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T1154 |
Rifaximin
|
|
DNA/RNA Synthesis
,
Antibacterial
,
Antibiotic
|
|
Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting... |
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T5051 |
Isopropamide Iodide
|
|
AChR
|
|
Isopropamide iodide is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders. It also acts as a muscarinic receptor antagonist which can be applied to the t... |
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T38612 |
Linaprazan glurate
|
|
Others
|
|
Linaprazan glurate inhibits exogenously or endogenously stimulated gastric acid secretion. Linaprazan glurate can be used in studies about gastrointestinal inflammatory diseases and peptic ulcer diseases. |
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T22671 |
CJ 033466
|
|
5-HT Receptor
|
|
CJ 033466 is a selective partial agonist of 5-HT4 receptor (EC50 = 9 nM) with gastroprokinetic effect. |
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T21422 |
Methylnaltrexone bromide
|
Relistor,MOA-728,MOA 728,Methylnaltrexone,MOA728 |
Opioid Receptor
|
|
Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists. Methylnaltrexone bromide acts to reverse some of the side effects of opioid drugs such as constipation without af... |
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T7022 |
PEG300
|
Polyethylene glycol 300 |
Others
|
|
PEG300 (Polyethylene glycol 300) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG300 is a neutral polymer with a molecular weight of 300. |
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T6935 |
Nirogacestat
|
PF-03084014,PF-3084014,PF03084014,PF 03084014 |
Apoptosis
,
Gamma-secretase
|
|
Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay). |
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T0794 |
Mepenzolate Bromide
|
Colibantil,Cantil,Cantilaque |
AChR
|
|
Mepenzolate Bromide (Colibantil) is a muscarinic antagonist used to treat gastrointestinal conditions. |
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T0199 |
Cephradine
|
Anspor,Cephradin,Velosef,SQ-11436,Sefril |
TOPK
,
Antibacterial
,
Antibiotic
|
|
Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. |
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T1551 |
Tegaserod maleate
|
HTF-919,SDZ-HTF-919 |
5-HT Receptor
|
|
Tegaserod maleate (SDZ-HTF-919) is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United States Food and Drug ... |
|
T24047 |
Etilevodopa hydrochloride
|
Levodopa ethyl ester,Etilevodopa HCl, L-DOPA ethyl ester |
Others
,
Dopamine Receptor
,
Drug Metabolite
|
|
Etilevodopa hydrochloride (L-DOPA ethyl ester) is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration. |
|
T1291 |
Cisapride
|
Prepulsid,R 51619,Pridesia,Kaudalit,(±)-Cisaprid,Kinestase |
Potassium Channel
,
5-HT Receptor
,
HER
|
|
Cisapride (R 51619) is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease... |
|
TP1793 |
Nociceptin (1-13), amide
|
|
Opioid Receptor
|
|
Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes. |
|
T16083 |
Mizagliflozin
|
GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base |
SGLT
|
|
Mizagliflozin (GSK-1614235 free base) is a sodium-glucose transporter inhibitor( Ki of 27 nM for human SGLT1). Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that ca... |
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T13570 |
Benzamide Derivative 1
|
|
Others
|
|
Benzamide Derivative 1 Benzamide derivative with gastrokinetic activity.Benzamide Derivative 1 can be used in the study of gastrointestinal diseases. |
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T13997 |
AU-224
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|
Others
|
|
AU-224 is an orally available benzamide derivative that is a potent gastrointestinal prokinetic. |
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T7569 |
Clebopride malate
|
|
Dopamine Receptor
|
|
Clebopride malate is a dopamine antagonist drug Used to treat functional gastrointestinal disorders such as nausea or vomiting. |
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T7901 |
Emodepside
|
Bay 44-4400 |
Parasite
|
|
Emodepside (Bay 44-4400) is an anthelmintic drug that is effective against a number of gastrointestinal nematodes,with broad-spectrum anthelmintic activity. |
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T0428 |
Alverine citrate
|
NSC 35459 |
5-HT Receptor
|
|
Alverine citrate (NSC 35459) is utilized in functional gastrointestinal disorders. |
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T1052 |
Proglumide
|
|
cholecystokinin
|
|
Proglumide (Binoside) is a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. Proglumide is a drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is... |
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T31597 |
Ecabapide
|
DQ2511,DQ 2511,DQ-2511 |
Others
|
|
Ecabapide (DQ-2511) is a novel gastrointestinal motility promoter that significantly enhances gastric emptying in SHRSP.Ecabapide activates cyclic GMP-dependent housekeeping Cl- channels in rabbit gastric wall cells. |
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T2387 |
Glycopyrrolate
|
Gastrodyn,Glycopyrronium bromide,Robinul,Glycopyrrolate bromide |
AChR
|
|
Glycopyrrolate (Glycopyrrolate bromide) is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics. |
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T19763 |
Cetraxate hydrochloride
|
DV-1006,DV 1006,Cetraxate HCl,DV1006 |
Serine/threonin kinase
|
|
Cetraxate hydrochloride (DV10062) is an oral gastrointestinal medication. It has a cytoprotective effect. |
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T4981 |
Anisotropine Methylbromide
|
|
Prostaglandin Receptor
,
AChR
|
|
Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion. |
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T1269 |
Tripelennamine hydrochloride
|
Pyribenzamine hydrochloride,Tripelennamine HCl,Pyribenzamine HCl |
Histamine Receptor
|
|
Tripelennamine hydrochloride (Pyribenzamine hydrochloride) is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. |
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T1115 |
Doxylamine succinate
|
Decapryn |
Histamine Receptor
|
|
Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and ... |
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T3361 |
Cambendazole
|
Bonlam,MK-905,Novazole |
Others
|
|
Cambendazole (Novazole) is one of the most effective agents for the therapy of human strongyloidiasis. Cambendazole is a nematocide effective against a variety of gastrointestinal parasites in cattle, sheep, and horses. |
|
TP1309 |
Gastric mucin
|
|
Antibacterial
,
Antibiotic
|
|
Gastric mucin is a large glycoprotein which is thought to play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma. |
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T62053 |
Lorpucitinib
|
JNJ-64251330 |
JAK
|
|
Lorpucitinib (JNJ-64251330) is an orally available, selective and potent JAK kinase inhibitor for the study of inflammatory and gastrointestinal disorders associated with Janus kinase (JAK) signaling. |
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TP1039 |
Secretin (33-59), rat
|
Secretin (rat) |
Glucagon Receptor
|
|
Secretin (33-59), rat (Secretin (rat)) is a classical hormone in the gastrointestinal system and a neuropeptide. |
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TP1024 |
Rusalatide acetate (497221-38-2 free base)
|
Rusalatide acetate,TP508 amide acetate |
Others
|
|
Rusalatide acetate (TP508 amide acetate), a regenerated peptide, alleviates radiation-induced gastrointestinal injury by activating stem cells and protecting recess integrity. |
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T11986L |
Mebeverine acid hydrochloride
|
|
|
|
Mebeverine acid hydrochloride is an effective, oral compound to act directly on the smooth muscle of the gastrointestinal tract to relieve spasticity symptoms. |
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T2525 |
Alosetron hydrochloride
|
Lotronex,GR 68755C,GR 68755,GR 68755X |
5-HT Receptor
|
|
Alosetron hydrochloride (GR 68755) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system,... |
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T0347 |
Phenol Red
|
Sulfonphthal,Sulphental,Fenolipuna |
Others
|
|
Phenol Red (Sulfonphthal) is a pH indicator, red dye, and diagnostic aid for measurement of renal function. It is used also for researches of the gastrointestinal and other systems. |
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T28043L |
Minesapride
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|
5-HT Receptor
|
|
Minesapride, a novel 5-hydroxytryptamine 4 (5-HT4) receptor partial agonist, is a potential gastrointestinal prokinetic agent for the treatment of irritable bowel syndrome with constipation. |
|
T3610 |
Ranitidine
|
HSDB 3925,Ranitidin |
P450
,
Antibacterial
,
Histamine Receptor
|
|
Ranitidine (HSDB 3925) is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers. |
|
T0287 |
Hexamethonium Bromide
|
Gangliostat,Simpatoblock,Hexamethonium Dibromide |
Apoptosis
,
Dopamine Receptor
,
AChR
|
|
Hexamethonium Bromide (Hexamethonium Dibromide), a specific antagonist of neuronal-type nicotinic AChR in ganglia, is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. |
|
T3996 |
Dapiprazole Hydrochloride
|
Glamidolo Hydrochloride,Reversil Hydrochloride |
Adrenergic Receptor
|
|
Dapiprazole Hydrochloride (Glamidolo Hydrochloride) is an alpha-1-adrenergic antagonist that acts by blocking alpha-adrenergic receptors in the smooth muscle of blood vessels (arteries, arterioles and veins), gastrointes... |
|
T5409 |
AZD3229
|
|
c-Kit
|
|
AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. It demonstrates potent single-digit nM growth inhibition across a broad cell panel. |
|
TP1705 |
Gastrin I (1-14), human
|
|
Others
|
|
Gastrin I (1-14), human, represents the 1-14 peptide fragment of human gastrin I, an endogenous gastrointestinal peptide hormone. This compound is the principal hormonal regulator of gastric acid secretion. |
|
TP1442 |
Neuromedin B
|
|
Endogenous Metabolite
|
|
Neuromedin B (NMB) is one of the bombesin (BN)-related peptides in mammals. It was originally purified from pig spinal cords, and it has been shown to be present in central nervous system as well as in gastrointestinal t... |
|
T0255 |
Clomipramine hydrochloride
|
Clomipramine HCl,Anafranil |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
,
GST
|
|
Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demeth... |
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T4510 |
Polaprezinc
|
Zinc L-carnosine |
Others
|
|
Polaprezinc is an bioavailable chelate comprised of zinc and L-carnosine, known for its gastrointestinal protective properties, as well as its anti-ulcer, antioxidant, and anti-inflammatory effects. |
|
T68116L |
(Rac)-Norcisapride
|
|
5-HT Receptor
|
|
Norcisapride is a 5-hydroxytryptamine receptor 3 (5-HT3) and (5-hydroxytryptamine receptor 4 (5-HT4) dual agonist used for the treatment of gastrointestinal disorders, orofacial disorders, and otorhinolaryngologic disord... |
|
T62107 |
E-3620
|
|
5-HT Receptor
|
|
E-3620 is a novel 5-HT3 receptor antagonist that inhibits cisplatin-induced vomiting in beagles. E-3620 can be used to study dyskinesia, gastrointestinal dyskinesia, psoriasis and psoriasis. |
|
T1338 |
Sucralfate
|
Sucrose octasulfate–aluminum complex |
FGFR
,
Others
,
Antibacterial
,
Prostaglandin Receptor
|
|
Sucralfate (Sucrose octasulfate–aluminum complex) is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of active duodenal ulcers. |
|
T22070 |
DBIBB
|
|
LPA Receptor
|
|
DBIBB is a non-lipid agonist of specific lysophosphatidic acid (LPA2) type 2 G-protein-coupled receptor. It is a potentially active molecule for the treatment of acute radiation syndrome caused by high intensity gamma ra... |
|
T5872 |
Faltan
|
Folpet |
Antifungal
|
|
Faltan (Folpet),a widely used dicarboximide fungicide,induces tumors in the mouse gastrointestinal tract,primarily in the duodenum,and is also cytotoxic effect on human bronchial epithelial cells. |
|
T0424 |
Bismuth Subsalicylate
|
Bismuth subsalicylat,Bismuth(III) salicylate basic,Bismuth oxysalicylate |
COX
,
PGE Synthase
|
|
Bismuth Subsalicylate (Bismuth subsalicylat) is the active ingredient in the popular medication Pepto-Bismol that is used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts ... |
|
T2400 |
Candesartan Cilexetil
|
TCV-116 |
Apoptosis
,
RAAS
|
|
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist (IC50: 0.26 nM). After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with... |
