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Search Results for " G2/M "

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196

阻害剤

天然化合物

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T22260	Aminopurvalanol A		CDK
	Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 n...		CDK
T1753	D-64131		Microtubule Associated
	D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.		Microtubule Associated
T9812	Tubulin inhibitor 24		Microtubule Associated
	Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization.		Microtubule Associated
T12575	Unesbulin	PTC596	Apoptosis , BMI-1
	Unesbulin (PTC596) is an orally active and selective inhibitor of B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1).		Apoptosis , BMI-1
T19664	ON1231320	GBO-006	Apoptosis , PLK
	ON1231320 (GBO-006) is a Polo-like kinase 2 (PLK2) inhibitor.		Apoptosis , PLK
T8342	BRD9876		Others , Kinesin , Microtubule Associated
	BRD9876 is a selective inhibitor of MM1S growth.		Others , Kinesin , Microtubule Associated
T3459	VK3-OCH3	2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na	Others
	VK3-OCH3 (2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na) is a selective antitumor agent via heme oxygenase (HO-1) related mechanisms; Vitamine K3 analogue.		Others
T4189	4-Oxofenretinide	3-Keto fenretinide	cell cycle arrest
	4-Oxofenretinide (3-Keto fenretinide) , a recently identified fenretinide metabolite, induces marked m>G2m>-M cell cycle arrest and apoptosis.		cell cycle arrest
T10723	CDC25B-IN-1	ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate	Phosphatase
	CDC25B-IN-1 is an inhibitor of CDC25B with a Ki of 8.5 μM. CDC25B-IN-1 increases the m>G2m>/M phase by inhibiting cell proliferation and colony formation.		Phosphatase
T3485	Probimane	AT-2153,MM-159	Others
	Probimane (AT-2153) had Anti-proliferative effects, cell cycle m>G2m>/M phase arrest and blocking of chromosome segregation in human tumor cell lines with MST-16.		Others
T9595	LP-261		Microtubule Associated
	LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing m>G2m>/M arrest.		Microtubule Associated
T5699	SSE15206		Apoptosis , Microtubule Associated
	SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in m>G2m>/M arrest due to incomplete spindle formation in cancer cells.		Apoptosis , Microtubule Associated
T63732	EGFR-IN-3		Apoptosis , EGFR
	EGFR-IN-3 is an EGFR inhibitor with potential antitumour activity.EGFR-IN-3 inhibits EGFRwt-TK and induces apoptosis (cell death), which can cause cells to block in the m>G2m>/M phase.		Apoptosis , EGFR
T78701	Tubulin inhibitor 32		Apoptosis
	Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in m>G2m>/M phase.		Apoptosis
T6864	Ixabepilone	BMS 247550,Ixempra,Azaepothilone B,BMS 247550-1	Apoptosis , Microtubule Associated
	Ixabepilone (Azaepothilone B) is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the m>G2m>-M phase of the cell ...		Apoptosis , Microtubule Associated
T60129	MT189	Antiproliferative agent-14	Microtubule Associated
	MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the abilit...		Microtubule Associated
T77729	MY-1076		Apoptosis , YAP
	MY-1076 is a potent YAP inhibitor with antigastric cancer activity.MY-1076 dose-dependently induced m>G2m>/M phase block, induced YAP degradation and apoptosis, and inhibited microtubule protein polymerization.MY-1076 inhibi...		Apoptosis , YAP
T64923	Sodium citrate	Citrosodine,Natrocitral	Others
	Sodium citrate (Natrocitral) is the sodium salt of citric acid.Citric acid trisodium induces apoptosis and cell cycle arrest at m>G2m>/M phase and S phase. Sodium citrate cause oxidative damage of the liver by means of the d...		Others
T67746	IMS2186		Others
	IMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in m>G2m>/M phase, result in exerting anti-proliferation and anti-angiogenesis effects. IMS2186 reduces the...		Others
T23601	ABC1183	ABC 1183,ABC-1183	GSK-3 , CDK
	ABC1183 is a novel diaminothiazole that inhibits GSK3α, GSK3β and CDK9. ABC1183 inhibits the growth of a numerous cancer cell lines by decreasing cell survival by inducing m>G2m>/M arrest and through altering GSK3, glycogen ...		GSK-3 , CDK
T16750	Rigosertib	ON-01910	Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
	Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kina...		Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
T28886	Suprafenacine	N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide	Microtubule Associated
	Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) is a cell-permeable microtubule destabilizer that induces cell cycle arrest and apoptosis in m>G2m>/M phase. Suprafenacine ...		Microtubule Associated
T63992	KS100
	KS100 is a potent inhibitor of ALDH, acting on ALDH1A1 (IC50: 334 nM), ALDH2 (IC50: 2137 nM) and ALDH3A1 (IC50: 360 nM). KS100 significantly increases ROS activity, lipid peroxidation and the accumulation of toxic aldehy...
T4451	Estramustine phosphate sodium	Ro 21-8837/001,Estramustine phosphate disodium	Apoptosis , Microtubule Associated
	Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the m>G2m>/M phase of the cell cycle.		Apoptosis , Microtubule Associated
T8756	KRAS inhibitor-9	DUN09716	Apoptosis , Ras
	KRAS inhibitor-9 (DUN09716) is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes m>G2m>/M cell cycle arrest and induces apoptosis. KRAS ...		Apoptosis , Ras
T77647	Tubulin polymerization-IN-43		Apoptosis , Microtubule Associated
	Tubulin polymerization-IN-43 is an inhibitor of tubulin polymerisation.Tubulin polymerization-IN-43 has multiple effects, disrupting the cellular microtubule network by targeting the colchicine locus and promoting cell c...		Apoptosis , Microtubule Associated
T27407	GDC0575 monohydrochloride	ARRY-575,GDC-0575,GDC 0575,ARRY575,GDC0575	Chk
	GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells by...		Chk
T78157	PARP-1-IN-3		Apoptosis , PARP
	PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-inflammatory activity, induces apoptosis, and arrests the cell...		Apoptosis , PARP
T2090	Lexibulin	CYT-997	Apoptosis , Reactive Oxygen Species , Microtubule Associated
	Lexibulin (CYT-997)(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and leading to cell cycle arrest at the m>G2m>/M phase; this...
T3124	Carbendazim	Bavistin,Carbendazole,Mercarzole	Antifungal
	Carbendazim (Mercarzole) is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities. Although the exact mechanism of action is unclear, carbendazim appears to binds to an unspec...		Antifungal
T41163	ZNL 02-096	Pomalidomide-C3-adavosertib	Apoptosis , Wee1
	ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL ...		Apoptosis , Wee1
T0009	Flubendazole	Flumoxanal,Flumoxane,NSC 313680,Fluvermal	Apoptosis , Microtubule Associated , Parasite
	Flubendazole (Flumoxane) is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.		Apoptosis , Microtubule Associated , Parasite
T19661	8-Chloroadenosine	NSC 354258,8-Cl-Ado,NSC354258,NSC-354258	AMPK
	8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Ch...		AMPK
T0440	Oxcarbazepine	GP 47680	Apoptosis , Sodium Channel
	Oxcarbazepine (GP 47680) is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity.		Apoptosis , Sodium Channel
T5818	Rigosertib sodium	Rigosertib,Estybon,ON-01910	Apoptosis , PLK , PI3K
	Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.		Apoptosis , PLK , PI3K
T71259	GNE-900	GNE900,GNE 900	Apoptosis , Chk
	GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 ...		Apoptosis , Chk
T13901	SS28		Microtubule Associated
	SS28 inhibits tubulin polymerization to cause cell cycle arrest at m>G2m>/M phase.		Microtubule Associated
T29449	5-AcTMF	5-ATMF,5-ATAN,5 ATMF
	5-AcTMF is an inducer of m>G2m>/M arrest, apoptosis and autophagy in cancer cells.
T31004	Compound 8H	Compound-8H,Compound 8-H,Compound 343
	Compound 8H is an inducer of m>G2m>/M-phase cell cycle arrest and cell death in cancer cell lines.
T30768	CB-403	UNII-4V9Q0C88UK,CB403,CB 403
	CB-403 is a cinnamaldehyde derivative that has antitumor effects by blocking cell cycle progression in the m>G2m>/M phase.
TQ0016	NKP-1339	IT-139,KP-1339	DNA/RNA Synthesis
	NKP-1339 (IT-139) induces m>G2m>/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway.		DNA/RNA Synthesis
T23726	WB-308	WB308
	WB-308 is an EGFR inhibitor that acts by decreasing NSCLC cell proliferation and colony formation and causing m>G2m>/M arrest and apoptosis.
T83020	Antiproliferative agent-37
	Antiproliferative agent-37 (compound 10J) inhibits cell proliferation by arresting cells at the m>G2m>/M phase of the cell cycle [1].
T13227	Tubulin inhibitor 1		Microtubule Associated
	Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, induces cellular apoptosis causes and cellular mitotic arrest in the m>G2m>/M phase.		Microtubule Associated
T23817	BPTQ	B-P-T-Q
	BPTQ is a typical intercalator of DNA that acts by inducing a dose-dependent inhibitory effect on the proliferation of cancer cells by arresting cells at the S and m>G2m>/M phase.
T73413	Cadein1
	Cadein1, an isoquinolinium derivative, induces m>G2m>/M phase delay and caspase-dependent apoptosis in cancer cells lacking functional p53.
T72817	Colibactin 742
	Colibactin 742, a stable derivative of colibactin, efficiently induces DNA interstrand cross-links, activates the Fanconi Anemia DNA repair pathway, and leads to m>G2m>/M arrest.
T62458	EGFR-IN-56
	EGFR-IN-56 (Compound 13a) is a potent inhibitor of EGFR, acting on EGFRT790M (IC50: 541.7 nM) and EGFRT790M/L858R (IC50: 132.1 nM). EGFR-IN-56 blocks the cell cycle of cancer cells in the m>G2m>/M phase and induces EGFR-IN-5...
T61129	Tubulin polymerization-IN-27
	Tubulin polymerization-IN-27 (compound 5j) is an inhibitor of tubulin polymerization. It has the ability to halt the cell cycle specifically at the m>G2m>/M phase and also induce apoptosis [1].
T64034	Antitumor agent-45
	Antitumor agent-45 has an inhibitory effect on c-Met expression and is able to block A549 cells in the G0/G1 and m>G2m>/M phases and induce apoptosis.

Compounds

Target: Microtubule Associated

Tubulin inhibitor 24

T9812

Synonym:

Target: Microtubule Associated

Unesbulin

T12575

Synonym: PTC596

Target: Apoptosis, BMI-1

ON1231320

T19664

Synonym: GBO-006

Target: Apoptosis, PLK

BRD9876

T8342

Synonym:

Target: Others, Kinesin, Microtubule Associated

VK3-OCH3

T3459

Synonym: 2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na

Target: Others

4-Oxofenretinide

T4189

Synonym: 3-Keto fenretinide

Target: cell cycle arrest

CDC25B-IN-1

T10723

Synonym: ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate

Target: Phosphatase

Probimane

T3485

Synonym: AT-2153,MM-159

Target: Microtubule Associated

SSE15206

T5699

Synonym:

Target: Apoptosis, Microtubule Associated

EGFR-IN-3

T63732

Synonym:

Target: Apoptosis, EGFR

Synonym: BMS 247550,Ixempra,Azaepothilone B,BMS 247550-1

Target: Apoptosis, Microtubule Associated

MT189

T60129

Synonym: Antiproliferative agent-14

Target: Microtubule Associated

MY-1076

T77729

Synonym:

Target: Apoptosis, YAP

Sodium citrate

T64923

Synonym: Citrosodine,Natrocitral

Synonym: ABC 1183,ABC-1183

Target: Apoptosis, FLT, PLK, PI3K, Bcr-Abl, CDK, PDGFR, Src

Suprafenacine

T28886

Synonym: N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide

Target: Microtubule Associated

Estramustine phosphate sodium

T4451

Synonym: Ro 21-8837/001,Estramustine phosphate disodium

Target: Apoptosis, Microtubule Associated

KRAS inhibitor-9

T8756

Synonym: DUN09716

Target: Apoptosis, Ras

Tubulin polymerization-IN-43

T77647

Synonym:

Target: Apoptosis, Microtubule Associated

GDC0575 monohydrochloride

T27407

Synonym: ARRY-575,GDC-0575,GDC 0575,ARRY575,GDC0575

Target: Apoptosis, PARP

Lexibulin

T2090

Synonym: CYT-997

Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated

Carbendazim

T3124

Synonym: Bavistin,Carbendazole,Mercarzole

Target: Antifungal

ZNL 02-096

T41163

Synonym: Pomalidomide-C3-adavosertib

Target: Apoptosis, Wee1

Flubendazole

T0009

Synonym: Flumoxanal,Flumoxane,NSC 313680,Fluvermal

Target: Apoptosis, Microtubule Associated, Parasite

8-Chloroadenosine

T19661

Synonym: NSC 354258,8-Cl-Ado,NSC354258,NSC-354258

Target: Apoptosis, Sodium Channel

Rigosertib sodium

T5818

Synonym: Rigosertib,Estybon,ON-01910

Target: Apoptosis, PLK, PI3K

GNE-900

T71259

Synonym: GNE900,GNE 900

Target: Apoptosis, Chk

SS28

T13901

Synonym:

Target: Microtubule Associated

5-AcTMF

T29449

Synonym: 5-ATMF,5-ATAN,5 ATMF

Target:

Compound 8H

T31004

Synonym: Compound-8H,Compound 8-H,Compound 343

Target:

CB-403

T30768

Synonym: UNII-4V9Q0C88UK,CB403,CB 403

Target:

NKP-1339

TQ0016

Synonym: IT-139,KP-1339

Target: DNA/RNA Synthesis

Antiproliferative agent-37

Target: Microtubule Associated

Tubulin polymerization-IN-27

カタログ番号	製品名	別名	ターゲット
TQ0089	Juglanin		Apoptosis , JNK , Autophagy
	Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.		Apoptosis , JNK , Autophagy
T5669	Citric acid monohydrate		Others
	Citric Acid Monohydrate is a tricarboxylic acid found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains stability of active ingredients a...		Others
T5S0636	Citric acid	Citro,Citretten	Apoptosis , Others , Endogenous Metabolite , Antibacterial , Antibiotic
	1. Citric acid (Citro) (1-2 g/kg) can decrease brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation. 2. Citric acid denture cleansers can reduce C. albicans biofilm accumulation and cell viabili...
T2764	(S)-10-Hydroxycamptothecin	10-Hydroxycamptothecin,10-HCPT	Apoptosis , Topoisomerase
	(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.		Apoptosis , Topoisomerase
T3981	Acacetin	4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin	Apoptosis , IAP , COX , Autophagy
	Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.		Apoptosis , IAP , COX , Autophagy
TN2058	Persicogenin		Anti-infection
	Persicogenin has anticancer, antimutagenic, and antileishmanial activities, it can inhibit the proliferation of mouse tsFT210 cancer cells, it mainly inhibits cell cycle at the m>G2m>/M phase in a dose-dependent manner.		Anti-infection
TN2554	1-Monopalmitin	Glyceryl palmitate	Apoptosis
	1-Monopalmitin (Glyceryl palmitate) is a small molecule compound extracted from Mougeotia nummuloides and Spirulina major with potential antitumor activity, inhibiting proliferation of A549 and SPC-A1 cells, and inducing...		Apoptosis
T4S1335	Daphnoretin	Dephnoretin,Thymelol	Influenza Virus , Caspase , PKC
	1. Daphnoretin (Thymelol) has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells, might through ...		Influenza Virus , Caspase , PKC
TN2254	Taccalonolide A		Apoptosis , Microtubule Associated
	Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these ...		Apoptosis , Microtubule Associated
T5S1952	9-Methoxycamptothecin		Apoptosis , Topoisomerase
	9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.		Apoptosis , Topoisomerase
T3S0081	Oxypeucedanin	(+-)-Oxypeucedanin,Oxypeucadanin	Potassium Channel
	1. Oxypeucedanin ((+-)-Oxypeucedanin) has novel anticancer effect, mediated via induction of m>G2m>-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells. 2. Oxypeucedanin is a kind of open-channel blocke...		Potassium Channel
T6S2315	Polyphyllin VI		Apoptosis , Antibacterial , Pyroptosis
	1. Polyphyllin VI has hemostasis , expectorant , bacteriostasis, anticytotoxic, anti pregnancy kill sperm effects.		Apoptosis , Antibacterial , Pyroptosis
T2966	Beta-Sitosterol	Cupreol,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,22,23-Dihydrostigmasterol,Betaprost	Apoptosis , Lipase , Endogenous Metabolite
	Beta-Sitosterol (SKF 14463) has recently been shown to induce m>G2m>/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol foun...		Apoptosis , Lipase , Endogenous Metabolite
T5497	AMAROGENTIN		Apoptosis , AMPK
	Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell cycle and apoptosis		Apoptosis , AMPK
T7032	Eupatorin		Others , P450
	Eupatorin has antiproliferative and antiangiogenic effects. Eupatorin has antiproliferative and cytostatic effects on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism. Eupatorin-induced cell death is ...		Others , P450
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
T0186	Docetaxel trihydrate	RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate	Apoptosis , BCL , Microtubule Associated
			Apoptosis , BCL , Microtubule Associated
T3895	Polyphyllin I		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
	Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha...		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
T5S0055	Chelidonine	Helidonine,Khelidonin,Stylophorin	Apoptosis , Others , Influenza Virus
	1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model ...		Apoptosis , Others , Influenza Virus
T81818	Metachromins X
	Metachromin X, a sesquiterpene quinone, halts the cell cycle of HeLa/Fucci2 cells at the S/m>G2m>/M phase [1].
TN4154	Gomisin L1		Others
	(-)-Gomisin L1 induces m>G2m>/M arrest and apoptosis in human ovarian cancer cells.		Others
TN6547	Angustifoline
	Angustifoline has activity against gram-positive bacteria. It inhibits human colon cancer cell growth by inducing autophagy along with mitochondrial-mediated apoptosis, suppression of cell invasion and migration and stim...
T75698	Xylopine
	Xylopine, an aporphine alkaloid, exhibits cytotoxic effects on cancer cells by inducing oxidative stress, provoking m>G2m>/M cell cycle arrest, and triggering apoptosis [1].
T72965	Inuviscolide
	Inuviscolide, an apoptosis inducer, demonstrates the capacity to induce m>G2m>/M arrest in human melanoma cell lines. Exhibiting both antineoplastic and anti-inflammatory activities, this compound shows potential in cancer t...
TN5336	9-Oxo-10,11-dehydroageraphorone	4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone
	9-Oxo-10,11-dehydroageraphorone has acaricidal activity. It induces hepatotoxicity and cholestasis in rats. 9-Oxo-10,11-dehydroageraphorone also effectively inhibits the proliferation of HeLa cells by arresting the cell ...
T75569	Xerophilusin B
	Xerophilusin B, isolated from Isodon xerophilus as an anticancer agent, demonstrates antiproliferative effects on esophageal squamous cell carcinoma (ESCC) cell lines. It induces m>G2m>/M cell cycle arrest and mediates apopt...
TN5190	Tryprostatin A		Topoisomerase , Antifection
	Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mammalian cell cycle at the m>G2m>/M phase.		Topoisomerase , Antifection
TN2344	Swainsonine	Tridolgosir	Apoptosis , Others , Antibiotic
	Swainsonine (Tridolgosir) is an alkaloid isolated from Astragalus membranaceus and is a potent and reversible inhibitor of alpha-mannosidase. swainsonine has antitumour activity and induces apoptosis and cell cycle arres...		Apoptosis , Others , Antibiotic
TN1953	Morusinol		ERK , MEK , Autophagy , Ras
	Morusinol is a flavonoid extracted from the root bark of Morus alba. Morusinol has antiplatelet and anticancer activities, inhibits arterial thrombosis in vivo, and exerts antitumor activity by inducing autophagy, m>G2m>/M c...		ERK , MEK , Autophagy , Ras
TN1617	Ergosta-4,6,8(14),22-tetraen-3-one		BCL , Caspase , p53
	Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce m>G2m>/M cell cycle arrest and apoptosis in human hepatocellular carcinoma Hepm>G2m> cells, these results would be useful...		BCL , Caspase , p53
T75602	Albanol B
	Albanol B, an arylbenzofuran derivative, is extracted from mulberries and demonstrates multifarious biological activities, including anti-Alzheimer's, anti-bacterial, and antioxidant effects. It inhibits the proliferatio...
T36961	Malformin C
	Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce m>G2m> arrest in human...
TN5639	Rocaglaol	Ferrugin,Aglaiastatin A
	Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its m>G2m>/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylatio...

天然物製品

Juglanin

TQ0089

Synonym:

Target: Apoptosis, JNK, Autophagy

Citric acid monohydrate

Synonym: Citro,Citretten

Target: Apoptosis, Others, Endogenous Metabolite, Antibacterial, Antibiotic

(S)-10-Hydroxycamptothecin

T2764

Synonym: 10-Hydroxycamptothecin,10-HCPT

Target: Apoptosis, Topoisomerase

Acacetin

T3981

Synonym: 4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin

Target: Apoptosis, IAP, COX, Autophagy

Persicogenin

TN2058

Synonym:

Target: Anti-infection

1-Monopalmitin

TN2554

Synonym: Glyceryl palmitate

Target: Apoptosis

Daphnoretin

T4S1335

Synonym: Dephnoretin,Thymelol

Target: Influenza Virus, Caspase, PKC

Taccalonolide A

TN2254

Synonym:

Target: Apoptosis, Microtubule Associated

9-Methoxycamptothecin

T5S1952

Synonym:

Target: Apoptosis, Topoisomerase

Oxypeucedanin

T3S0081

Synonym: (+-)-Oxypeucedanin,Oxypeucadanin

Target: Potassium Channel

Polyphyllin VI

T6S2315

Synonym:

Target: Apoptosis, Antibacterial, Pyroptosis

Beta-Sitosterol

T2966

Synonym: Cupreol,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,22,23-Dihydrostigmasterol,Betaprost

Target: Apoptosis, Lipase, Endogenous Metabolite

AMAROGENTIN

T5497

Synonym:

Target: Apoptosis, AMPK

Target: Apoptosis, BCL, COX, UGT

Docetaxel trihydrate

T0186

Synonym: RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate

Target: Apoptosis, BCL, Microtubule Associated

Polyphyllin I

T3895

Synonym:

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

Chelidonine

T5S0055

Synonym: Helidonine,Khelidonin,Stylophorin

Target: Apoptosis, Others, Influenza Virus

9-Oxo-10,11-dehydroageraphorone

TN5336

Synonym: 4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone

Target: Topoisomerase, Antifection

Swainsonine

TN2344

Synonym: Tridolgosir

Target: Apoptosis, Others, Antibiotic

Morusinol

TN1953

Synonym:

Target: ERK, MEK, Autophagy, Ras

Ergosta-4,6,8(14),22-tetraen-3-one

TN1617

Synonym:

Target: BCL, Caspase, p53

Synonym: Ferrugin,Aglaiastatin A

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-00604	CDTA Protein, E. coli, Recombinant (His)	E. coli	E. coli
	CDTs are cytotoxins which induce host cell distension, growth arrest in m>G2m>/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells. CdtA, along with CdtC, probably forms a heterodimeric subunit required for ...
TMPH-03269	COMMD5 Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle m>G2m>/M phase transition probably by transactivating p21/CDKN1A through the ...
TMPH-03748	KAT14 Protein, Human, Recombinant (His)	Human	E. coli
	Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltrans...
TMPH-00605	CDTB Protein, E. coli, Recombinant (His & Myc & SUMO)	E. coli	E. coli
	Part of the tripartite complex that is required for the CDT activity. CdtB exhibits a DNA-nicking endonuclease activity, and very probably causes DNA damage in intoxicated cells. This damage induces m>G2m>/M cell cycle arres...
TMPY-02046	PFDN1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to m>G2m>/M cell cycle blockage and cytoskeletal deficiency. PFDN1...
TMPY-03989	PFDN1 Protein, Human, Recombinant (His)	Human	E. coli
	PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to m>G2m>/M cell cycle blockage and cytoskeletal deficiency. PFDN1...
TMPY-03655	GADD45G Protein, Human, Recombinant	Human	E. coli
	GADD45G, also known as CR6, is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45G re...
TMPJ-00988	SEPHS1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Selenophosphate synthetase 1 (SEPHS1) belongs to the selenophosphate synthase 1 family, Class II subfamily. It has four different isoforms by alternative splicing. Isoform 1 and isoform 2 are gradually expressed during t...
TMPY-03672	Survivin Protein, Human, Recombinant	Human	E. coli
	BIRC5, also known as Survivin and EPR-1, is a member of theIAP family. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but BIRC5 has only a single BIR domain. It is expressed cell cycle-...
TMPH-00028	Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 Protein (His & MBP)	AAV-2	E. coli
	Plays an essential role in the initiation of viral DNA synthesis. Binds specifically to an inverted terminal repeat element (ITR) on the 3' and 5' ends of the viral DNA, where it cleaves a site specifically to generate a...
TMPH-00536	Epstein-Barr virus (strain AG876) EBNA2 Protein (His & Myc)	EBV	P. pastoris (Yeast)
	Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes inc...
TMPY-02496	Rad6/UBE2A Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A), encoded by human DNA repair genes HHR6A, belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication ...
TMPY-04547	PBK/TOPK Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the chara...
TMPY-04389	MAP3K8 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that ...
TMPY-04542	CDK2 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinas...
TMPH-02613	ATF-5 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific respo...

CDTA Protein, E. coli, Recombinant (His)

TMPH-00604

Species: E. coli

Expression System: E. coli

COMMD5 Protein, Rat, Recombinant (His & Myc)

TMPH-03269

Species: Rat

Expression System: E. coli

KAT14 Protein, Human, Recombinant (His)

TMPH-03748

Species: Human

Expression System: E. coli

CDTB Protein, E. coli, Recombinant (His & Myc & SUMO)

TMPH-00605

Species: E. coli

Expression System: E. coli

PFDN1 Protein, Mouse, Recombinant (His)

TMPY-02046

Species: Mouse

Expression System: E. coli

PFDN1 Protein, Human, Recombinant (His)

TMPY-03989

Species: Human

Expression System: E. coli

GADD45G Protein, Human, Recombinant

TMPY-03655

Species: Human

Expression System: E. coli

SEPHS1 Protein, Human, Recombinant (His)

TMPJ-00988

Species: Human

Expression System: HEK293 Cells

Survivin Protein, Human, Recombinant

TMPY-03672

Species: Human

Expression System: E. coli

Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 Protein (His & MBP)

TMPH-00028

Species: AAV-2

Expression System: E. coli

Epstein-Barr virus (strain AG876) EBNA2 Protein (His & Myc)

TMPH-00536

Species: EBV

Expression System: P. pastoris (Yeast)

Rad6/UBE2A Protein, Human, Recombinant (His)

TMPY-02496

Species: Human

Expression System: E. coli

PBK/TOPK Protein, Human, Recombinant (His)

TMPY-04547

Species: Human

Expression System: Baculovirus Insect Cells

MAP3K8 Protein, Human, Recombinant (GST)

TMPY-04389

Species: Human

Expression System: Baculovirus Insect Cells

CDK2 Protein, Human, Recombinant (His)

TMPY-04542

Species: Human

Expression System: Baculovirus Insect Cells

ATF-5 Protein, Mouse, Recombinant (His & Myc)

TMPH-02613

Species: Mouse

Expression System: E. coli

カタログ番号	製品名
L8100	Cell Cycle Compound Library		677 compounds
	A unique collection of xnum cell cycle related compounds for high throughput screening (HTS) and high content screening (HCS);

ライブラリー

Cell Cycle Compound Library

L8100

Compounds: 677