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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T11063 | DMT1 blocker 1 | Others | |
DMT1 blocker 1 is a blocker of divalent metal transporter 1 (DMT1) with IC50 of 0.64 μM, which is expected to block the absorption of iron by intestinal cells in vivo. | |||
T11064 | DMT1 blocker 2 | Others | |
DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo. | |||
T12504 | (+)-KCC2 blocker 1 | Potassium Channel | |
(+)-KCC2 blocker 1 is a selective blocker of KCC2 (IC50 = 0.4 μM). | |||
T10690 | Cav 2.2 blocker 1 | Calcium Channel | |
Cav 2.2 blocker 1 is an N-type calcium channel (Cav 2.2; IC50: 1 nM) blocker for the treatment of pain. | |||
T72170 | NaV1.2/1.6 channel blocker-1 | Sodium Channel | |
NaV1.2/1.6 channel blocker-1 is a potent NaV1.2/1.6 channel blocker with inhibitory effects on rNaV1.6 and hNaV1.2.NaV1.2 channel blocker-1 can be used in the study of generalised epilepsy and movement disorders. | |||
T39717 | VGSC blocker-1 | ||
VGSC blocker-1 is a powerful small molecule that serves as a blocker for the neonatal isoform of the VGSC subtype known as Nav1.5 (nNav1.5). It effectively blocks INa peak currents by 34.9% at a concentration of 1 μM, an... | |||
T11927 | M2 ion channel blocker | Others | |
M2 ion channel blocker ,Antiviral agent, is capable of inhibiting and blocking the activity of M2 ion channel. | |||
T28132 | NaV1.7 Blocker-801 | ||
NaV1.7 Blocker-801 is a potent NaV1.7 blocker. | |||
T69387 | NMO-IgG blocker A-01 | ||
NMO-IgG blocker A-01 is a idiotype-specific blocker of neuromyelitis opticaimmunoglobulin g (nmo-igg) binding to aquaporin-4 (aqp4) | |||
T12153 | N-type calcium channel blocker-1 | Calcium Channel | |
N-type calcium channel blocker-1 is an orally active analgesic agent,shows high affinity to functionally block N-type calcium channels. | |||
T80930 | TRPV2-selective blocker 1 | ||
TRPV2-selective blocker 1 (compound IV2-1) is a selective inhibitor of the TRPV2 channel, exhibiting an IC50 value of 6.3 μM. It specifically targets the TRPV2 channel without impacting related TRPV1, TRPV3, or TRPV4 cha... | |||
T62586 | Cav 2.2/3.2 blocker 1 | ||
Cav 2.2/3.2 blocker 1 (Compound 9e) is a neuronal calcium channel blocker that acts on Cav2.2 (IC50: 1.22 μM) and Cav3.2 (IC50: 80 μM). Can penetrate the central nervous system. | |||
T26817 | Bim-BLK-A | Bim Blocker A,Compound A,Bim BLK A,BimBLKA | |
Bim-BLK-A efficiently blocks Bim-induced apoptosis after Bax is activated on the mitochondria. The cellular target of Bim-BLK-A was identified to be the succinate dehydrogenase subunit B (SDHB) protein of complex II of t... | |||
T83705 | BING TFA | Blocker of Inter-membrane Stress Responses of Gram-negative Bacteria | |
BING, a antimicrobial peptide discovered in Japanese medaka fish (O. laptipes), originates from vacuolar protein sorting-associated protein 13D-like (Vps13D). It exhibits efficacy against a range of Gram-negative and Gra... | |||
T15385 | Glibornuride | Potassium Channel | |
Glibornuride is an ATP-sensitive K+ channels (KATP channel) blocker ( pKi: 5.75). It is an antidiabetic agent. | |||
T0440 | Oxcarbazepine | GP 47680 | Apoptosis , Sodium Channel |
Oxcarbazepine (GP 47680) is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity. | |||
T21454 | Nicardipine | Cardene,Dagan,Antagonil,Flusemide | Calcium Channel |
Nicardipine (Cardene), a calcium channel blockers belonging to the dihydropyridine class, is a drug used to treat angina and high blood pressure. | |||
T3574 | Sematilide hydrochloride | CK-1752A,CK-1752,Sematilide HCl | Potassium Channel |
Sematilide hydrochloride (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the ... | |||
T8388 | Vonoprazan | TAK-438 (free base) | Proton pump |
Vonoprazan (TAK-438 (free base)) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis | |||
T0866 | Propafenone | Rythmol,Propafenonum | Potassium Channel , MRP , Sodium Channel |
Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.... | |||
T1215 | Nicardipine hydrochloride | RS-69216,Nicardipine HCl,YC-93 Hydrochloride | Calcium Channel , Adrenergic Receptor , AChR , Autophagy |
Nicardipine hydrochloride (YC-93 Hydrochloride) is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine Family) blocks cal... | |||
T0342 | Carvedilol phosphate hemihydrate | Carvedilol phosphate,BM 14190 (phosphate hemihydrate) | VEGFR , Others , Potassium Channel , LDL , Integrin , Gap Junction Protein , NADPH , Adrenergic Receptor , Autophagy |
Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathom... | |||
T7806 | Licarbazepine | 10,11-hydroxy-10,11 Dihydrocarbamezer | Others |
Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial seizures and bipolar disorders. | |||
T21254 | Vonoprazan Fumarate | TAK-438,TAK 438,Vonoprazan Fumurate,TAK438 | Proton pump |
Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19... | |||
T1615 | Irbesartan | SR-47436,BMS-186295 | Apoptosis , RAAS |
Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist. | |||
T3280 | Clodronate disodium tetrahydrate | clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,Clodronate disodium | IL Receptor , TNF |
Clodronate disodium tetrahydrate (Clastoban) inhibits bone resorption and soft tissue calcification. | |||
T6666 | Sevelamer Carbonate | Others | |
Sevelamer carbonate is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. | |||
T22330 | Fenamic acid | 2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid | Chloride channel |
Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats. Fenamic acid serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), inc... | |||
T26081 | Ridazolol | Ridazololum | |
Ridazolol is a vasodilating and cardioselective beta adrenergic blocker. | |||
T11979 | McN5691 | RWJ26240 | Calcium Channel |
T10813 | Cilobradine hydrochloride | DK-AH 269 | HCN Channel |
Cilobradine hydrochloride (DK-AH 269) is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels. | |||
T26689 | AVE-0118 | AVE 0118,AVE0118 | Potassium Channel |
AVE-0118 is a potassium channel blocker and suppresses persistent atrial fibrillation. | |||
T29050 | UK 66914 | UK66914,UK-66914 | Potassium Channel |
UK 66914 is a K(+) channel blocker for the study of cardiac arrhythmias. | |||
T79835 | Aneratrigine hydrochloride | Sodium Channel | |
Aneratrigine hydrochloride is a sodium channel protein type 9 subunit blocker that may be used for the prevention or treatment of sodium channel blocker-related diseases. | |||
T3557 | GAL-021 | GAL 021 | Potassium Channel |
GAL-021 an intravenous BKCa-channel blocker. | |||
T20341 | DNDS | CFTR | |
DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR). | |||
T15143 | DMP-543 | XR-543 | Others , Potassium Channel |
DMP-543 (XR-543) is a potassium channel (KV7 channel) blocker that enhances the release of neurotransmitters. | |||
T9709 | TRPM8 antagonist 3 | TRP/TRPV Channel | |
TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM). | |||
T15174 | DSP-2230 | Sodium Channel | |
DSP-2230 is a selective blocker of Nav1.7/Nav1.8. | |||
T60010 | BTT-266 | Calcium Channel | |
BTT-266 is a blocker of voltage-gated calcium channel for pain management. | |||
T22745 | DPO-1 | Potassium Channel | |
DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels | |||
T17263 | XEN907 | Others | |
XEN907 is a novel spiro oxindole NaV1.7 blocker. XEN907 also inhibits hNaV1.7 (IC50: 3 nM). | |||
T16514 | PF 04531083 | Others , Sodium Channel | |
PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies. | |||
T3703 | ABT-639 | ABT 639 | Calcium Channel |
ABT-639 is a potent and selective T-type calcium channel blocker. | |||
T31716 | Etidocaine Hydrochloride | W-19053,Duranest,W19053,W 19053 | Sodium Channel |
Etidocaine Hydrochloride (W19053) is a long-acting anesthetic and a blocker of the voltage-gated sodium channel. | |||
T6577 | Manidipine | Iperten,Franidipine,Artedil | Calcium Channel |
Manidipine (Iperten), a calcium channel blocker, which is dihydropyridine type. It is utilized | |||
T1422 | Nilvadipine | FK235,FR34235,ARC029 | Calcium Channel |
Nilvadipine (FK235), a calcium channel blocker (CCB), is utilized for treatment of hypertension. | |||
T2093 | PF 03716556 | PF-3716556 | ATPase |
PF 03716556 (PF-3716556) , an effective and specific P-CAB (potassium-competitive acid blocker), is utilized for the treatment of gastroesophageal reflux disease. | |||
T5640 | GSK2193874 | TRP/TRPV Channel | |
GSK2193874 was identified as a selective, orally active TRPV4 blocker. | |||
T22675 | Co 102862 | V 102862 | Others , Sodium Channel |
Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies. |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T3S0081 | Oxypeucedanin | (+-)-Oxypeucedanin,Oxypeucadanin | Potassium Channel |
1. Oxypeucedanin ((+-)-Oxypeucedanin) has novel anticancer effect, mediated via induction of G2-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells. 2. Oxypeucedanin is a kind of open-channel blocke... | |||
T0801 | Tannic acid | Gallotannic acid | Potassium Channel , HER , CXCR |
Tannic acid (Gallotannic acid) is a novel hERG channel blocker. | |||
T23107 | Ononetin | 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone | TRP/TRPV Channel |
Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM). | |||
T3054 | Daurisoline | (R,R)-Daurisoline | Others , Potassium Channel , Autophagy |
Daurisoline ((R,R)-Daurisoline) is a hERG inhibitor. Daurisoline is also an autophagy blocker. | |||
T6631 | Quinine hydrochloride dihydrate | Quinine HCl Dihydrate | Potassium Channel , Parasite |
Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria. | |||
T0792 | (-)-Sparteine sulfate pentahydrate | (-)-Sparteine Sulfate,Lupinidine sulfate pentahydrate,(-)-Sparteine sulfate salt,sulfate pentahydrate | Sodium Channel |
(-)-Sparteine sulfate pentahydrate ((-)-Sparteine Sulfate) is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium. | |||
T16535 | Picrotoxinin | Chloride channel , GABA Receptor | |
Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties. | |||
T3S0807 | Berbamine | CaMK , NF-κB , Autophagy | |
Berbamine is a natural product extracted from Phellodendron amurense. It acts as a calcium channel blocker and possesses anti-tumor, immunomodulatory, and cardiovascular effects. | |||
T6S0084 | Tuberostemonine | Tuberstemonine | Parasite |
1. Tuberostemonine (Tuberstemonine) exhibits relatively higher intestinal permeabilities. 2. Tuberostemonine acts in part as an open-channel blocker at the crayfish neuromuscular junction. | |||
T7853 | (+)-Sparteine | Pachycarpine | AChR |
(+)-Sparteine (Pachycarpine) is a natural product extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent | |||
T8716 | Physalin F | Apoptosis | |
Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBM... | |||
T27191 | D-Mannuronic Acid | ||
D-Mannuronic Acid is a blocker of the TLR2 and TLR4 downstream signaling pathway. D-Mannuronic Acid effectively inhibits mRNA expression of MyD88 and p65, major subunit of nuclear factor-kappaB. | |||
TMA2106 | (-)-Sparteine | P450 | |
Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 protein in the livers of poor metabolizers. | |||
T3029 | Sparteine sulfate | Depasan,Tocosimplex,Actospar | Others , Sodium Channel |
Sparteine sulfate (Tocosimplex) is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium. | |||
T62265 | (+)-Sparteine sulfate pentahydrate | ||
(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons. | |||
TN3636 | Chlorahololide C | Potassium Channel | |
Chlorahololide C is a potent and selective potassium channel blocker, it exerts potent and selective inhibition on the delayed rectifier (I(K)) K(+) current with the IC(50) value of 3.6 +/- 10.1 mu M. | |||
T75722 | Chlorotoxin TFA | ||
Chlorotoxin TFA, a peptide derived from the Leiurus quinquestriatus scorpion venom, functions as a chloride channel blocker [1] and exhibits anti-cancer activity [2]. | |||
T21266 | Quinine sulfate | ||
Quinidine is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a blocker of K + channel with an IC 50 of 19.9 μM. Quinidine has potential to be used ... | |||
TN3587 | Capillarisin | MMP , ERK , IL Receptor , BCL , VEGFR , TNF , NOS , NF-κB , TLR , MAPK , COX , DNA/RNA Synthesis , Prostaglandin Receptor , JNK , STAT | |
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by ... | |||
TN5061 | Stephanine | Adrenergic Receptor , Antifection | |
l-Stephanine is a potent and highly selective alpha 1 adrenoceptor blocker, inhibits anococcygeus muscle contraction induced by phenylephrine with pA2 values of 6.76. Stephanine shows significant antiplasmodial activitie... | |||
T75697 | 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone | ||
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, exhibits IC50 values of 20.1 μM and 34.1 μM, respectively. Additionally, it demonstr... |
カタログ番号 | 製品名 | ||
---|---|---|---|
L7300 | Potassium Channel Blocker Library | 152 compounds | |
A unique collection of 152 potassium channel blockers and agonists for high throughput and high content screening; | |||
L7400 | Sodium Channel Blocker Library | 118 compounds | |
A unique collection of 118 sodium channel blockers and agonists for high throughput and high content screening; | |||
L5800 | Drug Metabolite/Impurity Library | 197 compounds | |
A unique collection of 197 drug isomers/metabolites for high throughput screening (HTS) and high content screening (HCS); | |||
L7110 | Anti-Hypertension Compound Library | 678 compounds | |
678 hypertension-related small molecules for high-throughput and high-content screening. |