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T62899 |
Tau-aggregation and neuroinflammation-IN-1
|
|
Microtubule Associated
,
NO Synthase
|
|
Tau-aggregation and neuroinflammation-IN-1 is a potent inhibitor of tau protein aggregates, showing significant inhibitory activity against AcPHF6 and full-length tau protein aggregates. Tau-aggregation and neuroinflamma... |
|
T79590 |
Anti-neuroinflammation agent 1
|
|
NOD-like Receptor (NLR)
|
|
Anti-neuroinflammation Agent 1 effectively modulates BV2 microglia cell polarization, shifting from an M1 to an M2 phenotype [1]. |
|
T22012 |
7BIO
|
|
FLT
,
DYRK
,
Aurora Kinase
|
|
7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases. |
|
T1814 |
ICILIN
|
AG-3-5 |
TRP/TRPV Channel
|
|
ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist. |
|
T23146 |
PHA 568487 free base
|
PHA 568487 |
AChR
|
|
The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia... |
|
T21233 |
Dihydrolipoic acid
|
Reduced thioctic acid,Reduced lipoic acid,DHLA,USAF XR-12,6,8-Dihydrothioctic acid |
Antioxidant
|
|
Dihydrolipoic acid (USAF XR-12), a dithiol-containing carboxylic acid, acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including peroxynitirite, hydroxyl radicals, hydr... |
|
T33519 |
MTOB
|
α-keto-γ-Methylthiobutyric acid,KMBA,MTOB salt,4-methylthio 2-oxobutyric acid |
Others
|
|
MTOB (α-keto-γ-Methylthiobutyric acid) is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, lea... |
|
T1406 |
Amantadine hydrochloride
|
1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride |
Dopamine Receptor
,
Influenza Virus
|
|
Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease. |
|
T4450 |
GIBH-130
|
|
IL Receptor
,
TNF
,
Interleukin
|
|
GIBH-130 markedly inhibits the IL-1β secretion by activated microglia (IC50: 3.4 nM). GIBH-130 is an effective inhibitor of neuroinflammation. |
|
T22378 |
Nilotinib hydrochloride
|
AMN-107 HCl |
Bcr-Abl
,
Autophagy
|
|
Nilotinib hydrochloride(AMN-107 HCl) is an orally available Bcr-Abl tyrosine kinase inhibitor with antitumor activity for modulation of neuroinflammation and cognitive deficits, and may be used in studies of chronic myel... |
|
T33535 |
MW01-2-151SRM
|
MW 151,MW-151,MW012151SRM,MW151,MW01 2 151SRM |
Others
|
|
MW01-2-151SRM is a novel small molecule inhibitor of microglia activation that crosses the blood-brain barrier, has anti-neuroinflammatory effects, attenuates the up-regulation of glial cytokines in models of neuroinflam... |
|
TQ0057 |
AVE 0991
|
|
Others
|
|
AVE 0991, a nonpeptide analog of angiotensin-(1-7) [Ang-(1-7)], is an orally active Mas agonist with inhibitory effects on [125I]-Ang-(1-7) binding to bovine aortic endothelial cell membranes, and inhibits astrocyte-medi... |
|
T33514 |
MSC 2032964A
|
MSC-2032964A,MSC2032964A |
ASK
|
|
MSC 2032964A is a potent selective ASK1 inhibitor (IC50 = 93 nM) that is oral bioavailable and brain permeable. It inhibited neuroinflammation in mouse EAE models and blocked LPS-induced phosphorylation of ASK1 and p38 i... |
|
T73286 |
SRI-42127
|
|
HuR
|
|
SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR, which inhibits tumor growth, attenuates glial activation in a lipopolysaccharide-induced neuroinflammation model, and reduces neuropathic pa... |
|
T11662L |
INT-777
|
S-EMCA |
GPCR19
|
|
|
|
T15162 |
DPA-714
|
|
Others
|
|
DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM). It is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. ... |
|
T124358 |
Deferoxamine
|
Deferoxamine B,Desferrioxamine B |
Apoptosis
,
Antioxidant
,
HIF
,
Autophagy
|
|
Deferoxamine（Desferrioxamine B） is an iron chelator (binds Fe(III) and many other metal cations) that inhibits neuronopathy, may be used to modify the reduction of iron accumulation and deposition in tissues, and may imp... |
|
T25752 |
Lonchocarpic acid
|
AI3-01135,AI301135,AI3 01135 |
|
|
Lonchocarpic acid shows an anti-inflammatory mechanism of lonchocarpine in LPS- or poly(I:C)-induced neuroinflammation. |
|
T1158L |
Phenoxybenzamine
|
NSC-37448,A688,NSC 37448,NSC37448,A-688 |
|
|
Phenoxybenzamine is an α-1 adrenergic receptor antagonist. Phenoxybenzamine may exert a neuroprotective effect by reducing neuroinflammation after traumatic brain injury. |
|
T38912 |
Vicasinabin
|
|
|
|
Vicasinabin, a potent agonist of cannabinoid receptor 2 (CB2), exhibits promising potential for researching chronic pain, atherosclerosis, regulation of bone mass, neuroinflammation, and related human diseases. |
|
T38787 |
ER176
|
|
|
|
ER176 is a novel PET radioligand utilized for the visualization of 18 kDa translocator protein (TSPO), a neuroinflammation biomarker, marking the advancement in imaging technology. |
|
T61566 |
P2X7 receptor antagonist-2
|
|
|
|
P2X7 receptor antagonist-2 is a highly potent antagonist of the P2X7 receptor, exhibiting a pIC50 value range of 6.5-7.5. Its efficacy in combating neuroinflammation has been demonstrated [1]. |
|
T74409 |
EVT-401
|
|
|
|
EVT-401 (P2X7 receptor antagonist-1), a purinergic P2X7 receptor antagonist, demonstrates efficacy in combating neuroinflammation [1]. |
|
T81075 |
SUCNR1-IN-2
|
|
|
|
SUCNR1-IN-2 (Statement 35) serves as an inhibitor of both succinate and succinate receptor 1, utilized in research pertaining to neurodegenerative disorders, including neuroinflammation [1]. |
|
T61620 |
AChE/PDE4-IN-1
|
|
|
|
AChE/PDE4-IN-1 (compound 12c) is a highly effective and specific dual inhibitor of PDE4 and AChE, with IC50 values of 0.28 μM and 1.88 μM for AChE and PDE4D, respectively. This compound demonstrates notable potential in ... |
|
T61987 |
PHA 568487
|
|
|
|
PHA 568487 a selective agonist of alpha-7 nicotinic acetylcholine receptor ( α-7 nAchR ). PHA-568487 shows rapid brain penetration. PHA 568487 reduces oxidative stress and neuroinflammation. |
|
T37815 |
PM226
|
PM 226 |
|
|
Potent and selective CB2 receptor agonist (Ki = 12.8 nM; EC50 = 38.67 nM). Exhibits negligible affinity for the CB1 receptor (Ki > 40,000 nM) and no activity at the GPR55. Suppresses neuroinflammation by reducing microg... |
|
TP1620 |
Cyclic MKEY
|
|
|
|
MKEY, a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, has been shown to protect against atherosclerosis and aortic aneurysm formation by mediating inflammation, but whether it modulates neuroinf... |
|
T70595 |
Artemisinin B
|
|
|
|
Artemisinin B is a drug which may improve spatial memory in dementia patients and alter the levels of inflammatory cytokines in the hippocampus and the cortex. Artemisinin B may inhibit neuroinflammation and exert neurop... |
|
T39677 |
MY33-3
|
MY33-3 |
|
|
MY33-3 is a powerful and specific inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, demonstrating an IC50 value of approximately 0.1 μM. Moreover, MY33-3 exhibits inhibitory activity against PTP-1B with an IC... |
|
T69664 |
Umibecestat HCl
|
|
|
|
Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD... |
|
T36851 |
Peptide5
|
|
|
|
Connexin43 mimetic peptide. Reduces swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Exhibits analgesic effects in models of neuropathic pain.
O'Carroll ... |
|
T78969 |
PB131
|
|
HDAC
|
|
PB131, a selective and brain-permeable HDAC6 inhibitor, exhibits high binding affinity (IC50: 1.8 nM) and potent anti-inflammatory activity, making it suitable for inflammation research, particularly in neuroinflammation... |
|
T79577 |
CB2 PET Radioligand 1
|
|
Cannabinoid Receptor
|
|
CB2 PET Radioligand 1 (compound [18F]9) is a positron emission tomography (PET) radioligand with high affinity for the human cannabinoid receptor 2 (hCB2, Ki=7.7 nM). It is synthesized via Cu-mediated 18F-fluorination an... |
|
T72874 |
SEH/AChE-IN-2
|
|
|
|
sEH/AChE-IN-2 and acetylcholinesterase ( AChE ). sEH/AChE-IN-2 provides cumulative effects against neuroinflammation and memory impairment. sEH/AChE-IN-2 has the potential for the research of Alzheimer's disease (AD) . |
|
T64181 |
SEH/AChE-IN-1
|
|
|
|
sEH/AChE-IN-1 (Compound 12a) is a dual inhibitor of soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). sEH/AChE-IN-1 has a cumulative effect against neuroinflammation and memory impairment. sEH/AChE-IN-1 ha... |
|
T73302 |
FAAH-IN-7
|
|
|
|
FAAH-IN-7, a potent and reversible inhibitor of fatty acid amide hydrolase (FAAH), demonstrates significant neuroprotective effects, particularly by mitigating oxidative stress in 1321N1 astrocytes. With an IC50 value of... |
|
T13036 |
Sulfosuccinimidyl oleate
|
Sulfo-N-succinimidyl oleate |
Mitophagy
|
|
Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibit... |
|
T73504 |
MR2938
|
|
|
|
MR2938 is a potent acetylcholinesterase (AChE) inhibitor, evidenced by an IC50 value of 5.04 μM, and significantly inhibits nitric oxide (NO) production with an IC50 of 3.29 μM. Additionally, it mitigates neuroinflammati... |
|
T62442 |
MY33-3 hydrochloride
|
|
|
|
MY33-3 hydrochloride is a potent and selective inhibitor of the protein tyrosine phosphatase RPTPβ/ζ (IC50~0.1 μM). MY33-3 hydrochloride inhibits PTP-1B (IC50~0.7 μM). MY33-3 hydrochloride reduces ethanol consumption and... |
|
T35836 |
PMX-205 (trifluoroacetate salt)
|
|
|
|
PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3... |
|
T79637 |
CIAC001
|
|
|
|
CIAC001, a pyruvate kinase PKM2 inhibitor, exhibits anti-neuroinflammatory properties. It effectively suppresses LPS-induced production of proinflammatory nitric oxide (NO) and provides protection to immunologically acti... |
|
T79484 |
Nrf2 activator-8
|
|
|
|
Nrf2 Activator-8 (Compound 10e), with an EC50 of 37.9 nM, is a potent Nrf2 activator that demonstrates significant antioxidant and anti-inflammatory properties in BV-2 microglial cells. Furthermore, this compound notably... |
|
T79670 |
Anti-inflammatory agent 56
|
|
COX
|
|
Anti-inflammatory agent 56 (Compound 9), a selective COX-2 inhibitor with an IC50 of 0.54 μM, exhibits anti-oxidant and anti-inflammatory properties by inhibiting oxidative stress-induced cell death and neuroinflammation... |
|
T74860 |
MAO-B-IN-21
|
|
Monoamine Oxidase
|
|
MAO-B-IN-21 is an MAO-B inhibitor characterized by superior antioxidant and anti-Aβ aggregation activities. The compound additionally shows metal-ion chelating capabilities, mitigates neuroinflammation (NO, TNF-α), and d... |
|
T60868 |
NF-κB-IN-4
|
|
|
|
NF-κB-IN-4 (compound 17) is a potent inhibitor of NF-κB pathway which can cross blood brain barrier (BBB). NF-κB-IN-4 shows potential anti-neuroinflammatory activity with low toxicity which can be used for the research o... |
|
T73511 |
SZM679
|
|
RIP kinase
|
|
SZM679 is an orally active, selective RIPK1 inhibitor displaying potent affinity with a dissociation constant (Kd) of 8.6 nM for RIPK1, while exhibiting minimal activity towards RIPK3, with a Kd of >5000 nM. It effective... |
|
T78876 |
DNL343
|
|
|
|
DNL343, a brain-penetrating eIF2B (eukaryotic initiation factor 2B) activator, suppresses the abnormal integrated stress response (ISR). By inhibiting ISR activity in the central nervous system (CNS), DNL343 ameliorates ... |
|
T36015 |
PDMP (hydrochloride)
|
|
|
|
PDMP is a ceramide analog first prepared in a search for inhibitors of glucosylceramide synthase. PDMP has two adjacent chiral centers (C1 and C2) allowing for the formation of four possible isomers. PDMP contains all fo... |
|
T83962 |
C 101248
|
|
|
|
C 101248 is a selective and potent inhibitor targeting both mouse and human tandem pore domain halothane-inhibited K+ channel 1 (THIK-1, IC50= 50 nM), without affecting the K2P family members (TREK-1, TWIK-2) and Kv2.1. ... |
