|
T12877L |
Seltorexant
|
JNJ-42847922 |
OX Receptor
|
|
Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human a... |
|
T0165 |
Urapidil
|
Mediatensyl,Ebrantil,Eupressyl |
5-HT Receptor
,
Adrenergic Receptor
|
|
Urapidil (Ebrantil), a sympatholytic antihypertensive drug, acts as a 5-HT1A receptor agonist and as an α1-adrenoceptor antagonist. |
|
T0080 |
Trapidil
|
Rocornal,Trapymine,Avantrin,Trapymin,AR-12008 |
PDGFR
,
PDE
|
|
Trapidil (Avantrin) is a coronary vasodilator agent. It was originally developed as a vasodilator and anti-platelet agent and has been used to treat patients with ischemic coronary heart, liver, and kidney disease. |
|
T0088 |
Urapidil hydrochloride
|
Urapidil HCl |
5-HT Receptor
,
Adrenergic Receptor
|
|
Urapidil hydrochloride (Urapidil HCl) is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist. |
|
T26393 |
5-Methylurapidil
|
5Methylurapidil,5-Methyl-urapidil |
|
|
5-Methylurapidil is an alpha1A-adrenoceptor antagonist. |
|
T9046 |
Morpholinylmercaptobenzothiazole
|
|
Others
|
|
Morpholinylmercaptobenzothiazole is an aftereffect rapid vulcanization accelerator |
|
T9004 |
TM2-115
|
|
Parasite
|
|
TM2-115 is a inhibitor of malaria parasite histone methyltransferases that results in rapid and irreversible parasite death [1]. |
|
T6955 |
Propafenone hydrochloride
|
Propafenone HCl,Arythmol,SA-79 (hydrochloride),Rytmonorm,Rythmol |
Sodium Channel
|
|
Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias. |
|
T27947L |
LY339434 HCl
|
LY339434 HCl(219566-62-8 Free base) |
GluR
,
NMDAR
|
|
LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA) receptors. |
|
T21445 |
Naphazoline
|
AK-Con,Naphcon-a,Clear Eyes,All Clear |
Adrenergic Receptor
|
|
Naphazoline (Naphcon-a) is a sympathomimetic compound with marked alpha adrenergic activity. Naphazoline can be used as a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane. |
|
T1148 |
Menbutone
|
Naftobil,Genabilic acid,Genabilin |
Others
|
|
Menbutone (Genabilin) is a derivative of oxobutyric acid, and is a choleretic. Menbutone shows a rapid onset of action, reaching its maximum plasma level within 1 hour and lasting for roughly 10 hours. |
|
T9284 |
Dexketoprofen trometamol
|
|
COX
|
|
Dexketoprofen trometamol is a modified non-selective COX inhibitor with a rapid onset of action that is available as both oral and parenteral formulations. |
|
T79468 |
Antimicrobial agent-22
|
|
|
|
Antimicrobial agent-22 (THI 6c) constitutes a broad-spectrum, multi-target antibacterial with notable rapid bactericidal efficacy and effective anti-biofilm activity, paired with low cytotoxicity and hemolytic properties... |
|
T0954 |
Halothane
|
Narcotane,Anestan |
Potassium Channel
,
Chloride channel
,
GABA Receptor
,
NMDAR
|
|
Halothane (Anestan) is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly.... |
|
T27677 |
JNJ-37822681
|
JNJ37822681,JNJ 37822681 |
Dopamine Receptor
|
|
JNJ-37822681 is a novel, highly selective dopamine D₂ receptor antagonist characterized by a rapid dissociation rate from the dopamine D₂ receptor. |
|
T7942 |
Tranylcypromine hemisulfate
|
Tranylcypromine Sulfate,Tranylcypromine (hemisulfate) |
Histone Demethylase
,
MAO
,
Monoamine Oxidase
|
|
Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity. |
|
T4250 |
Bilastine
|
Bilaxten |
Histamine Receptor
|
|
Bilastine (Bilaxten) is a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action. |
|
T77767L1 |
GLF16 HCl
|
|
Others
|
|
GLF16 HCl is a fluorophore-coupled Sudan Black B analog that allows rapid detection, isolation and real-time tracking of senescent cells by fluorescence microscopy and flow cytometry. |
|
TP1127L1 |
Nemifitide acetate(173240-15-8 free base)
|
INN 00835 acetate |
5-HT Receptor
|
|
Nemifitide acetate(173240-15-8 free base) (INN 00835 acetate) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. It is a peptide analog of melanocyte-inhibiting factor (MIF). |
|
TP1018L |
Urechistachykinin II acetate
|
Urechistachykinin II acetate(149097-04-1 free base),Uru-TK II acetate |
Others
|
|
Urechistachykinin II acetate (Uru-TK II acetate) is an invertebrate rapid kinin-related peptide (TRPs) isolated from carotenoid worms, shows antimicrobial activities without a hemolytic effect |
|
T67843 |
GSK215
|
|
FAK
,
PROTACs
|
|
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4). GSK215 is designed by the FAK inhibitor VS-4718 and a binder for the VHL E3 ligase. GSK215 can induce rapid and prolonged FAK deg... |
|
T33613 |
NCGC00135472
|
NCGC 00135472,DRV1 (GPR32) agonist C2A,C2A,NCGC-00135472 |
Others
|
|
NCGC00135472 (DRV1 (GPR32) agonist C2A) is a human Resolvin DI receptor DRV1 agonist with pro-catabolic properties that activates the human soluble protein D1 receptor DRV1/GPR32 receptor in beta-blocker and cAMP assays ... |
|
T22371 |
Mivacurium dichloride
|
Mivacurium chloride |
AChR
|
|
Mivacurium dichloride (Mivacurium chloride) is a non-depolarising, rapid neuromuscular blocker of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emerg... |
|
T19084 |
1-Naphthyl acetate
|
|
AChE
|
|
1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is a potent chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity.... |
|
T7295 |
Miridesap
|
Ro63-8695,CPHPC,GSK2315698 |
Others
|
|
Miridesap (GSK2315698) is a divalent crosslinker of SAP that causes rapid depletion of circulating SAP via hepatic clearance. It also produces significant reduction of SAP from cerebrospinal fluid and visceral amyloid de... |
|
T6273 |
Vadimezan
|
DMXAA,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404 |
Influenza Virus
,
VDA
,
STING
,
IFNAR
|
|
Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without aff... |
|
T20539 |
Pirimiphos-methyl
|
R 33986,AI3-27699,Caswell No. 334B,PP511,Actelic |
AChE
,
Parasite
|
|
Pirimiphos-methyl (AI3-27699) is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, moths, sn... |
|
T2134 |
Dorzolamide hydrochloride
|
MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,Dorzolamide HCl |
Carbonic Anhydrase
|
|
Dorzolamide hydrochloride (MK507 hydrochloride) is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water ... |
|
T1669 |
Liothyronine sodium
|
3,3',5-Triiodo-L-thyronine sodium,Triostat,T3 Sodium salt,Sodium L-3,3',5-triiodothyronine,Cytomel |
Thyroid hormone receptor(THR)
|
|
Liothyronine Sodium is the sodium salt form of liothyronine, a synthetic form of the levorotatory isomer of the naturally occurring thyroid hormone triiodothyronine (T3). Liothyronine sodium (3,3',5-Triiodo-L-thyronine s... |
|
T1435 |
Praziquantel
|
Pyquiton,Droncit,Biltricide |
Calcium Channel
,
Antibiotic
,
Parasite
|
|
Praziquantel (Droncit) increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and paralysis of the worm's musculatur... |
|
T1790 |
Fosaprepitant dimeglumine
|
L785298,MK-0517,Fosaprepitant dimeglumine salt |
Neurokinin receptor
|
|
Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion... |
|
T10497 |
Benralizumab
|
BIW-8405,MEDI-563 |
Apoptosis
,
IL Receptor
,
Interleukin
|
|
|
|
T4364 |
Aftin-4
|
Aftin 4,Aftin4 |
Beta Amyloid
,
Gamma-secretase
|
|
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus... |
|
T19658 |
Enflurane
|
NSC115944,Ethrane,NSC-115944,Efrane,NSC 115944 |
Others
|
|
Enflurane (Efrane), a volatile anaesthetic, is a potent inhibitor of high conductance Ca2+-activated K+ channels of Chara australis. Enflurane is an internal standard in monitoring halogenated volatile anaesthetics by he... |
|
T6476 |
Dofetilide
|
UK 68789,UK-68798,Tikosyn |
Potassium Channel
|
|
Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ik... |
|
T15257 |
Etripamil
|
MSP-2017,(-)-MSP-2017 |
Calcium Channel
|
|
Etripamil (MSP-2017) displays atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells... |
|
T11722 |
JNJ-37822681 dihydrochloride
|
|
Dopamine Receptor
|
|
|
|
T1600 |
Doxifluridine
|
Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine |
Nucleoside Antimetabolite/Analog
,
DNA/RNA Synthesis
|
|
Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by... |
|
T3716 |
Rolapitant
|
SCH619734 |
Neurokinin receptor
|
|
Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. ... |
|
T36256 |
LC-2
|
LC 2,PROTAC KRASG12C Degrader-LC-2,LC2 |
PROTACs
|
|
LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a PROTAC that covalently binds KRAS G12C with MRTX849 and recru... |
|
T5148 |
Atosiban acetate
|
RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164 |
Oxytocin Receptor
,
Vasopressin Receptor
|
|
Atosiban acetate (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban acetate (RW22164) inhibits... |
|
T41163 |
ZNL 02-096
|
Pomalidomide-C3-adavosertib |
Apoptosis
,
Wee1
|
|
ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL ... |
|
T6707 |
Tiotropium Bromide hydrate
|
BA-679 BR hydrate,BA 679BR |
AChR
|
|
Tiotropium Bromide hydrate (BA-679 BR hydrate) is a potent anticholinergic and bronchodilator, serving as a muscarinic receptor antagonist, specifically targeting mAChR. It is developed for treating chronic obstructive a... |
|
T0807 |
Tribromoethyl alcohol
|
2,2,2-Tribromoethanol,Avertin,Basibrol,Tribromoethanol,TBE |
Others
|
|
Tribromoethyl alcohol (Avertin) is an organic compound used to anesthetize mice. |
|
TP1956L |
PKC ζ pseudosubstrate acetate
|
PKC ζ pseudosubstrate acetate (799764-07-1 free base) |
PKC
|
|
PKC ζ pseudosubstrate acetate is an inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by... |
|
T23079 |
NPE-caged-proton
|
|
Others
|
|
Generates rapid acidifications down to pH 2 |
|
T30250 |
AZD0865
|
AZD-0865,AZD 0865 |
|
|
AZD0865 is an effective drug that inhibits gastric H(+), K(+) -ATPase activity and acid formation in vitro, with rapid onset. |
|
T69655 |
Ac-ATS010-KE
|
|
|
|
Ac-ATS010-KE is a novel Selective, irreversible, and Rapid Cell-Permeable Inhibitor of Human Caspase-3. |
|
T71541 |
ASP9133
|
|
|
|
ASP9133 is a long-acting muscarinic antagonist (LAMA) which shows more selective inhibition of bronchoconstriction against salivation and more rapid onset of action than tiotropium bromide. |
|
T16410 |
Otamixaban
|
FXV673 |
Others
|
|
Otamixaban(FXV673) is an effective (Ki = 0.5 nM), selective, rapid-acting, competitive, and reversible fXa inhibitor. It also effectively inhibits both free and prothrombinase-bound fXa. |
