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Search Results for " bone resorption "

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天然化合物

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カタログ番号	製品名	別名	ターゲット
T21616	L-006235	L 006235	Cysteine Protease
	L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.		Cysteine Protease
T13324	VUF11207 fumarate		CXCR , Arrestin
	VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).		CXCR , Arrestin
T6451	Clodronic acid disodium salt	Loron,Clodronate Disodium,Lodronate	Others
	Clodronic acid disodium salt (Lodronate), a bisphosphonate, is a potent antiosteolytic agent which inhibits bone resorption.		Others
T7566	GRGDSPK	EMD 56574	Others
	GRGDSPK (EMD 56574) is an inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules.		Others
T0575	1-Methylimidazole		Others
	1-Methylimidazole is a metabolite of 1-methyl-2-thioimidazole (methimazole) which inhibits bone resorption.		Others
T0379	Risedronic Acid	Risedronate	Others , Transferase
	Risedronic Acid (Risedronate), a pyridinyl biphosphonate, can inhibit osteoclast-mediated bone resorption.		Others , Transferase
T6373	Alendronate sodium hydrate	G-704650,Alendronate,MK 217,Alendronate sodium trihydrate,G-704650 Adronat,Fosamax	Transferase
	Alendronate sodium hydrate (MK 217) is a nitrogen-containing bisphosphonate, which is an effective inhibitor of bone resorption. It is utilized for the treatment and prevention of osteoporosis.		Transferase
T7566L1	GRGDSPK acetate	GRGDSPK acetate(111119-28-9 Free base)	Beta Amyloid
	GRGDSPK acetate shows inhibitory activity against integrin-fibronectin binding and can be used in research on integrins in bone formation and resorption.		Beta Amyloid
T0308	Etidronic acid	HEDPA,Etidronate,HEDP	Apoptosis , Phosphatase , Others , HBV
	Etidronic acid (HEDP) is a diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.		Apoptosis , Phosphatase , Others , HBV
T1041	Risedronate Sodium	NE 58095 Sodium,Risedronic Acid Sodium	HBV , Transferase
	Risedronate Sodium (NE 58095 Sodium) is an aminobisphosphonate derivative of etidronic acid and CALCIUM CHANNEL BLOCKER that inhibits BONE RESORPTION and is used for the treatment of OSTEOPOROSIS.		HBV , Transferase
T0309	Ipriflavone	Osteofix	advanced glycation end products
	Ipriflavone (Osteofix) (Osteofix) is a feed additive and a catabolic agent. It is used to inhibit bone resorption.		advanced glycation end products
T8489	Minodronic acid monohydrate		Transferase
	Minodronic acid monohydrate is an farnesyl diphosphate synthase inhibitor that acts as a bone resorption inhibitor.		Transferase
T21299	Zoledronic acid monohydrate	zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate	Apoptosis , Others , Autophagy
	Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.		Apoptosis , Others , Autophagy
T16394	ONO-5334		SARS-CoV , Cysteine Protease
	ONO-5334 is a selective, orally active and potent histone K inhibitor with anti-SAR-COV-2 and anti-bone resorption activity for the study of osteoporosis.		SARS-CoV , Cysteine Protease
TP1906L1	DPC AJ1951 acetate		Thyroid hormone receptor(THR)
	DPC-AJ1951 acetate, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). And characterized the activity of DPC-AJ1951 acetate in ex vivo and in vivo a...		Thyroid hormone receptor(THR)
T3280	Clodronate disodium tetrahydrate	clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,Clodronate disodium	IL Receptor , TNF
	Clodronate disodium tetrahydrate (Clastoban) inhibits bone resorption and soft tissue calcification.		IL Receptor , TNF
T2188	Thonzonium Bromide		Proton pump , Antibacterial , Autophagy
	Thonzonium bromide is a mono-cationic surfactant that is structurally similar to Farnesol as an antimicrobial agent. It inhibits proton transport in a dose-dependent manner (EC50=69 μM). It inhibits RANKL-induced osteocl...		Proton pump , Antibacterial , Autophagy
T1641	Strontium ranelate	Distrontium renelate,S12911	Calcium Channel , CaSR
	Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both in...		Calcium Channel , CaSR
T0291	Flurbiprofen	dl-Flurbiprofen	Apoptosis , COX , MRP
	Flurbiprofen (dl-Flurbiprofen) is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.		Apoptosis , COX , MRP
T1210	Sodium etidronate	Didronel	Phosphatase
	Sodium etidronate (Didronel) is a synthetic therapeutic diphosphonate analog of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, Sodium etidronate differs from endogenous pyrophospha...		Phosphatase
T70305	Zoledronate trisodium hydrate
	Zoledronate trisodium is a Bone Resorption Inhibitor and Osteoporosis Therapy Adjunct
T27366	FR 78844	FR78844,FR-78844
	FR 78844 is an antagonist of bone resorption.
T69996	A-75943
	A-75943 is a bone resorption inhibitor from streptomyces.
T30836	Cgp 47072	Cgp-47072,Cgp47072
	Cgp 47072 is a bisphosphonate, used in the treatment of bone diseases, particularly where there is uncontrolled bone resorption.
T31902	Galactosylhydroxylysine	Hydroxylysine-galactose
	Galactosylhydroxylysine residues present in bone type I collagen are terminal degradation products of the bone matrix that are released during bone resorption and excreted in the urine.
T20338	Methopterin	NSC 107144,alpha-Methopterin,NSC-107144,10-Methylfolic acid,NSC107144
	Methopterin shows the activation and bone resorption function of murine osteoclasts.
T40463	Relacatib	SB-462795
	Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relac...
T31940	Glucosylgalactosylhydroxylysine	Hydroxylysine-glucose-galactose
	Glucosylgalactosylhydroxylysine is a bone formation and bone resorption marker that is related to bone turnover processes during growth and development as well as metabolic bone diseases.
T29109	VPC12249	VPC-12249,VPC 12249
	VPC12249, a lysophosphatidic acid receptor type 1 (LPA1) antagonist, plays a functional role in osteoclast differentiation and bone resorption activity.
T69443	Aminobutane bisphosphonate
	Aminobutane bisphosphonate is a powerful inhibitor of bone resorption. It can potentially be a useful measure for controlling hypercalcemia in patients with carcinoma.
TP1779	C-telopeptide
	C-telopeptide, a cross-linked peptide derived from type I collagen, is liberated through bone resorption and has demonstrated a correlation with bone mineral density (BMD).
TP2055	Calcitonin (human)
	Endogenous calcitonin receptor agonist. Lowers systemic blood calcium levels and inhibits bone resorption.
T26512	ABD-295
	ABD-295 is an antiresorptive agent, osteoclast inhibitor, and biphenylsulfide derivative. ABD-295 has potent inhibitory effects on osteoclastic bone resorption in vitro. ABD-295 prevents ovariectomy-induced bone loss in ...
T78278	Blosozumab
	Blosozumab (LY2541546), an anti-sclerostin (SOST) antibody, promotes bone formation while decreasing bone resorption, with potential applications in osteoporosis research [1] [2].
T10187	6-Raloxifene-β-D-glucopyranoside		Others
	6-Raloxifene-β-D-glucopyranoside is a benzothiophene glucuronidated at the 6' position. It is a selective and orally active estrogen receptor antagonist. 6-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone l...		Others
T15206	Eldecalcitol	ED-71,2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3	Others
	Eldecalcitol possesses a potent inhibitory effect on bone resorption and induces a significant increase in bone mineral density. Eldecalcitol is an orally active analogue of active vitamin D. It also is used in the treat...		Others
T27602	Incadronate Disodium	YM-175,Cimadronate,YM175,YM 175
	Incadronate Disodium is a bone resorption inhibitor. Incadronate disodium inhibits macrophage migration to site of inflammation in vivo and proliferation and causes apoptosis in cancer cells in vitro.
T36065	N-Oleoyl-L-Serine
	Bone mass and shape is continuously remodeled by the concerted and balanced action of osteoblasts (bone forming cells) and osteoclasts (bone-resorbing cells). The endocannabinoid system plays an essential role in the mai...
T69082	Flurbiprofen sodium
	Flurbiprofen sodium is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting carbonic anhydrase.
T71150	Incadronic acid
	Incadronate, also known as Cimadronate and YM-175, is a bone resorption inhibitor. Incadronate disodium inhibits macrophage migration to site of inflammation in vivo and proliferation and causes apoptosis in cancer cell...
T73770	Galactosylhydroxylysine hydrochloride
	Galactosylhydroxylysine hydrochloride, a bone collagen component generated through hydroxylysine's post-translational glycosylation, is liberated during bone resorption. Its levels increase in cases of metabolic bone los...
TP1779L	C-telopeptide acetate	C-telopeptide acetate(162929-64-8 free base)	Others
			Others
T16092	L-873724		Others
	L-873724 inhibits bone resorption. L-873724 is an effective, selective, and reversible non-basic cathepsin K inhibitor (IC50s: 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respective...		Others
T37413	Calcitonin (salmon) (trifluoroacetate salt)
	Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption. It belongs to the calcitonin family of peptides, which also includes amylin , calcitonin gene-related peptide , and adrenomedu...
T35826	PKC fragment (530-558)
	PKC fragment (530-558) is a peptide fragment of protein kinase C (PKC) and is a potent PKC activator. Protein Kinase C (530-558) significantly inhibits osteoclastic bone resorption.
T36127	TNF-α Antagonist
	TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact sit...
T37409	DPC-AJ1951 (trifluoroacetate salt)	DPC-AJ1951 (trifluoroacetate salt)
	DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogen...
T76657	Human PTH-(1-31)
	Human PTH-(1-31), the 1-31 fragment of human parathyroid hormone, stimulates cAMP release and mildly activates 25-hydroxyvitamin D-1α-hydroxylase. Unlike its full-length counterpart, it promotes bone formation without tr...
T81591	Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat)	Human PTHrP(107-111) amide
	Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat), also known as Human PTHrP (107-111) amide, is a C-terminal fragment of parathyroid hormone-related protein that inhibits bone resorption [1] [2].
T74736	2MD
	2MD, an orally active vitamin D analog, both stimulates periosteal bone formation and decreases trabecular bone resorption, effectively restoring trabecular and cortical bone mass and strength. Additionally, 2MD regulate...

Compounds

L-006235

T21616

Synonym: L 006235

Target: Cysteine Protease

VUF11207 fumarate

T13324

Synonym:

Target: CXCR, Arrestin

Clodronic acid disodium salt

T6451

Synonym: Loron,Clodronate Disodium,Lodronate

Target: Others, Transferase

Alendronate sodium hydrate

T6373

Synonym: G-704650,Alendronate,MK 217,Alendronate sodium trihydrate,G-704650 Adronat,Fosamax

Target: Transferase

GRGDSPK acetate

T7566L1

Synonym: GRGDSPK acetate(111119-28-9 Free base)

Target: Beta Amyloid

Etidronic acid

T0308

Synonym: HEDPA,Etidronate,HEDP

Target: Apoptosis, Phosphatase, Others, HBV

Risedronate Sodium

T1041

Synonym: NE 58095 Sodium,Risedronic Acid Sodium

Target: HBV, Transferase

Ipriflavone

T0309

Synonym: Osteofix

Target: advanced glycation end products

Minodronic acid monohydrate

T8489

Synonym:

Target: Transferase

Zoledronic acid monohydrate

T21299

Synonym: zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate

Target: Apoptosis, Others, Autophagy

ONO-5334

T16394

Synonym:

Target: SARS-CoV, Cysteine Protease

DPC AJ1951 acetate

TP1906L1

Synonym:

Target: Thyroid hormone receptor(THR)

Clodronate disodium tetrahydrate

T3280

Synonym: clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,Clodronate disodium

Target: IL Receptor, TNF

Thonzonium Bromide

T2188

Synonym:

Target: Proton pump, Antibacterial, Autophagy

Strontium ranelate

T1641

Synonym: Distrontium renelate,S12911

Target: Calcium Channel, CaSR

Flurbiprofen

T0291

Synonym: dl-Flurbiprofen

Target: Apoptosis, COX, MRP

Zoledronate trisodium hydrate

Synonym: FR78844,FR-78844

Synonym: Cgp-47072,Cgp47072

Target:

Galactosylhydroxylysine

T31902

Synonym: Hydroxylysine-galactose

Target:

Methopterin

T20338

Synonym: NSC 107144,alpha-Methopterin,NSC-107144,10-Methylfolic acid,NSC107144

Glucosylgalactosylhydroxylysine

T31940

Synonym: Hydroxylysine-glucose-galactose

Target:

VPC12249

T29109

Synonym: VPC-12249,VPC 12249

Target:

Aminobutane bisphosphonate

6-Raloxifene-β-D-glucopyranoside

Synonym: ED-71,2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3

Target: Others

Incadronate Disodium

T27602

Synonym: YM-175,Cimadronate,YM175,YM 175

Galactosylhydroxylysine hydrochloride

T73770

Synonym:

Target:

C-telopeptide acetate

TP1779L

Synonym: C-telopeptide acetate(162929-64-8 free base)

Calcitonin (salmon) (trifluoroacetate salt)

T37413

Synonym:

Target:

PKC fragment (530-558)

DPC-AJ1951 (trifluoroacetate salt)

T37409

Synonym: DPC-AJ1951 (trifluoroacetate salt)

Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat)

T81591

Synonym: Human PTHrP(107-111) amide

カタログ番号	製品名	別名	ターゲット
TN1494	Cimicifugoside H-1		Others
	Cimicifugoside H1 shows the protective function to cerebral neuron during cerebral ischemia.		Others
T2988	(-)-Epigallocatechin Gallate	Epigallocatechol Gallate,EGCG	Ferroptosis , Reactive Oxygen Species , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite , Autophagy
	(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG) blocks the activation of EGF receptors and HER-2 receptor...
TN1117	Veraguensin		p38 MAPK , NF-κB , Antibiotic , Parasite , Antifection
	Veraguensin is derived from Magnolia sp.. Veraguensin inhibits bone resorption and shows high antileishmanial activity.		p38 MAPK , NF-κB , Antibiotic , Parasite , Antifection
T3488	Tectorigenin	4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine	Apoptosis
	Tectorigenin (4',5,7-Trihydroxy-6-methoxyisoflavone) is an O-methylated isoflavone. Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Re...		Apoptosis
T3808	Icariside I	Lcariside I,Icariin I,Icarisid I	Others
	Icariside I (Lcariside I) is isolated from Epimedium herb. It can stimulate osteogenic differentiation of BMSCs and inhibit bone resorption activity of osteoclasts.		Others
T3S0137	Bavachalcone		Antibacterial , Antibiotic
	Bavachalcone is a major bioactive compounds isolated from Psoralea corylifolia L. it may be useful as a therapeutic drug for bone resorption-associated diseases.Bavachalcone can protect the endothelial function by increa...		Antibacterial , Antibiotic
TN2143	3,7,4'-Trihydroxyflavone	Resokaempferol,5-Deoxykampferol	DNA
	3,7,4'-Trihydroxyflavone(5-Deoxykampferol) is a DNA-breaking flavonoid isolated from rosewood heartwood. It inhibits osteoclast differentiation, actin ring formation, and bone resorption in RAW 264.7 cells and bone marro...		DNA
T3804	Neomangiferin	Mangiferin 7-glucoside	Phosphatase
	Neomangiferin (Mangiferin 7-glucoside) has beneficial effects on high fat diet-induced nonalcoholic fatty liver disease in rats. Neomangiferin and mangiferin inhibit tartrate-resistant acid phosphatase, a biochemical mar...		Phosphatase
TN1711	Gossypetin		Antioxidant , p38 MAPK , MAPK , Antibacterial
	Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signaling pathway.Gossypetin exhibits antimutagenic, antiatherosc...		Antioxidant , p38 MAPK , MAPK , Antibacterial
T6316	Calcitriol	Topitriol,Rocaltrol,Calcijex,RO215535,1,25-Dihydroxyvitamin D3	Endogenous Metabolite
	Calcitriol (1,25-Dihydroxyvitamin D3) is a metabolite of vitamin D and a vitamin D receptor (VDR) agonist (IC50=0.4 nM). Calcitriol increases intestinal absorption of calcium and phosphorus, and increases bone resorption...		Endogenous Metabolite
T3S2312	Poncirin	Isosakuranetin-7-neohesperidoside	Apoptosis , Others
	1. Poncirin (Isosakuranetin-7-neohesperidoside) shows a significant in vitro inhibitory effect on the growth of the human gastric cancer cells, SGC-791, in a dose-dependent manner. 2. Poncirin prevents adipogenesis, enha...		Apoptosis , Others
TN1215	(2S)-2'-Methoxykurarinone	2'-Methoxykurarinone,2'-O-Methylkurarinone	Akt , Antifection
	(2S)-2'-Methoxykurarinone is isolated from the roots of Sophora flavescens. (2S)-2'-Methoxykurarinone has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone inhibits osteo...		Akt , Antifection
T4237	Rubiadin-1-methyl ether	Rubiadin 1-methyl ether	Anti-infection , NF-κB
	Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nu...		Anti-infection , NF-κB
T4S0969	Obtusifolin		Antioxidant , NF-κB
	1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be...		Antioxidant , NF-κB
T6677	Sophocarpine		ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT
	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.		ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT
T38799	2,3-Bis(3-indolylmethyl)indole
	2,3-Bis(3-indolylmethyl)indole exhibits concentration-dependent inhibition of RANKL-induced osteoclastogenesis, actin ring formation, and bone resorption.
TN1536	Curculigoside B		Others
	Curculigoside B shows antioxidative and antiosteoporotic activities, it can decrease area of bone resorption pit, osteoclastic formation and TRAP activity.		Others
T31382	Deoxypyridinoline	Lysylpyridinoline
	Deoxypyridinoline is one of two pyridinium cross-links that provide structural stiffness to type I collagen found in bones. It is excreted unmetabolized in urine and is a specific marker of bone resorption and osteoclast...
T72916	Justicidin B
	Justicidin B, a potent lignan, exhibits anticancer and proapoptotic properties, additionally serving as a bone resorption inhibitor. This compound demonstrates robust antiviral, fungicidal, and antiprotozoal effects, alo...
T36295	Echistatin TFA
	Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorpti...
T37008	Reveromycin A
	Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp. It inhibits the mitogenic activity of epidermal growth factor in Balb/MK cells (IC50 = 0.7 μg/ml), displays antip...
TN2775	2-Methoxystypandrone		MMP , BCL , IκB/IKK , GSK-3 , TNF , NOS , NF-κB , Wnt/beta-catenin , COX , JAK , STAT
	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflammation and oxidative stress for preservation of BBB integrit...

天然物製品

(-)-Epigallocatechin Gallate

T2988

Synonym: Epigallocatechol Gallate,EGCG

Target: Ferroptosis, Reactive Oxygen Species, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite, Autophagy

Veraguensin

TN1117

Synonym:

Target: p38 MAPK, NF-κB, Antibiotic, Parasite, Antifection

Tectorigenin

T3488

Synonym: 4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine

Target: Apoptosis

Icariside I

T3808

Synonym: Lcariside I,Icariin I,Icarisid I

Target: Antibacterial, Antibiotic

3,7,4'-Trihydroxyflavone

TN2143

Synonym: Resokaempferol,5-Deoxykampferol

Target: DNA

Neomangiferin

T3804

Synonym: Mangiferin 7-glucoside

Target: Antioxidant, p38 MAPK, MAPK, Antibacterial

Calcitriol

T6316

Synonym: Topitriol,Rocaltrol,Calcijex,RO215535,1,25-Dihydroxyvitamin D3

Target: Endogenous Metabolite

Poncirin

T3S2312

Synonym: Isosakuranetin-7-neohesperidoside

Target: Apoptosis, Others

(2S)-2'-Methoxykurarinone

TN1215

Synonym: 2'-Methoxykurarinone,2'-O-Methylkurarinone

Target: Akt, Antifection

Rubiadin-1-methyl ether

T4237

Synonym: Rubiadin 1-methyl ether

Target: Anti-infection, NF-κB

Obtusifolin

T4S0969

Synonym:

Target: Antioxidant, NF-κB

Sophocarpine

T6677

Synonym:

Target: ERK, p38 MAPK, NF-κB, TLR, COX, HER, JNK, STAT

2,3-Bis(3-indolylmethyl)indole

Synonym: Lysylpyridinoline

Target: MMP, BCL, IκB/IKK, GSK-3, TNF, NOS, NF-κB, Wnt/beta-catenin, COX, JAK, STAT

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00327	M-CSF/CSF1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and th...
TMPH-03262	Cathepsin K Protein, Rat, Recombinant (His)	Rat	E. coli
	Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in...
TMPH-03259	Carbonic Anhydrase 2 Protein, Rat, Recombinant (His)	Rat	E. coli
	Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide abso...
TMPH-01061	Cathepsin K Protein, Human, Recombinant (His)	Human	E. coli
	Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in...
TMPH-02565	Cathepsin K Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thy...
TMPJ-00799	ANXA2 Protein, Human, Recombinant	Human	E. coli
	Annexin A2 (ANXA2) is a member of the annexin family and has roles in the regulation of cellular growth and in signal transduction pathways. ANXA2 protein is associated with sickle cell osteonecrosis and the expression r...
TMPJ-01000	CCL9 Protein, Mouse, Recombinant	Mouse	E. coli
	C-C motif chemokine 9(CCL9) is an 11 kDa, secreted, monomeric polypeptide that belongs to the beta (or CC) intercrine family of chemokines. It is expressed mainly in the liver, lung, and the thymus, although some express...
TMPJ-00508	CTSL Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsin L is an enzyme. Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain-like family of cysteine proteinases. Cathepsin L plays a major role in antigen processing, tu...
TMPJ-01218	M-CSF/CSF1 Protein, Rat, Recombinant	Rat	HEK293 Cells
	Rat Macrophage colony-stimulating factor 1(MCSF,CSF1) is a single-pass type I membrane cytokine. It is a hematopoietic growth factor that plays an essential role in the regulation of survival, proliferation and different...
TMPY-01877	CA5A Protein, Human, Recombinant (His)	Human	E. coli
	Carbonic anhydrase 5A, mitochondrial, also known as Carbonate dehydratase VA, Carbonic anhydrase VA, CA-VA and CA5A, is a member of thealpha-carbonic anhydrase family. Carbonic anhydrases (CAs) are a large family of z...
TMPY-02277	Carbonic Anhydrase 7 Protein, Human, Recombinant (His)	Human	E. coli
	Carbonic anhydrase 7, also known as carbonate dehydratase VII, carbonic anhydrase VII, CA-VII and CA7, is a cytoplasm protein which belongs to thealpha-carbonic anhydrase family. Carbonic anhydrases are a large family...
TMPJ-00701	Carbonic Anhydrase 11 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Carbonic Anhydrase-Related Protein 11 (CA11) is a secreted protein member of the α-carbonic anhydrase family. Carbonic Anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of ...
TMPJ-00731	Carbonic Anhydrase 1 Protein, Human, Recombinant (His)	Human	E. coli
	Carbonic Anhydrase 1 (CA1) is a cytosolic enzyme, belonging to the alpha-carbonic anhydrase family. It is highly expressed in erythrocytes and acts as an early marker for erythroid differentiation. Carbonic anhydrase 1 p...
TMPY-02236	PTH1R Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane pr...
TMPJ-01419	CSF1R Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-l...
TMPJ-01418	CSF1R Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293 Cells
	Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-l...
TMPH-02264	TNFSF11 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator...
TMPH-02571	CD9 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays...
TMPY-00732	Cathepsin C Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsins are proteases found in many types of cells conserved in all animals, which have a vital role in mammalian cellular turnover such as bone resorption. The lysosomal cysteine protease Cathepsin C (CTSC), also kno...
TMPY-02133	Carbonic Anhydrase VB Protein, Human, Recombinant (His)	Human	E. coli
	Carbonic anhydrase 5B, also known as carbonate dehydratase VB, carbonic anhydrase VB, CA-VB and CA5B, is amember of the alpha-carbonic anhydrase family. The strongest expression of CA5B / CA-VB is in heart, pancreas, ...
TMPY-01761	Carbonic Anhydrase 3 Protein, Human, Recombinant (His)	Human	E. coli
	Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including re...

M-CSF/CSF1 Protein, Human, Recombinant (His)

TMPJ-00327

Species: Human

Expression System: HEK293 Cells

Cathepsin K Protein, Rat, Recombinant (His)

TMPH-03262

Species: Rat

Expression System: E. coli

Carbonic Anhydrase 2 Protein, Rat, Recombinant (His)

TMPH-03259

Species: Rat

Expression System: E. coli

Cathepsin K Protein, Human, Recombinant (His)

TMPH-01061

Species: Human

Expression System: E. coli

Cathepsin K Protein, Mouse, Recombinant (His)

TMPH-02565

Species: Mouse

Expression System: E. coli

ANXA2 Protein, Human, Recombinant

TMPJ-00799

Species: Human

Expression System: E. coli

CCL9 Protein, Mouse, Recombinant

TMPJ-01000

Species: Mouse

Expression System: E. coli

CTSL Protein, Human, Recombinant (His)

TMPJ-00508

Species: Human

Expression System: HEK293 Cells

M-CSF/CSF1 Protein, Rat, Recombinant

TMPJ-01218

Species: Rat

Expression System: HEK293 Cells

CA5A Protein, Human, Recombinant (His)

TMPY-01877

Species: Human

Expression System: E. coli

Carbonic Anhydrase 7 Protein, Human, Recombinant (His)

TMPY-02277

Species: Human

Expression System: E. coli

Carbonic Anhydrase 11 Protein, Human, Recombinant (His)

TMPJ-00701

Species: Human

Expression System: HEK293 Cells

Carbonic Anhydrase 1 Protein, Human, Recombinant (His)

TMPJ-00731

Species: Human

Expression System: E. coli

PTH1R Protein, Human, Recombinant (His)

TMPY-02236

Species: Human

Expression System: HEK293 Cells

CSF1R Protein, Cynomolgus, Recombinant (His)

TMPJ-01419

Species: Cynomolgus

Expression System: HEK293 Cells

CSF1R Protein, Cynomolgus, Recombinant (hFc)

TMPJ-01418

Species: Cynomolgus

Expression System: HEK293 Cells

TNFSF11 Protein, Human, Recombinant (His)

TMPH-02264

Species: Human

Expression System: HEK293 Cells

CD9 Protein, Mouse, Recombinant (His)

TMPH-02571

Species: Mouse

Expression System: E. coli

Cathepsin C Protein, Human, Recombinant (His)

TMPY-00732

Species: Human

Expression System: HEK293 Cells

Carbonic Anhydrase VB Protein, Human, Recombinant (His)

TMPY-02133

Species: Human

Expression System: E. coli

Carbonic Anhydrase 3 Protein, Human, Recombinant (His)

TMPY-01761

Species: Human

Expression System: E. coli

カタログ番号	製品名
L7900	Osteogenesis Compound Library		317 compounds
	A unique collection of 317 osteogenesis related compounds for high throughput and high content screening;

ライブラリー

Osteogenesis Compound Library

L7900

Compounds: 317