|
T7779 |
Nelfinavir
|
AG1341 |
HIV Protease
|
|
Nelfinavir (AG1341) is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV) (Ki=2 nM). Nelfinavir is a broad-spectrum, anticancer agent. |
|
T31208 |
Dasolampanel
|
NGX-426,NGX 426,NGX426 |
GluR
,
iGluR
|
|
Dasolampanel (NGX-426) is an orally available ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders, including neuropathic pain and migraine. |
|
T22798 |
Gavestinel
|
GV 150526,Gavestinel sodium salt |
NMDAR
,
iGluR
|
|
Gavestinel (GV 150526) is a non-competitive NMDA receptor antagonist that is potent, selective and orally active.Gavestinel binds to the glycine site of the NMDA receptor with a binding affinity (pKi value) of 8.5.Gavest... |
|
T5432 |
Eganelisib
|
IPI-549 |
PI3K
|
|
Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively) |
|
T6999 |
Teneligliptin hydrobromide
|
Teneligliptin hydrobromide anhydrous,MP-513 (hydrobromide) |
Others
,
Proteasome
,
DPP-4
|
|
Teneligliptin hydrobromide (MP-513 (hydrobromide)) is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 ... |
|
T12441 |
Phenelzine sulfate
|
|
Monoamine Oxidase
|
|
Phenelzine sulfate is a non-selective and irreversible inhibitor of monoamine oxidase (MAOI), and with antidepressant and anxiolytic. |
|
T77710 |
Calcium Channel antagonist 2
|
WAY-327363 |
Calcium Channel
|
|
Calcium Channel antagonist 2 is a calcium channel antagonist (IC50=5-20 μM) that can be used to study diseases due to Ca2+ channels like pain and diabetes. |
|
T77712 |
Calcium Channel antagonist 3
|
|
Calcium Channel
|
|
Calcium Channel antagonist 3 is a voltage-gated calcium channel inhibitor (IC50 : 5-20 μM). |
|
T77711 |
Calcium Channel antagonist 4
|
|
Calcium Channel
|
|
Calcium Channel antagonist 4 is a voltage-gated calcium channel inhibitor (IC50 : 5-20 μM). |
|
T10659 |
Ca2+ channel agonist 1
|
|
Calcium Channel
,
CDK
|
|
Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction. |
|
T3407L |
Rapastinel acetate
|
Rapastinel acetate (117928-94-6 Free base) |
NMDAR
,
iGluR
|
|
Rapastinel acetate is a modulator of N-methyl-D-aspartate (NMDA) receptor and a partial agonist of glycine site long-lasting antidepressant effects. |
|
T28153 |
Nelivaptan
|
SSR149415,SR 149415,SR-149415 |
Vasopressin Receptor
|
|
Nelivaptan (SR 149415) is a vasopressin V1b receptor antagonist. |
|
T10101 |
Calcium channel-modulator-1
|
|
Others
,
Calcium Channel
|
|
Calcium channel-modulator-1 is a calcium channel-modulator (IC50:0.8 μM) with specialisation to block aortic constriction. |
|
T3407 |
Rapastinel
|
GLYX-13,Thr-Pro-Pro-Thr-NH2,TPPT-amide |
NMDAR
,
iGluR
|
|
Rapastinel (TPPT-amide) (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator. |
|
T13312L |
Seviteronel
|
VT-464 |
P450
,
Androgen Receptor
|
|
Seviteronel (VT-464) is a novel CYP17 cleavage enzyme inhibitor and androgen receptor antagonist for the study of breast and prostate cancer. |
|
T5819 |
Rapastinel Trifluoroacetate
|
Thr-Pro-Pro-Thr-NH2 Trifluoroacetate,GLYX-13 Trifluoroacetate |
NMDAR
,
iGluR
|
|
Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties. |
|
T1641 |
Strontium ranelate
|
Distrontium renelate,S12911 |
Calcium Channel
,
CaSR
|
|
Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both in... |
|
T7350 |
Nelotanserin
|
APD125 |
5-HT Receptor
|
|
Nelotanserin (APD125) is a potent 5-HT2A inverse agonist(IC50 : 1.7 nM), a moderately potent 5-HT2C partial inverse agonist t(IC50 :79 nM )and a weak 5-HT2B inverse agonistt(IC50 : 791 nM). |
|
T16286 |
Nelonemdaz
|
Salfaprodil free base,Neu2000 |
Antioxidant
,
NMDAR
|
|
Nelonemdaz (Neu2000) is an NMDA receptor antagonist with antioxidant activity and neuroprotective activity used in the study of cerebral infarction reperfusion injury and acute ischemic stroke. |
|
T27828 |
Licostinel
|
CGP 63446,ACEA1021,ACEA 1021,ACEA-1021,CGP-63446 |
GluR
|
|
Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia. |
|
T12042 |
Minnelide
|
|
Others
|
|
Minnelide is a prodrug of triptolide,and shows potent antitumor activity in a number of tumor types. |
|
T6603 |
Nelarabine
|
GW 506U78,Nelzarabine,506U78 |
Apoptosis
,
Nucleoside Antimetabolite/Analog
,
DNA/RNA Synthesis
|
|
Nelarabine (GW 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. |
|
T61535 |
Neldazosin
|
|
Adrenergic Receptor
|
|
Neldazosin is used as a potent α1-adrenoceptor antagonist. |
|
T72170 |
NaV1.2/1.6 channel blocker-1
|
|
Sodium Channel
|
|
NaV1.2/1.6 channel blocker-1 is a potent NaV1.2/1.6 channel blocker with inhibitory effects on rNaV1.6 and hNaV1.2.NaV1.2 channel blocker-1 can be used in the study of generalised epilepsy and movement disorders. |
|
T26645 |
Aptiganel
|
CNS 1102,CNS-1102,CNS1102 |
NMDAR
|
|
Aptiganel (CNS-1102) is a non-competitive NMDA antagonist, a peptide that may be used to study acute ischemic stroke. |
|
T76830 |
Teneliximab
|
Chi220,Anti-Human CD40 Recombinant Antibody,BMS 224819 |
TNF
|
|
Teneliximab (Chi220) is a chimeric monoclonal antibody and a tumor necrosis factor receptor superfamily member 5 (CD40) inhibitor that blocks CD40-CD40L interactions.Teneliximab exerts partial agonist activity through CD... |
|
T16977 |
Talampanel
|
GYKI-53773,LY-300164 |
Apoptosis
,
GluR
|
|
Talampanel (LY-300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models. |
|
T6001 |
Nelfinavir Mesylate
|
Viracept,Nelfin,AG1343,AG 1343 Mesylate |
HIV Protease
|
|
Nelfinavir Mesylate (Viracept) is an effective HIV protease inhibitor (Ki: 2 nM). |
|
T7201 |
Nelociguat
|
BAY60-4552 |
Guanylate cyclase
|
|
Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway. |
|
T34609 |
Selurampanel
|
BGG-492,BGG 492,BGG492 |
iGluR
|
|
Selurampanel (BGG492) is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in the study of epilepsy, migraine and tinnitus. |
|
T10674 |
Potassium Channel Activator 1
|
ZINC34634569 |
Potassium Channel
|
|
Potassium Channel Activator 1 can be used in studies about the treatment of disorders or conditions wherein the dopaminergic system is disrupted such as mood disorders ADHD, schizophrenia, and other psychotic states. |
|
T64203 |
T-Type calcium channel inhibitor 2
|
|
|
|
T-Type calcium channel inhibitor 2 (compound 6g) is a potent inhibitor of the T-type calcium channel, acting on Cav3.1 (α1G) (IC50: 31.0 μM), Cav3.2 (α1H) (IC50: 83.1 μM), Cav3.3 (α1I) (α1H) ( T-Type calcium channel inhi... |
|
T60986 |
KCa2 channel modulator 2
|
|
|
|
KCa2 channel modulator 2 (compound 2q) is an effective subtype-selective K/Ca 2 channel positive modulator which shows similar potency on the human K Ca 2.3 channel and rat K Ca 2.2a subtypes, with EC50 values of 0.60 μM... |
|
T68178 |
Neltenexine HCl
|
|
|
|
Neltenexine HCl is the salt form of Neltenexine free base, an elastase inhibitor that may be useful for preventing pulmonary emphysema. |
|
T6051 |
Orteronel
|
TAK-700,(S)-Orteronel |
P450
|
|
|
|
T13313 |
Seviteronel racemate
|
VT-464 (racemate) |
Others
|
|
|
|
T39241 |
PA Janelia Fluor® 549, SE
|
PA Janelia Fluor® 549, SE,PA-JF549-NHS |
|
|
PA Janelia Fluor 549, SE (PA-JF549-NHS) is a bright photoactivatable fluorophore of JF549, SE (JF549, NHS). JF549, SE (JF549, NHS) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maxim... |
|
T39936 |
HM Janelia Fluor® 526, SE
|
HM-JF526 NHS |
|
|
HM Janelia Fluor 526, SE (HM-JF526 NHS) is a derivative of hydroxymethyl JF526 (HM-JF526). SMLM (single-molecule localization microscopy) imaging in standard phosphate-buffered saline (pH 7.4) revealed that the HM-JF526 ... |
|
T71806 |
Tenellin
|
|
|
|
Tenellin is a fungal metabolite that inhibits Mg2+-, Ca2+-, and Na+/K+-ATPase activities in erythrocytes. Tenellin is cytotoxic to Sf9 and Sf21 insect cells. |
|
T38157 |
Ricinelaidic Acid
|
|
|
|
Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 μM in porcine neutrophil membranes). It inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neu... |
|
T25860 |
Neluxicapone
|
Neluxicapona,Neluxicaponum |
|
|
Neluxicapone is an antiparkinsonian agent. |
|
T23870 |
Cefcanel daloxate
|
Cefcanel daloxato,Cefcanelum daloxatum |
|
|
Cefcanel daloxate is a pro-drug of KY-087. |
|
T12951 |
Sodium Channel inhibitor 2
|
|
Sodium Channel
|
|
|
|
T72195 |
KCa1.1 channel activator-2
|
|
|
|
KCa1.1 channel activator-2, a hybrid derivative of Quercetin, selectively stimulates the vascular KCa1.1 channels. This compound demonstrates significant myorelaxant activity. |
|
T12948 |
Sodium Channel inhibitor 1
|
|
Others
|
|
Sodium Channel inhibitor1 is a novel and selective voltage-gated sodium channel for pain treatment. (IC50 Value of 0.16 uM and 0.41 uM for Na v1.7, V hold-90mV and Na v1.7, V hold-90mV) |
|
T23718 |
Amfonelic Acid
|
|
|
|
Amfonelic Acid is a dopamine uptake blocker. |
|
T72194 |
KCa1.1 channel activator-1
|
|
|
|
KCa1.1 Channel Activator-1, a hybrid derivative of Quercetin, selectively stimulates the vascular KCa1.1 channels while also blocking CaV1.2 channels. Additionally, it demonstrates weak myorelaxant activity. |
|
T61605 |
SK3 Channel-IN-1
|
|
|
|
SK3 Channel-IN-1 (compound 7a) is a powerful and selective modulator of the SK3 channel. It demonstrates significant efficacy in inhibiting breast cancer MDA-MB-435 cell migration while maintaining low cytotoxicity in ot... |
|
T60923 |
Zelquistinel
|
|
|
|
Zelquistinel can be used for the depression, anxiety and other related psychiatric disorders research which is an agonist of N-methyl-D-aspartate (NMDA) receptor [1]. |
|
T16281 |
Nelonicline
|
ABT-126 |
Adenosine Receptor
|
|
Nelonicline is a selective agonist of neuronal nicotinic receptors. |
