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Search Results for " anti-oxidative "

ターゲット

OXPHOS Reactive Oxygen Species Mitochondrial Metabolism Autophagy

阻害剤

天然化合物

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T9211	Mito-LND	Mito-Loidamine	OXPHOS , Reactive Oxygen Species , Mitochondrial Metabolism , Autophagy
	Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
T23550	YM-750	YM 750	Acyltransferase
	YM-750 is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with an IC50 value of 0.18 μM. ACAT is an enzyme that catalyzes the conversion of cholesterol and long-chain fatty-acyl-coenzyme A into cholest...		Acyltransferase
T22309	2,5-Dimethyl-3(2H)-furanone	2,5-Dimethyl-2,3-dihydrofuran-3-one	Others
	2,5-Dimethyl-3(2H)-furanone (2,5-Dimethyl-2,3-dihydrofuran-3-one) is a non-genotoxic flavoring substance [1].		Others
T13920L	Terlipressin Acetate	Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous	Vasopressin Receptor
	Terlipressin Acetate, a highly selective vasopressin V1 receptor agonist, on oxygen and glucose deprivation/re-oxygenation (OGD/R)-induced damage in intestinal epithelial cells (IEC-6).Terlipressin acetate exerts anti-in...		Vasopressin Receptor
T8842	IMT1B	3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974	Others , DNA/RNA Synthesis
	IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of the mitochondrial RNA polymerase (POLRMT), effectively suppressing mitochondrial DNA (mtDNA) expression. This action confers it...		Others , DNA/RNA Synthesis
T10512	Prenyl-IN-1		Transferase
	Prenyl-IN-1 is a potent and selective prenylation inhibitor of geranylgeranyltransferase or farnesyltransferase.Prenyl-IN-1 shows anti-oxidative stress effects in a Parkinson's model. Prenyl-IN-1 showed anti-oxidative st...		Transferase
T4360	ML385		Others , Ferroptosis , Nrf2
	ML385 is an NRF2 inhibitor (IC50=1.9 μM) with novelty and specificity. ML385 has anti-inflammatory activity by modulating anti-oxidative stress through the inhibition of NRF2. ML385 also exhibits anti-tumor activity.		Others , Ferroptosis , Nrf2
T3647	HTHQ	HX 1171,HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone),1-O-hexyl-2,3,5-trimethylhydroquinone	Reactive Oxygen Species
	HTHQ (HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)), a hydroquinone monoalkyl ether, is an effective anti-oxidative agent. HTHQ is a potent anti-lipid-peroxidative compound and its antioxidation activity to be extremely e...		Reactive Oxygen Species
TP1088	N-Acetylcarnosine	N-Acetyl-L-carnosine	Others
	N-Acetylcarnosine (N-Acetyl-L-carnosine) is thought to be able to combat some of the effects of oxidative stress as it has anti-oxidant properties.		Others
T22317	DRB18		transporter
	DRB18 is a highly effective pan-class inhibitor of glucose transporter proteins (GLUT). It significantly modulates energy-related metabolism in A549 cells by inducing alterations in the abundance of metabolites associate...		transporter
T31615	Elsibucol	AGI-1096,UNII-O7T92N1Y8T,AGI 1096	Antioxidant
	Elsibucol (AGI 1096) is a VCAM1 inhibitor for the study of organ transplant rejection.Elsibucol is a metabolically stable propanol derivative with antioxidant, anti-inflammatory and anti-proliferative properties. It lowe...		Antioxidant
T30087	Antroquinonol		Reactive Oxygen Species , Nrf2
	Antroquinonol is a ubiquinone derivative from Antrodia camphorata with anti-inflammatory and anticancer activities.Antroquinonol reduces oxidative stress and inhibits inflammation and sclerosis in mice with focal segment...		Reactive Oxygen Species , Nrf2
T14991	CMS-121	CMS121	Acetyl-CoA Carboxylase
	CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotect...		Acetyl-CoA Carboxylase
T16478	PF-04447943	PF 04447943,Edelinontrine,PF04447943	PDE
	PF-04447943 (Edelinontrine) is a potent and selective phosphodiesterase 9A inhibitor with an IC50 of 12 nM, which is 78-fold more selective than that used for other PDE family members (IC50>1000 nM).PF-04447943 exhibits ...		PDE
T4313	Tinoridine hydrochloride	Nonflamin,Y-3642 hydrochloride	COX , Glutathione Peroxidase
	Tinoridine hydrochloride (Y-3642 hydrochloride) is a non-steroidal anti-inflammatory drug. Tinoridine hydrochloride (5-100 μM), produced a concentration-dependent inhibition on the simultaneous increases in lipid peroxid...		COX , Glutathione Peroxidase
T50032	5-(2-furyl)-N-propylisoxazole-3-carboxamide		Others
	5-(2-furyl)-N-propylisoxazole-3-carboxamide is a compound used as a molecular structural unit and is thought to be a modulator of NMDA receptors, and has been shown to be protective against glutamate-induced excitotoxici...		Others
T27041	Clidanac	Clidanaco,TAI 284,Britai,TAI-284,TAI284
	Clidanac is a potent anti-inflammatory drug and is found to uncouple the oxidative phosphorylation.
T28878	Sul-121 HCl	Sul-121 Hydrochloride
	Sul-121 has anti-oxidative capacity. In experimental chronic obstructive pulmonary disease (COPD) models, Sul-121 HCl inhibits airway inflammation and hyperresponsiveness (AHR) prospectively through inhibition of oxidati...
T74414	S-Allylmercaptocysteine
	S-allylmercaptocysteine, an organic sulfur compound derived from garlic, possesses anti-inflammatory and anti-oxidative properties beneficial in treating various pulmonary diseases. It exerts its anti-cancer effects thro...
T83050	Anti-inflammatory agent 62
	Anti-inflammatory agent 62 mitigates acetaminophen-induced hepatotoxicity in HepG2 cells by modulating inflammatory and oxidative stress pathways [1].
TP1464	Risuteganib hydrochloride
	Risuteganib hydrochloride is an anti-integrin that downregulates oxidative stress and restores homeostasis, and targets three integrin receptors that are implicated in dry age-related macular degeneration (AMD) in order ...
T36614	DL-Sulforaphane N-acetyl-L-cysteine
	Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressor...
T63364	Nrf2 activator-5
	Nrf2 activator-5 is a potent activator of Nrf2 that attenuates H2O2-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglia, exhibiting antioxidant and anti-inflammatory activity.
T37148	TML-6
	TML-6, an oral curcumin derivative, demonstrates inhibitory effects on the synthesis of β-amyloid precursor protein and β-amyloid (Aβ). Additionally, TML-6 exhibits upregulation of Apo E, suppression of NF-κB and mTOR, a...
T60447	α-Amylase-IN-3
	α-Amylase-IN-3 (Compound 4) is a non-competitive inhibitor of α-Amylase with an IC50 value of 18.04 μM. α-Amylase-IN-3 has radical scavenging activities with IC50 values of 16.04 μM for DPPH and 16.99 μM for ABTS, respec...
T79670	Anti-inflammatory agent 56		COX
	Anti-inflammatory agent 56 (Compound 9), a selective COX-2 inhibitor with an IC50 of 0.54 μM, exhibits anti-oxidant and anti-inflammatory properties by inhibiting oxidative stress-induced cell death and neuroinflammation...		COX
T81109	Squalene synthase-IN-1
	Squalene synthase-IN-1 (compound 1) is a potent antihyperlipidemic agent that inhibits Squalene Synthase and demonstrates exceptional antioxidant and anti-inflammatory activities. It significantly reduces both glucose an...
T60521	Doxepin
	As a tricyclic antidepressant, Doxepin inhibits the reuptake of serotonin and norepinephrine. Doxepin shows therapeutic effects on atopic dermatitis and chronic urticaria that also improves cognitive processes as well as...
T78113	Tylvalosin	Acetylisovaleryltylosin	Antibiotic
	Tylvalosin (Acetylisovaleryltylosin) is a broad-spectrum macrolide antibiotic with antibacterial and antiviral properties, effective against PRRSV infection. It induces apoptosis and possesses anti-inflammatory activity....		Antibiotic
T79226	AMPK activator 11		Mitochondrial Metabolism
	AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-activated protein kinase (AMPK) and enhancement of oxidative...		Mitochondrial Metabolism
T78698	Aβ-IN-6
	Aβ-IN-6 is an orally active compound exhibiting anti-inflammatory, antioxidant, and anti-oligomeric activities, with significant implications for Alzheimer's disease (AD) research [1]. It effectively reduces the release ...
T63987	Keap1-Nrf2-IN-14
	Keap1-Nrf2-IN-14 is a KEAP1-NRF2 inhibitor that effectively disrupts the KEAP1-NRF2 interaction (IC50: 75 nM) with a Kd=24 nM for KEAP1. Keap1-Nrf2-IN-14 induces the expression of NRF2 target genes and is able to enhance...
T69262	ABE171
	ABE171, also known as NVP-ABE171, is a potent and novel phosphodiesterase 4 inhibitor with anti-inflammatory activities. NVP-ABE171 inhibited the activity of phosphodiesterase 4A, 4B, 4C, and 4D with respective IC(50) v...
T35961	Prostaglandin Bx
	PGBx is a mixture of oligomers of PGB1 with a molecular weight of 1,000-1,500. It has antioxidant and free radical trapping activity that was first studied in isolated mitochondria.1 PGBx has anti-inflammatory and cytopr...

Compounds

Mito-LND

T9211

Synonym: Mito-Loidamine

Target: OXPHOS, Reactive Oxygen Species, Mitochondrial Metabolism, Autophagy

YM-750

T23550

Synonym: YM 750

Target: Acyltransferase

2,5-Dimethyl-3(2H)-furanone

T22309

Synonym: 2,5-Dimethyl-2,3-dihydrofuran-3-one

Target: Others

Terlipressin Acetate

T13920L

Synonym: Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous

Target: Vasopressin Receptor

IMT1B

T8842

Synonym: 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974

Target: Others, DNA/RNA Synthesis

Target: Others, Ferroptosis, Nrf2

HTHQ

T3647

Synonym: HX 1171,HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone),1-O-hexyl-2,3,5-trimethylhydroquinone

Target: Reactive Oxygen Species

N-Acetylcarnosine

TP1088

Synonym: N-Acetyl-L-carnosine

Synonym: AGI-1096,UNII-O7T92N1Y8T,AGI 1096

Target: Antioxidant

Antroquinonol

T30087

Synonym:

Target: Reactive Oxygen Species, Nrf2

CMS-121

T14991

Synonym: CMS121

Target: Acetyl-CoA Carboxylase

PF-04447943

T16478

Synonym: PF 04447943,Edelinontrine,PF04447943

Target: PDE

Tinoridine hydrochloride

T4313

Synonym: Nonflamin,Y-3642 hydrochloride

Target: COX, Glutathione Peroxidase

5-(2-furyl)-N-propylisoxazole-3-carboxamide

Synonym: Clidanaco,TAI 284,Britai,TAI-284,TAI284

Target:

Sul-121 HCl

T28878

Synonym: Sul-121 Hydrochloride

Target:

S-Allylmercaptocysteine

T74414

Synonym:

Target:

Anti-inflammatory agent 62

T83050

Synonym:

Target:

Risuteganib hydrochloride

TP1464

Synonym:

Target:

DL-Sulforaphane N-acetyl-L-cysteine

Anti-inflammatory agent 56

T79670

Synonym:

Target: COX

Squalene synthase-IN-1

Synonym: Acetylisovaleryltylosin

Target: Mitochondrial Metabolism

カタログ番号	製品名	別名	ターゲット
T2738	Dehydroandrographolide		NOS , Influenza Virus
	Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees.		NOS , Influenza Virus
T3S1265	Liriopesides B	Nolinospiroside F	Others
	Liriopesides B (Nolinospiroside F) exhibited potential anticancer activity against human ovarian cancer A2780 cells.		Others
T3S1319	(+)-Magnoflorine	Escholin,Magnoflorine,Thalictrin,Escholine	Others , Antifungal
	(+)-Magnoflorine (Thalictrin) has sedative and anxiolytic effects, probably mediated by Magnoflorine through a GABAergic mechanism of action. Magnoflorine and Sinomenine have protective effects, are mediated by some mech...		Others , Antifungal
T2800	L-Theanine		Apoptosis , Others
	L-Theanine is a relaxing and nondietary amino acid found pretty much exclusively in teas from Camellia sinensis and is known to promote relaxation without sedation.		Apoptosis , Others
T8678	Naphthazarin	5,8-Dihydroxy-1,4-naphthoquinone,DHNQ	Apoptosis
	Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, inter...		Apoptosis
T2230	Paeoniflorin	Peoniflorin	HSP , COX
	Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.		HSP , COX
T3S1320	(+)-Magnoflorine iodide	Magnoflorine iodide,Thalictrine iodide,Corytuberine Methiodide	Others , Antifungal
	(+)-Magnoflorine iodide (Thalictrine iodide) has anti-inflammatory activity, it can inhibit inflammations.		Others , Antifungal
TN1039	Tamarixetin	4'-O-Methyl Quercetin	Endogenous Metabolite , Immunology/Inflammation related
	Tamarixetin (4'-O-Methyl Quercetin) (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin, with anti-inflammatory and anti-oxidative effects. Tamarixetin protects against cardiac hypertrophy.		Endogenous Metabolite , Immunology/Inflammation related
T4S1321	(+)-Magnoflorine chloride	Magnoflorine chloride,Corytuberine methochloride,Thalictrine chloride,Escholine chloride	Others , Antifungal
	(+)-Magnoflorine chloride (Escholine chloride) has anti-inflammatory activity, it can inhibit inflammations.		Others , Antifungal
TN1926	Methyl caffeate	Methyl caffeate acid	Others , Antibacterial
	Methyl caffeate (Methyl caffeate acid) acid		Others , Antibacterial
T8193	α-Thujone	Thujone,ALPHA-(-)-THUJONE	Apoptosis , Reactive Oxygen Species , GABA Receptor , AChR , Parasite , Autophagy
	α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
T2870	Matrine	Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine	Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
	Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.		Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
TN6909	Polyporusterone B	(1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one	Others
	Polyporusterone B ((1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one) is a triterpene carboxylic aci...		Others
TN6924	Anhydrosafflor yellow B	(2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,AHSYB	Others
	Anhydrosafflor yellow B ((2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,...		Others
T2S1008	Oxysophoridine	Sophoridine N-oxide	Apoptosis , Antioxidant
	Oxysophoridine (Sophoridine N-oxide) has a protective effect on focal cerebral ischemic injury through antioxidant and anti-apoptotic mechanisms; it may be a potential neuroprotective agent for cerebral ischemia injury, ...		Apoptosis , Antioxidant
T5S2102	Leonurine	SCM-198	Autophagy
	Leonurine (SCM-198) is an alkaloid that has been found in H. leonuri and with anti-oxidative and anti-inflammatory.		Autophagy
T2813	Madecassoside	Asiaticoside A	Apoptosis , Antioxidant , Endogenous Metabolite
	Madecassoside (Asiaticoside A) is a pentacyclic triterpene extracted from Centella asitica (L.) with anti-inflammatory, anti-oxidative and anti-aging activities.		Apoptosis , Antioxidant , Endogenous Metabolite
T8030	Ethyl pyruvate		Apoptosis , Antioxidant
	Ethyl pyruvate is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, and anti-apoptotic functions.		Apoptosis , Antioxidant
T5311	Crocin (Gardenia Fruits Extract)		Others
	Crocin is a water-soluble carotenoid pigment of saffron (Crocus sativus L.). Crocin has anti-inflammatory, anti-oxidative, anti-apoptotic, anti-asthma, anti-cancer, and hypolipidemic effects.		Others
TN1295	5-O-Caffeoylshikimic acid		IL Receptor , TNF , NO Synthase
	5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB.		IL Receptor , TNF , NO Synthase
TN1600	Eclalbasaponin I		Others
	Eclalbasaponin I has anti-oxidative, and antitumor activities, it reduces oxidative stress-induced neural cell death by autophagy activation, it can dose-dependently inhibit the proliferation of hepatoma cell smmc-7721 w...		Others
T0539	Dihydrocaffeic acid	Hydrocaffeic acid	Antioxidant , p38 MAPK , Endogenous Metabolite
	Dihydrocaffeic acid (Hydrocaffeic acid), a metabolite of chlorogenic acid, is a well-known anti-oxidant component, has anti-oxidative, anti-Alzheimer's, neuroprotective, arousal, and lipid-lowering effects.		Antioxidant , p38 MAPK , Endogenous Metabolite
T5S0662	Gelsemine	Gelsemin	Antioxidant
	1. Gelsemine (Gelsemin) has antitumor activity. 2. Gelsemine has anti-oxidative activity. 3. Gelsemine has anti-hyperlipidemic activity. 4. Gelsemine has marked antinociception in inflammatory, neuropathic and bone cance...		Antioxidant
T3834	8-Epideoxyloganic acid		ROS , Immunology/Inflammation related
	8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibl...		ROS , Immunology/Inflammation related
T7113	Paradol	6-paradol,[6]-Gingerone	COX
	Paradol ([6]-Gingerone) is a pungent phenolic substance found in ginger and other Zingiberaceae plants, and exhibits a variety of biological activities including anti-cancer, anti-inflammatory, and anti-oxidative activit...		COX
T12451	Phosphoenolpyruvic acid tricyclohexylammonium salt	PEP 3 CHA,phosphoenolpyruvic-acid-tricyclohexylammonium-salt,phosphoenolpyruvic-acid-tricyclohexylammoniu-m-salt	Others
	Phosphoenolpyruvic acid tricyclohexylammonium salt (PEP 3 CHA) is a functional carbohydrate metabolite with cytoprotective and anti-oxidative activity. Phosphoenolpyruvic acid tricyclohexylammonium salt is able to penetr...		Others
T6S1966	Curculigoside	Curculigoside A	Antioxidant , NF-κB , JAK , STAT
	1. Curculigoside (Curculigoside A) can prevent bone loss , improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disord...		Antioxidant , NF-κB , JAK , STAT
T2821	Ethyl ferulate	Ethyl 4'-hydroxy-3'-methoxycinnamate,Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate,Ferulic acid ethyl ester	Reactive Oxygen Species
	Ethyl ferulate (Ethyl 4'-hydroxy-3'-methoxycinnamate) is the alkyl ester derivative of ferulic acid which is a naturally occurring plant product with anti-oxidative, anti-inflammatory, neuroprotective, and antiproliferat...		Reactive Oxygen Species
T5S1262	Methylophiopogonanone A		Others
	1. Methylophiopogonanone A has anti-inflammatory and anti-oxidative properties. 2. Methylophiopogonanone A has therapeutic potential against cerebral I/R injury through its ability to attenuate BBB disruption by regulati...		Others
T9279	Nerolidol acetate		Others
	Nerolidol acetate is a natural sesquiterpene with anti-cancer, anti-inflammatory, antibacterial and anti-insect activities. Nerolidol acetate can inhibit parasite activity and inhibit schistosomiasis, nematodes, malaria,...		Others
TWS1977	Kamebakaurin	Kamebakaurine	NF-κB
	1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression...		NF-κB
T11685	Isolongifolene	(-)-Isolongifolene	Apoptosis , Others
	Isolongifolene ((-)-Isolongifolene), a tricyclic sesquiterpene isolated from Murraya koenigii, exhibits antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. It mitigates Rotenone-induced oxidative ...		Apoptosis , Others
T3857	Magnolin	(+)-Magnolin	ERK
	Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects.		ERK
T6718	Zingerone	Gingerone,Vanillylacetone,NSC 15335	NF-κB
	Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antidiarrhoeic, antilipolytic, antispasmodic and anti-tumor properties. Zingerone(Gi...		NF-κB
T2938	(E/Z)-Polydatin	Polydatin,(E/Z)-Piceid	Phospholipase
	(E/Z)-Polydatin (Polydatin), is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be det...		Phospholipase
T68953	Arecoline		Reactive Oxygen Species , AChR
	Arecoline is a natural alkaloid derived from areca nut in the palm family and is a potent nicotine and partial agonist of muscarinic acetylcholine receptors. Arecoline has anti-anxiety and anti-parasitic activity, can in...		Reactive Oxygen Species , AChR
T5429	Theaflavin 3,3'-digallate	8-Gingerol,TFDG	Virus Protease , Antioxidant , HIV Protease , HSV
	Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregul...		Virus Protease , Antioxidant , HIV Protease , HSV
TN1594	DL-Syringaresinol	(±)-Syringaresinol	Antioxidant , Antifungal
	DL-Syringaresinol ( (±)-Syringaresinol) is a lignan from ginseng berries with anti-inflammatory, antioxidant, analgesic and weak anti-mycobacterial activities.DL-Syringaresinol can delay oxidative stress-induced skin agi...		Antioxidant , Antifungal
T3S1553	Trans-Cinnamaldehyde	Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein	COX , Endogenous Metabolite
	1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic aldehyde induces apoptosis of CML cells...		COX , Endogenous Metabolite
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
TN2244	Sulfuretin		NF-κB , Autophagy
	Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 thr...		NF-κB , Autophagy
T6S1784	Brazilin	Natural Red 24,Braziletto,Brasilin,Superbresiline	Apoptosis , Others , AMPK , Autophagy
	1. Brazilin (Braziletto) exhibits anti-hepatotoxic, antiplatelet effects. 2. Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell death through a c-Fos-mediated and tumor cell specific sign...		Apoptosis , Others , AMPK , Autophagy
TJS1779	Protosappanin A	PTA	NADPH-oxidase , IL Receptor , IκB/IKK , TNF , NF-κB , TLR , ROS , COX , HIV Protease , JAK , NO Synthase , STAT
	Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammation signal pathway; it exerts anti-neuroinflammatory ...
TN1831	Macranthoside A	Kalopanaxsaponin H	Antioxidant
	Macranthoside A (Kalopanaxsaponin H) is a triterpenoid glycoside extracted from rehmannia and belongs to the iridoterpenoid synthesis. Macranthoside A has anti-inflammatory, antioxidant, antibacterial and neuroprotective...		Antioxidant
T2854	Phillyrin	Forsythin	P450 , Influenza Virus , AMPK
	Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activ...		P450 , Influenza Virus , AMPK
T3779	Crocin II	Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B	Caspase , COX , NO Synthase
	Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expres...		Caspase , COX , NO Synthase
T3414	Morroniside		Apoptosis , MMP , Pyroptosis
	Morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice. It exhibits protective effects against diabetic renal damage and human umbilical vein endothelial cells, by inhib...		Apoptosis , MMP , Pyroptosis
T3753	Sinapinic Acid	Sinapic acid,Synapoic acid	Apoptosis , RAAS , Reactive Oxygen Species , HDAC
	Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinap...		Apoptosis , RAAS , Reactive Oxygen Species , HDAC
T4S0969	Obtusifolin		Antioxidant , NF-κB
	1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be...		Antioxidant , NF-κB
T6S0735	Flavokawain B	Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone	Apoptosis , Others
	1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, in...		Apoptosis , Others
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天然物製品

Dehydroandrographolide

T2738

Synonym:

Target: NOS, Influenza Virus

Liriopesides B

T3S1265

Synonym: Nolinospiroside F

Target: Others

(+)-Magnoflorine

T3S1319

Synonym: Escholin,Magnoflorine,Thalictrin,Escholine

Target: Others, Antifungal

L-Theanine

T2800

Synonym:

Target: Apoptosis, Others

Naphthazarin

T8678

Synonym: 5,8-Dihydroxy-1,4-naphthoquinone,DHNQ

(+)-Magnoflorine iodide

T3S1320

Synonym: Magnoflorine iodide,Thalictrine iodide,Corytuberine Methiodide

Target: Others, Antifungal

Tamarixetin

TN1039

Synonym: 4'-O-Methyl Quercetin

Target: Endogenous Metabolite, Immunology/Inflammation related

(+)-Magnoflorine chloride

T4S1321

Synonym: Magnoflorine chloride,Corytuberine methochloride,Thalictrine chloride,Escholine chloride

Target: Others, Antifungal

Methyl caffeate

TN1926

Synonym: Methyl caffeate acid

Target: Others, Antibacterial

α-Thujone

T8193

Synonym: Thujone,ALPHA-(-)-THUJONE

Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, AChR, Parasite, Autophagy

Matrine

T2870

Synonym: Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine

Target: Mitophagy, Ferroptosis, Opioid Receptor, Autophagy

Polyporusterone B

TN6909

Synonym: (1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one

Target: Others

Anhydrosafflor yellow B

TN6924

Synonym: (2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,AHSYB

Target: Others

Oxysophoridine

T2S1008

Synonym: Sophoridine N-oxide

Target: Apoptosis, Antioxidant

Synonym: Asiaticoside A

Target: Apoptosis, Antioxidant, Endogenous Metabolite

Ethyl pyruvate

T8030

Synonym:

Target: Apoptosis, Antioxidant

Crocin (Gardenia Fruits Extract)

T5311

Synonym:

Target: Others

5-O-Caffeoylshikimic acid

TN1295

Synonym:

Target: IL Receptor, TNF, NO Synthase

Synonym: Hydrocaffeic acid

Target: Antioxidant, p38 MAPK, Endogenous Metabolite

Gelsemine

T5S0662

Synonym: Gelsemin

Target: Antioxidant

8-Epideoxyloganic acid

T3834

Synonym:

Target: ROS, Immunology/Inflammation related

Paradol

T7113

Synonym: 6-paradol,[6]-Gingerone

Target: COX

Phosphoenolpyruvic acid tricyclohexylammonium salt

T12451

Synonym: PEP 3 CHA,phosphoenolpyruvic-acid-tricyclohexylammonium-salt,phosphoenolpyruvic-acid-tricyclohexylammoniu-m-salt

Target: Others

Curculigoside

T6S1966

Synonym: Curculigoside A

Target: Antioxidant, NF-κB, JAK, STAT

Ethyl ferulate

T2821

Synonym: Ethyl 4'-hydroxy-3'-methoxycinnamate,Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate,Ferulic acid ethyl ester

Target: Reactive Oxygen Species

Methylophiopogonanone A

Synonym: Kamebakaurine

Target: NF-κB

Isolongifolene

T11685

Synonym: (-)-Isolongifolene

Target: Apoptosis, Others

magnolin

T3857

Synonym: (+)-Magnolin

Target: ERK

Zingerone

T6718

Synonym: Gingerone,Vanillylacetone,NSC 15335

Target: NF-κB

(E/Z)-Polydatin

T2938

Synonym: Polydatin,(E/Z)-Piceid

Target: Phospholipase

Arecoline

T68953

Synonym:

Target: Reactive Oxygen Species, AChR

Theaflavin 3,3'-digallate

T5429

Synonym: 8-Gingerol,TFDG

Target: Virus Protease, Antioxidant, HIV Protease, HSV

DL-Syringaresinol

TN1594

Synonym: (±)-Syringaresinol

Target: Antioxidant, Antifungal

trans-Cinnamaldehyde

T3S1553

Synonym: Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein

Target: COX, Endogenous Metabolite

Jaceosidin

T3824

Synonym:

Target: Apoptosis, BCL, COX, UGT

Sulfuretin

TN2244

Synonym:

Target: NF-κB, Autophagy

Brazilin

T6S1784

Synonym: Natural Red 24,Braziletto,Brasilin,Superbresiline

Target: Apoptosis, Others, AMPK, Autophagy

Protosappanin A

TJS1779

Synonym: PTA

Target: NADPH-oxidase, IL Receptor, IκB/IKK, TNF, NF-κB, TLR, ROS, COX, HIV Protease, JAK, NO Synthase, STAT

Macranthoside A

TN1831

Synonym: Kalopanaxsaponin H

Target: Antioxidant

Phillyrin

T2854

Synonym: Forsythin

Target: P450, Influenza Virus, AMPK

Crocin II

T3779

Synonym: Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B

Target: Caspase, COX, NO Synthase

Morroniside

T3414

Synonym:

Target: Apoptosis, MMP, Pyroptosis

Sinapinic Acid

T3753

Synonym: Sinapic acid,Synapoic acid

Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC

Obtusifolin

T4S0969

Synonym:

Target: Antioxidant, NF-κB

Flavokawain B

T6S0735

Synonym: Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone

Target: Apoptosis, Others

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Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPK-00077	EPO/Erythropoietin Protein, Human, Recombinant	Human	HEK293 Cells
	Erythropoietin (EPO) is a circulating hormone conventionally considered to be responsible for erythropoiesis. In addition to facilitating red blood cell production, EPO has pluripotent potential, such as for cognition im...
TMPK-01168	LOX-1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion...
TMPY-02084	Thioredoxin 2/TRX2 Protein, Human, Recombinant (His)	Human	E. coli
	Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanot...
TMPY-04122	ATOX1 Protein, Human, Recombinant (His)	Human	E. coli
	ATOX1 is a cytoplasmic copper chaperone that interacts with the copper-binding domain of the membrane copper transporters ATP7A and ATP7B. ATOX1 has also been suggested to have a potential anti-oxidant activity. As the t...
TMPY-03962	AFM Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Afamin is an 87 kDa glycoprotein with five predicted N-glycosylation sites. Afamin's glycan abundance contributes to conformational and chemical inhomogeneity presenting great challenges for molecular structure determina...
TMPH-01502	Humanin Protein, Human, Recombinant (GST)	Human	E. coli
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...
TMPH-01503	Humanin Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...

EPO/Erythropoietin Protein, Human, Recombinant

TMPK-00077

Species: Human

Expression System: HEK293 Cells

LOX-1 Protein, Mouse, Recombinant (His)

TMPK-01168

Species: Mouse

Expression System: HEK293 Cells

Thioredoxin 2/TRX2 Protein, Human, Recombinant (His)

TMPY-02084

Species: Human

Expression System: E. coli

ATOX1 Protein, Human, Recombinant (His)

TMPY-04122

Species: Human

Expression System: E. coli

AFM Protein, Human, Recombinant (His)

TMPY-03962

Species: Human

Expression System: HEK293 Cells

Humanin Protein, Human, Recombinant (GST)

TMPH-01502

Species: Human

Expression System: E. coli

Humanin Protein, Human, Recombinant (hFc)

TMPH-01503

Species: Human

Expression System: HEK293 Cells

カタログ番号	製品名
L6140	Saccharide and Glycoside Natural Product Library	362 compounds
	A unique collection of 362 saccharides and glycosides compounds can be used for HTS and HCS；
L6120	Flavonoid Natural Product Library	514 compounds
	A unique collection of 514 flavonoids can be used for high throughput and high content screening；
L6110	Alkaloid Natural Product Library	464 compounds
	A unique collection of 464 natural alkaloids can be used for high throughput and high content screening；
L9840	Anti-Alzheimer's Disease Compound Library	986 compounds
	A unique collection of 986 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS.

ライブラリー

Saccharide and Glycoside Natural Product Library

L6140

Compounds: 362

Flavonoid Natural Product Library

L6120

Compounds: 514

Alkaloid Natural Product Library

L6110

Compounds: 464

Anti-Alzheimer's Disease Compound Library

L9840

Compounds: 986