|
T7824 |
Eberconazole Nitrate
|
Ebernet |
Antifungal
|
|
Eberconazole Nitrate (Ebernet) is an azole antifungal agent and broad-spectrum imidazole derivative. |
|
T22976 |
MFZ 10-7
|
|
Others
,
GluR
|
|
MFZ 10-7 is anegative allosteric modulator of the mGluR5. |
|
T8959 |
OS-3-106
|
|
Dopamine Receptor
|
|
OS-3-106 is a novel arylamide phenylpiperazines, as partial agonists at the D3R in the adenylyl cyclase inhibition assay. |
|
T15799 |
LY2940094
|
LY-2940094 |
Opioid Receptor
|
|
LY2940094 (LY-2940094) decreases ethanol self-administration in animal models. LY2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist pot... |
|
T39161 |
Ro60-0175
|
Ro60-0175 |
5-HT Receptor
|
|
Ro60-0175 a selective agonist for both the 5-hydroxytryptamine 2B (5-HT2B) and 5-hydroxytryptamine 2C (5-HT2C)serotonin receptor subtypes, commonly used as fumarate salt. It has a role as a 5-hydroxytryptamine 2B recept... |
|
T6322 |
Copanlisib
|
BAY 80-6946 |
Apoptosis
,
PI3K
|
|
Copanlisib (BAY 80-6946) is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor c... |
|
T14998 |
Copanlisib dihydrochloride
|
BAY 80-6946 dihydrochloride |
Apoptosis
,
PI3K
,
mTOR
|
|
Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is an ATP-competitive pan-class I PI3K inhibitor (IC50s: 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ). Copanlisib dihydrochloride has super... |
|
T1459 |
Cisatracurium besylate
|
51W89 |
Adrenergic Receptor
,
AChR
,
Autophagy
|
|
Cisatracurium besylate (51W89) is a nondepolarizing skeletal muscle relaxant for intravenous administration. |
|
T21983L |
PKI 14-22 amide, myristoylated Acetate
|
PKI 14-22 amide, myristoylated Acetate(201422-03-9 Free base) |
PKA
|
|
PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP. |
|
T28396 |
PGP-4008
|
PGP 4008,PGP4008 |
P-gp
|
|
PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin. |
|
T5467 |
SAR125844
|
SAR125884 |
Apoptosis
,
c-Met/HGFR
|
|
SAR125844, a potent and highly selective inhibitor of the MET receptor tyrosine kinase (RTK), for intravenous administration. (IC50 value of 4.2 nmol/L) |
|
T10124 |
Antiulcer Agent 1
|
|
Others
|
|
Antiulcer Agent 1 is a 2-(3,4-dimethoxyphenyl)ethylamine derivative for oral administration. |
|
T69467 |
Azacosterol
|
IMD760,Diazasterol |
Others
|
|
Azacosterol (Diazasterol) is a DHCR24 inhibitor.Azacosterol undergoes a series of reactions in cortical neurons following oral or intraperitoneal administration. |
|
T2322 |
Fimasartan
|
BR-A-657,Kanarb |
Apoptosis
,
RAAS
|
|
Fimasartan (BR-A-657) is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Concurrent administration of fimasartan with diuretic hydrochlorothiazide has show... |
|
T79909 |
AEF0117
|
|
Cannabinoid Receptor
|
|
AEF0117, a signaling-specific inhibitor of cannabinoid receptor 1 (CB1-SSi), inhibits cannabinoid self-administration and behavioral disorders associated with THC, and can be used to study cannabis withdrawal. |
|
T71012 |
Nemazoline Free Base
|
|
|
|
Nemazoline Free Base is a nasal decongestant. It has alpha 1-agonist/alpha 2-antagonist activity and was more effective and long-acting than oxymetazoline on canine nasal mucosa, in-vitro and in-vivo. Upon intranasal adm... |
|
T9422 |
Fosciclopirox
|
CPX-POM |
Gamma-secretase
|
|
Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire urinary tract following parenteral administration. |
|
T1551 |
Tegaserod maleate
|
HTF-919,SDZ-HTF-919 |
5-HT Receptor
|
|
Tegaserod maleate (SDZ-HTF-919) is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United States Food and Drug ... |
|
T13730 |
Hydroxocobalamin acetate
|
|
Others
|
|
Hydroxocobalamin acetate is used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia. Hydroxocobalamin, an injectable naturally occurring form of vitamin B12 with a favorable ad... |
|
T1066 |
Ketanserin
|
R41468,Ketanserin tartrate,Ketanserinum |
Potassium Channel
,
5-HT Receptor
,
Autophagy
|
|
Ketanserin (Ketanserinum) is a quinazoline derivative and serotonin (5-hydroxytryptamine, 5HT) receptor subtype 2 (5-HTR2) antagonist with potential antihypertensive and antiplatelet activities. Following administration,... |
|
T4121 |
Bicyclol
|
SY801 |
HBV
,
Autophagy
|
|
Bicyclol (SY801)(SY 801) is an anti-hepatitis drug. Oral administration of bicyclol normalizes the elevated serum transaminases (ALT, AST) by 50% in chronic viral hepatitis B and C, and also has a certain level of inhibi... |
|
T4235 |
Roblitinib
|
FGF-401 |
FGFR
|
|
Roblitinib (FGF-401) is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, Roblitinib binds to and inhibits the activity of FGFR4, which leads ... |
|
T0500 |
Chloroxine
|
Capitrol |
Antibacterial
,
Antibiotic
|
|
Chloroxine (Capitrol) is a synthetic quinoline derivative with antibacterial activity. Although the mechanism of action is not fully understood, topical administration of chloroxine diminishes mitotic activity in the epi... |
|
T1386 |
Phenazopyridine hydrochloride
|
Urodine,Pyridium,Phenazopyridine HCl |
Sodium Channel
|
|
Phenazopyridine hydrochloride (Pyridium) is used orally as a urinary tract analgesic. Side effects of phenazopyridine hydrochloride administration can include nausea, interference with the oxygen-carrying capacity of red... |
|
T4990 |
Cefcapene pivoxil hydrochloride hydrate
|
Cefcapene Pivoxil Hydrochloride |
Antibacterial
,
Antibiotic
|
|
Cefcapene pivoxil hydrochloride hydrate is the pivalate ester prodrug form of cefcapene, a semi-synthetic third-generation cephalosporin with antibacterial activity. After oral administration of cefcapene pivoxil, the es... |
|
T4236 |
AR-M 1000390 hydrochloride
|
ARM390 Hydrochloride,ARM-390 HCl |
Opioid Receptor
|
|
AR-M 1000390 hydrochloride (ARM-390 HCl) , also known as ARM-390, is a low-internalizing nonpeptidic δ-selective opioid receptor agonist; derivative of SNC 80. Does not trigger acute desensitization of the analgesic resp... |
|
T36520 |
COR659
|
|
Cannabinoid Receptor
,
GABA Receptor
|
|
COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1].
COR659 apparently exerts its effects via a composite mechanism, including positive allosteri... |
|
T22277L |
BMS-P5 free base
|
|
PAD
|
|
BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma. Administration of BMS-... |
|
T1184 |
Rivaroxaban
|
BAY 59-7939 |
Factor Xa
,
Thrombin
|
|
Rivaroxaban (BAY 59-7939) is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both ... |
|
T3489 |
Dasabuvir
|
ABT-333 |
HCV Protease
|
|
Dasabuvir (ABT-333) is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intra... |
|
T9930 |
Secukinumab
|
|
IL Receptor
|
|
Secukinumab is a fully humanized monoclonal anti-IL-17A antibody and the first in its class to be approved by the US Food and Drug Administration for the treatment of moderate to severe plaque psoriasis. |
|
T0357 |
Potassium iodide
|
|
Tyrosinase
|
|
Potassium iodide is used as the treatment of overactive thyroid and as protection of the thyroid gland from the influences of radiation from swallowed or inhaled radioactive iodine. It may be used after accidental exposu... |
|
T2078 |
Fimepinostat
|
CUDC-907,PI3K/HDAC Inhibitor,CUDC 907 |
Apoptosis
,
PI3K
,
HDAC
|
|
Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, C... |
|
TP2111L |
TAT-GluA2 3Y acetate(1404188-93-7 free base)
|
|
GluR
|
|
TAT-GluA2 3Y acetate is an inhibitor of AMPA receptor endocytosis.Systemic administration of Tat-GluA2(3Y) during the induction phase of d-amphetamine blocked maintenance of behavioural sensitization and attenuated the m... |
|
TP1898 |
HS024
|
HS 024 |
Melanocortin Receptor
|
|
HS024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-... |
|
T1024 |
Roflumilast
|
B9302-107,BYK 20869,APTA 2217,BY 217 |
PDE
,
RSV
|
|
Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activities. Upon administration, roflumilast and its act... |
|
T27806 |
Lecozotan HCl
|
SRA-333,SRA333,SRA 333,Lecozotan hydrochloride |
5-HT Receptor
|
|
Lecozotan HCl (SRA-333) is a potent and selective 5-HT antagonist that significantly enhances KCl-stimulated glutamate and acetylcholine release from the hippocampal dentate gyrus and has cognitive enhancing properties. ... |
|
T13683 |
Epsilon-momfluorothrin
|
Momfluorothrin, (Z,1R,3R)- |
Others
|
|
Epsilon-momfluorothrin (Momfluorothrin, (Z,1R,3R)-), a type I synthetic pyrethroid insecticide, exerts its insecticidal properties and triggers activation of the constitutive androstane receptor (CAR). Notably, its admin... |
|
T1281 |
Tropicamide
|
Ro 1-7683 |
AChR
|
|
Tropicamide (Ro 1-7683) is a synthetic muscarinic antagonist with actions similar to atropine and with an anticholinergic property. Upon ocular administration, tropicamide binds to and blocks the muscarinic receptors in ... |
|
T13193 |
TPN171
|
|
PDE
|
|
TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary arterial hypertension (PAH). TPN171 was proven to exert a longer l... |
|
T68043 |
Ciamexon
|
Ciamexone,BM 41332,BM41332,BM-41332 |
Others
|
|
Ciamexon (Ciamexone) is a novel immunomodulator that has shown promising results in experimental models of autoimmune disease with little demonstrated cytotoxicity.Ciamexon can be used to study endocrine ophthalmopathies... |
|
T1790 |
Fosaprepitant dimeglumine
|
L785298,MK-0517,Fosaprepitant dimeglumine salt |
Neurokinin receptor
|
|
Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion... |
|
T4978 |
Sarpogrelate hydrochloride
|
MCI-9042 |
5-HT Receptor
|
|
Sarpogrelate hydrochloride (MCI-9042) , a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD. Target: 5-HT2 Recepter Sarpogrelate is a drug which acts as an antagonist at ... |
|
T71356 |
Lanperisone HCl
|
|
|
|
Lanperisone, also known as NK433, is a muscle relaxant. NK433 inhibited the facilitation of the flexor reflex mediated by group II afferent fibers that was induced by intrathecal administration of noradrenaline-HCl. NK43... |
|
T3661 |
Citarinostat
|
ACY241,HDAC-IN-2 |
HDAC
|
|
ACY-241, also known as Citarinostat (ACY241), is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activ... |
|
T3712 |
Mivebresib
|
ABBV-075 |
Apoptosis
,
Epigenetic Reader Domain
|
|
Mivebresib (ABBV-075), also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing protein) with potential antineoplastic activity. Upon administration, the bromodomain inhibitor ABBV-075 binds to the... |
|
T60538 |
SARS-CoV-2-IN-14
|
3',5-Dichlorosalicylanilide |
SARS-CoV
|
|
SARS-CoV-2-IN-14 is a potent and oral inhibitor of SARS-CoV-2 (IC50:0.39 μM), which is an analogue of niclosamide. SARS-CoV-2-IN-14 was more stable than niclosamide in the determination of human plasma and liver S9 enzym... |
|
T3560 |
Desmethylanethol trithione
|
ADT-OH |
VEGFR
,
Akt
|
|
Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly... |
|
T1242 |
Alvimopan
|
|
Opioid Receptor
|
|
Alvimopan (LY 246736) is a synthetic trans-3, 4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid... |
|
T3716 |
Rolapitant
|
SCH619734 |
Neurokinin receptor
|
|
Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. ... |
