| T41044 |
Naringinase
|
|
Glucosidase
|
|
Naringinase is a hydrolytic enzymatic complex that exhibits α-L-rhamnosidase and β-D-glucosidase activities. It is widely found in nature and is primarily utilized for the biotransformation of steroids, antibiotics, and ... |
| T1160 |
Fusidic acid
|
Fusidine |
Others
,
CAT
,
Antibacterial
,
Antibiotic
|
|
Fusidic acid (Fusidine) is an antibiotic isolated from the fermentation broth of Fusidium coccineum. |
| T8117 |
Metenolone acetate
|
Methenolone acetate |
Others
,
Androgen Receptor
|
|
Metenolone acetate (Methenolone acetate) is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure. |
| T1289 |
Fusidic acid sodium salt
|
Sodium fusidate,Fusidate Sodium,Fucidin,SQ-16360 |
Others
,
CAT
,
Antibacterial
,
Antibiotic
|
|
Fusidic acid sodium salt (SQ-16360) is a sodium salt form of fusidic acid, a bacteriostatic antibiotic derived from the fungus Fusidium coccineum and used as a topical medication to treat skin infections. |
| T4970 |
LANOSTEROL
|
3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol |
Endogenous Metabolite
|
|
Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived. |
| T5514 |
Epibrassinolide
|
24-Epibrassinolide,B1105,BP55 |
Apoptosis
|
|
Epibrassinolide (BP55) (EBR) is a biologically active compound of the brassinosteroids, is a natural brassinosteroid (BR) derivative, is a plant regulator with a similar structure to mammalian steroids. |
| T5240 |
Cholestenone
|
(+)-4-Cholesten-3-one |
Others
,
Endogenous Metabolite
|
|
Cholestenone ((+)-4-Cholesten-3-one) is an intestinal metabolite of Cholesterol. It shows an anti-obesity effect on animals. |
| T5A2455 |
Arenobufagin
|
|
Others
|
|
Arenobufagin is a natural bufadienolide from toad venom with potent antineoplastic activity against HCC HepG2 cells and corresponding multidrug-resistant HepG2/ADM cells. |
| T4878 |
Hecogenin
|
Hocogenin |
Others
,
Antifungal
|
|
Hecogenin (Hocogenin), a steroid saponin derived from Agave sisalana, serves as a specific inhibitor for human UDP-glucuronosyltransferases. Notably, it exhibits a broad range of pharmacological activities, such as anti-... |
| TN2329 |
Zingiberen newsaponin
|
Zingiberensis saponin I |
PARP
,
PAFR
,
Caspase
|
|
Zingiberen newsaponin is a steroidal saponin from Dioscorea zingiberensis. |
| T2965 |
Deoxycholic acid
|
Cholorebic,Deoxycholate,Desoxycholic acid,Cholanoic Acid,Cholerebic |
Endogenous Metabolite
,
GPCR19
|
|
Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorptio... |
| T0799 |
Lactulose
|
Duphalac,4-O-β-D-Galactopyranosyl-D-fructose,D-Lactulose,Lactulosum |
Others
|
|
Lactulose (Lactulosum) , a synthetic disaccharide , is used in the treatment of constipation and hepatic encephalopathy. |
| T4S1247 |
14-Hydroxy sprengerinin C
|
|
Others
|
|
14-Hydroxy sprengerinin C is a natural product from Ophiopogon japonicus. |
| TN6737 |
(25R)-Spirost-4-ene-3,12-dione
|
|
Others
|
|
(25R)-Spirost-4-ene-3,12-dione is a natural product. |
| T2220 |
2-Methoxyestradiol
|
NSC-659853,2-MeOE2,2-ME2 |
Apoptosis
,
Reactive Oxygen Species
,
Microtubule Associated
,
Endogenous Metabolite
,
HIF
,
Autophagy
|
|
2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli... |
| T5352 |
GLYCODEOXYCHOLIC ACID
|
|
Others
,
Endogenous Metabolite
|
|
Glycodeoxycholic Acid is a bile acid that induces severe pancreatitis in rats. It can induce the apoptosis of SMMC-7721 cells. |
| T1009 |
Estrone
|
Oestrone,Fluoroethyl,Aquacrine |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
,
Endogenous Metabolite
|
|
Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is pr... |
| T0478 |
Progesterone
|
Pregn-4-ene-3,20-dione |
Estrogen/progestogen Receptor
,
Progesterone Receptor
,
Opioid Receptor
,
Endogenous Metabolite
|
|
Progesterone (Pregn-4-ene-3,20-dione) is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is require... |
| TN2215 |
Taurochenodeoxycholic acid sodium
|
Sodium taurochenodeoxycholate |
Apoptosis
,
Endogenous Metabolite
|
|
Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and... |
| TQ0170 |
Desacetylcinobufagin
|
Deacetylcinobufagin |
Others
|
|
Desacetylcinobufagin (Deacetylcinobufagin) , a natural product, shows potent activities against Hela and A375 cells in vitro. |
| T5S0246 |
Pseudoprotodioscin
|
|
Others
,
Fatty Acid Synthase
|
|
1. Pseudoprotodioscin has moderate cytotoxicity. |
| T4A2399 |
Cinobufotalin
|
|
IL Receptor
,
Akt
,
MRP
,
P-gp
|
|
Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide production. Cinobufotalin is also an effective reversal agent... |
| T5239 |
Cholesteryl sulfate sodium
|
Cholesterol 3-Sulfate Sodium Salt,Sodium Cholesteryl Sulfate |
Endogenous Metabolite
,
PKC
|
|
Cholesteryl sulfate sodium (Sodium Cholesteryl Sulfate) is a sterol sulfate in human plasma. Cholesteryl sulfate sodium is a component of cell membrane and has a regulatory function. Cholesteryl sulfate sodium also activ... |
| T3809 |
Liriope muscari baily saponins C
|
|
Others
|
|
Liriope muscari baily saponins C has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of TF and IL-6. |
| T5077 |
Deoxycholic acid sodium salt
|
Sodium deoxycholate,Sodium Desoxycholate |
Endogenous Metabolite
,
GPCR19
|
|
Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity. |
| T3870 |
Cyasterone
|
Cyasteron |
Apoptosis
,
EGFR
|
|
Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising anti-cancer agent. Cyasterone has antifeeding activity. |
| TN2105 |
Proscillaridin A
|
|
Topoisomerase
|
|
Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively. |
| T6S1256 |
Ruscogenin
|
|
NOS
,
NF-κB
,
NOD-like Receptor (NLR)
|
|
1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin inhibited adhesion of leukocytes to a human umbilical vein ... |
| T7024 |
Qingyangshengenin
|
Qingyangshengenin A,Cynanchagenin |
Others
|
|
Qingyangshengenin (Cynanchagenin) is a steroid used in the preparation of antiepileptic agents. |
| T2884 |
Cortisone
|
Kendall's compound E,17-Hydroxy-11-dehydrocorticosterone |
Glucocorticoid Receptor
,
Endogenous Metabolite
|
|
Cortisone (17-Hydroxy-11-dehydrocorticosterone) is a corticosteroid with potent glucocorticoid activity. |
| T2733 |
Sarsasapogenin
|
Parigenin,Sarsagenin |
Apoptosis
,
NF-κB
,
Endogenous Metabolite
|
|
Sarsasapogenin (Parigenin) is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. It is named after sarsaparilla (Smilax sp.), a family of climbing plants found in subtropical regions. It was one o... |
| T3395 |
Timosaponin AIII
|
Filiferin B,AneMarsaponin A3,Timosaponin A3 |
AChE
,
mTOR
|
|
Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC... |
| TN2349 |
Taurodeoxycholate sodium salt
|
Sodium taurodeoxylate |
Endogenous Metabolite
|
|
Taurodeoxycholate sodium salt (Sodium taurodeoxylate) is a bile salt-related anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. and it inhibits various inflammatory... |
| T5S1982 |
Periplocin
|
Periplocoside |
Apoptosis
,
Others
|
|
1. Periplocin (Periplocoside) has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway. 2. Periplocin is used for treatment of rheumato... |
| T1719 |
Bufalin
|
|
ATPase
|
|
Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potenti... |
| T2827 |
Asiatic acid
|
Asiantic acid,Dammarolic acid |
Apoptosis
,
p38 MAPK
,
Parasite
|
|
Asiatic acid (Dammarolic acid) is the aglycone of asiaticoside used in wound healing with antioxidant, anti-inflammatory, and neuroprotective properties. |
| T3220 |
Euphorbiasteroid
|
Euphobiasteroid,Euphorbia factor L1 |
Others
,
AMPK
|
|
Euphorbiasteroid (Euphobiasteroid) (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation. |
| T0851 |
Pregnenolone
|
3β-Hydroxy-5-pregnen-20-one,Arthenolone |
Cannabinoid Receptor
,
Endogenous Metabolite
,
TRP/TRPV Channel
,
AChR
,
Autophagy
|
|
Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease. |
| T1571 |
Estriol
|
NSC-12169,Oestriol |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
,
MRP
,
Endogenous Metabolite
|
|
Estriol (Oestriol) is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is... |
| T5259 |
Glycochenodeoxycholic acid sodium salt
|
GCDCA,Sodium glycochenodeoxycholate |
Apoptosis
,
Others
,
Endogenous Metabolite
|
|
Glycochenodeoxycholic acid sodium salt (GCDCA) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environmen... |
| TN6908 |
Polyporusterone A
|
(1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R,5S)-2,3-dihydroxy-5,6-dimethylheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one |
|
|
Polyporusterone A is a triterpene carboxylic acid derived from the substrates of P. umbellatus.Polyporusterone A inhibits free radical-induced erythrocyte cleavage (hemolysis), and can be used in studies of hair regenera... |
| T4S1983 |
Periplogenin
|
5-beta-Hydroxydigitoxigenin,Desoxostrophanthidin |
Others
|
|
1. Periplogenin (Desoxostrophanthidin) plays protective roles against thyrotoxicosis and associated cardiovascular problems, are mediated through its direct antithyroidal and/or LPO inhibiting properties. |
| T4A2462 |
Telocinobufagin
|
Telobufotoxin,Telocinobufogenin |
Others
|
|
1. Telocinobufagin (Telobufotoxin) is the major endogenous digitalis-like factor. 2. Telocinobufagin significantly decreases the bacterial burdens in the spleen and prolongs the survival time of FIST-immunized mice chall... |
| T3771 |
Methyl protodioscin
|
Smilax saponin B,NSC-698790 |
Apoptosis
|
|
Methyl protodioscin (Smilax saponin B) potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides. Methyl protodioscin has antitumor property. Methyl protodioscin induced apoptotic process in h... |
| TN2054 |
Periplocymarin
|
|
Calcium Channel
|
|
Periplocymarin is a cardiac glycoside with anticancer potential isolated from Periploca sepium and Periploca graeca. |
| T2918 |
Cholesteryl Acetate
|
Cholesterin acetate,Cholesterol acetate,Acebrochol |
Others
|
|
Cholesteryl Acetate is a cholesterol ester obtained from the esterification of the hydroxyl group of cholesterol with acetic acid. It functions as a metabolite in the human body and is both a cholesterol ester and an ace... |
| T2758 |
Madecassic acid
|
6-Deoxy-L-Galactose,L-Fucose,Brahmic acid,L-fucopyranose |
Others
,
TNF
,
COX
,
NO Synthase
,
Interleukin
|
|
Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica. |
| T1688 |
Pregnanediol
|
5Beta-Pregnane-3Alpha,20alpha-Diol,Pregnandiol |
Estrogen/progestogen Receptor
,
Endogenous Metabolite
|
|
Pregnanediol (5Beta-Pregnane-3Alpha,20alpha-Diol) is an inactive metabolite of PROGESTERONE by reduction at C5, C3, and C20 position. Pregnanediol(5Beta-Pregnane-3Alpha,20alpha-Diol) has two hydroxyl groups, at 3-alpha a... |
| T12536 |
Pregnenolone monosulfate
|
3β-Hydroxy-5-pregnen-20-one monosulfate |
NMDAR
|
|
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings, and can be used in studies of neuroticism and depression. |
| TN1198 |
19-Hydroxybufalin
|
|
Others
|
|
19-Hydroxybufalin is a natural product, inhibits epithelial-mesenchymal transition and attenuates the migration and invasion of PC3 cells. |
