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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T13865 | Resorcinolnaphthalein | RAAS | |
Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5 μM). | |||
T12268 | NTP42 | Prostaglandin Receptor , PPAR | |
NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM) | |||
T11339 | Furegrelate sodium | U-63557A | PPAR |
T0114 | Trichlormethiazide | Naqua,Metahydrin,Trichlormetazid | ATPase , Carbonic Anhydrase |
Trichlormethiazide (Naqua) is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appears to block the active reabsorption of chloride and ... | |||
T1385 | Amlodipine | UK-48340 | Calcium Channel |
Amlodipine (UK-48340) is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties. | |||
T1484 | Perindoprilat | Perindoprilate | RAAS , MRP , AChR |
Perindoprilat (Perindoprilate) is an angiotensin-converting enzyme inhibitor. | |||
T8900 | Seralutinib | GB002 | PDGFR |
Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension. | |||
T8372 | VU0134992 | VU 0134992 | Potassium Channel |
VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 μM | |||
T14315 | AR-9281 | APAU | Epoxide Hydrolase |
AR-9281 (APAU) is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes | |||
T0231 | Amlodipine Besylate | Amlodipine benzenesulfonate | Calcium Channel |
Amlodipine Besylate(Amlodipine benzenesulfonate) is a long-lasting calcium channel blocker. | |||
T4316 | ML365 | Potassium Channel | |
ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3). | |||
T6595 | Moexipril hydrochloride | Moexipril HCl,RS-10085,SPM 925,CI-925 | Apoptosis , RAAS |
Moexipril hydrochloride (Moexipril HCl) is a potent orally active nonsulfhydrylangiotensin converting enzyme (ACE)inhibitor, used for the treatment of hypertension and congestive heart failure. | |||
T2561 | Macitentan | ACT-064992 | Apoptosis , Endothelin Receptor |
Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). | |||
T1489 | Fosinopril sodium | SQ28555 | RAAS |
Fosinopril sodium is a phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. It is a prodrug that is converted to its active metabolite fosinoprilat. | |||
T13316 | VU0134992 hydrochloride | Potassium Channel | |
VU0134992 hydrochloride is the first subtype-preferring, orally active and selective blocker of Kir4.1 potassium channel pore(IC50 : 0.97 µM). | |||
T1057 | Azilsartan | TAK-536 | RAAS |
Azilsartan (TAK-536) is an Angiotensin 2 Receptor Blocker. The mechanism of action of azilsartan is as an Angiotensin 2 Type 1 Receptor Antagonist. The physiologic effect of azilsartan is by means of Decreased Blood Pres... | |||
T0386L | Ropivacaine | LEA-103 HCl | Potassium Channel , Sodium Channel |
Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group. | |||
T14782 | Brilaroxazine | RP5063 | Dopamine Receptor , 5-HT Receptor |
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-... | |||
T1461 | Candesartan | CV 11974 | RAAS |
Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure. | |||
T0119 | Nitrendipine | BAY-E-5009,Bayotensin | Calcium Channel , Autophagy |
Nitrendipine (BAY-E-5009) is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtr... | |||
TP1929L1 | Saralasin acetate(34273-10-4 free base) | RAAS | |
Saralasin acetate is a Non-selective angiotensin II antagonist. | |||
T0287 | Hexamethonium Bromide | Gangliostat,Simpatoblock,Hexamethonium Dibromide | Apoptosis , Dopamine Receptor , AChR |
Hexamethonium Bromide (Hexamethonium Dibromide), a specific antagonist of neuronal-type nicotinic AChR in ganglia, is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. | |||
T5329 | Trandolapril | Angiotensin-converting Enzyme (ACE) | |
Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat. | |||
T2141 | Mecamylamine hydrochloride | Inversine,Mevasin | AChR |
Mecamylamine hydrochloride (Mevasin) is a nicotinic antagonist, used as a ganglionic blocker in hypertension. | |||
T1275 | Phentolamine mesylate | Phentolamine methanesulfonate,Phentolamine mesilate | Adrenergic Receptor |
Phentolamine mesylate (Phentolamine methanesulfonate) is a nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEAS... | |||
T0386 | Ropivacaine hydrochloride | Ropivacaine monohydrochloride | Potassium Channel , Sodium Channel |
Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity. | |||
T7714 | Temocapil | Tyrosinase | |
Temocapril is an inhibitor of tyrosine kinase. | |||
T0083 | Eplerenone | Epoxymexrenone,CGP 30083,SC-66110 | Glucocorticoid Receptor |
Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with transient elevations in serum aminotransferase ... | |||
T1158 | Phenoxybenzamine hydrochloride | NCI-c01661,NSC 37448,Phenoxybenzamine HCl | CaMK , Adrenergic Receptor |
Phenoxybenzamine hydrochloride (NCI-c01661) is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non... | |||
T20570 | Labetalol | Apo-Labetalol,Albetol,Trandate,Dilevalol,Normodyne | Adrenergic Receptor |
Labetalol (Apo-Labetalol) is a mixed alpha/beta-adrenergic antagonist.It is used to treat high blood pressure. It can be given by mouth for long term hypertension management or intravenously in severe hypertensive situat... | |||
T1439 | Lacidipine | SN-305,GX-1048,GR-43659X | Apoptosis , Calcium Channel , Reactive Oxygen Species |
Lacidipine (SN-305) is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex tachycardia. It displays specifi... | |||
T6340 | Enalaprilat Dihydrate | MK-422,MK-422 Dihydrate | RAAS , Autophagy |
Enalaprilat Dihydrate (MK-422 Dihydrate) (IC50=1.94 nM) is a potent angiotensin-converting enzyme (ACE) inhibitor. | |||
T1462 | Captopril | SQ 14225,SQ-14534,SA333 | RAAS |
Captopril (SA333) is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II, a vasoconstrictor and important regulator of arterial blood pressure. | |||
T3096 | Canrenoate potassium | Potassium aldadiene,Canrenoic acid potassium salt,Potassium canrenoate,Soldactone | Glucocorticoid Receptor |
Canrenoate potassium (Soldactone) is a synthetic pregnadiene derivative with anti-aldosterone activity. | |||
T1520 | Aliskiren hemifumarate | CGP 60536,SPP 100,CGP60536B | RAAS , Autophagy |
Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity. | |||
T2318 | Sacubitril/Valsartan | Sacubitril mixture with Valsartan,Valsartan,Sacubitril,LCZ696 | Apoptosis , RAAS , Neprilysin |
Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure. | |||
T0154 | Nebivolol hydrochloride | R 065824 hydrochloride,Nebivolol HCl,R-65824 | Apoptosis , Adrenergic Receptor |
Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is us... | |||
T6698 | Temocapril hydrochloride | CS-622 HCl,Acecol,Temocapril HCl,CS-622 | RAAS |
Temocapril hydrochloride (CS-622 HCl), the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension. | |||
T6645 | Ropivacaine hydrochloride monohydrate | Ropivacaine HCl,Ropivacaine HCl monohydrate,LEA 103,LEA-103 HCl | Potassium Channel , Sodium Channel |
Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly. | |||
T0487 | Metoprolol tartrate | CGP 2175E | Adrenergic Receptor |
Metoprolol Tartrate is a blocker of the cardioselective β-adrenergic receptor. | |||
T3148 | MK-571 sodium | L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid | Leukotriene Receptor , LTR |
MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ... | |||
T0143 | Bisoprolol hemifumarate | (±)-Bisoprolol hemifumarate,Bisoprolol fumarate,Bisoprolol hemifumarate salt,EMD33512,(±)-Bisoprolol (hemifumarate) | Adrenergic Receptor |
Bisoprolol, a selective beta-1 adrenergic receptor antagonist, selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, thereby with antihypertensive activity and devoid of intrinsic sy... | |||
T28759 | Sesamodil | Sesamodil fumarate,SD-3211,SD 3211,SD3211,DS-4823 | Calcium Channel |
Sesamodil (SD 3211) is a novel calcium antagonist that can be used to study hypertension. | |||
T68076L | Fosopamine(HCl) | Dopamine Receptor | |
Fosopamine(HCl) is a DRDs agonist that can be used to study hypertension. | |||
T27087 | Cronidipine | LF 2.0254,LF-20254,LF20254,LF 20254 | Calcium Channel |
Cronidipine (LF 20254), a calcium channel antagonist, is used potentially for the treatment of hypertension and myocardia ischemia. | |||
T30219 | AVE-9488 | AVE 9488,AVE9488 | NOS , NO Synthase |
AVE-9488 is a novel endothelial NO synthase (eNOS) enhancer that upregulates eNOS expression, induces NO production, and may ameliorate portal hypertension. | |||
T14219 | Aminaftone | Aminaphthone | Endothelin Receptor |
Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and can be used to study hypertension and systemic sclerosis. | |||
T1422 | Nilvadipine | FK235,FR34235,ARC029 | Calcium Channel |
Nilvadipine (FK235), a calcium channel blocker (CCB), is utilized for treatment of hypertension. | |||
T60388 | MIF098 | Others | |
MIF098 is a macrophage migration inhibitory factor (MIF) antagonist.MIF098, inhibits pulmonary hypertension associated with SLE and inhibits pulmonary smooth muscle cell (PASMC) proliferation and migration.MIF098 may be ... | |||
T68036 | Carprazidil | Others | |
Carprazidil is a potent vasodilator used to treat severe hypertension and mild heart failure. |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T3055 | Liensinine Perchlorate | Apoptosis , Others | |
Liensinine is the active constituent of plumula nelambinis with anti-hypertension. | |||
TN1416 | Ayanin | IL Receptor , P450 , PARP , PDE | |
Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethylether) is 2.2microM for inhibiting interleukin (IL)-4 productio... | |||
T1135 | Vitamin D3 | Cholecalciferol,Colecalciferol | Endogenous Metabolite |
Vitamin D3 (Cholecalciferol) , a naturally occurring form of vitamin D, activates an H305F/H397Y mutant vitamin D receptor (VDR). | |||
T4454 | Traumatic Acid | Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,Trans-2-Dodecenedioic Acid | Antioxidant |
Traumatic Acid (Dodec-2-Enedioic Acid) is a product of the hydroperoxide lyase pathway in plants. Potential as a wound healing agent that stimulates cell division near a wound site to form a protective callus. | |||
T21095 | 4-Hydroxybenzylamine | 4-(Aminomethyl)phenol,4-HOBA | Endogenous Metabolite |
4-Hydroxybenzylamine (4-HOBA) is a less reactive isomer of 2-HOBA as well as related compounds in a mouse model of hypertension. | |||
T1680 | Tolazoline hydrochloride | Imidaline hydrochloride,Imidaline (hydrochloride),Benzidazol hydrochloride,Tolazoline HCl,NSC35110 (hydrochloride) | Adrenergic Receptor |
Tolazoline hydrochloride (NSC35110 (hydrochloride)) is a non-selective competitive α-adrenergic receptor antagonist used in treatment of persistent pulmonary hypertension of the newborn. | |||
T4A2458 | Resibufogenin | Bufogenin,Recibufogenin | Others |
1. Resibufogenin (Bufogenin) is a cytotoxic steroid isolated from the Chinese drug ChanSu. 2. Resibufogenin can inhibit rectifier potassium current ( I K ) and transient potassium current ( I A ), it has pathological eff... | |||
T17056 | Tetrahydrobiopterin | Sapropterin,BH4,(Rac)-Sapropterin | NOS , Endogenous Metabolite |
Tetrahydrobiopterin (BH4) is a cofactor for aromatic amino acid hydroxylases and an essential cofactor for nitric oxide synthase (NOS), which is used in the study of endothelial dysfunction such as hypertension, hypercho... | |||
TN7129 | Methyl maslinate | Maslinic acid methyl ester,Crategolic acid methyl ester | Adrenergic Receptor |
T8301 | Amaranth | Acid Red 27 | Others |
Amaranth (Acid Red 27) as a potential component of lifestyle modification to improve cardiovascular risk profiles by modifying cardiovascular risk factors such as cholesterol, diabetes, and hypertension. | |||
TN2285 | DL-Tryptophan | (±)-Tryptophan,Tryptophan | Serotonin Transporter , Endogenous Metabolite |
DL-Tryptophan ((±)-Tryptophan) containing dipeptides are interesting ingredients for functional foods as a natural prevention for hypertension with reduced side effects due to its selective inhibition of the C-domain. Lo... | |||
T3S2007 | MRE-269 | MRE 269,ACT-333679,MRE269 | Prostaglandin Receptor |
MRE-269 (ACT-333679) is an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269(ACT-333679) is used for the treatment of pulmonary arterial hypertension. MRE-269(ACT-333679) is an active metabo... | |||
TN7079 | Coreopsin | Butein-4-O-β-D-glucopyranoside | Others |
Coreopsin(Butein-4-O-β-D-glucopyranoside) is one of the main components from Coreopsis tinctoria Nutt. Flower(CTF). CTF has been used traditionally in China for treating hypertension and diabetes as well as reducing body... | |||
T5S0802 | Palmatine | Berbericinine,Burasaine | Indoleamine 2,3-Dioxygenase (IDO) , AChR , AChE , Aurora Kinase |
1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treatment of jaundice, dysentery,... | |||
T2803 | Monocrotaline | Crotaline | TGF-beta/Smad |
Monocrotaline (Crotaline) is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hyp... | |||
T3123 | Allicin | ERK , IL Receptor , Others , IκB/IKK , p38 MAPK , TNF , ROS , Caspase , Antifection | |
Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth mus... | |||
T6S1487 | Ginsenoside Rg5 | NF-κB , COX , IGF-1R | |
1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ... | |||
T38649 | Lyciumin A | ||
Lyciumin A, a cyclic octapeptide, possesses inhibitory properties against proteases, renin, and angiotensin-converting enzyme. It holds potential for hypertension research. | |||
TN4654 | Niazirin | Others | |
The Moringa oleifera extract(including niaziridin and Niazirin) can successfully attenuate the development of pulmonary hypertension via direct vasodilatation and a potential increase in antioxidant activity. | |||
TN4323 | Isorauhimbine | Antibiotic | |
Isorauhimbine is an alkaloid derived from R. serpentina with anticancer, anti-inflammatory and antimicrobial activities and is used in the treatment of cardiovascular diseases such as hypertension, arrhythmia and angina ... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPH-01126 | COMMD5 Protein, Human, Recombinant (His & Myc) | Human | Baculovirus Insect Cells |
COMMD5 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus. | |||
TMPH-01127 | COMMD5 Protein, Human, Recombinant (His) | Human | E. coli |
COMMD5 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-03269 | COMMD5 Protein, Rat, Recombinant (His & Myc) | Rat | E. coli |
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the ... | |||
TMPY-00545 | Dermcidin Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths due to its often late stage diagnosis, and dermcidin (DCD) may have the potential to be used as a serum biomarker for HCC for more timely dia... | |||
TMPY-02575 | PPAR gamma/PPARG Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling even... | |||
TMPJ-00504 | Serpin A8 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Angiotensinogen is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Genetic variations in Angiotensinogen are associated with susceptibility to essential hyperten... | |||
TMPJ-01129 | SMAD1 Protein, Human, Recombinant (GST) | Human | E. coli |
SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcripti... | |||
TMPJ-01379 | TAC3 Protein, Human, Recombinant (His) | Human | E. coli |
Tachykinin 3 (TAC3) is a secreted protein that belongs to the Tachykinin family. Tachykinins are active peptides that excite neurons and evoke behavioral responses; they are potent vasodilators and secretagogues, and con... | |||
TMPJ-01199 | BTN2A1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Butyrophilin 2A1 (BTN2A1) is an approximately widely expressed and variably glycosylated type I transmembrane glycoprotein. Mature human Butyrophilin 2A1 consisits of a 220 amino acid (aa) extracellular domain with two i... | |||
TMPJ-01304 | C1QTNF1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
C1QTNF1 is a secreted protein,contains 1 C1q domain and 1 collagen-like domain. C1qTNF proteins constitute a highly conserved family of Acrp30/Adiponectin paralogs that share a modular organization comprising an N-termin... | |||
TMPY-02574 | Chymase 1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
The STR polymorphism in the CMA1 gene is associated with asthma and that this association is even stronger with atopic asthma. CMA1 and IL-4 in atopic asthma and for IL-4 in atopy in general. The local angiotensin II sys... |
カタログ番号 | 製品名 | ||
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L7110 | Anti-Hypertension Compound Library | 678 compounds | |
678 hypertension-related small molecules for high-throughput and high-content screening. | |||
L7200 | Calcium Channel Compound Library | 140 compounds | |
A unique collection of 140 calcium channel blockers and agonists for high throughput and high content screening; | |||
L1510 | Nuclear Receptor Compound Library | 531 compounds | |
A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening; | |||
L2560 | Metabolism Compound Library | 2320 compounds | |
L8500 | HIF-1 Signaling Pathway Compound Library | 1336 compounds | |
A unique collection of 1336 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies; |