| T0332 |
D-Sorbitol
|
Glucitol,Sorbitol,D-Glucitol |
Others
,
Endogenous Metabolite
|
|
D-Sorbitol (Sorbitol) is a polyhydric alcohol with about half the sweetness of sucrose. D-Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be use... |
| T0583 |
Meso-Erythritol
|
Erythrit,Erythritol,Phycitol |
Endogenous Metabolite
|
|
meso-Erythritol (Phycitol) is a four-carbon sugar that is found in algae, fungi, and lichens. It is twice as sweet as sucrose and can be used as a coronary vasodilator. |
| T20576 |
Lactitol
|
NSC 231323,Lactit,D-Lactitol,NSC231323,NSC-231323,Lactosit Miruhen |
Others
|
|
Lactitol (Lactit) is a agent that acts on the gastrointestinal tract. |
| TN6512 |
Tectol
|
|
Transferase
,
Parasite
|
|
Tectol has anti-plasmodial activity, it as a moderately active growth inhibitor with an IC50 3.44±0.20μM. It exhibited significant activity against human leukemia cell lines HL60 and CEM. Tectol may cause itchy dermatiti... |
| T4872 |
Palmitoleic acid
|
(Z)-Hexadec-9-enoic acid,(Z)-9-hexadecenoic acid |
Endogenous Metabolite
|
|
Palmitoleic acid ((Z)-Hexadec-9-enoic acid) is found to be associated with isovaleric acidemia, which is an inborn error of metabolism. |
| T13522 |
7-Ketolithocholic acid
|
3α-Hydroxy-7-oxo-5β-cholanic acid |
Endogenous Metabolite
|
|
7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid) (3α-Hydroxy-7-oxo-5β-cholanic acid) is capable of absorption and serves to suppress the production of endogenous bile acid and the secretion of biliary cholester... |
| TN6822 |
3,5-Dimethoxytoluene
|
Orcinol dimethyl ether,1,3-dimethoxy-5-methylbenzene |
Others
|
|
3,5-Dimethoxytoluene (Orcinol dimethyl ether), the main fragrance component in roses, has a sedative effect and can be used as a pest attractant. |
| T7052 |
Gnetol
|
|
Tyrosinase
,
COX
,
HDAC
,
AChR
|
|
Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. ... |
| T5727 |
CAFESTOL
|
|
ERK
,
NF-κB
,
COX
,
PGE Synthase
|
|
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production... |
| TQ0195 |
1,5-Anhydrosorbitol
|
|
Others
,
Endogenous Metabolite
|
|
1,5-Anhydrosorbitol is a validated marker of short-term glycemic control. This substance is derived mainly from food. |
| T13305 |
Viridicatol
|
|
Anti-infection
,
Antifungal
|
|
Viridicatol, with potent antibacterial activity against Staphylococcus aureus(MIC: 15.6 μg/mL), is isolated from the fermentation of an endophytic fungus Penicillium sp. R22 in Nerium indicum. |
| T8068 |
O-Toluic acid
|
|
Others
|
|
o-Toluic acid, also 2-methylbenzoic acid, is an aromatic carboxylic acid. It is a human xenobiotic metabolite. |
| T1664 |
Meglutol
|
Dicrotalic acid,3-Hydroxy-3-methylglutaric acid |
Endogenous Metabolite
,
HMG-CoA Reductase
,
Autophagy
|
|
Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conve... |
| T6S1292 |
Levistolide A
|
Levistilide A,Diligustilide |
Apoptosis
,
Others
|
|
1. Levistolide A (Diligustilide) inhibits liver fibrosis and angiogenesis. |
| TMS0719 |
Sequoyitol
|
5-O-Methyl-Myo-Inositol |
Others
|
|
Sequoyitol (5-O-Methyl-Myo-Inositol), a methyl derivative of inositol, is often used to treat diabetes. |
| TWS1229 |
Aristolone
|
Aristofone |
Others
|
|
Aristolone (Aristofone) has potential anti-cancer activity. |
| T6640 |
Ribitol
|
Adonite,Adonitol |
Others
,
Endogenous Metabolite
|
|
Ribitol is a pentitol that can be formed by ribose reduction. Enhancement of the D-glucose to pentose phosphate pathway in Saccharomyces cerevisiae can be used to produce ribitol and D-ribose. |
| TN1787 |
Isomucronulatol 7-O-glucoside
|
Isomucronulatol 7-O-beta-glucoside |
Others
|
|
Cholesteryl linoleate is the major cholesteryl ester in LDL and atherosclerotic lesions. It is present in LDL as a cholesteryl ester that is oxidized to form cholesteryl linoleate hydroperoxides using LDL receptor-associ... |
| T8276 |
Methyl palmitoleate
|
|
Others
|
|
O-PHOSPHO-L-SERINE is an ester of serine and phosphate, which are normal metabolites in human biofluids.O-phospho-L-serine is a phagocytosis inhibitor that inhibits glial cell proliferation and cone cell regeneration aft... |
| T7988 |
3,4-Diaminotoluene
|
|
Others
|
|
3,4-Diaminotoluene, an aromatic amine derived from toluene, has been used in the synthesis of a variety of compounds such as polyurethanes, polyureas and polyamides, as well as in the synthesis of amino acids, peptides a... |
| Fr14438 |
P-Toluic Acid
|
4-Methylbenzoic acid |
Endogenous Metabolite
|
|
p-Toluic Acid (4-Methylbenzoic acid) belongs to the class of organic compounds known as benzoic acids. 4-Methylbenzoic acid has been primarily detected in saliva. Within the cell, 4-methylbenzoic acid is primarily locate... |
| TN3231 |
Pratol
|
7-Hydroxy-4'-methoxyflavone |
Others
|
|
Pratol (7-Hydroxy-4'-methoxyflavone) significantly increased melanin content and tyrosinase activity in the cells without being cytotoxic. |
| T0414 |
D-Mannitol
|
Mannite,Mannitol,Osmitrol |
Apoptosis
,
Dehydrogenase
,
Endogenous Metabolite
|
|
D-Mannitol (Mannitol) is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to t... |
| T2791 |
Pectolinarin
|
|
Apoptosis
,
Others
,
NO Synthase
,
Prostaglandin Receptor
,
Interleukin
|
|
Pectolinarin is a Cirsium isolate with anti-inflammatory activity. |
| T9297 |
Perseitol
|
|
Others
|
|
Perseitol is a sugar that is specific to avocado honey. Perseitol have recently been reported as candidate biomarkers for avocado intake. |
| T5729 |
L-quebrachitol
|
|
Wnt/beta-catenin
|
|
L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin signaling pathway. |
| T1529 |
Miglitol
|
BAY1099,BAY-m1099 |
Others
|
|
Miglitol (BAY1099) is an alpha-Glucosidase Inhibitor with antihyperglycemic activity. |
| TN7252 |
Olivetolic acid
|
2,4-Dihydroxy-6-pentylbenzoic acid |
Antibiotic
|
|
Olivetolic acid (OLA) is a precursor of cannabinoids from Cannabis sativa and has shown anticonvulsant activity in a mouse model of Dravet syndrome.Olivetolic acid has potential antimicrobial activity. |
| T15245 |
Erythromycin estolate
|
Phtalic anhydride,ilosone |
Antibacterial
|
|
Erythromycin estolate is a derivative of erythromycin, which belongs to the macrolide class of antibiotics and is often used to study a variety of bacterial infections. Erythromycin estolate has an inhibitory effect on b... |
| TN6985 |
Anhydronotoptol
|
|
NO Synthase
|
|
Anhydronotoptol (4-{[(2E,5E)-3,7-dimethylocta-2,5,7-trien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one), a natural compound extracted from the umbelliferae plant Qiangwu, is a potent inhibitor of nitric oxide production, inhibi... |
| T3823 |
D-Pinitol
|
Pinitol,Inzitol,D-(+)-Pinitol,Methylinositol,3-O-Methyl-D-chiro-inositol |
Others
,
Influenza Virus
|
|
D-Pinitol (Methylinositol) has anti-inflammatory activity. D-Pinitol(Methylinositol) exerts insulin-like activity, used for many diabetic associated conditions. D-Pinitol(Methylinositol) is a safe nutrient to reduce calo... |
| T3S1227 |
Aristolactam I
|
Aristolactam,Aristololactam I,Aristololactum |
Apoptosis
,
Caspase
|
|
1.Aristolactam I (Aristololactum) has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I may be mediated by different mechanisms except TGF... |
| T5915 |
D-chiro-Inositol
|
D-(+)-CHIRO-INOSITOL |
Endogenous Metabolite
|
|
D-chiro-Inositol (D-(+)-CHIRO-INOSITOL) is an epimer of myo-inositol that is found in certain mammalian glycosylphosphatidylinositol protein anchors and inositol phosphoglycans possessing insulin-like bioactivity. |
| T2801 |
Aristolochic acid A
|
TR 1736,Aristolochin,Aristolochine,Aristolochic Acid I,Aristolochic Acid |
Others
,
NF-κB
|
|
Aristolochic acid A (TR 1736) is a compound of mutagenic, carcinogenic, and nephrotoxic compounds commonly found in the Birthwort (Aristolochiaceae) family of plants. |
| T2179 |
Triptolide
|
PG490,NSC 163062 |
Apoptosis
,
Mdm2
,
HSP
,
NF-κB
|
|
Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and ... |
| T6S0413 |
Pectolinarigenin
|
Pectolinaringenin |
Others
,
Lipoxygenase
,
COX
|
|
1. Pectolinarigenin (Pectolinaringenin) exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity and that they may inhibit eicosanoid formation in ... |
| T41288 |
Myristoleic acid
|
cis-9-tetradecenoic acid,9-Tetradecenoic acid,(Z)-Tetradec-9-enoic acid |
Apoptosis
|
|
Myristoleic acid (9-Tetradecenoic acid) is a cytotoxic component in the extract from Serenoa repens. Myristoleic acid induces apoptosis and necrosis in human prostatic LNCaP cells. |
| T5281 |
Skatole
|
Scatole,3-Methylindole,3-Methylindole,3-Methyl-1H-indole,beta-Methylindole |
AhR
,
p38 MAPK
,
Aryl Hydrocarbon Receptor
,
Endogenous Metabolite
,
Antibacterial
,
Autophagy
,
Antifungal
|
|
Skatole (3-Methyl-1H-indole) is produced by intestinal bacteria. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. |
| TN1064 |
Aristolochic acid C
|
|
Others
|
|
Aristolochic acid C could as the larval feeding stimulants. |
| T13750 |
L-Fucitol
|
1-Deoxy-D-galactitol |
Others
|
|
L-Fucitol (1-Deoxy-D-galactitol) is a galactitol analogue isolated from Myristica fragrans (Nutmeg), inhibits galactitol-positive strains of Escherichia coli K12. |
| TL0008 |
Gigantol
|
|
Wnt/beta-catenin
,
Glucosidase
|
|
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a... |
| T3387 |
Phytolaccagenin
|
|
Others
,
Antibacterial
|
|
Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phtolaccae which are widely used in East Asian countries for the treatment of inflammation-related diseases. |
| T2896 |
Alantolactone
|
helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,Inula camphor |
Apoptosis
,
STAT
,
TGF-beta/Smad
|
|
Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3... |
| TN7251 |
Olivetol Dimethyl Ether
|
1,3-dimethoxy-5-pentylbenzene |
Others
|
|
Olivetol Dimethyl Ether is a monoacylglycerol with analgesic activity and potential anti-inflammatory activity that inhibits fatty acid synthesis. |
| T3848 |
(Iso)-Isomucronulatol 7-O-glucoside
|
Isomucronulatol 7-O-glucoside,7,2'-dihydroxy-3',4'-dimethoxyisoflavane-7-O-glucoside,7,2′-Dihydroxy-3′,4′-dimethoxyisoflavan 7-O-β-D-glucoside |
Others
|
|
Isomucronulatol 7-O-glucoside is a biologically active isoflavone isolated from Astragalus membranaceus. |
| T5268 |
D-Arabitol
|
D-Lyxitol |
Others
,
Endogenous Metabolite
|
|
D-Arabitol is a polyol that can lead to neurotoxicity when accumulated in the body. |
| T5545 |
Maltol
|
Veltol,Larixinic acid,Palatone |
Antioxidant
,
Endogenous Metabolite
|
|
Maltol is a type of aromatic compound found in high concentrations in red ginseng and is a potent antioxidant used to enhance flavor and preserve food. |
| TN2539 |
1beta-Hydroxyalantolactone
|
|
IL Receptor
,
TNF
|
|
1beta-Hydroxyalantolactone is a small molecular compound isolated from the flower head of the medicinal plant giant British flower, which can inhibit the expression of TNF-α, IL-17 and IFN-γ in cells, promote the secreti... |
| T1680 |
Tolazoline hydrochloride
|
Imidaline hydrochloride,Imidaline (hydrochloride),Benzidazol hydrochloride,Tolazoline HCl,NSC35110 (hydrochloride) |
Adrenergic Receptor
|
|
Tolazoline hydrochloride (NSC35110 (hydrochloride)) is a non-selective competitive α-adrenergic receptor antagonist used in treatment of persistent pulmonary hypertension of the newborn. |
| T0421 |
I-Inositol
|
Inositol,myo-Inositol,meso-Inositol |
Endogenous Metabolite
|
|
i-Inositol (myo-Inositol) is a intracellular phosphate compound, involved in cell signaling and may stimulate tumor cell differentiation. |
