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Search Results for " phosphodiesterase "

343

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天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T76138	Phosphodiesterase
	Phosphodiesterase (PDE), an enzyme capable of catalyzing the hydrolysis of the 3' ring phosphate bond in cyclic nucleotides, plays a crucial role in biochemical research and acts as a vital regulator in signal transducti...
T36018	Phosphodiesterase 4 Inhibitor
	Phosphodiesterase 4 (PDE4) inhibitor is an inhibitor of PDE4 with an IC50 value of 0.10 μM for the human recombinant enzyme.
T76133	Phosphodiesterase II
	Phosphodiesterase 2 (II), a key enzyme prominently involved in the hydrolysis of vital second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), is frequently utilized in biochem...
T76156	Sphingomyelin phosphodiesterase
	Sphingomyelin phosphodiesterase, a hydrolase, plays a crucial role in sphingomyelin metabolism by catalyzing the conversion of sphingomyelin into phosphocholine and ceramide. Furthermore, it is instrumental in cellular d...
T10676	Carbodenafil		PDE
	Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).		PDE
T12150	N-Methylbenzamide		PDE
	N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.		PDE
T27172	Difamilast		PDE
	Difamilast is an inhibitor of phosphodiesterase IV.		PDE
T6462	Deltarasin		PDE , Ras
	Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.		PDE , Ras
T6054	GSK256066		PDE
	GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2.		PDE
T2129	Zaprinast		PDE
	Zaprinast is a cGMP-selective phosphodiesterase (PDE) inhibitor and a GPR35 agonist. It has a strong activating effect on rat GPR35 and a certain activating effect on human GPR35. It reduces vascular remodeling through a...		PDE
T27475	GSK356278	GSK-356278,GSK 356278	PDE
	GSK356278 is an effective and selective inhibitor of phosphodiesterase 4 (PDE4), with pIC50s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively. GSK356278 has anti-inflammatory, anxiolytic, and cognitio...		PDE
T7954	YM976		PDE
	YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)		PDE
T0160	Anagrelide	Anagrelida,Xagrid,Anagrelidum	PDE
	Anagrelide (Xagrid) is a Platelet-reducing Agent. The mechanism of action of anagrelide is as a Phosphodiesterase 3 Inhibitor. The physiologic effect of anagrelide is by means of Decreased Platelet Production.		PDE
T21965	MBCQ		PDE
	MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.		PDE
T4695	CP671305		PDE
	CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.		PDE
T7888	Enpp-1-IN-1		PDE
	Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)		PDE
T3631	PF-8380		PDE
	PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhib...		PDE
T12267	NSP-805		PDE
	NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.		PDE
T10410	ATX inhibitor 1		PDE
	ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).		PDE
T5106	BRL-50481		PDE
	BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.		PDE
T5496	ML-030		PDE
	ML-030 is a potent and selective inhibitor of PDE4(PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2 with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM, respectively)		PDE
T2646	HA130		PDE
	HA130 is a selective ATX (autotaxin) inhibitor.		PDE
T13448	(R)-(-)-Rolipram	(R)-Rolipram,(-)-Rolipram	DNA-PK , Others
	(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.		DNA-PK , Others
T4462	Roflumilast N-oxide		PDE
	Roflumilast N-oxide is an inhibitor of PDE type 4.		PDE
T1618	Dipyridamole	Persantin,Dypyridamole,Dipyridamol,NSC-515776,Dipyudamine	PDE
	Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.		PDE
T6649	(S)-(+)-Rolipram	(S)-Rolipram,(+)-Rolipram,S- (+)-Rolipram	Apoptosis , PDE
	(S)-(+)-Rolipram ((+)-Rolipram) inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.		Apoptosis , PDE
T6445	Cilomilast	SB-207499,Ariflo	PDE
	Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.		PDE
T4041	Ziritaxestat	GLPG1690	PDE
	Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.		PDE
T7346	Lodenafil	Hydroxyhomosildenafil	PDE
	Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)		PDE
T3465	Vesnarinone	OPC-8212,Arkin,Piteranometozine	HIV Protease , PDE
	Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cel...		HIV Protease , PDE
T5474	D159687	D 159687	PDE
	D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant or anxiolytic benefit.		PDE
T1096	Milrinone	Win 47203	PDE
	Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.		PDE
T12913	Siguazodan	SKF 94836	PDE
			PDE
T10590	Zatolmilast	BPN14770	Others , PDE
	Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).		Others , PDE
T8515	Osoresnontrine	BI-409306	PDE
	Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.		PDE
T6548	Irsogladine	Dicloguamine	PDE , AChR
	Irsogladine (Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.		PDE , AChR
T24656	PQ-10	A844337,PQ 10,A-844337,A 844337	PDE
	PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.		PDE
T23154	Piclamilast	RPR 73401,RP 73401	PDE
	Piclamilast (RP 73401) is a PDE4 inhibitor.		PDE
T6147	Nortadalafil	Demethyl Tadalafil	PDE
	Nortadalafil (Demethyl Tadalafil) is demethyl Tadalafil, which is a PDE5 inhibitor, treating erectile dysfunction (ED) ; and under the name Adcirca for the treatment of pulmonary arterial hypertensio.		PDE
T2923	Apremilast	CC-10004	Apoptosis , TNF , PDE
	Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.		Apoptosis , TNF , PDE
T7542	Amino Tadalafil		PDE
	Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.		PDE
T8919	Homo Sildenafil		PDE
	Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.		PDE
T16499	Mardepodect	PF-2545920	PDE
	Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE. It is potentially useful for the treatment of schizophrenia. Phosphodie...		PDE
T21865	BC 11-38		PDE
	BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).		PDE
T8506	THPP-1		PDE
	THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).		PDE
T5033	Olprinone	Loprinone	PDE
	Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output ...		PDE
T1745	Balipodect	TAK063,TAK-063,TAK 063	PDE
	Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.		PDE
T11689	ITI-214	ITI214	PDE
	ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = ...		PDE
T5101	BW-A 78U	BW-A78U	PDE
	BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.		PDE
T9805	BAY 2666605		PDE
	BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.		PDE

Compounds

Phosphodiesterase 4 Inhibitor

T36018

Synonym:

Target:

Phosphodiesterase II

T76133

Synonym:

Target:

Sphingomyelin phosphodiesterase

Synonym: GSK-356278,GSK 356278

Synonym: Anagrelida,Xagrid,Anagrelidum

Synonym: (R)-Rolipram,(-)-Rolipram

Target: DNA-PK, Others

Synonym: Persantin,Dypyridamole,Dipyridamol,NSC-515776,Dipyudamine

Target: PDE

(S)-(+)-Rolipram

T6649

Synonym: (S)-Rolipram,(+)-Rolipram,S- (+)-Rolipram

Target: Apoptosis, PDE

Cilomilast

T6445

Synonym: SB-207499,Ariflo

Synonym: Hydroxyhomosildenafil

Target: PDE

Vesnarinone

T3465

Synonym: OPC-8212,Arkin,Piteranometozine

Target: HIV Protease, PDE

Synonym: Dicloguamine

Target: PDE, AChR

PQ-10

T24656

Synonym: A844337,PQ 10,A-844337,A 844337

Target: PDE

Piclamilast

T23154

Synonym: RPR 73401,RP 73401

Target: PDE

Nortadalafil

T6147

Synonym: Demethyl Tadalafil

Target: Apoptosis, TNF, PDE

Synonym: TAK063,TAK-063,TAK 063

カタログ番号	製品名	別名	ターゲット
TN1266	3-O-Methylquercetin		IL Receptor , cAMP , PDE
	3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentr...		IL Receptor , cAMP , PDE
TN2159	Robustine		PDE
	Robustine is a natural product, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro.		PDE
T8787	Drotaverine hydrochloride		PDE
	Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor，and is an antispasmodic drug, used to enhance cervical dilation during childbirth. Drotaverine hydrochloride is structurally rela...		PDE
T1681	Aminophylline	Phyllocontin	PDE , Adenosine Receptor
	Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor giving a bronchodilatory effect.		PDE , Adenosine Receptor
TN1416	Ayanin		IL Receptor , P450 , PARP , PDE
	Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethylether) is 2.2microM for inhibiting interleukin (IL)-4 productio...		IL Receptor , P450 , PARP , PDE
T7027	EURYCOMANONE	Pasakbumin A	Others
	Eurycomanone (Pasakbumin A) is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.Eurycomanone has anti-cancer activity, inhibits A549 lung cancer cell p...		Others
T0892	Diphylline	Dyphylline,Diprophylline	PDE , Adenosine Receptor
	Diphylline (Diprophylline) is a xanthine derivative. Diphylline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Diphylline probably acts as a competitive inhibitor of phosphodies...		PDE , Adenosine Receptor
T2855	Icariin	Ieariline	PDE , PPAR , Autophagy
	Icariin (Ieariline) is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.		PDE , PPAR , Autophagy
T3783	Fraxin	Fraxoside,Fraxetin-8-O-glucoside,Paviin	OAT , transporter , PDE
	Fraxin (Fraxoside) is a glucoside of fraxetin.		OAT , transporter , PDE
T0480	Doxofylline	Doxophylline	PDE , Adenosine Receptor
	Doxofylline (Doxophylline) is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with s...		PDE , Adenosine Receptor
T1083	Theophylline	Theo-24,1,3-Dimethylxanthine	Endogenous Metabolite , HDAC , PDE , Adenosine Receptor , Autophagy
	Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3...
T6427	Butein	2’,3,4,4’-tetrahydroxy Chalcone	Apoptosis , EGFR , Others , PDE , Autophagy
	Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.		Apoptosis , EGFR , Others , PDE , Autophagy
T2205	Acefylline	Theophylline-7-acetic acid,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid	TNF , PAD , PKA , HDAC , PDE , Adenosine Receptor
	Acefylline (Theophylline-7-acetic acid), a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical preparation Etanautine to help...		TNF , PAD , PKA , HDAC , PDE , Adenosine Receptor
T0167	Vinpocetine	RGH-4405,Ethyl apovincaminate	IκB/IKK , NF-κB , Sodium Channel , PDE
	Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).		IκB/IKK , NF-κB , Sodium Channel , PDE
T5S2059	Glaucine		Calcium Channel , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , PDE
	Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of h...
T0070	Pentoxifylline	Oxpentifylline,PTX,BL-191	HIV Protease , PDE , Adenosine Receptor , Autophagy
	Pentoxifylline (PTX) modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It also inhibits platelet ...		HIV Protease , PDE , Adenosine Receptor , Autophagy
T17199	Udenafil		PDE
	Udenafil is an inhibitor of PDE5 .		PDE
T4S0792	Pinoresinol 4-O-β-D-glucopyranoside	(+)-pinor,(+)-pinoresinol-β-D-glucoside; (+)-pinor,(+)-pinoresinol-β-D-glucoside	Others
	(+)-Pinoresinol-β-D-glucoside, also known as (+)-pinor, is a major active lignan furanoid found in Forsythia. It exhibits antioxidative, antihypertensive activities, and acts as an inhibitor of cyclic adenosine monophosp...		Others
TN2217	Sophoflavescenol		Others , Beta-Secretase , BACE , PDE , AChR , AChE
	Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , these effects might contribute to the antitumor activity witho...		Others , Beta-Secretase , BACE , PDE , AChR , AChE
TN3091	5,7-Diacetoxy-8-methoxyflavone	ZINC77031696	PDE
	5,7-Diacetoxy-8-methoxyflavone is derived from the roots of Scutellaria baicalensis and inhibits cAMP phosphodiesterase.		PDE
TN4510	(+)-Medioresinol Di-O-β-D-glucopyranoside	(+)-Mediresinol Di-O-beta-D-glucopyranoside,(+)-Medioresinol Di-O-β-D-glucopyranoside	PDE
	(+)-Medioresinol Di-O-β-D-glucopyranoside has strong inhibitory activity of cyclic AMP phosphodiesterase.		PDE
T5940	Proxyphylline	7-(2-Hydroxypropyl)theophylline	PDE , Adenosine Receptor
	Proxyphylline (7-(2-Hydroxypropyl)theophylline) is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and bronchodilator.		PDE , Adenosine Receptor
T10822	Cirsimarin	Cirsitakaoside	Adenosine Receptor
	Cirsimarin (Cirsitakaoside) is a flavonoid isolated from Microtea debilis. It shows a potent antilipogenic effect and decreases adipose tissue deposition in mice. Cirsimarin has antagonist activity on the adenosine A1 re...		Adenosine Receptor
TN6120	Nauclefine	Parvine	PDE
	Nauclefine (Parvine) is a plant indole alkaloid natural product and induces apoptosis of diverse cancer cells via a PDE3A-SLFN12 dependent death pathway. Nauclefine binds PDE3A but does not inhibit the PDE3A's phosphodie...		PDE
TN1950	Moracin M		PDE
	Moracin M, a phenolic compound found in the skin of Morus alba Linn., effectively inhibits phosphodiesterase-4 (PDE4), exhibiting IC50 values of 2.9 μM and 4.5 μM for PDE4D2 and PDE4B2, respectively, and showing signific...		PDE
T4973	Paraxanthine	1,7-DIMETHYLXANTHINE	Endogenous Metabolite
	Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is struc...		Endogenous Metabolite
TN3466	Atherosperminine		cAMP , Calcium Channel , AChR , Parasite
	Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong anti-plasmodial activity against Plasmodium falciparum, with t...		cAMP , Calcium Channel , AChR , Parasite
T4721	β-Nicotinamide mononucleotide	β-NM	Others , Endogenous Metabolite
	β-Nicotinamide mononucleotide (β-NM) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Mammals predominantly use nicotinamide rather than nicotinic acid as a precursor for NAD...		Others , Endogenous Metabolite
TN3013	4,5-Dimethoxycanthin-6-one	Methylnigakinone	P450 , Antibacterial , PDE
	4,5-Dimethoxycanthin-6-one is an alkaloid isolated from Picrasma quassioides BENNET (Simaroubaceae).4,5-Dimethoxycanthin-6-one was isolated from Picrasma quassioides BENNET (Simaroubaceae) with antimicrobial activity.4,5...		P450 , Antibacterial , PDE
T28019	(-)-Mesembrine	Mesembrin,Mesembrine,Mesembranone
	Mesembrine is a serotonin reuptake inhibitor and is also a weak inhibitor of the enzyme phosphodiesterase 4 (PDE4).
T27436	GS 389	GS-389,GS389
	GS 389 is a novel tetrahydroisoquinoline analog with vasorelaxant properties. GS-389 significantly inhibited cGMP phosphodiesterase from the rabbit brain and increased cGMP levels in the rat aorta.
TN4886	Quinovic acid 3-O-alpha-L-rhamnopyranoside		Others
	Quinovic acid 3-O-alpha-L-rhamnopyranoside shows significant inhibitory activity against snake venom phosphodiesterase-I.		Others
TN4397	Kuraridine		PDE , Parasite
	Kuraridine is measured against cGMP PDE5 to identify potent cGMP specific phosphodiesterase type 5 inhibitory constituents.		PDE , Parasite
TN2974	3-O-Methylquercetin tetraacetate		IL Receptor , TNF , PDE
	Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiveness.		IL Receptor , TNF , PDE
TN1841	Kushenol A	Leachianone E	cAMP
	Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushenol A and kushenol C exhibit inhibitory activity against So...		cAMP
TN1504	Citreorosein		cAMP , NF-κB , PI3K
	Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation an...		cAMP , NF-κB , PI3K
T28522	Reticulol
	Reticulol is an isocoumarin derivative produced by certain species of Streptomyces. Reticulol inhibits cAMP phosphodiesterase (IC50 = 41 µM). Recticulol (M.W. 222.2) exhibits a potent in vitro cytotoxicity against the hu...
TN1843	Kushenol K		PDE , HSV
	Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K shows weak antiviral activity against Herpes simplex virus t...		PDE , HSV
T79957	4'-Methoxyisoagarotetrol
	4'-Methoxyisoagarotetrol, a chromone derivative, exhibits moderate phosphodiesterase 3A (PDE3A) inhibitory activity with an IC50 value of 54 μM [1].
T16397	Ophiobolin A		Others
	Ophiobolin A is a fungal metabolite and a phytotoxin and is an effective and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase (IC50: 9 μM). Ophiobolin A also has antimicrobial and antica...		Others
TN3537	Braylin		IL Receptor , TNF , NF-κB
	Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition of the transcriptional activity of NF-ÎºB. Braylin is also ...		IL Receptor , TNF , NF-κB
TN4433	Licoarylcoumarin		cAMP , HIV Protease , Antifection
	Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effe...		cAMP , HIV Protease , Antifection
T4700	1,3,5-Trihydroxy-4-prenylxanthone
	1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylch...
T75486	Toddacoumalone
	Toddacoumalone, a natural compound, exhibits moderate potency as an inhibitor of phosphodiesterase 4 (PDE4) and possesses traits that are not fully ideal for an agent. It has potential application in the study of inflamm...
T73857	Mesembrine
	Mesembrine ((+)-Mesembrine), a primary alkaloid distinguished by its aryloctahydroindole structure, acts as a potent 5-HT transporter inhibitor with an inhibition constant (K i) of 1.4 nM. Additionally, it demonstrates i...
TN4551	Methyl orsellinate		Phosphatase , cAMP , Antifection
	Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus and Echinochloa crus-galli, interact with bovine-brain cal...		Phosphatase , cAMP , Antifection
T38108	Fulvic Acid		Antioxidant , PDE
	Fulvic Acid is a natural product of humus produced by microorganisms in soil, sediment or aquatic environments. Fulvic acid is a phenolic acid and fungal metabolite isolated from Penicillium for the first time. Fulvic Ac...		Antioxidant , PDE

天然物製品

3-O-Methylquercetin

TN1266

Synonym:

Target: IL Receptor, cAMP, PDE

Drotaverine hydrochloride

Synonym: Phyllocontin

Target: PDE, Adenosine Receptor

Ayanin

TN1416

Synonym:

Target: IL Receptor, P450, PARP, PDE

EURYCOMANONE

T7027

Synonym: Pasakbumin A

Target: Others

Diphylline

T0892

Synonym: Dyphylline,Diprophylline

Target: PDE, Adenosine Receptor

Icariin

T2855

Synonym: Ieariline

Target: PDE, PPAR, Autophagy

Fraxin

T3783

Synonym: Fraxoside,Fraxetin-8-O-glucoside,Paviin

Target: OAT, transporter, PDE

Doxofylline

T0480

Synonym: Doxophylline

Target: PDE, Adenosine Receptor

Theophylline

T1083

Synonym: Theo-24,1,3-Dimethylxanthine

Target: Endogenous Metabolite, HDAC, PDE, Adenosine Receptor, Autophagy

Butein

T6427

Synonym: 2’,3,4,4’-tetrahydroxy Chalcone

Target: Apoptosis, EGFR, Others, PDE, Autophagy

Acefylline

T2205

Synonym: Theophylline-7-acetic acid,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid

Target: TNF, PAD, PKA, HDAC, PDE, Adenosine Receptor

Vinpocetine

T0167

Synonym: RGH-4405,Ethyl apovincaminate

Target: IκB/IKK, NF-κB, Sodium Channel, PDE

Glaucine

T5S2059

Synonym:

Target: Calcium Channel, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, PDE

Pentoxifylline

T0070

Synonym: Oxpentifylline,PTX,BL-191

Target: HIV Protease, PDE, Adenosine Receptor, Autophagy

Pinoresinol 4-O-β-D-glucopyranoside

T4S0792

Synonym: (+)-pinor,(+)-pinoresinol-β-D-glucoside; (+)-pinor,(+)-pinoresinol-β-D-glucoside

Target: Others, Beta-Secretase, BACE, PDE, AChR, AChE

5,7-Diacetoxy-8-methoxyflavone

TN3091

Synonym: ZINC77031696

Target: PDE

(+)-Medioresinol Di-O-β-D-glucopyranoside

TN4510

Synonym: (+)-Mediresinol Di-O-beta-D-glucopyranoside,(+)-Medioresinol Di-O-β-D-glucopyranoside

Target: PDE

Proxyphylline

T5940

Synonym: 7-(2-Hydroxypropyl)theophylline

Target: PDE, Adenosine Receptor

Cirsimarin

T10822

Synonym: Cirsitakaoside

Target: Adenosine Receptor

Synonym: 1,7-DIMETHYLXANTHINE

Target: Endogenous Metabolite

Atherosperminine

TN3466

Synonym:

Target: cAMP, Calcium Channel, AChR, Parasite

β-Nicotinamide mononucleotide

T4721

Synonym: β-NM

Target: Others, Endogenous Metabolite

4,5-Dimethoxycanthin-6-one

TN3013

Synonym: Methylnigakinone

Target: P450, Antibacterial, PDE

(-)-Mesembrine

T28019

Synonym: Mesembrin,Mesembrine,Mesembranone

Target:

GS 389

T27436

Synonym: GS-389,GS389

Target:

Quinovic acid 3-O-alpha-L-rhamnopyranoside

Target: PDE, Parasite

3-O-Methylquercetin tetraacetate

TN2974

Synonym:

Target: IL Receptor, TNF, PDE

Kushenol A

TN1841

Synonym: Leachianone E

Target: cAMP, NF-κB, PI3K

4'-Methoxyisoagarotetrol

Target: IL Receptor, TNF, NF-κB

Licoarylcoumarin

TN4433

Synonym:

Target: cAMP, HIV Protease, Antifection

1,3,5-Trihydroxy-4-prenylxanthone

Target: Phosphatase, cAMP, Antifection

Fulvic Acid

T38108

Synonym:

Target: Antioxidant, PDE

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-00571	ACP phosphodiesterase Protein, E. coli, Recombinant (His & Myc)	E. coli	E. coli
	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.
TMPY-04006	ENPP3 Protein, Rhesus, Recombinant (His)	Rhesus	Baculovirus Insect Cells
	ENPP3 Protein, Rhesus, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 97.2 kDa and the accession number is XP_001103528.1.
TMPY-00463	ENPP2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	ENPP2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96 kDa and the accession number is XP_005564040.1.
TMPY-02585	Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	Sphingomyelin phosphodiesterase 1 (SMPD1) , also known as ASM ( acid sphingomyelinase ), is a member of the acid sphingomyelinase family of enzymes. Three isoforms have been identified, isoform 1 is 631 amino acids (aa) ...
TMPY-02778	ENPP2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	ENPP2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96 kDa and the accession number is AAH34961.1.
TMPY-01922	PDE9A Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	PDE9A Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 89.5 kDa and the accession number is O76083-2.
TMPY-01921	PDE9A Protein, Human, Recombinant (His)	Human	E. coli
	PDE9A Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 40 kDa and the accession number is O76083-2.
TMPH-02425	ENPP3 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	ENPP3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 98.7 kDa and the accession number is A0A2K5TKP4.
TMPY-01819	PDE1B Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE1 subfamily. Pho...
TMPY-03278	SMPDL3A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	SMPDL3A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.3 kDa and the accession number is Q92484.
TMPY-02253	ENPP7 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	ENPP7 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession number is Q3TIW9.
TMPY-02880	ENPP5 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	ENPP5 is a member of the nucleotide pyrophosphatase/phosphodiesterase family (NPP). It is a family comprised of dimeric enzymes that catalyze the hydrolysis of phosphate diester bonds. There are seven isoforms in NPP fam...
TMPY-02081	PDE2A Protein, Human, Recombinant (aa 215-900, His)	Human	Baculovirus Insect Cells
	cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 sub...
TMPY-02977	PDE1C Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds ...
TMPY-04512	SMPDL3A Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	SMPDL3A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.1 kDa and the accession number is P70158.
TMPY-01070	ENPP7 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	ENPP7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49 kDa and the accession number is Q6UWV6.
TMPY-02055	ENPP2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	ENPP2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96 kDa and the accession number is Q9R1E6-1.
TMPY-06858	ENPP3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	ENPP3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96.44 kDa and the accession number is O14638.
TMPH-01024	Calbindin Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Calbindin Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecul...
TMPK-00854	ENPP1 Protein, Human, Recombinant (C-His)	Human	HEK293 Cells
	Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (eP...
TMPK-00852	ENPP1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (eP...
TMPK-00853	ENPP1 Protein, Human, Recombinant (N-His)	Human	HEK293 Cells
	Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (eP...
TMPK-00781	ENPP1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (eP...
TMPH-00270	GNAT2 Protein, Bovine, Recombinant (His)	Bovine	E. coli
	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that perfor...
TMPH-02575	PDE5A Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-gen...
TMPK-00573	ENPP3 Protein, Canine, Recombinant (His)	Canine	HEK293 Cells
	Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENP...
TMPK-00715	ENPP3 Protein, Human, Recombinant (aa 558-875, His)	Human	HEK293 Cells
	Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENP...
TMPK-00713	ENPP3 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENP...
TMPK-00711	ENPP3 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENP...
TMPK-00712	ENPP3 Protein, Human, Recombinant (aa 48-157, His & Avi)	Human	HEK293 Cells
	Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENP...
TMPK-00714	ENPP3 Protein, Human, Recombinant (aa 48-157, His & Avi), Biotinylated	Human	HEK293 Cells
	Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENP...