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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T8322 | BL-918 | Autophagy | |
BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM. | |||
T1414 | Sodium 2-mercaptoethanesulfonate | Mitexan,Uromitexan,Mesna,Mesnum,Mesnex | Others |
Sodium 2-mercaptoethanesulfonate (Uromitexan) is a sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from antineoplastic agents, such as ifosfamide or cyclophosphamide. | |||
T3289 | Amifostine | Ethyol,WR2721,Gammaphos | Others , HIF/HIF Prolyl-Hydroxylase |
Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity. | |||
T6381 | Amifostine trihydrate | Ethyol trihydrate,WR2721,Amifostine | Others , HIF/HIF Prolyl-Hydroxylase |
Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin. | |||
T37538 | Amifostine thiol | ||
Amifostine thiol (WR-1065), the active metabolite of cytoprotector Amifostine, serves as a cytoprotective agent possessing radioprotective properties. It activates p53 via a JNK-dependent signaling pathway[1][2][3]. | |||
T19763 | Cetraxate hydrochloride | DV-1006,DV 1006,Cetraxate HCl,DV1006 | Serine/threonin kinase |
Cetraxate hydrochloride (DV10062) is an oral gastrointestinal medication. It has a cytoprotective effect. | |||
T6710 | Troxipide | Aplace | Others |
Troxipide (Aplace), a new-type systemic non-antisecretory gastric cytoprotective agent, which is mucus-secreting, anti-ulcer, and anti-inflammatory properties irrespective of pH of stomach or duodenum. | |||
T6919 | Omaveloxolone | RTA-408 | Apoptosis , Others , Nrf2 , STING |
Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2. | |||
T1338 | Sucralfate | Sucrose octasulfate–aluminum complex | FGFR , Others , Antibacterial , Prostaglandin Receptor |
Sucralfate (Sucrose octasulfate–aluminum complex) is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of active duodenal ulcers. | |||
T0988 | Trimetazidine dihydrochloride | Yoshimilon,Kyurinett,Vastarel F | Autophagy , Fatty Acid Synthase |
Trimetazidine dihydrochloride (Vastarel F) can improve myocardial glucose utilization by inhibiting fatty acid metabolism. Trimetazidine is the first cytoprotective anti-ischemic agent, also used as a vasodilator in isch... | |||
T16865 | SCH28080 | ATPase , Proton pump | |
SCH28080 is a reversible and K+-competitive inhibitor of gastric H+/K+-ATPase with an IC50 value of 20 nM (rabbit microsomal membrane).SCH28080 is a potent inhibitor of acid secretion in vivo with anti-ulcer activity, an... | |||
T31773 | Fenlean | FLZ | Beta Amyloid , Src |
Fenlean (FLZ) is a tyrosine kinase Src inhibitor, a synthetic cyclic derivative of squamous amide from Annona glabra, with cytoprotective activity, which protects tyrosine hydroxylase function in a chronic MPTP/prostagla... | |||
T0825 | Ebselen | SPI-1005,PZ-51,CCG-39161 | Phosphatase , Virus Protease , Calcium Channel , COX , HIV Protease |
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b... | |||
T2170 | SKF-96365 hydrochloride | SKF96365 | Apoptosis , Potassium Channel , Calcium Channel , TRP/TRPV Channel , Autophagy |
SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autopha... | |||
T32230 | Isosalipurposide | Phlorizin chalcone | |
Isosalipurposide, a chalcone compound, exerts a cytoprotective effect against oxidative injury via Nrf2 activation. | |||
T28929 | TBE-31 | TBE 31 | |
TBE-31 is a highly potent activator of Nrf2, a liver carcinogenesis blocker and a potent phase 2 cytoprotective pathway inducer. | |||
T34450 | Rumbrin | ||
Rumbrin is a cytoprotective compound produced by Auxarthron umbrinum. | |||
T25498 | Hexapradol | ||
Hexapradol is a new antiulcer compound with a cytoprotective action. | |||
T40802 | Poloxamer 188 | ||
Poloxamer 188, a nonionic linear copolymer possessing surfactant properties, demonstrates anti-thrombotic, anti-inflammatory, and cytoprotective activities across different tissue injury models. | |||
T33390 | MIND4 | MIND 4,MIND-4 | |
Mind4 is an inducer of cytoprotective Nrf2 activity. Mind4 induces Nrf2 activation and reduces the production of reactive oxygen species and nitrogen intermediates in neurons and non neurons. | |||
T68374 | 8-Nitro-cGMP | ||
8-Nitro-cGMP is a unique cytoprotective mediator which inhibits oxidative stress. 8-Nitro-cGMP is also a probe of the protein S-guanylation. | |||
T11752 | Keap1-Nrf2-IN-1 | Keap1–Nrf2-IN-1 | Src |
Keap1–Nrf2 IN-1 activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models. Keap1–Nrf2 IN-1 is a Kelch-like ECH-associated protein 1-nuclear fa... | |||
TP1124 | IGF-I (24-41) | Insulin-like Growth Factor I (24-41),IGF-I 24-41 | |
IGF-I (24-41) is a 24-41 amino acid fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, a... | |||
TP1123 | IGF-I (24-41) TFA (135861-49-3 free base) | Insulin-like Growth Factor I (24-41) (TFA),IGF-I (24-41) TFA | |
IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions).IGF-I (24-41) (TFA) is amino acids 24 to ... | |||
T38800 | MMPI-1154 | ||
MMPI-1154 is a highly promising imidazole-carboxylic acid (ICA) MMP-2 inhibitor (IC 50 = 6.6 μM) with excellent cardio-cytoprotective properties. It is specifically designed for the study of acute myocardial infarction. ... | |||
TP1247 | ACTH (1-13) | Adrenocorticotropic Hormone (1-13),ACTH 1-13 | |
ACTH (1-13) is a 13-aa peptide, with cytoprotective effects in the model of ethanol induced gastric lesions in rats.Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the anterio... | |||
T12662 | (Rac)-BL-918 | Others | |
(Rac)-BL-918 is the racemate of BL-918. BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM, inducing cytoprotective autophagy for Parkinson’s disease treatment [1]. | |||
T73156 | LabMol-301 | ||
LabMol-301, a chemical compound, effectively inhibits NS5 RdRp and NS2B-NS3pro activity with IC50 values of 0.8 μM and 7.4 μM, respectively. Additionally, it exhibits cytoprotective effects, safeguarding against Zika vir... | |||
T35961 | Prostaglandin Bx | ||
PGBx is a mixture of oligomers of PGB1 with a molecular weight of 1,000-1,500. It has antioxidant and free radical trapping activity that was first studied in isolated mitochondria.1 PGBx has anti-inflammatory and cytopr... | |||
T78690 | MAO-B-IN-18 | Monoamine Oxidase | |
MAO-B-IN-18 is a potent, selective inhibitor of MAO B, demonstrating IC50 values of 52 nM for hMAO B and 14 μM for hMAO A. It exhibits cytoprotective effects against hydrogen peroxide-induced damage in neuroblastoma and ... | |||
T64218 | Keap1-Nrf2-IN-1 TFA | ||
Keap1-Nrf2-IN-1 TFA (compound35) is a Keap1-Nrf2 protein-protein interaction inhibitor (IC50: 43 nM) that activates Nrf2-regulated cytoprotective responses. Keap1-Nrf2-IN-1 TFA antagonizes acetaminophen-induced liver inj... | |||
T41251 | Taprostene | ||
Taprostene (CG-4203), a synthetic and chemically stable analogue of Prostacyclin (PGI2), effectively protects the endothelium and myocardium following acute myocardial ischemia and reperfusion in cats. It enhances cytopr... | |||
T76012 | IGF-I (30-41) (TFA) | ||
IGF-I (30-41) (TFA) is a fragment consisting of amino acids 30 to 41 from Insulin-like Growth Factor I (IGF-I), a compound responsible in part for systemic GH (Growth Hormone) activities. It exhibits an array of properti... | |||
T35860 | AP39 | ||
AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an ... | |||
T36614 | DL-Sulforaphane N-acetyl-L-cysteine | ||
Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressor... | |||
T75074 | 6-Methoxypurine-9-β-D-5’(R)-C-methylriboside | ||
6-Methoxypurine-9-β-D-5’(R)-C-methylriboside, an analog of hypoxanthine—a purine base predominantly found in muscle tissue and a metabolite generated when purine oxidase acts on xanthine—displays anti-inflammatory proper... | |||
T76014 | IGF-I (24-41) (TFA) | ||
Insulin-like Growth Factor I (24-41) TFA, a fragment comprising amino acids 24 to 41 of the full IGF-I TFA molecule, is a variant of IGF-I TFA, which itself is a 70 amino acid polypeptide hormone. This hormone serves as ... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T8276 | Methyl palmitoleate | Others | |
Palmitoleic acid methyl ester is an ester version of palmitoleic acid, an ω-7 monounsaturated fatty acid that is a common constituent of the triglycerides of human adipose tissue. | |||
T3761 | 1-Octacosanol | n-Octacosanol,Montanyl alcohol,Cluytyl alcohol,Octacosanol,Octacosyl alcohol,Octanosol | Others |
1-Octacosanol (Octanosol) is a straight-chain aliphatic 28-carbon primary fatty alcohol that is used as a nutritional supplement. It is reported to possess cholesterol-lowering effects, antiaggregatory properties, cytopr... | |||
T7792 | Hispidin | Endogenous Metabolite , PKC | |
Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective properties | |||
TN2259 | Taurocholic acid | N-Choloyltaurine | TNF , PI3K |
Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-alpha-induced cholangiocyte damage via a PI3K-mediated pathwa... | |||
TN1917 | Mauritianin | Topoisomerase | |
Mauritianin is a kaempferol glycoside isolated from the flowers and leaves of Acalypha indica and is a topoisomerase I inhibitor.Mauritianin has cytoprotective activity. | |||
T5720 | Boldine | 1,10-Dimethoxy-2,9-dihydroxyaporphine,ex Peumus boldus | RANKL/RANK |
Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) is a natual product .Boldine displays anti-cancer, cytoprotective , anti-oxidant and anti-inflammatory activities. | |||
TN1016 | Kukoamine A | NF-κB , Lipoxygenase , DNA/RNA Synthesis , Parasite | |
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative stress and apoptosis after whole-brain irradiation (WBI) i... | |||
T12451 | PEP 3CHA | PEP 3 CHA,Phosphoenolpyruvic acid tricyclohexylammonium salt | Others |
Phosphoenolpyruvic acid tricyclohexylammonium salt (PEP 3 CHA) is a functional carbohydrate metabolite with cytoprotective and anti-oxidative activity. Phosphoenolpyruvic acid tricyclohexylammonium salt is able to penetr... | |||
T29078 | Ursodeoxycholic acid sodium | UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium | FXR , Endogenous Metabolite , GPCR19 |
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts as signaling molecule, exerting it... | |||
TN1711 | Gossypetin | Antioxidant , p38 MAPK , MAPK , Antibacterial | |
Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signaling pathway.Gossypetin exhibits antimutagenic, antiatherosc... | |||
TN3048 | 4-Methoxycinnamaldehyde | p-Methoxycinnamaldehyde | RSV |
4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde) is an active ingredient of Agastache rugosa.4-Methoxycinnamaldehyde has cytoprotective activity against respiratory syncytial virus (RSV) in human laryngeal carcinoma cel... | |||
T3228 | Fosfructose | D-fructose-1,6-diphosphate,Betulanonaprenol,4937-84-2,Diphosphofructose,Fructose 1,6-diphosphate,D-fructofuranose 1,6-bisphosphate,Esafosfan | Others , Endogenous Metabolite |
D-fructose-1,6-diphosphate (D-fructose-1,6-diphosphate), also known as Fosfructose, is a cytoprotective natural sugar phosphate. It functions by promoting anaerobic glycolysis, which generates adenosine triphosphate (ATP... | |||
T8074 | Esafosfan trisodium | Fosfructose trisodium,D-Fructose-1,6-diphosphate trisodium salt octahydrate,FDP trisodium,Diphosphofructose trisodium | Others , Endogenous Metabolite |
Esafosfan trisodium (FDP trisodium) is a cytoprotective natural sugar phosphate for the potential treatment of sickle cell anemia, cardiovascular ischemia and asthma. It acts by stimulating anaerobic glycolysis which gen... | |||
TN1413 | Atranorin | Endogenous Metabolite , NO Synthase , Ras | |
Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent depending on the radical, also, it will exert cytoprotectiv... | |||
T37152 | 3-Methyl-2-cyclopenten-1-one | Endogenous Metabolite | |
3-Methyl-2-cyclopenten-1-one can be used as a food additive to improve the flavor of meat and meat products at 2-5 ppm. Addition of 3-Methyl-2-cyclopenten-1-one showed gastric cytoprotective activity when administered or... | |||
T3426 | Bacoside A | MMP , Others , TNF , Dopamine Receptor , NOS , ROS | |
Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotective efficacy by attenuation of ROS generated through oxidat... | |||
T3415 | Secoisolariciresinol diglucoside | LGM2605 | ROS |
Secoisolariciresinol diglucoside (LGM2605) was cytoprotective in an in vitro model of iron overload-induced redox-inflammatory damage. Secoisolariciresinol diglucoside (25 mg/kg b.w.) exerts the antihyperglycemic effect ... | |||
T3S0509 | Gaultherin | COX | |
Gaultherin has analgesic, and anti-inflammatory activities.Gaultherin lacks gastric ulcerogenic effect, because of it released salicylate in intestine slowly, not in stomach and it left the cyclooxygenase-1 unaffected, w... | |||
T6429 | Caffeic Acid Phenethyl Ester | Phenylethyl Caffeate,CAPE | Apoptosis , NF-κB |
Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective... | |||
TN1269 | 3β-Methoxy-2,3-dihydrowithaferin A | 3beta-Methoxy-2,3-dihydrowithaferin A | MAPK , Akt |
3beta-Methoxy-2,3-dihydrowithaferin A has cytoprotective activity, it protects normal cells against stress. | |||
TN2249 | (+)-Syringaresinol | Sirtuin , Antifection | |
(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2. | |||
TN6510 | Cordifolioside A | ||
Cordifolioside A possesses immunomodulatory activity, it has a potential in vivo radioprotective effect as well as in vitro cytoprotective activity. | |||
TN1670 | Ganodermanondiol | HIV Protease , Nrf2 , AMPK | |
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK. | |||
TN1578 | Dihydroconiferyl alcohol | Others | |
Dihydroconiferyl alcohol exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2. | |||
TN1366 | Alcesefoliside | Others | |
Alcesefoliside has statistically significant cytoprotective activity similar to that of silymarin, tested at 60 ug/mL. | |||
TN4426 | Leojaponin | AChR | |
Leojaponin is a prolyl oligopeptidase (POP) inhibitor. Leojaponin exhibits significant cytoprotective activities against glutamate-induced toxicity at concentrations ranging from 0.1 microm to 10 microm. | |||
TN2936 | 3-Hydroxy-11-ursen-28,13-olide | Others | |
3β-Hydroxy-urs-11-en-28,13β-olide shows a potent concentration-independent cytoprotective effect against CCl4-induced injury on human hepatoma cell line relative to silymarin as a reference standard. It exhibits weak-mod... | |||
TN5369 | Dehydroleucodine | Dehydroleucodin | |
Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating a... | |||
T81532 | Pedaliin 6''-acetate | ||
Pedaliin 6''-acetate (compound 10), a natural product extracted from Dracocephalum tanguticum, exhibits antioxidative properties and a cytoprotective effect against doxorubicin (DOX)-induced toxicity in H9c2 cardiomyocyt... | |||
T83319 | 4-epi-Withaferin A | ||
4-epi-Withaferin A (compound 28), an analogue of Withaferin A, exhibits enhanced cytotoxicity and cytoprotective heat-shock-inducing activity (HSA). It shows promise for the investigation of protein aggregation-associate... | |||
TN4635 | Neoechinulin A | NADPH-oxidase , Beta Amyloid , ASK , IκB/IKK , p38 MAPK , TNF , NOS , NF-κB , COX , Prostaglandin Receptor | |
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) ... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPH-01432 | HMOX1 Protein, Human, Recombinant (His) | Human | E. coli |
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygena... | |||
TMPH-02615 | CBS Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cystei... | |||
TMPY-01577 | ORP150 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Hypoxia up-regulated protein 1, also known as 15 kDa oxygen-regulated protein, 17 kDa glucose-regulated protein, ORP-15, GRP-17, and HYOU1, is a member of the heat shock protein 7 family. Seven members from four differen... | |||
TMPJ-00091 | G-CSF Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Granulocyte colony-stimulating factor (G-CSF) is a growth factor and an essential cytokine which belongs to the IL-6 superfamily. Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis ... |