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T9988 |
Wnt/β-catenin agonist 3
|
|
Wnt/beta-catenin
|
|
Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist. |
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T41094 |
Wnt/β-catenin agonist 2
|
|
GSK-3
,
Wnt/beta-catenin
|
|
Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist. Wnt/β-catenin agonist 2 can be used in the study of diseases related to signal transduction and is closely related to cancer inva... |
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T60803 |
Wnt/β-catenin agonist 4
|
|
Wnt/beta-catenin
|
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Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling. |
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T13344 |
Wnt/β-catenin agonist 1
|
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Others
|
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Wnt/β-catenin agonist 1 is an agonist of Wnt/β-catenin signalling pathway(EC50 of 0.27 μM). |
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T6868 |
KYA1797K
|
|
Wnt/beta-catenin
|
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KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay. |
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T8400 |
Pamidronic acid
|
|
Wnt/beta-catenin
|
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Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells |
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T8710 |
MSAB
|
|
Wnt/beta-catenin
|
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MSAB is a selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. |
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T6989 |
SKL2001
|
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Wnt/beta-catenin
|
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SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction. |
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T15137 |
DK419
|
|
Wnt/beta-catenin
,
AMPK
|
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DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK. |
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T15677 |
KY1220
|
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Wnt/beta-catenin
|
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KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells. |
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T9151 |
Teplinovivint
|
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Wnt/beta-catenin
|
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Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy research. |
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T7204 |
PNU-74654
|
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Apoptosis
,
Wnt/beta-catenin
|
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PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway. |
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T2413 |
FH535
|
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Wnt/beta-catenin
,
PPAR
|
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FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities. |
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T2161 |
Cardiogenol C
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Wnt/beta-catenin
|
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Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells. |
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T3635 |
IQ 1
|
IQ1,IQ-1 |
Wnt/beta-catenin
|
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IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions, and so on. |
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T10904 |
CWP232228
|
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Wnt/beta-catenin
|
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CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting t... |
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T22884 |
JW 67
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Wnt/beta-catenin
|
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JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1. |
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TP1263 |
Fz7-21
|
(Ac)-LPSDDLEFWCHVMY-NH2 |
Wnt/beta-catenin
|
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Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2) is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with e... |
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T11284 |
FIDAS-3
|
|
Others
,
Wnt/beta-catenin
,
Methionine Adenosyltransferase (MAT)
|
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FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by effectively competing with S-adenosylmethionine (SAM) for ... |
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T82235 |
HCA/Wnt/β-catenin-IN-1
|
|
|
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hCA/Wnt/β-catenin-IN-1 (Compd 15) serves as an inhibitor with selective affinity for hCA isoforms II, IX, and XII, exhibiting K i values of 33.6, 24.1, and 6.8 nM, respectively. Additionally, this compound attenuates P-g... |
|
T2310 |
CHIR-99021
|
Laduviglusib,CT99021,CHIR-99021 |
GSK-3
,
Wnt/beta-catenin
,
Autophagy
|
|
CHIR-99021 (CT99021) is an activator of the Wnt/β-catenin signaling pathway and a GSK-3α/β inhibitor (IC50=10/6.7 nM) with selective and oral activity.CHIR-99021 induces cellular autophagy, which enhances self-renewal in... |
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T6150 |
TAK-715
|
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p38 MAPK
,
Casein Kinase
,
JNK
|
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TAK-715 is a p38 MAPK inhibitor for p38α. |
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T16079 |
Mirodenafil
|
SK3530 |
PDE
|
|
Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction. |
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T8005 |
Cardiogenol C hydrochloride
|
Cardiogenol C HCl,Cardiogenol C |
Wnt/beta-catenin
|
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Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM). |
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T11571 |
HLY78
|
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine |
Wnt/beta-catenin
|
|
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling. |
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TQ0126 |
Mirodenafil dihydrochloride
|
SK-3530 dihydrochloride |
PDE
|
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Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction. |
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T9025 |
KY19382
|
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382,A3051 |
Others
,
GSK-3
,
Wnt/beta-catenin
|
|
KY19382 (2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382) is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β( IC50s of 19 and 10 nM, respectively). It... |
|
T4302 |
ICRT3
|
|
Apoptosis
,
Wnt/beta-catenin
|
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iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor. |
|
T27582 |
ICRT-5
|
iCRT 5,iCRT5 |
Apoptosis
,
Wnt/beta-catenin
|
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iCRT-5 is a potent inhibitor of the Wnt pathway. iCRT-5 has antiproliferative activity, blocking Wnt/β-catenin expression and inducing apoptosis. iCRT-5 can be used in the study of multiple myeloma. |
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T4022 |
QS11
|
QS 11 |
GTPase
|
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QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also r... |
|
T6113 |
ICG-001
|
|
Apoptosis
,
Epigenetic Reader Domain
,
Wnt/beta-catenin
|
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ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. |
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T9662 |
SRI 37892
|
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Wnt/beta-catenin
|
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SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability. |
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T3062 |
WIKI4
|
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PARP
,
Wnt/beta-catenin
|
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WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2). |
|
T7399 |
LF3
|
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Wnt/beta-catenin
|
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LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM) |
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T15363 |
FzM1.8
|
|
Wnt/beta-catenin
|
|
FzM1.8 is an allosteric FZD4 agonist with a pEC50 of 6.4. FzM1.8 binds to FZD4, promotes TCF/LEF transcriptional activity in the absence of any WNT ligand, and activates the WNT/β-catenin pathway. |
|
T4486 |
ICRT 14
|
|
Wnt/beta-catenin
|
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iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity). |
|
T39508 |
KY-02327
|
|
Others
|
|
KY-02327, a metabolically stabilized analog of KY-02061, serves as a potent inhibitor of the Dishevelled (Dvl)-CXXC5 interaction. This compound activates the Wnt/β-catenin pathway, thereby promoting osteoblast differenti... |
|
T1878 |
XAV-939
|
XAV939,NVP-XAV939 |
PARP
,
Wnt/beta-catenin
|
|
XAV-939 (NVP-XAV939) is a Tankyrase (TNKS) inhibitor that inhibits TNKS1 and TNKS2 (IC50=11/4 nM). XAV-939 selectively inhibits Wnt/β-catenin-mediated transcription. |
|
T67884 |
β-catenin modulator IIa-661
|
|
Wnt/beta-catenin
|
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β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity. |
|
T5642 |
Tegatrabetan
|
BC2059 |
Wnt/beta-catenin
|
|
Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity. |
|
T2237 |
ICG001
|
|
Epigenetic Reader Domain
,
Wnt/beta-catenin
|
|
ICG001 (PRI-724 isomer) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coacti... |
|
T73415 |
Miclxin
|
DS37262926 |
Wnt/beta-catenin
|
|
Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent inhibitor of mutant β-catenin, which is involved in the Wnt sign... |
|
T9500 |
M435-1279
|
|
E1/E2/E3 Enzyme
|
|
M435-1279 is a UBE2T inhibitor. M435-1279 blocks UBE2T-mediated degradation of RACK1, leading to inhibit the hyperactivation of Wnt/β-catenin signaling pathway. |
|
T1971 |
WAY-262611
|
|
Wnt/beta-catenin
|
|
WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay. |
|
T22775 |
Exo-IWR-1
|
exo-IWR 1 |
Wnt/beta-catenin
|
|
exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway. |
|
T9557 |
TNIK-IN-2
|
|
Wnt/beta-catenin
|
|
TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway. |
|
T7333 |
Pyrvinium pamoate
|
Pyrvinium embonate |
Wnt/beta-catenin
|
|
Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition of Wnt/β-catenin pathway in some types ... |
|
T36848 |
Combretastatin A-1
|
Combretastatin A1 |
Akt
,
Microtubule Associated
|
|
Combretastatin A-1 is a potent microtubule inhibitor with anti-tumour and anti-vascular activity, acting through microtubule protein depolymerisation-mediated inactivation of AKT to inhibit the Wnt/β-catenin pathway, and... |
|
T60485 |
DIF-3
|
|
|
|
DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins. In addition, DIF-3 inhibits Wnt/β-catenin signal... |
|
T4013 |
SGC2085 HCl
|
|
Histone Methyltransferase
|
|
SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulat... |
