T2481

Synonym: FK520,Immunomycin,FR-900520

Target: Phosphatase, Others, Antibiotic, Parasite, Antifungal

2,6-Dimethoxyquinone

T3739

Synonym: 2,6-Dimethoxy-1,4-benzoquinone,2,6-Dimethoxy-p-benzoquinone,2,6-Dimethoxybenzoquinone

Target: Others

Rapanone

TN4893

Synonym: 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone,2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione

Target: Apoptosis, Phospholipase, Antibacterial, Parasite

α-Thujone

T8193

Synonym: Thujone,ALPHA-(-)-THUJONE

Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, AChR, Parasite, Autophagy

Avermectin B1

T0956

Synonym: Avermectin B1a-Avermectin B1b mixt.,Abamectin

Target: Antibiotic, Parasite, Autophagy

Quinine hydrochloride dihydrate

T6631

Synonym: Quinine HCl Dihydrate

Target: Potassium Channel, Parasite

Cynaroside

T3376

Synonym: Luteoloside,Luteolin 7-β-D-Glucopyranoside,Luteolin 7-O-Glucoside,Luteolin 7-O-β-D-glucoside,Luteolin 7-glucoside

Target: Others, Influenza Virus, DNA/RNA Synthesis

Synonym: Raddeanoside R13

Target: Apoptosis, ERK, MEK, Akt, PI3K, Parasite, mTOR

Warangalone

TQ0072

Synonym: Scandenolone

Target: Antifection

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04180	PfLDH Protein, P. falciparum, Recombinant (His)	P. falciparum	E. coli
	Plasmodium falciparum lactate dehydrogenase (PfLDH) is a key enzyme for energy generation of malarial parasites and is considered to be a potential antimalarial target. The ability of PfLDH- or PfIDEh-based immuno-PCR as...

PfLDH Protein, P. falciparum, Recombinant (His)

TMPY-04180

Species: P. falciparum

Expression System: E. coli

カタログ番号	製品名
L4510	Anti-Parasitic Compound Library	419 compounds
	419 well-chosen unique anti-parasitic small molecules;
L1800	Anti-Infection Compound Library	2938 compounds
	A unique collection of 2938 anti-infective compounds including anti-bacterial, anti-fungi, anti-Human Cytomegalovirus (HCMV), anti-HIV, anti-SARS, anti-influenza, etc;
L6500	Microbial Natural Product Library	550 compounds
	A unique collection of 550 microbial natural products for high throughput screening (HTS) and high content screening (HCS);

ライブラリー

Anti-Parasitic Compound Library

L4510

Compounds: 419

Anti-Infection Compound Library

L1800

Compounds: 2938

Microbial Natural Product Library

L6500

Compounds: 550