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Search Results for " Phosphatidylinositol "

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天然化合物

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カタログ番号	製品名	別名	ターゲット
T27499	GSK-A1		HCV Protease , PI4K
	GSK-A1 is a specific inhibitor of PI4KA, also inhibited calcium-driven PRL secretion without affecting calcium signaling and Prl expression. GSK-A1 has anti-hepatitis C virus (HCV) potential.		HCV Protease , PI4K
T16530	BF738735		Antiviral , PI4K
			Antiviral , PI4K
TQ0009	UCB9608		PI4K
	UCB9608 is a selective and orally active PI4KIIIβ inhibitor (IC50: 11 nM), selective over PI3KC2 α, β, and γ lipid kinases.		PI4K
T16967	T-00127_HEV1		PI4K
	T-00127_HEV1 is an inhibitor of phosphatidylinositol 4-kinase III beta (IC50: 60 nM).		PI4K
T13386	Zandelisib		PI3K
	Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.		PI3K
T16125	MMV390048		Parasite , PI4K
	MMV390048 is an antimalarial agent and is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. fal...		Parasite , PI4K
T12454	PI-273		Apoptosis , PI4K
	PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells		Apoptosis , PI4K
T12468	PI4KIIIbeta-IN-10		PI3K , PI4K
	PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).		PI3K , PI4K
T2616	PIK-93	PIK 93	ATM/ATR , DNA-PK , Virus Protease , PI3K , Carbonic Anhydrase , PI4K , mTOR , HSV
	PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T5421	KDU691		Parasite , PI4K
	KDU691 is a PI4K inhibitor.		Parasite , PI4K
T12469	PI4KIIIbeta-IN-9		PI3K , PI4K
	PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .		PI3K , PI4K
T4220	BQR-695	BQR695,NVP-BQR695	PI3K , Parasite , PI4K
	BQR-695 (NVP-BQR695) is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.		PI3K , Parasite , PI4K
T19840	GSK-F1	PI4KA inhibitor-F1	PI4K
	GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.		PI4K
T4079	LY-294002 hydrochloride	SF 1101,LY 294002,NSC 697286	PI3K
	LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation...		PI3K
T77212	L-α-lysophosphatidylinositol (Soy) (sodium)
	L-α-Lysophosphatidylinositol Soy Sodium, an endogenous ligand of GPR55, is an endocannabinoid neurotransmitter and lysophospholipid. This compound falls within the class of lysophospholipids [1].
T12365	PARP/PI3K-IN-1		PARP , PI3K
	PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic ...		PARP , PI3K
T26698	AZ044		PI4K
	AZ044 is a potent, selective inhibitor of type III phosphatidylinositol-4-kinase alpha-subtype (PI4KIIIalpha).		PI4K
T26195	SMI481	NPPM-6748-481,NPPM 6748-481,NPPM6748481,SMI-481 SMI 481,NPPM 6748481	Others
	SMI481 (NPPM6748481) is the first small-molecule Sec14-like phosphatidylinositol transfer proteins (PITPs) inhibitor.		Others
T16528	PI-828	LY 294002, 4gamma-NH2	Casein Kinase , PI3K
	PI-828 is a phosphatidylinositol 3-kinase (PI3K) inhibitor, which is widely used to study the physiological function of PI3K and also promotes stem cell differentiation into mesoderm.		Casein Kinase , PI3K
T2061	APY0201		PI3K , Interleukin
	APY0201 is a effective, highly specific, ATP-competitive PIKfyve inhibitor (IC50: 5.2 nM). It can interrupt the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3, 5)P2.		PI3K , Interleukin
T67837	(3S)-GSK-F1	PI4KA inhibitor-F1	PI4K
	(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα), pIC50=8.3.		PI4K
T28416	PIK-108	PIK 108,PIK108	PI3K
	PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).		PI3K
T1999	Taselisib	RG-7604,GDC-0032	PI3K , Carbonic Anhydrase
	Taselisib (GDC-0032) is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplastic activity.		PI3K , Carbonic Anhydrase
T3556	NIH-12848		PI3K
	NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.		PI3K
T67845	ARUK2001607		PI3K
	ARUK2001607 is a selective inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ, Kd= 7.1 nM). ARUK2001607 exhibits high selectivity over other >150 kinases.		PI3K
T6168	ZSTK474		PI3K , Autophagy
	PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity.		PI3K , Autophagy
T13623	Compound 48/80 trihydrochloride	C48/80 trihydrochloride	Phospholipase
	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde in a condensation reaction.Compound 48/80 trihydrochloride is a mast cell degranulator and hista...		Phospholipase
T1861	Omipalisib	GSK458,GSK2126458	PI3K , mTOR , Autophagy
	Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.		PI3K , mTOR , Autophagy
T72032	PI5P4Ks-IN-2		PI3K
	PI5P4Ks-IN-2 is an inhibitor of the phosphatidylinositol 5-phosphate 4-kinase PI5P4Kγ. Targeting the PI5P4K isoforms, PI5P4Ks-IN-2 inhibited PI5P4Kα, PI5P4Kβ, PI5P4Kγ, and PI5P4Kγ+, with IC50 values of <4.3, <4.6, 6.2, a...		PI3K
T2370	AC-55541	AOB2796	Proteasome , Protease-activated Receptor
	AC-55541 (AOB2796) is a novel PAR2 agonist; activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM.		Proteasome , Protease-activated Receptor
T27094	CT-2584	CT2584
	CT-2584 is an angiogenesis inhibitor and lysophosphatidic acid acyltransferase inhibitor. CT-2584 inhibits phospholipid signaling. By inhibiting CTP:choline-phosphate cytidylyltransferase (CT), CT-2584 caused de novo pho...
T68130	Pobilukast	SKF 104353 Z2,SKF 104353	Leukotriene Receptor
	Pobilukast (SKF 104353) is a selective cysteinyl leukotriene receptor antagonist that blocks phosphatidylinositol metabolism and leukotriene D-induced thromboxane synthesis, and can be used to study limiting myocardial d...		Leukotriene Receptor
T67703	MTOR inhibitor 9b		mTOR
	mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTOR inhibitor 9b possesses anticancer activity and can be used to ...		mTOR
T36083	DS-7423		PI3K , mTOR
	DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2]. DS-7423 increases TP53 expression, the level of p-TP53 on Ser...		PI3K , mTOR
T67702	MTOR inhibitor 9d		PI3K , mTOR
	mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia, skin cancer, breast cancer, lung cancer and colon cancer.		PI3K , mTOR
T69912	AS2541019
	AS2541019 is a selective Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibitor.
T24637	PI3K inhibitor C 96	PI3K IN C96,PI3K-IN-C96
	PI3K inhibitor C 96 is an inhibitor of phosphatidylinositol 3-kinase. It shows effective activity against multiple myeloma in vitro and in vivo.
T22759	Edelfosine		Others
	inhibits phosphatidylinositol phospholipase C		Others
T32950	Lumi-PI
	Lumi-PI is used as a chemiluminescent substrate for detecting phosphatidylinositol-specific phospholipase C.
T71798	Demethoxyviridiol
	Demethoxyviridiol is a mycotoxin that inhibits phosphatidylinositol 3-kinase (PI3K).
T28627	RV-1729	RV1729
	RV-1729, a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitor, is used potentially for the treatment of asthma.
T39581	PI3K-IN-19 hydrochloride	PI3K-IN-19 hydrochloride
	PI3K-IN-19 hydrochloride (WO2017153220, step 5) acts as a phosphatidylinositol-3-kinase (PI3K) inhibitor.
T29159	WJD008	WJD-008,WJD 008
	WJD008 is a dual inhibitor of phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin. WJD008 prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant. WJD008 has ...
T27526	Halenaquinone
	Halenaquinone is a phosphatidylinositol 3-kinase inhibitor. Halenaquinone specifically inhibits the secondary DNA binding of RAD51. Halenaquinone inhibits RANKL-induced osteoclastogenesis. Halenaquinone induces apoptosis...
T60980	PIKfyve-IN-1
	PIKfyve-IN-1 is a cell-active and highly potent chemical probe that can be used for the PIKfyve research in virology. PIKfyve-IN-1 inhibits phosphatidylinositol-3phosphate 5-kinase (PIKfyve) (IC 50 = 6.9 nM)[1].
T37030	PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)	PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dio...
TP1977	187-1, N-WASP inhibitor
	Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not di...
T27157	Dezapelisib	INCB-040093,INCB 040093,INCB040093
	Dezapelisib is an orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K). INCB040093 prevents both the production of the second messeng...
T4186	AC-264613	AC264613	Protease-activated Receptor
	AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613(AC264613) suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macropha...		Protease-activated Receptor
T36937	PtdIns-(1,2-dioctanoyl) (sodium salt)
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(1,2-dioctanoyl...

Compounds

GSK-A1

T27499

Synonym:

Target: HCV Protease, PI4K

BF738735

T16530

Synonym:

Target: Antiviral, PI4K

Target: Parasite, PI4K

PI-273

T12454

Synonym:

Target: Apoptosis, PI4K

Target: ATM/ATR, DNA-PK, Virus Protease, PI3K, Carbonic Anhydrase, PI4K, mTOR, HSV

KDU691

T5421

Synonym:

Target: Parasite, PI4K

Synonym: BQR695,NVP-BQR695

Target: PI3K, Parasite, PI4K

GSK-F1

T19840

Synonym: PI4KA inhibitor-F1

Target: PI4K

LY-294002 hydrochloride

T4079

Synonym: SF 1101,LY 294002,NSC 697286

Target: PI3K

L-α-lysophosphatidylinositol (Soy) (sodium)

Synonym: NPPM-6748-481,NPPM 6748-481,NPPM6748481,SMI-481 SMI 481,NPPM 6748481

Target: Others

PI-828

T16528

Synonym: LY 294002, 4gamma-NH2

Target: Casein Kinase, PI3K

APY0201

T2061

Synonym:

Target: PI3K, Interleukin

(3S)-GSK-F1

T67837

Synonym: PI4KA inhibitor-F1

Target: PI4K

PIK-108

T28416

Synonym: PIK 108,PIK108

Target: PI3K

Taselisib

T1999

Synonym: RG-7604,GDC-0032

Target: PI3K, Carbonic Anhydrase

Target: PI3K, Autophagy

Compound 48/80 trihydrochloride

T13623

Synonym: C48/80 trihydrochloride

Target: Phospholipase

Omipalisib

T1861

Synonym: GSK458,GSK2126458

Target: PI3K, mTOR, Autophagy

Target: Proteasome, Protease-activated Receptor

Synonym: SKF 104353 Z2,SKF 104353

Target: Leukotriene Receptor

Synonym: PI3K IN C96,PI3K-IN-C96

PI3K-IN-19 hydrochloride

T39581

Synonym: PI3K-IN-19 hydrochloride

Target:

WJD008

T29159

Synonym: WJD-008,WJD 008

PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)

T37030

Synonym: PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)

Target:

187-1, N-WASP inhibitor

Synonym: INCB-040093,INCB 040093,INCB040093

Target: Protease-activated Receptor

PtdIns-(1,2-dioctanoyl) (sodium salt)

T36937

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
T73812	Phosphatidylinositol 4,5-bisphosphate
	Phosphatidylinositol 4,5-bisphosphate (L-alpha-Phosphatidylinositol-4,5-bisphosphate), serving as a critical phospholipid in cell membranes, functions as a substrate for both phospholipase C (PLC) and phosphoinositide 3-...
T3399	Psoralidin		Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial
	Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties.
TN2019	Orobol	3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon	BCL , Caspase , PI3K
	Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α/β/γ/K/δ. Orobol exhibit...		BCL , Caspase , PI3K
T4S21320	ISOGINKGETIN	4',4'''-Dimethylamentoflavone	MMP , Others
	1. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponecti...		MMP , Others
TMA0291	Dehydroglyasperin D		GSK-3 , p38 MAPK , ROS , Akt , COX , PI3K , DNA/RNA Synthesis , Prostaglandin Receptor , JNK
	Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction wit...

天然物製品

Phosphatidylinositol 4,5-bisphosphate

Target: Others, Estrogen/progestogen Receptor, Reactive Oxygen Species, Lipoxygenase, Gamma-secretase, Akt, COX, Antibacterial

Orobol

TN2019

Synonym: 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon

Target: BCL, Caspase, PI3K

ISOGINKGETIN

T4S21320

Synonym: 4',4'''-Dimethylamentoflavone

Target: GSK-3, p38 MAPK, ROS, Akt, COX, PI3K, DNA/RNA Synthesis, Prostaglandin Receptor, JNK

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00547	PITPN Protein, Human, Recombinant (His)	Human	HEK293 Cells
	PITPN Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.3 kDa and the accession number is Q00169.
TMPJ-00978	PIP4K2A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain...
TMPJ-00166	SCF Protein, Mouse, Recombinant	Mouse	E. coli
	Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gameto...
TMPY-02953	TEM8/ANTXR1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are ser...
TMPY-02028	RON/CD136 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. ...
TMPY-03453	Pleckstrin Protein, Human, Recombinant (His)	Human	E. coli
	Pleckstrin is a protein found in platelets. Pleckstrin is the source of the name pleckstrin homology domain. Pleckstrin homology domain (PH domain) is a protein domain of approximately 12 amino acids that occurs in a wid...
TMPH-03453	GPI3 Protein, S. cerevisiae, Recombinant (His & Myc)	Saccharomyces cerevisiae	E. coli
	Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. GPI3 Protein, S. cerevisiae, Recombinant (His & My...
TMPH-02905	TRPC1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled recep...
TMPH-02147	TACR1 Protein, Human, Recombinant (GST)	Human	E. coli
	This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor ...
TMPH-01294	EDNRA Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
TMPH-03749	CYSLTR1 Protein, Human, Recombinant (His)	Human	E. coli
	Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and...
TMPH-02671	Gasdermin-D Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-term...
TMPH-01660	PITPNM3 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. PITPNM3 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10...
TMPH-01609	LGI1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regula...
TMPJ-00541	CD177 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CD177 is polymorphic and has at least two alleles: PRV1 and NB1. Human PRV1 is a Glycosyl-Phosphatidylinositol (GPI)-linked cell surface glycoprotein that belongs to the uPAR/CD59/Ly6 family of receptors. PRV1 is express...
TMPH-01209	DENND1A Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulat...
TMPH-01100	CLINT1 Protein, Human, Recombinant (His)	Human	E. coli
	Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. CLI...
TMPJ-01271	PIK3IP1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Phosphoinositide-3-kinase-interacting protein 1(PIK3IP1) is an enzyme that in humans is encoded by the PIK3IP1 gene.It is a negative regulator of phosphatidylinositol-3-kinase (PI3K), suppresses the development of hepato...
TMPH-02670	Gasdermin-A3 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Precursor of a pore-forming protein involved in the transition from catagen to telogen at the end of hair follicle morphogenesis. This form constitutes the precursor of the pore: upon cleavage, the released N-terminal mo...
TMPH-01346	FPR1 Protein, Human, Recombinant (GST & His & Myc)	Human	E. coli
	High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release...
TMPJ-00984	INPP1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Inositol Polyphosphate 1-Phosphatase (INPP1) is a member of the inositol monophosphatase family. INPP1 is widely expressed in tissues, with highest expression levels observed in the pancreas and kidney. INPP1 is inhibite...
TMPH-02675	GCGR Protein, Mouse, Recombinant (GST)	Mouse	E. coli
	G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and g...
TMPH-01663	GRM5 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Sign...
TMPJ-00396	SEMA4D Protein, Human, Recombinant (aa 22-734, His)	Human	HEK293 Cells
	Semaphorin-4D is also known as A8,BB18, GR3, CD100. Semaphorin-4D belongs to the semaphorin family containing 1 Ig-like C2-type domain, 1 PSI domain and 1 Sema domain. It is the cell surface receptor for PLXN1B and PLXNB...
TMPJ-00895	SCF Protein, Rat, Recombinant (HEK293, His)	Rat	HEK293 Cells
	SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, ...
TMPK-00327	CD19 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)	Cynomolgus,Rhesus	HEK293 Cells
	CD19 is a 95 kDa transmembrane glycoprotein that plays a central role in B cell activation and humoral immune responses.Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases th...
TMPJ-00202	CD157 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	The cluster of differentiation (CD) system is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family.It is generally used in immunophynotyping. CD157 was discovered in a bone marrow str...
TMPY-03977	DAP10 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	HCST (Hematopoietic Cell Signal Transducer, also known as DAP1) is a Protein Coding gene. HCST belongs to the DAP10 family. It is a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. Th...
TMPJ-00418	TRAIL R3/TNFRSF10C Protein, Human, Recombinant (hFc & His)	Human	HEK293 Cells
	Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-ri...
TMPH-01065	CCR4 Protein-VLP, Human, Recombinant (His)	Human	HEK293 Cells
	High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger...
TMPH-01064	CCR4 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger...
TMPH-02658	FPR1 Protein, Mouse, Recombinant (GST & His & Myc)	Mouse	E. coli
	High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release...
TMPJ-00791	HER2/ERBB2 Protein, Rat, Recombinant (E. coli, His)	Rat	E. coli
	ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. It contains a protein kinase domain. ERBB2 is widely expressed in epithelial cells, and amplification and/or overexpr...
TMPH-02143	NR5A1 Protein, Human, Recombinant (His)	Human	E. coli
	Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B an...
TMPJ-00086	CT-1 Protein, Human, Recombinant (His)	Human	E. coli
	Cardiotrophin-1, also known as CT-1 and CTF1, is a member of the IL-6 superfamily. It is a sreted cytokine that is expressed in heart, skeletal muscle, prostate and ovary, and to lower levels in lung, kidney, pancreas, t...
TMPJ-00660	IMPase2 Protein, Human, Recombinant (His)	Human	E. coli
	Inositol monophosphatase 2, also known as Inositol-1(or 4)-monophosphatase 2, Myo-inositol monophosphatase A2 and IMPA2, is an enzyme which belongs to the inositol monophosphatase family. IMPA2 catalyzes the dephosphoylr...
TMPY-02394	IMPA1 Protein, Human, Recombinant (His)	Human	E. coli
	IMPA1 (Inositol Monophosphatase 1) is a Protein Coding gene. This gene encodes an enzyme that dephosphorylates Myo-inositol monophosphate to generate free Myo-inositol, a precursor of phosphatidylinositol, and is, theref...
TMPJ-00894	SCF Protein, Rat, Recombinant (His)	Rat	E. coli
	Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesi...
TMPH-02538	Beclin-1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways...
TMPY-00473	NRBF2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	NRBF2 (Nuclear Receptor Binding Factor 2) is a Protein Coding gene. The encoded protein may modulate transcriptional activation by target nuclear receptors. It is widely expressed in the appendix, placenta, and other tis...
TMPJ-00858	Ezrin Protein, Human, Recombinant	Human	E. coli
	Ezrin is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a E...
TMPJ-00395	SEMA4D Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	SEMA4D is a member of the semaphorin family,contains one Ig-like C2-type domain, one PSI domain and one Sema domain. SEMA4D is strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous t...
TMPY-02236	PTH1R Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane pr...
TMPJ-00220	B3GAT1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	B3GAT1 is the key enzyme during the biosynthesis of the carbohydrate epitope HNK-1, which is present on a number of cell adhesion molecules important in neurodevelopment. It adds a glucuronic residue to the terminal lact...

PITPN Protein, Human, Recombinant (His)

TMPY-00547

Species: Human

Expression System: HEK293 Cells

PIP4K2A Protein, Human, Recombinant (His)

TMPJ-00978

Species: Human

Expression System: HEK293 Cells

SCF Protein, Mouse, Recombinant

TMPJ-00166

Species: Mouse

Expression System: E. coli

TEM8/ANTXR1 Protein, Human, Recombinant (hFc)

TMPY-02953

Species: Human

Expression System: HEK293 Cells

RON/CD136 Protein, Human, Recombinant (His)

TMPY-02028

Species: Human

Expression System: HEK293 Cells

Pleckstrin Protein, Human, Recombinant (His)

TMPY-03453

Species: Human

Expression System: E. coli

GPI3 Protein, S. cerevisiae, Recombinant (His & Myc)

TMPH-03453

Species: Saccharomyces cerevisiae

Expression System: E. coli

TRPC1 Protein, Mouse, Recombinant (His)

TMPH-02905

Species: Mouse

Expression System: E. coli

TACR1 Protein, Human, Recombinant (GST)

TMPH-02147

Species: Human

Expression System: E. coli

EDNRA Protein, Human, Recombinant (His)

TMPH-01294

Species: Human

Expression System: P. pastoris (Yeast)

CYSLTR1 Protein, Human, Recombinant (His)

TMPH-03749

Species: Human

Expression System: E. coli

Gasdermin-D Protein, Mouse, Recombinant (His & Myc)

TMPH-02671

Species: Mouse

Expression System: E. coli

PITPNM3 Protein, Human, Recombinant (His & Myc)

TMPH-01660

Species: Human

Expression System: E. coli

LGI1 Protein, Human, Recombinant (His & Myc)

TMPH-01609

Species: Human

Expression System: E. coli

CD177 Protein, Human, Recombinant (His)

TMPJ-00541

Species: Human

Expression System: HEK293 Cells

DENND1A Protein, Human, Recombinant (His & SUMO)

TMPH-01209

Species: Human

Expression System: E. coli

CLINT1 Protein, Human, Recombinant (His)

TMPH-01100

Species: Human

Expression System: E. coli

PIK3IP1 Protein, Human, Recombinant (His)

TMPJ-01271

Species: Human

Expression System: HEK293 Cells

Gasdermin-A3 Protein, Mouse, Recombinant (His)

TMPH-02670

Species: Mouse

Expression System: E. coli

FPR1 Protein, Human, Recombinant (GST & His & Myc)

TMPH-01346

Species: Human

Expression System: E. coli

INPP1 Protein, Human, Recombinant (His)

TMPJ-00984

Species: Human

Expression System: HEK293 Cells

GCGR Protein, Mouse, Recombinant (GST)

TMPH-02675

Species: Mouse

Expression System: E. coli

GRM5 Protein, Human, Recombinant (His & Myc)

TMPH-01663

Species: Human

Expression System: E. coli

SEMA4D Protein, Human, Recombinant (aa 22-734, His)

TMPJ-00396

Species: Human

Expression System: HEK293 Cells

SCF Protein, Rat, Recombinant (HEK293, His)

TMPJ-00895

Species: Rat

Expression System: HEK293 Cells

CD19 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

TMPK-00327

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

CD157 Protein, Human, Recombinant (hFc)

TMPJ-00202

Species: Human

Expression System: HEK293 Cells

DAP10 Protein, Human, Recombinant (mFc)

TMPY-03977

Species: Human

Expression System: HEK293 Cells

TRAIL R3/TNFRSF10C Protein, Human, Recombinant (hFc & His)

TMPJ-00418

Species: Human

Expression System: HEK293 Cells

CCR4 Protein-VLP, Human, Recombinant (His)

TMPH-01065

Species: Human

Expression System: HEK293 Cells

CCR4 Protein, Human, Recombinant (His & SUMO)

TMPH-01064

Species: Human

Expression System: E. coli

FPR1 Protein, Mouse, Recombinant (GST & His & Myc)

TMPH-02658

Species: Mouse

Expression System: E. coli

HER2/ERBB2 Protein, Rat, Recombinant (E. coli, His)

TMPJ-00791

Species: Rat

Expression System: E. coli

NR5A1 Protein, Human, Recombinant (His)

TMPH-02143

Species: Human

Expression System: E. coli

CT-1 Protein, Human, Recombinant (His)

TMPJ-00086

Species: Human

Expression System: E. coli

IMPase2 Protein, Human, Recombinant (His)

TMPJ-00660

Species: Human

Expression System: E. coli

IMPA1 Protein, Human, Recombinant (His)

TMPY-02394

Species: Human

Expression System: E. coli

SCF Protein, Rat, Recombinant (His)

TMPJ-00894

Species: Rat

Expression System: E. coli

Beclin-1 Protein, Mouse, Recombinant (His & SUMO)

TMPH-02538

Species: Mouse

Expression System: E. coli

NRBF2 Protein, Human, Recombinant (His & GST)

TMPY-00473

Species: Human

Expression System: Baculovirus Insect Cells

Ezrin Protein, Human, Recombinant

TMPJ-00858

Species: Human

Expression System: E. coli

SEMA4D Protein, Mouse, Recombinant (hFc)

TMPJ-00395

Species: Mouse

Expression System: HEK293 Cells

PTH1R Protein, Human, Recombinant (His)

TMPY-02236

Species: Human

Expression System: HEK293 Cells

B3GAT1 Protein, Human, Recombinant (His)

TMPJ-00220

Species: Human

Expression System: HEK293 Cells

カタログ番号	製品名
L1300	PI3K-AKT-mTOR Compound Library		420 compounds
	A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;

ライブラリー

PI3K-AKT-mTOR Compound Library

L1300

Compounds: 420