|
T12268 |
NTP42
|
|
Prostaglandin Receptor
,
PPAR
|
|
NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM) |
|
T11831 |
LDN-27219
|
|
Others
|
|
LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM. |
|
T11339 |
Furegrelate sodium
|
U-63557A |
PPAR
|
|
|
|
T0308 |
Etidronic acid
|
HEDPA,Etidronate,HEDP |
Apoptosis
,
Phosphatase
,
Others
,
HBV
|
|
Etidronic acid (HEDP) is a diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover. |
|
T8900 |
Seralutinib
|
GB002 |
PDGFR
|
|
Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension. |
|
T1210 |
Sodium etidronate
|
Didronel |
Phosphatase
|
|
Sodium etidronate (Didronel) is a synthetic therapeutic diphosphonate analog of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, Sodium etidronate differs from endogenous pyrophospha... |
|
T1613 |
Hydralazine hydrochloride
|
Hydralazine HCl,Apresoline |
MAO
,
HIF/HIF Prolyl-Hydroxylase
|
|
Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release an... |
|
T2561 |
Macitentan
|
ACT-064992 |
Apoptosis
,
Endothelin Receptor
|
|
Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). |
|
T5329 |
Trandolapril
|
|
Angiotensin-converting Enzyme (ACE)
|
|
Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat. |
|
T14782 |
Brilaroxazine
|
RP5063 |
Dopamine Receptor
,
5-HT Receptor
|
|
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-... |
|
T3034 |
Eprazinone dihydrochloride
|
Resplen,Mucitux,Eftapan,NSC 317935,Eprazinone 2HCl |
Others
,
Neurokinin receptor
|
|
Eprazinone dihydrochloride (NSC 317935) is a mucolytic with antitussive and mucolytic effect. |
|
T70793 |
Parogrelil Free Base
|
|
|
|
Parogrelil Free Base is a phosphodiesterase inhibitor, improves claudication-limited exercise performance in patients with peripheral arterial disease. |
|
T11339L |
Furegrelate
|
|
PPAR
|
|
FUREGRELATE, a thromboxane A2 (TxA2) synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets. |
|
T26841 |
BMS 182874
|
BMS182874,BMS-182874 |
Endothelin Receptor
|
|
BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for ETA.BMS 182874 is able to reduce arterial pressure in a rat ... |
|
T34146 |
Propanidid
|
FBA 1420,Epontol,Sombrevin,Fabontal,Fabantol |
GABA Receptor
|
|
Propanidid (Sombrevin) is a gamma-aminobutyric acid type A receptor (GABAA) agonist and a fast-acting intravenous anesthetic that lowers arterial blood pressure. |
|
T0112L |
Diltiazem
|
Diltiazem free base,Dilticard,CRD-401,CRD401,Dilzen,CRD 401 |
|
|
Diltiazem is a non-dihydropyridine (non-DHP) calcium channel blocker that relaxes the smooth muscle in arterial walls, thus opening (dilating) arteries, allowing easier blood flow, and lowering blood pressure, and is use... |
|
T0163 |
Nisoldipine
|
BAY-k 5552 |
Calcium Channel
,
Reactive Oxygen Species
|
|
Nisoldipine (BAY-k 5552) is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. |
|
T6147 |
Nortadalafil
|
Demethyl Tadalafil |
PDE
|
|
Nortadalafil (Demethyl Tadalafil) is demethyl Tadalafil, which is a PDE5 inhibitor, treating erectile dysfunction (ED) ; and under the name Adcirca for the treatment of pulmonary arterial hypertensio. |
|
T0317 |
Buflomedil hydrochloride
|
Buflomedil HCl,Fonzylane,Loftyl |
Adrenergic Receptor
|
|
Buflomedil hydrochloride (Fonzylane), a vasodilator, is used in therapy of claudication or the symptoms of the peripheral arterial disease. |
|
T3469 |
PCI-27483
|
PCI27483 |
Others
|
|
PCI-27483 is an activated coagulation factor VIIa inhibitor with antithrombotic effects in a baboon model of arterial thrombosis. It also inhibits the growth of BxPC3 xenografts by 42% and 85% at doses of 60 and 90 mg/kg... |
|
T9881 |
Benzoquinamide hydrochloride
|
3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride |
Others
|
|
Benzoquinamide hydrochloride (3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride) is an antiemetic agent and increases intra-arterial pressure due to the incre... |
|
T3216 |
Selexipag
|
NS-304,ACT-293987,Uptravi |
Others
,
Prostaglandin Receptor
|
|
Selexipag (ACT-293987)(NS-304) is prostacyclin receptor agonist that causes vasodilation in pulmonary vasculature and is used in the therapy of pulmonary arterial hypertension (PAH). |
|
TP1323 |
CGRP 8-37 (rat)
|
|
CGRP Receptor
|
|
CGRP 8-37 (rat) is a CGRP receptor antagonist, a CGRP fragment with potential anti-injury effects that induces arterial relaxation. |
|
T13684 |
Equilin
|
7-Dehydroestrone |
Calcium Channel
|
|
Equilin (7-Dehydroestrone) is a neurotrophic estrogenic steroid with vasodilatory activity that increases monocyte-endothelial adhesion through NF-κB signalling.Equilin similarly relaxes mesenteric arterial resistance by... |
|
T6968 |
Riociguat
|
BAY 632521 |
Guanylate cyclase
|
|
Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension. |
|
T36506 |
Tempone
|
4-Oxo-tempo |
|
|
Tempone is an aminooxyalkane that acts as a free radical scavenger and reacts with reactive oxygen species (ROS). Intravenous Tempone reduces mean arterial pressure in spontaneously hypertensive rats. |
|
T1655 |
Ambrisentan
|
BSF-208075,BSF 208075,LU 208075 |
Endothelin Receptor
|
|
Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but ha... |
|
TP2075L |
Bombinakinin M acetate
|
Bombinakinin M acetate(509151-65-9 free base) |
Bradykinin Receptor
|
|
Bombinakinin M acetate is a potent bradykinin receptor agonist with high selectivity for mammalian arterial smooth muscle bradykinin receptors and is approximately 50 times more potent than bradykinin. |
|
T1462 |
Captopril
|
SQ 14225,SQ-14534,SA333 |
RAAS
|
|
Captopril (SA333) is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II, a vasoconstrictor and important regulator of arterial blood pressure. |
|
T28643 |
Ex26
|
S1P1-IN-Ex26 |
S1P Receptor
|
|
Ex26 (S1P1-IN-Ex26) is a selective and potent sphingosine 1-phosphate receptor 1 (S1P1) antagonist that disrupts SR-B1-S1PR1 interactions and inhibits S1P-S1PR1 signaling.Ex26 can be used in experimental autoimmune encep... |
|
T29215 |
Zifaxaban
|
TY 602,TY602,TY-602 |
Factor Xa
|
|
Zifaxaban (TY-602) is an orally active, competitive and selective inhibitor of factor Xa (FXa) with an IC50 of 11.1 nM for human FXa.Zifaxaban has a very high affinity, more than 10,000-fold higher than that of other ser... |
|
T36008 |
Nebentan potassium
|
YM598 |
Endothelin Receptor
|
|
Nebentan potassium (YM598) is an orally active and selective nonpeptide endothelin receptor (ETA receptor) antagonist.Nebentan potassium inhibits pulmonary arterial hypertension and may be useful in the study of neurolog... |
|
T31615 |
Elsibucol
|
AGI-1096,UNII-O7T92N1Y8T,AGI 1096 |
Antioxidant
|
|
Elsibucol (AGI 1096) is a VCAM1 inhibitor for the study of organ transplant rejection.Elsibucol is a metabolically stable propanol derivative with antioxidant, anti-inflammatory and anti-proliferative properties. It lowe... |
|
T68086 |
Imitrodast
|
|
Thrombin
|
|
Imitrodast is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor for the treatment of immune system disorders, respiratory disorders, and cardiovascular diseases, and can be used in studies of arterial th... |
|
T2753 |
Avasimibe
|
PD-148515,CI-1011 |
P450
,
Acyltransferase
|
|
Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenz... |
|
T11994 |
Melagatran
|
|
Thrombin
|
|
Melagatran, a direct and orally active thrombin inhibitor, specifically inhibits thrombin without affecting other enzymes in the coagulation cascade or fibrinolytic enzymes. It does not rely on endogenous co-factors to e... |
|
T6264 |
Bosentan
|
Actelion,Ro 47-0203,Benzenesulfonamide |
Endothelin Receptor
|
|
Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks th... |
|
T27624 |
Iptakalim Hydrochloride
|
|
Potassium Channel
,
AChR
|
|
Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Iptakalim is also a K(ir) 6.1/SUR2... |
|
T13193 |
TPN171
|
|
PDE
|
|
TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary arterial hypertension (PAH). TPN171 was proven to exert a longer l... |
|
T13604 |
CDDO-dhTFEA
|
|
Others
,
NF-κB
,
Nrf2
|
|
CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expressi... |
|
T1215 |
Nicardipine hydrochloride
|
RS-69216,Nicardipine HCl,YC-93 Hydrochloride |
Calcium Channel
,
Adrenergic Receptor
,
AChR
,
Autophagy
|
|
Nicardipine hydrochloride (YC-93 Hydrochloride) is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine Family) blocks cal... |
|
T0075 |
Nicorandil
|
SG-75 |
Potassium Channel
|
|
Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. Firstly, by activating potassium channels, and secondly b... |
|
TP1369L |
[Sar9,Met(O2)11]-Substance P acetate
|
[Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base) |
Neurokinin receptor
|
|
[Sar9,Met(O2)11]-Substance P acetate is a tachykinin NK1 receptor selective agonist. [Sar9,Met(O2)11]-Substance P acetate is a selective tachykinin NK1 receptor agonist.[Sar9,Met(O2)11]-Substance P acetate and septide (1... |
|
T0871 |
Noradrenaline bitartrate
|
|
Adrenergic Receptor
|
|
Norepinephrine bitartrate acts directly on the α- and β-adrenergic receptors. Norepinephrine Bitartrate is a bitartrate salt of norepinephrine, a synthetic phenylethylamine that mimics the sympathomimetic actions of the ... |
|
T0317L |
Buflomedil
|
Buflomedilum |
|
|
Buflomedil is a vasoactive compound. Buflomedil has been used for peripheral arterial diseases. |
|
T27930 |
LY-127210 free base
|
LY 127210,LY127210 |
|
|
LY-127210 free base is peripheral arterial vasodilator with antihypertensive activity. |
|
T19660 |
QCC-374
|
QCC374 |
|
|
QCC-374 is a prostanoid agonist. It potentially for the treatment of pulmonary arterial hypertension. |
|
T24760 |
Satigrel
|
E 5510,E5510 |
|
|
Satigrel is a new antiplatelet agent. It also inhibits platelet accumulation in prosthetic arterial grafts. |
|
T29200 |
Z-335 sodium
|
Z 335,Z335,Z-335 |
|
|
Z-335 Salt, a thromboxane A2 receptor antagonist, is used potentially for the treatment of arterial occlusive disease. |
|
T30501 |
BMS-193884
|
BMS193884,BMS 193884 |
|
|
BMS-193884 is an oral endothelin antagonist for the treatment of congestive heart failure (CHF) and pulmonary arterial hypertension. |
