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Search Results for " serine/threonine "

ターゲット

100

阻害剤

9

天然化合物

75

リコンビナントタンパク質

2

ライブラリー

カタログ番号 製品名 別名 ターゲット
TP1277 Bradykinin Endogenous Metabolite , Bradykinin Receptor
Bradykinin is an inflammatory mediator. It is a peptide that causes blood vessels to dilate (enlarge) via the release of prostacyclin, nitric oxide, and Endothelium-Derived Hyperpolarizing Factor. Bradykinin is a physiol...
T7017 WNK463 Serine/threonin kinase
WNK463 is a pan-WNK-kinase inhibitor. It effectively inhibits the in vitro kinase activity of all four WNK family members (WNK1/2/3/4).
T11666 IPR-803 Serine/threonin kinase
IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity. IPR-803 binds directly to uPAR with a Ki of 0.2 μM.
T10547 BioE-1115 Serine/threonin kinase , Casein Kinase
T8350 TPCK Proteasome
TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis
T4058 R-IMPP Others , Serine/threonin kinase
R-IMPP is an inhibitor of PCSK9 translation. R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin.
T11885 LSP-249 Others
LSP-249 is a plasma kallikrein inhibitor under the study for angioedema, with an EC50 less than 100 nM in cell.
T13257 Upamostat PAI-1 , Serine/threonin kinase , Serine Protease
Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.
T4524 SBC-110736 SBC110736 Others , Serine/threonin kinase
SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor
T9920 Evolocumab Others
Evolocumab is a human IgG2 monoclonal antibody that binds to human PCSK9 Proprotein Convertase Subtilisin Kexin Type 9).
T13408 ZK824190 Others , Serine Protease
ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively).
T14358 Avoralstat BCX4161 Others
Avoralstat (BCX4161) is an oral plasma kallikrein (PKK) inhibitor. Which is used for the treatment of hereditary angioedema.
T9276 SBC-115337 Others , Serine/threonin kinase
SBC-115337 is a PCSK9 inhibitor.
T5456 WNK-IN-11 Allosteric WNK Kinase Inhibitor Serine/threonin kinase
WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)
T8866 GW779439X Apoptosis , Antibacterial , CDK , Aurora Kinase
GW779439X is an inhibitor of CDK.
T8645 PF-06446846 Others
PF 06446846 is a potent and selective PCSK9 inhibitor
T2626 SBC-115076 SBC115076 Others , Serine/threonin kinase
SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.
T8676 FOY 251 Others , Serine/threonin kinase , SARS-CoV
FOY 251 is a proteinase inhibitor, and is an anti-proteolytic active metabolite camostate.
T6370 AEBSF hydrochloride AEBSF HCl,Pefabloc SC Thrombin , Serine Protease , Influenza Virus
AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.
T8362 Benzamidine hydrochloride Benzamidine HCl Serine/threonin kinase , Serine Protease
Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively).
T31206 Darexaban YM 150,Darexaban, Tanexaban,YM150 Factor Xa
Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati...
T3359 Aprotinin Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin Others , Serine Protease , Influenza Virus , Proteasome
Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activat...
T2392 Nafamostat mesylate FUT-175 Apoptosis , Serine/threonin kinase , SARS-CoV , Serine Protease
Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
T5125 LY3200882 TGF-beta/Smad
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
T19763 Cetraxate hydrochloride DV-1006,DV 1006,Cetraxate HCl,DV1006 Serine/threonin kinase
Cetraxate hydrochloride (DV10062) is an oral gastrointestinal medication. It has a cytoprotective effect.
T8936 Proteinase K proteinase K for tritirachium album,Protease K Others
Proteinase K (proteinase K for tritirachium album) is a nonspecific serine protease that is useful for general digestion of proteins. It is active in the presence of SDS or urea and over a wide range of pH (4-12), salt c...
T50103 NFAT Inhibitor-2 Others
NFAT Inhibitor-2 is a compound used as a molecular building block.
T2391 Camostat mesylate FOY-S980,FOY305,Camostat mesilate Serine/threonin kinase , SARS-CoV , Sodium Channel
Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.
T3041 ALK inhibitor 2 FAK , ALK
ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
T10285 ALK inhibitor 1 FAK , IGF-1R , ALK
ALK inhibitor 1 is a selective ALK kinase inhibitor.
T1911 Afuresertib GSK2110183C,GSK2110183 ROCK , Akt , PKC
Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
T9993 SBP-3264 Others
SBP-3264 is a novel inhibitor of serine/threonine-protein kinases 3 and 4 (STK3 and STK4).
T62684 Lartesertib ATM Inhibitor-5,M4076 ATM/ATR
Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancer.
T6095 JNJ-38877605 c-Met/HGFR
JNJ-38877605 is an ATP-competitive c-Met inhibitor (IC50: 4 nM), 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.
T11942 MAP4K4-IN-3 Compound 17 MAPK
MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.
T9589 SI-113 SGK
SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.
T81417 PP5-IN-1 Apoptosis , Phosphatase
PP5-IN-1 is a potent and competitive serine/threonine protein phosphatase-5 (PP5) inhibitor with potential anticancer activity that induces apoptosis in cancer cells.
T7151 GSK2982772 RIP kinase
GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
T10727 Cdc7-IN-5 CDK
Cdc7-IN-5 is a potent inhibitor of Cdc7 kinase. Cdc7, a serine-threonine protein kinase enzyme, is essential for the initiation of DNA replication in the cell cycle.
T77333L (Iso)-BMT-124110 Formate (R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate(1679370-98-9 Free base) AAK1 (AP2 associated kinase 1)
(Iso)-BMT-124110 Formate has an inhibitory effect on the protein serine/threonine kinase AAK, and is used in the treatment of Parkinson's disease, schizophrenia, neuropathic pain, and Alzheimer's disease.
T60688 MKI-1 MASTL Kinase Inhibitor-1 Others
MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM). MKI-1 exerts radiosensitizer and antitumor activities through PP2A activation in breast cance...
T34973 Tyrphostin 8 4-Hydroxybenzylidenemalononitrile EGFR , GTPase
Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 μM.Tyrphostin 8 inhibits protein serine/threonine calmodulin phosphatases (IC50=21 μM), enhances ...
TP1875L CDK2 acetate(255064-79-0 free base) Others
CDK2 acetate is a member of the eukaryotic S/T protein kinase family and its function is to catalyze the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/T0) in a protein substrate.
T6496 Vactosertib TEW-7197,EW-7197 ALK , TGF-beta/Smad
Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potentia...
T3980 Su1498 Tyrphostin SU 1498,AG 1498 VEGFR
Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1,...
T6904 Necrosulfonamide (E)-Necrosulfonamide MLK
(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during nec...
T10406 Tuvusertib M1774,ATR inhibitor 1 Apoptosis , ATM/ATR , Others , Chk
Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks...
T37207L Cdk5 Substrate acetate CDK
Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 Substrate aceta...
T9542 NS3861 AChR
NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and bind with high affinity to heteromeric α3β4 and α4β2 nAChRs. NS3861 displays the β-subunit preference and a complete lack of activation at α4-contain...
T37185 D-(-)-3-Phosphoglyceric acid disodium 3-Phospho-D-glyceric acid disodium Others
D-(-)-3-Phosphoglyceric acid disodium (3-Phospho-D-glyceric acid disodium) is an intermediate in several biological pathways, most notably glycolysis/gluconeogenesis and the biosynthesis of serine, glycine, and threonine...

Compounds

Bradykinin
TP1277
Synonym:
Target: Endogenous Metabolite, Bradykinin Receptor
WNK463
T7017
Synonym:
Target: Serine/threonin kinase
IPR-803
T11666
Synonym:
Target: Serine/threonin kinase
BioE-1115
T10547
Synonym:
Target: Serine/threonin kinase, Casein Kinase
TPCK
T8350
Synonym:
Target: Proteasome
R-IMPP
T4058
Synonym:
Target: Others, Serine/threonin kinase
LSP-249
T11885
Synonym:
Target: Others
Upamostat
T13257
Synonym:
Target: PAI-1, Serine/threonin kinase, Serine Protease
SBC-110736
T4524
Synonym: SBC110736
Target: Others, Serine/threonin kinase
Evolocumab
T9920
Synonym:
Target: Others
ZK824190
T13408
Synonym:
Target: Others, Serine Protease
Avoralstat
T14358
Synonym: BCX4161
Target: Others
SBC-115337
T9276
Synonym:
Target: Others, Serine/threonin kinase
WNK-IN-11
T5456
Synonym: Allosteric WNK Kinase Inhibitor
Target: Serine/threonin kinase
GW779439X
T8866
Synonym:
Target: Apoptosis, Antibacterial, CDK, Aurora Kinase
PF-06446846
T8645
Synonym:
Target: Others
SBC-115076
T2626
Synonym: SBC115076
Target: Others, Serine/threonin kinase
FOY 251
T8676
Synonym:
Target: Others, Serine/threonin kinase, SARS-CoV
AEBSF hydrochloride
T6370
Synonym: AEBSF HCl,Pefabloc SC
Target: Thrombin, Serine Protease, Influenza Virus
Benzamidine hydrochloride
T8362
Synonym: Benzamidine HCl
Target: Serine/threonin kinase, Serine Protease
Darexaban
T31206
Synonym: YM 150,Darexaban, Tanexaban,YM150
Target: Factor Xa
Aprotinin
T3359
Synonym: Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin
Target: Others, Serine Protease, Influenza Virus, Proteasome
Nafamostat mesylate
T2392
Synonym: FUT-175
Target: Apoptosis, Serine/threonin kinase, SARS-CoV, Serine Protease
LY3200882
T5125
Synonym:
Target: TGF-beta/Smad
Cetraxate hydrochloride
T19763
Synonym: DV-1006,DV 1006,Cetraxate HCl,DV1006
Target: Serine/threonin kinase
Proteinase K
T8936
Synonym: proteinase K for tritirachium album,Protease K
Target: Others
NFAT Inhibitor-2
T50103
Synonym:
Target: Others
Camostat mesylate
T2391
Synonym: FOY-S980,FOY305,Camostat mesilate
Target: Serine/threonin kinase, SARS-CoV, Sodium Channel
ALK inhibitor 2
T3041
Synonym:
Target: FAK, ALK
ALK inhibitor 1
T10285
Synonym:
Target: FAK, IGF-1R, ALK
Afuresertib
T1911
Synonym: GSK2110183C,GSK2110183
Target: ROCK, Akt, PKC
SBP-3264
T9993
Synonym:
Target: Others
Lartesertib
T62684
Synonym: ATM Inhibitor-5,M4076
Target: ATM/ATR
JNJ-38877605
T6095
Synonym:
Target: c-Met/HGFR
MAP4K4-IN-3
T11942
Synonym: Compound 17
Target: MAPK
SI-113
T9589
Synonym:
Target: SGK
PP5-IN-1
T81417
Synonym:
Target: Apoptosis, Phosphatase
GSK2982772
T7151
Synonym:
Target: RIP kinase
Cdc7-IN-5
T10727
Synonym:
Target: CDK
(Iso)-BMT-124110 Formate
T77333L
Synonym: (R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate(1679370-98-9 Free base)
Target: AAK1 (AP2 associated kinase 1)
MKI-1
T60688
Synonym: MASTL Kinase Inhibitor-1
Target: Others
Tyrphostin 8
T34973
Synonym: 4-Hydroxybenzylidenemalononitrile
Target: EGFR, GTPase
CDK2 acetate(255064-79-0 free base)
TP1875L
Synonym:
Target: Others
Vactosertib
T6496
Synonym: TEW-7197,EW-7197
Target: ALK, TGF-beta/Smad
Su1498
T3980
Synonym: Tyrphostin SU 1498,AG 1498
Target: VEGFR
Necrosulfonamide
T6904
Synonym: (E)-Necrosulfonamide
Target: MLK
Tuvusertib
T10406
Synonym: M1774,ATR inhibitor 1
Target: Apoptosis, ATM/ATR, Others, Chk
Cdk5 Substrate acetate
T37207L
Synonym:
Target: CDK
NS3861
T9542
Synonym:
Target: AChR
D-(-)-3-Phosphoglyceric acid disodium
T37185
Synonym: 3-Phospho-D-glyceric acid disodium
Target: Others
1 2
カタログ番号 製品名 別名 ターゲット
TN2082 Pinostrobin Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppress...
T5S0689 Demethylwedelolactone Serine Protease
Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells.
T7444 6-(Dimethylamino)purine N,N-Dimethyladenine Serine/threonin kinase , CDK
6-(Dimethylamino)purine (N,N-Dimethyladenine) is a serine threonine protein kinase and CDK inhibitor
T4915 β-Glycerophosphate disodium salt hydrate Phosphatase , Endogenous Metabolite
β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It func...
T4713 Phosphorylcholine chloride calcium salt tetrahydrate Phosphocholine chloride calcium salt tet,CalciuM Phosphorylcholine Tetrahydrate Others , Endogenous Metabolite
Phosphorylcholine chloride calcium salt tetrahydrate (Phosphocholine chloride calcium salt tet) is a small haptenic molecule, is found in a wide variety of organisms. Human hepatic tumors undergo an elevation in the conc...
T4839 Ac-Ala-OH N-Acetylalanine,N-Acetyl-L-alanine Others , Endogenous Metabolite
Ac-Ala-OH (N-Acetyl-L-alanine) is a substrate for Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit, Myelin basic protein, GTP-binding nuclear protein Ran, Tropomyosin alpha 4 chain, HIV-1 Rev binding pro...
T4825 D-(+)-Xylose D(+)-Xylose,(+)-Xylose,Wood sugar Endogenous Metabolite
D-(+)-Xylose (Wood sugar) is an aldopentose - a monosaccharide containing five carbon atoms and an aldehyde functional group. It has chemical formula C5H10O5 and is 40% as sweet as sucrose. Xylose is also found in mucopo...
T19365 Hydroxypyruvic acid 3-Hydroxypyruvic acid,β-Hydroxypyruvic acid Others
Hydroxypyruvic acid is an intermediate in the metabolism of glycine, serine, and threonine. It is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase.
T16381 Okadaic acid Others
Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A, and PP3 inhibitor (IC50s: 10-15 nM, 0.5 nM, and 4 nM, respectively). Okadaic acid is extracted fr...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-01059 BMPR2 Protein, Human, Recombinant (His) Human HEK293 Cells
BMPR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.6 kDa and the accession number is Q13873.
TMPY-04407 LOK Protein, Human, Recombinant (His) Human E. coli
Serine / threonine-protein kinase 1, also known as Lymphocyte-oriented kinase, STK1 and LOK, belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and STE2 subfamily. Protein kinases constitute a...
TMPY-04466 STK40 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
STK40 is localized to both the cytoplasm and the nucleus. It is ubiquitously expressed. Mechanistically, Stk40 interacts with Rcn2, which also activates Erk1/2 to induce ExEn specification in mouse ESCs. Stk40 is able to...
TMPY-04374 MST4 Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
MST4, also known as mammalian STE2-like protein kinase 4, is a novel member of the germinal center kinase subfamily of human Ste2-like kinases and is closely related to MST3. The 416 amino acid full-length MST4 contains ...
TMPY-04468 STK16 Protein, Human, Recombinant (His & NusA) Human E. coli
Serine/threonine-protein kinase 16, also known as myristoylated and palmitoylated serine/threonine-protein kinase, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, MPSK1 and STK16, is a membrane protein that is...
TMPY-04398 MST1 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The t...
TMPH-00340 ATG1 Protein, Candida glabrata, Recombinant (His) Candida glabrata E. coli
ATG1 Protein, Candida glabrata, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 38.4 kDa and the accession number is Q6FL58.
TMPH-03456 CAK1 Protein, S. cerevisiae, Recombinant (His & Myc) Saccharomyces cerevisiae Baculovirus Insect Cells
CAK1 Protein, S. cerevisiae, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 46.1 kDa and the accession number is P43568.
TMPH-03457 CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc) Saccharomyces cerevisiae E. coli
CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 49.6 kDa and the accession number is P43568.
TMPY-05095 RAF1 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds direct...
TMPJ-00944 PPP1CC Protein, Human, Recombinant (His) Human E. coli
Serine/Threonine-Protein Phosphatase PP1-Υ Catalytic Subunit (PPP1CC) is a member of the PPP phosphatase family. It is essential for cell division, participates in the regulation of glycogen metabolism, muscle contractil...
TMPY-04424 MST3 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation. STK24/CCM3-regulated exocytosis pla...
TMPY-02198 ILKAP Protein, Human, Recombinant (His) Human HEK293 Cells
Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is a cytoplasm protein that belongs to the PP2C family. ILKAP contains one PP2C-like domain. ILKAP is widely expressed. Highest leve...
TMPY-00683 BMPR2 Protein, Human, Recombinant (His & hFc) Human HEK293 Cells
BMPR2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 42 kDa and the accession number is Q13873.
TMPJ-00325 BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His) Human HEK293 Cells
Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily, including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A i...
TMPJ-00304 ALK-1 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angi...
TMPH-01171 CDK5 Protein, Human, Recombinant Human E. coli
CDK5 Protein, Human, Recombinant is expressed in E. coli.
TMPH-01173 CDK7 Protein, Human, Recombinant Human E. coli
CDK7 Protein, Human, Recombinant is expressed in E. coli.
TMPH-01172 CDK7 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
CDK7 Protein, Human, Recombinant (His) is expressed in Baculovirus.
TMPJ-00254 TGF beta 3 Protein, Human/Mouse/Rat, Recombinant Human,Mouse,Rat HEK293 Cells
Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes acti...
TMPY-02953 TEM8/ANTXR1 Protein, Human, Recombinant (hFc) Human HEK293 Cells
ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are ser...
TMPY-04552 AKT1 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to ...
TMPY-04559 CDC42BPB Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
CDC42BPB is a member of the serine / threonine protein kinase family that contains a Cdc42 / Rsc-binding p21 binding domain similar to that of PAK kinase. The kinase domain of this protein is related to the myotonic dyst...
TMPY-03810 GALNT2 Protein, Human, Recombinant (His) Human HEK293 Cells
GALNT2, also known as GalNAc-T2, is a member of the GalNAc-transferases family. Members of this family transfer an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-link...
TMPY-04565 SRPK3 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Serine / threonine-protein kinase SRPK3, also known as Muscle-specific serine kinase 1, Serine/arginine-rich protein-specific kinase 3, SR-protein-specific kinase 3, Serine / threonine-protein kinase 23, MSSK-1, SRPK3 an...
TMPH-03458 STE11 Protein, S. cerevisiae, Recombinant Saccharomyces cerevisiae E. coli
Serine/threonine protein kinase required for cell-type-specific transcription and signal transduction in yeast. It is thought that it phosphorylates the STE7 protein kinase which itself, phosphorylates the FUS3 and or KS...
TMPY-04463 CDKL2 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Cyclin-dependent kinase-like 2 (Cdkl2) is a member of cdc2-related serine / threonine protein kinase family and it is found expressed in various brain regions, including the cerebral cortex, entorinal cortex, hippocampus...
TMPY-04420 TLK1 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Tousled-like kinase 1 (or protein kinase ubiquitous, PKU-beta/TLK1) is a serine/threonine protein kinase that is implicated in chromatin remodeling, DNA replication and mitosis. TLK1 has a function important for proper c...
TMPH-02180 TTBK2 Protein, Human, Recombinant (His & Myc) Human E. coli
Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother cent...
TMPK-00972 PK-1/PROK1 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
PK-1 (Ac10) is a baculovirus-encoded serine/threonine kinase,a pk-1 knockout AcMNPV failed to produce infectious progeny, while the pk-1 repair virus could rescue this defect.the kinase activity of PK-1 is essential in r...
TMPJ-01109 EIF4EBP2 Protein, Human, Recombinant (His) Human E. coli
Eukaryotic Translation Initiation Factor 4E-Binding Protein 2 (EIF4EBP2) is a member of the Eukaryotic Translation Initiation Factor 4E Binding Protein Family. EIF4EBP2 regulates eIF4E activity by preventing its assembly...
TMPY-04402 CSNK1G1 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Casein kinase I isoform gamma-1, also known as CSNK1G1, is a member of the protein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Thecasein kinase I family of protein kinases are ...
TMPY-04357 RSK4 Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
Ribosomal protein S6 kinase alpha-6, also known as Ribosomal S6 kinase 4, 9 kDa ribosomal protein S6 kinase 6,RSK-4, RSK4 and RPS6KA6, is a protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kina...
TMPK-00677 PKA/PRKACA Protein, Canine, Recombinant (His) Canine E. coli
The cAMP-dependent protein kinase PKA is a well-characterized member of the serine-threonine protein AGC kinase family and is the effector kinase of cAMP signaling. As such, PKA is involved in the control of a wide varie...
TMPH-01539 ILK Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered ...
TMPH-02648 PKDCC Protein, Mouse, Recombinant (His & Myc) Mouse Baculovirus Insect Cells
Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylati...
TMPJ-01223 GALNTL1 Protein, Human, Recombinant (His) Human HEK293 Cells
Putative polypeptide N-acetylgalactosaminyltransferase-like protein 1, also known as Polypeptide GalNAc transferase-like protein 1, Protein-UDP acetylgalactosaminyltransferase-like protein 1, UDP-GalNAc:polypeptide N-ace...
TMPY-04403 NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Nemo-like kinase contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. It also contains a TQE activation loop motif in which autopho...
TMPJ-00886 ATF1 Protein, Human, Recombinant (His) Human E. coli
Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by r...
TMPY-04567 SRPK1 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Serine / threonine-protein kinase SRPK1, also known as SFRS protein kinase 1, Serine/arginine-rich protein-specific kinase 1, SR-protein-specific kinase 1 and SRPK1, is a cytoplasm and nucleus protein that belongs to the...
TMPY-04406 Protein Kinase D2/PRKD2 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Serine/threonine-protein kinase D2, also known as PRKD2 and PKD2, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD2 / PKD2 is ...
TMPY-04373 CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
Ca2+/calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca2+/ calmodulin-dependent protein kinase subfamily...
TMPJ-00314 ACVR2B Protein, Human, Recombinant (hFc & His) Human HEK293 Cells
Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors...
TMPJ-00315 ACVR2A Protein, Human, Recombinant (hFc & His) Human HEK293 Cells
Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation fact...
TMPJ-00996 VHR Protein, Human, Recombinant (His) Human E. coli
Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues...
TMPJ-01074 PKCE Protein, Human, Recombinant (His) Human E. coli
Protein Kinase C Epsilon type is a member of the serine- and threonine-specific protein kinase family that can be activated by calcium and the second messenger diacylglycerol. Protein Kinase C Epsilon contains these doma...
TMPY-04456 PKC nu Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
Serine/threonine-protein kinase D3, also known as Protein kinase C nu type, Protein kinase EPK2, PRKD3, EPK2 and PRKCN, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr pro...
TMPY-03052 MFAP5 Protein, Human, Recombinant (His) Human HEK293 Cells
MFAP5 (Microfibril Associated Protein 5, also known as MAGP2) is a Protein Coding gene. MFAP5 is a component of the elastin-associated microfibrils. It belongs to the MFAP family. As a 25-kD microfibril-associated glycop...
TMPY-02496 Rad6/UBE2A Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A), encoded by human DNA repair genes HHR6A, belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication ...
TMPY-02592 Annexin VI/ANXA6 Protein, Human, Recombinant (His) Human E. coli
Annexin A6, also known as ANXA6 or ANXAⅥ, belongs to a family of Ca2+-dependent membrane and phospholipid binding proteins. Members of this family have been implicated in membrane-related events along exocytotic and endo...
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BMPR2 Protein, Human, Recombinant (His)
TMPY-01059
Species: Human
Expression System: HEK293 Cells
LOK Protein, Human, Recombinant (His)
TMPY-04407
Species: Human
Expression System: E. coli
STK40 Protein, Human, Recombinant (His & GST)
TMPY-04466
Species: Human
Expression System: Baculovirus Insect Cells
MST4 Protein, Human, Recombinant (GST)
TMPY-04374
Species: Human
Expression System: Baculovirus Insect Cells
STK16 Protein, Human, Recombinant (His & NusA)
TMPY-04468
Species: Human
Expression System: E. coli
MST1 Protein, Human, Recombinant (His)
TMPY-04398
Species: Human
Expression System: Baculovirus Insect Cells
ATG1 Protein, Candida glabrata, Recombinant (His)
TMPH-00340
Species: Candida glabrata
Expression System: E. coli
CAK1 Protein, S. cerevisiae, Recombinant (His & Myc)
TMPH-03456
Species: Saccharomyces cerevisiae
Expression System: Baculovirus Insect Cells
CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc)
TMPH-03457
Species: Saccharomyces cerevisiae
Expression System: E. coli
RAF1 Protein, Human, Recombinant (His & GST)
TMPY-05095
Species: Human
Expression System: Baculovirus Insect Cells
PPP1CC Protein, Human, Recombinant (His)
TMPJ-00944
Species: Human
Expression System: E. coli
MST3 Protein, Human, Recombinant (His)
TMPY-04424
Species: Human
Expression System: Baculovirus Insect Cells
ILKAP Protein, Human, Recombinant (His)
TMPY-02198
Species: Human
Expression System: HEK293 Cells
BMPR2 Protein, Human, Recombinant (His & hFc)
TMPY-00683
Species: Human
Expression System: HEK293 Cells
BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His)
TMPJ-00325
Species: Human
Expression System: HEK293 Cells
ALK-1 Protein, Mouse, Recombinant (hFc)
TMPJ-00304
Species: Mouse
Expression System: HEK293 Cells
CDK5 Protein, Human, Recombinant
TMPH-01171
Species: Human
Expression System: E. coli
CDK7 Protein, Human, Recombinant
TMPH-01173
Species: Human
Expression System: E. coli
CDK7 Protein, Human, Recombinant (His)
TMPH-01172
Species: Human
Expression System: Baculovirus Insect Cells
TGF beta 3 Protein, Human/Mouse/Rat, Recombinant
TMPJ-00254
Species: Human,Mouse,Rat
Expression System: HEK293 Cells
TEM8/ANTXR1 Protein, Human, Recombinant (hFc)
TMPY-02953
Species: Human
Expression System: HEK293 Cells
AKT1 Protein, Human, Recombinant (His)
TMPY-04552
Species: Human
Expression System: Baculovirus Insect Cells
CDC42BPB Protein, Human, Recombinant (His & GST)
TMPY-04559
Species: Human
Expression System: Baculovirus Insect Cells
GALNT2 Protein, Human, Recombinant (His)
TMPY-03810
Species: Human
Expression System: HEK293 Cells
SRPK3 Protein, Human, Recombinant (His & GST)
TMPY-04565
Species: Human
Expression System: Baculovirus Insect Cells
STE11 Protein, S. cerevisiae, Recombinant
TMPH-03458
Species: Saccharomyces cerevisiae
Expression System: E. coli
CDKL2 Protein, Human, Recombinant (His)
TMPY-04463
Species: Human
Expression System: Baculovirus Insect Cells
TLK1 Protein, Human, Recombinant (His & GST)
TMPY-04420
Species: Human
Expression System: Baculovirus Insect Cells
TTBK2 Protein, Human, Recombinant (His & Myc)
TMPH-02180
Species: Human
Expression System: E. coli
PK-1/PROK1 Protein, Mouse, Recombinant (hFc)
TMPK-00972
Species: Mouse
Expression System: HEK293 Cells
EIF4EBP2 Protein, Human, Recombinant (His)
TMPJ-01109
Species: Human
Expression System: E. coli
CSNK1G1 Protein, Human, Recombinant (His & GST)
TMPY-04402
Species: Human
Expression System: Baculovirus Insect Cells
RSK4 Protein, Human, Recombinant (GST)
TMPY-04357
Species: Human
Expression System: Baculovirus Insect Cells
PKA/PRKACA Protein, Canine, Recombinant (His)
TMPK-00677
Species: Canine
Expression System: E. coli
ILK Protein, Human, Recombinant (His)
TMPH-01539
Species: Human
Expression System: Baculovirus Insect Cells
PKDCC Protein, Mouse, Recombinant (His & Myc)
TMPH-02648
Species: Mouse
Expression System: Baculovirus Insect Cells
GALNTL1 Protein, Human, Recombinant (His)
TMPJ-01223
Species: Human
Expression System: HEK293 Cells
NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST)
TMPY-04403
Species: Human
Expression System: Baculovirus Insect Cells
ATF1 Protein, Human, Recombinant (His)
TMPJ-00886
Species: Human
Expression System: E. coli
SRPK1 Protein, Human, Recombinant (His & GST)
TMPY-04567
Species: Human
Expression System: Baculovirus Insect Cells
Protein Kinase D2/PRKD2 Protein, Human, Recombinant (His & GST)
TMPY-04406
Species: Human
Expression System: Baculovirus Insect Cells
CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST)
TMPY-04373
Species: Human
Expression System: Baculovirus Insect Cells
ACVR2B Protein, Human, Recombinant (hFc & His)
TMPJ-00314
Species: Human
Expression System: HEK293 Cells
ACVR2A Protein, Human, Recombinant (hFc & His)
TMPJ-00315
Species: Human
Expression System: HEK293 Cells
VHR Protein, Human, Recombinant (His)
TMPJ-00996
Species: Human
Expression System: E. coli
PKCE Protein, Human, Recombinant (His)
TMPJ-01074
Species: Human
Expression System: E. coli
PKC nu Protein, Human, Recombinant (GST)
TMPY-04456
Species: Human
Expression System: Baculovirus Insect Cells
MFAP5 Protein, Human, Recombinant (His)
TMPY-03052
Species: Human
Expression System: HEK293 Cells
Rad6/UBE2A Protein, Human, Recombinant (His)
TMPY-02496
Species: Human
Expression System: E. coli
Annexin VI/ANXA6 Protein, Human, Recombinant (His)
TMPY-02592
Species: Human
Expression System: E. coli
カタログ番号 製品名
L1400 MAPK Inhibitor Library

365 compounds
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;
L1300 PI3K-AKT-mTOR Compound Library

420 compounds
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;